Rational design of cationic lipids for siRNA delivery von Semple, Sean C, Akinc, Akin, Chen, Jianxin, Sandhu, Ammen P, Mui, Barbara L, Cho, Connie K, Sah, Dinah W Y, Stebbing, Derrick, Crosley, Erin J, Yaworski, Ed, Hafez, Ismail M, Dorkin, J Robert, Qin, June, Lam, Kieu, Rajeev, Kallanthottathil G, Wong, Kim F, Jeffs, Lloyd B, Nechev, Lubomir, Eisenhardt, Merete L, Jayaraman, Muthusamy, Kazem, Mikameh, Maier, Martin A, Srinivasulu, Masuna, Weinstein, Michael J, Chen, Qingmin, Alvarez, Rene, Barros, Scott A, De, Soma, Klimuk, Sandra K, Borland, Todd, Kosovrasti, Verbena, Cantley, William L, Tam, Ying K, Manoharan, Muthiah, Ciufolini, Marco A, Tracy, Mark A, de Fougerolles, Antonin, MacLachlan, Ian, Cullis, Pieter R, Madden, Thomas D, Hope, Michael J

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A combinatorial library of lipid-like materials for delivery of RNAi therapeutics von Anderson, Daniel G, Akinc, Akin, Zumbuehl, Andreas, Goldberg, Michael, Leshchiner, Elizaveta S, Busini, Valentina, Hossain, Naushad, Bacallado, Sergio A, Nguyen, David N, Fuller, Jason, Alvarez, Rene, Borodovsky, Anna, Borland, Todd, Constien, Rainer, de Fougerolles, Antonin, Dorkin, J Robert, Narayanannair Jayaprakash, K, Jayaraman, Muthusamy, John, Matthias, Koteliansky, Victor, Manoharan, Muthiah, Nechev, Lubomir, Qin, June, Racie, Timothy, Raitcheva, Denitza, Rajeev, Kallanthottathil G, Sah, Dinah W Y, Soutschek, Jürgen, Toudjarska, Ivanka, Vornlocher, Hans-Peter, Zimmermann, Tracy S, Langer, Robert

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Peritoneal Macrophage-Specific TNF‑α Gene Silencing in LPS-Induced Acute Inflammation Model Using CD44 Targeting Hyaluronic Acid Nanoparticles von Kosovrasti, Verbena Y, Nechev, Lubomir V, Amiji, Mansoor M

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Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates von Frank-Kamenetsky, Maria, Grefhorst, Aldo, Anderson, Norma N, Racie, Timothy S, Bramlage, Birgit, Akinc, Akin, Butler, David, Charisse, Klaus, Dorkin, Robert, Fan, Yupeng, Gamba-Vitalo, Christina, Hadwiger, Philipp, Jayaraman, Muthusamy, John, Matthias, Jayaprakash, K. Narayanannair, Maier, Martin, Nechev, Lubomir, Rajeev, Kallanthottathil G, Read, Timothy, Röhl, Ingo, Soutschek, Jürgen, Tan, Pamela, Wong, Jamie, Wang, Gang, Zimmermann, Tracy, de Fougerolles, Antonin, Vornlocher, Hans-Peter, Langer, Robert, Anderson, Daniel G, Manoharan, Muthiah, Koteliansky, Victor, Horton, Jay D, Fitzgerald, Kevin

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RNA Interference-Mediated Silencing of the Respiratory Syncytial Virus Nucleocapsid Defines a Potent Antiviral Strategy von ALVAREZ, Rene, ELBASHIR, Sayda, VAN RANST, Mark, TRIPP, Ralph A, DEVINCENZO, John P, PANDEY, Rajendra, MAIER, Martin, NECHEV, Lubomir, MANOHARAN, Muthiah, KOTELIANSKI, Victor, MEYERS, Rachel, BORLAND, Todd, TOUDJARSKA, Ivanka, HADWIGER, Philipp, JOHN, Mathias, ROEHL, Ingo, SHULGA MORSKAYA, Svetlana, MARTINELLO, Rick, KAHN, Jeffrey

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DNA Interchain Cross-Links Formed by Acrolein and Crotonaldehyde von Kozekov, Ivan D, Nechev, Lubomir V, Moseley, M. Scott, Harris, Constance M, Rizzo, Carmelo J, Stone, Michael P, Harris, Thomas M

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RNAi-mediated gene silencing in non-human primates von Wheat, Amanda J, Vornlocher, Hans-Peter, Röhl, Ingo, Lam, Kieu, McClintock, Kevin, Koteliansky, Victor, Yaworski, Ed, Jeffs, Lloyd B, MacLachlan, Ian, Soutschek, Jürgen, Toudjarska, Ivanka, Palmer, Lorne R, Heyes, James A, Zedalis, William, Akinc, Akin, Lee, Amy C. H, Bumcrot, David, Manoharan, Muthiah, Judge, Adam D, Racie, Timothy, Shanmugam, Sumi, Sood, Vandana, Seiffert, Stephan, Bramlage, Birgit, Fedoruk, Matthew N, Harborth, Jens, Zimmermann, Tracy S, John, Matthias, Nechev, Lubomir V

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Unique Gene-Silencing and Structural Properties of 2′-Fluoro-Modified siRNAs von Manoharan, Muthiah, Akinc, Akin, Pandey, Rajendra K, Qin, June, Hadwiger, Philipp, John, Matthias, Mills, Kathy, Charisse, Klaus, Maier, Martin A, Nechev, Lubomir, Greene, Emily M, Pallan, Pradeep S, Rozners, Eriks, Rajeev, Kallanthottathil G, Egli, Martin

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Mammalian cell mutagenesis of the DNA adducts of vinyl chloride and crotonaldehyde von Fernandes, Priscilla H., Kanuri, Manorama, Nechev, Lubomir V., Harris, Thomas M., Lloyd, R. Stephen

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Error Prone Translesion Synthesis Past γ-Hydroxypropano Deoxyguanosine, the Primary Acrolein-derived Adduct in Mammalian Cells von Kanuri, Manorama, Minko, Irina G., Nechev, Lubomir V., Harris, Thomas M., Harris, Constance M., Lloyd, R. Stephen

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Convergent Biocatalytic Mediated Synthesis of siRNA von Paul, Stephanie, Gray, Darren, Caswell, Jill, Brooks, Joshua, Ye, Wenjie, Moody, Thomas S., Radinov, Roumen, Nechev, Lubomir

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Spectroscopic Characterization of Interstrand Carbinolamine Cross-Links Formed in the 5‘-CpG-3‘ Sequence by the Acrolein-Derived γ-OH-1,N  2-Propano-2‘-deoxyguanosine DNA Adduct... von Cho, Young-Jin, Kim, Hye-Young, Huang, Hai, Slutsky, Alvira, Minko, Irina G, Wang, Hao, Nechev, Lubomir V, Kozekov, Ivan D, Kozekova, Albena, Tamura, Pamela, Jacob, Jaison, Voehler, Markus, Harris, Thomas M, Lloyd, R. Stephen, Rizzo, Carmelo J, Stone, Michael P

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Structural Studies of an Oligodeoxynucleotide Containing a Trimethylene Interstrand Cross-Link in a 5‘-(CpG) Motif: Model of a Malondialdehyde Cross-Link von Dooley, Patricia A, Tsarouhtsis, Dimitrios, Korbel, Gregory A, Nechev, Lubomir V, Shearer, Jill, Zegar, Irene S, Harris, Constance M, Stone, Michael P, Harris, Thomas M

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Interchain Cross-Linking of DNA Mediated by the Principal Adduct of Acrolein von Kozekov, Ivan D, Nechev, Lubomir V, Sanchez, Ana, Harris, Constance M, Lloyd, R. Stephen, Harris, Thomas M

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NMR Determination of the Conformation of a Trimethylene Interstrand Cross-Link in an Oligodeoxynucleotide Duplex Containing a 5‘-d(GpC) Motif von Dooley, Patricia A, Zhang, Mingzhou, Korbel, Gregory A, Nechev, Lubomir V, Harris, Constance M, Stone, Michael P, Harris, Thomas M

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Evaluation of the Mutagenic Potential of the Principal DNA Adduct of Acrolein von VanderVeen, Laurie A., Hashim, Muhammed F., Nechev, Lubomir V., Harris, Thomas M., Harris, Constance M., Marnett, Lawrence J.

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DNA Interstrand Cross-Links Induce Futile Repair Synthesis in Mammalian Cell Extracts von Mu, David, Bessho, Tadayoshi, Nechev, Lubomir V., Chen, David J., Harris, Thomas M., Hearst, John E., Sancar, Aziz

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Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV) von DeVincenzo, John, Cehelsky, Jeffrey E., Alvarez, Rene, Elbashir, Sayda, Harborth, Jens, Toudjarska, Iva, Nechev, Lubomir, Murugaiah, Veeravagu, Vliet, Andre Van, Vaishnaw, Akshay K., Meyers, Rachel

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Stereospecific Synthesis of Oligonucleotides Containing Crotonaldehyde Adducts of Deoxyguanosine von Nechev, Lubomir V, Kozekov, Ivan, Harris, Constance M, Harris, Thomas M

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Structure of the 1,4-Bis(2‘-deoxyadenosin-N 6-yl)-2S,3S-butanediol Intrastrand DNA Cross-Link Arising from Butadiene Diepoxide in the Human N-ras Codon 61 Sequence von Xu, Wen, Merritt, W. Keither, Nechev, Lubomir V, Harris, Thomas M, Harris, Constance M, Lloyd, R. Stephen, Stone, Michael P

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