Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity von Sivick, Kelsey E., Desbien, Anthony L., Glickman, Laura Hix, Reiner, Gabrielle L., Corrales, Leticia, Surh, Natalie H., Hudson, Thomas E., Vu, Uyen T., Francica, Brian J., Banda, Tamara, Katibah, George E., Kanne, David B., Leong, Justin J., Metchette, Ken, Bruml, Jacob R., Ndubaku, Chudi O., McKenna, Jeffrey M., Feng, Yan, Zheng, Lianxing, Bender, Steven L., Cho, Charles Y., Leong, Meredith L., van Elsas, Andrea, Dubensky, Thomas W., McWhirter, Sarah M.

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Inhibiting the deubiquitinating enzymes (DUBs) von Ndubaku, Chudi, Tsui, Vickie

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Synergy of a STING agonist and an IL-2 superkine in cancer immunotherapy against MHC I-deficient and MHC I + tumors von Wolf, Natalie K, Blaj, Cristina, Picton, Lora K, Snyder, Gail, Zhang, Li, Nicolai, Christopher J, Ndubaku, Chudi O, McWhirter, Sarah M, Garcia, K Christopher, Raulet, David H

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Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer von Kinkead, Heather L, Hopkins, Alexander, Lutz, Eric, Wu, Annie A, Yarchoan, Mark, Cruz, Kayla, Woolman, Skylar, Vithayathil, Teena, Glickman, Laura H, Ndubaku, Chudi O, McWhirter, Sarah M, Dubensky, Jr, Thomas W, Armstrong, Todd D, Jaffee, Elizabeth M, Zaidi, Neeha

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Discovery of 2‑{3-[2-(1-Isopropyl-3-methyl‑1H‑1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2‑d][1,4]oxazepin-9-yl]‑1H‑pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β‑Sparing... von Ndubaku, Chudi O, Heffron, Timothy P, Staben, Steven T, Baumgardner, Matthew, Blaquiere, Nicole, Bradley, Erin, Bull, Richard, Do, Steven, Dotson, Jennafer, Dudley, Danette, Edgar, Kyle A, Friedman, Lori S, Goldsmith, Richard, Heald, Robert A, Kolesnikov, Aleksandr, Lee, Leslie, Lewis, Cristina, Nannini, Michelle, Nonomiya, Jim, Pang, Jodie, Price, Steve, Prior, Wei Wei, Salphati, Laurent, Sideris, Steve, Wallin, Jeffery J, Wang, Lan, Wei, BinQing, Sampath, Deepak, Olivero, Alan G

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Discovery of a Potent and Selective BCL‑XL Inhibitor with in Vivo Activity von Tao, Zhi-Fu, Hasvold, Lisa, Wang, Le, Wang, Xilu, Petros, Andrew M, Park, Chang H, Boghaert, Erwin R, Catron, Nathaniel D, Chen, Jun, Colman, Peter M, Czabotar, Peter E, Deshayes, Kurt, Fairbrother, Wayne J, Flygare, John A, Hymowitz, Sarah G, Jin, Sha, Judge, Russell A, Koehler, Michael F. T, Kovar, Peter J, Lessene, Guillaume, Mitten, Michael J, Ndubaku, Chudi O, Nimmer, Paul, Purkey, Hans E, Oleksijew, Anatol, Phillips, Darren C, Sleebs, Brad E, Smith, Brian J, Smith, Morey L, Tahir, Stephen K, Watson, Keith G, Xiao, Yu, Xue, John, Zhang, Haichao, Zobel, Kerry, Rosenberg, Saul H, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J

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Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR von Heffron, Timothy P, Ndubaku, Chudi O, Salphati, Laurent, Alicke, Bruno, Cheong, Jonathan, Drobnick, Joy, Edgar, Kyle, Gould, Stephen E, Lee, Leslie B, Lesnick, John D, Lewis, Cristina, Nonomiya, Jim, Pang, Jodie, Plise, Emile G, Sideris, Steve, Wallin, Jeffrey, Wang, Lan, Zhang, Xiaolin, Olivero, Alan G

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Bio-inspired synthesis of xishacorenes A, B, and C, and a new congener from fuscol von Rovira, Alexander R, Müller, Nicolas, Deng, Weiwen, Ndubaku, Chudi, Sarpong, Richmond

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Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window von Rudolph, Joachim, Murray, Lesley J, Ndubaku, Chudi O, O’Brien, Thomas, Blackwood, Elizabeth, Wang, Weiru, Aliagas, Ignacio, Gazzard, Lewis, Crawford, James J, Drobnick, Joy, Lee, Wendy, Zhao, Xianrui, Hoeflich, Klaus P, Favor, David A, Dong, Ping, Zhang, Haiming, Heise, Christopher E, Oh, Angela, Ong, Christy C, La, Hank, Chakravarty, Paroma, Chan, Connie, Jakubiak, Diana, Epler, Jennifer, Ramaswamy, Sreemathy, Vega, Roxanne, Cain, Gary, Diaz, Dolores, Zhong, Yu

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Discovery of Selective 4‑Amino-pyridopyrimidine Inhibitors of MAP4K4 Using Fragment-Based Lead Identification and Optimization von Crawford, Terry D, Ndubaku, Chudi O, Chen, Huifen, Boggs, Jason W, Bravo, Brandon J, DeLaTorre, Kelly, Giannetti, Anthony M, Gould, Stephen E, Harris, Seth F, Magnuson, Steven R, McNamara, Erin, Murray, Lesley J, Nonomiya, Jim, Sambrone, Amy, Schmidt, Stephen, Smyczek, Tanya, Stanley, Mark, Vitorino, Philip, Wang, Lan, West, Kristina, Wu, Ping, Ye, Weilan

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Inhibiting the Deubiquitinating Enzymes (DUBs): Miniperspective von Ndubaku, Chudi, Tsui, Vickie

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Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity von Sivick, Kelsey E., Desbien, Anthony L., Glickman, Laura Hix, Reiner, Gabrielle L., Corrales, Leticia, Surh, Natalie H., Hudson, Thomas E., Vu, Uyen T., Francica, Brian J., Banda, Tamara, Katibah, George E., Kanne, David B., Leong, Justin J., Metchette, Ken, Bruml, Jacob R., Ndubaku, Chudi O., McKenna, Jeffrey M., Feng, Yan, Zheng, Lianxing, Bender, Steven L., Cho, Charles Y., Leong, Meredith L., van Elsas, Andrea, Dubensky, Thomas W., McWhirter, Sarah M.

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Design of Selective PAK1 Inhibitor G‑5555: Improving Properties by Employing an Unorthodox Low‑pK a Polar Moiety von Ndubaku, Chudi O, Crawford, James J, Drobnick, Joy, Aliagas, Ignacio, Campbell, David, Dong, Ping, Dornan, Laura M, Duron, Sergio, Epler, Jennifer, Gazzard, Lewis, Heise, Christopher E, Hoeflich, Klaus P, Jakubiak, Diana, La, Hank, Lee, Wendy, Lin, Baiwei, Lyssikatos, Joseph P, Maksimoska, Jasna, Marmorstein, Ronen, Murray, Lesley J, O’Brien, Thomas, Oh, Angela, Ramaswamy, Sreemathy, Wang, Weiru, Zhao, Xianrui, Zhong, Yu, Blackwood, Elizabeth, Rudolph, Joachim

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Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors von Wang, Lan, Stanley, Mark, Boggs, Jason W., Crawford, Terry D., Bravo, Brandon J., Giannetti, Anthony M., Harris, Seth F., Magnuson, Steven R., Nonomiya, Jim, Schmidt, Stephen, Wu, Ping, Ye, Weilan, Gould, Stephen E., Murray, Lesley J., Ndubaku, Chudi O., Chen, Huifen

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Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis von Ndubaku, Chudi O, Crawford, Terry D, Chen, Huifen, Boggs, Jason W, Drobnick, Joy, Harris, Seth F, Jesudason, Rajiv, McNamara, Erin, Nonomiya, Jim, Sambrone, Amy, Schmidt, Stephen, Smyczek, Tanya, Vitorino, Philip, Wang, Lan, Wu, Ping, Yeung, Stacey, Chen, Jinhua, Chen, Kevin, Ding, Charles Z, Wang, Tao, Xu, Zijin, Gould, Stephen E, Murray, Lesley J, Ye, Weilan

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Antagonism of c-IAP and XIAP Proteins Is Required for Efficient Induction of Cell Death by Small-Molecule IAP Antagonists von Ndubaku, Chudi, Varfolomeev, Eugene, Wang, Lan, Zobel, Kerry, Lau, Kevin, Elliott, Linda O, Maurer, Brigitte, Fedorova, Anna V, Dynek, Jasmin N, Koehler, Michael, Hymowitz, Sarah G, Tsui, Vickie, Deshayes, Kurt, Fairbrother, Wayne J, Flygare, John A, Vucic, Domagoj

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anti-1,2-Diols via Ni-Catalyzed Reductive Coupling of Alkynes and α-Oxyaldehydes von Luanphaisarnnont, Torsak, Ndubaku, Chudi O, Jamison, Timothy F

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USP7 small-molecule inhibitors interfere with ubiquitin binding von Kategaya, Lorna, Di Lello, Paola, Rougé, Lionel, Pastor, Richard, Clark, Kevin R., Drummond, Jason, Kleinheinz, Tracy, Lin, Eva, Upton, John-Paul, Prakash, Sumit, Heideker, Johanna, McCleland, Mark, Ritorto, Maria Stella, Alessi, Dario R., Trost, Matthias, Bainbridge, Travis W., Kwok, Michael C. M., Ma, Taylur P., Stiffler, Zachary, Brasher, Bradley, Tang, Yinyan, Jaishankar, Priyadarshini, Hearn, Brian R., Renslo, Adam R., Arkin, Michelle R., Cohen, Frederick, Yu, Kebing, Peale, Frank, Gnad, Florian, Chang, Matthew T., Klijn, Christiaan, Blackwood, Elizabeth, Martin, Scott E., Forrest, William F., Ernst, James A., Ndubaku, Chudi, Wang, Xiaojing, Beresini, Maureen H., Tsui, Vickie, Schwerdtfeger, Carsten, Blake, Robert A., Murray, Jeremy, Maurer, Till, Wertz, Ingrid E.

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MAP4K4 regulates integrin-FERM binding to control endothelial cell motility von Vitorino, Philip, Yeung, Stacey, Crow, Ailey, Bakke, Jesse, Smyczek, Tanya, West, Kristina, McNamara, Erin, Eastham-Anderson, Jeffrey, Gould, Stephen, Harris, Seth F., Ndubaku, Chudi, Ye, Weilan

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Abstract B28: Selective antagonism of IAP proteins for regulating apoptosis and TNF pathways von Ndubaku, Chudi

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