Identifying early pulmonary arterial hypertension biomarkers in systemic sclerosis: Machine learning on proteomics from the DETECT cohort von Bauer, Yasmina, de Bernard, Simon, Hickey, Peter, Ballard, Karri, Cruz, Jeremy, Cornelisse, Peter, Chadha-Boreham, Harbajan, Distler, Oliver, Rosenberg, Daniel, Doelberg, Martin, Roux, Sebastien, Nayler, Oliver, Lawrie, Allan

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Slow receptor dissociation kinetics differentiate macitentan from other endothelin receptor antagonists in pulmonary arterial smooth muscle cells von Gatfield, John, Mueller Grandjean, Celia, Sasse, Thomas, Clozel, Martine, Nayler, Oliver

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The Antifibrotic Activity of Prostacyclin Receptor Agonism Is Mediated through Inhibition of YAP/TAZ von Zmajkovicova, Katarina, Menyhart, Katalin, Bauer, Yasmina, Studer, Rolf, Renault, Berengere, Schnoebelen, Marie, Bolinger, Matthias, Nayler, Oliver, Gatfield, John

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GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1 von Zmajkovicova, Katarina, Bauer, Yasmina, Menyhart, Katalin, Schnoebelen, Marie, Freti, Diego, Boucher, Maxime, Renault, Bérengère, Studer, Rolf, Birker-Robaczewska, Magdalena, Klenk, Axel, Nayler, Oliver, Gatfield, John

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Novel high-throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP2 and EP4 receptors von Sieber, Patrick, Schäfer, Anny, Lieberherr, Raphael, Le Goff, François, Stritt, Manuel, Welford, Richard W D, Gatfield, John, Peter, Oliver, Nayler, Oliver, Lüthi, Urs

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A fully automated image analysis method to quantify lung fibrosis in the bleomycin-induced rat model von Seger, Shanon, Stritt, Manuel, Vezzali, Enrico, Nayler, Oliver, Hess, Patrick, Groenen, Peter M A, Stalder, Anna K

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FTY720 Phosphate Activates Sphingosine-1-Phosphate Receptor 2 and Selectively Couples to Gα12/13/Rho/ROCK to Induce Myofibroblast Contraction von Sobel, Katrin, Monnier, Lucile, Menyhart, Katalin, Bolinger, Matthias, Studer, Rolf, Nayler, Oliver, Gatfield, John

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The selective sphingosine 1-phosphate receptor 1 agonist ponesimod protects against lymphocyte-mediated tissue inflammation von Piali, Luca, Froidevaux, Sylvie, Hess, Patrick, Nayler, Oliver, Bolli, Martin H, Schlosser, Eva, Kohl, Christopher, Steiner, Beat, Clozel, Martine

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Promotion of sleep by targeting the orexin system in rats, dogs and humans von Jenck, François, Brisbare-Roch, Catherine, Dingemanse, Jasper, Koberstein, Ralf, Hoever, Petra, Aissaoui, Hamed, Flores, Susan, Mueller, Celia, Nayler, Oliver, van Gerven, Joop, de Haas, Sanne L, Hess, Patrick, Qiu, Changbin, Buchmann, Stephan, Scherz, Michael, Weller, Thomas, Fischli, Walter, Clozel, Martine

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MMP-7 is a predictive biomarker of disease progression in patients with idiopathic pulmonary fibrosis von Bauer, Yasmina, White, Eric S, de Bernard, Simon, Cornelisse, Peter, Leconte, Isabelle, Morganti, Adele, Roux, Sebastien, Nayler, Oliver

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Serotonin biosynthesis as a predictive marker of serotonin pharmacodynamics and disease-induced dysregulation von Welford, Richard W. D., Vercauteren, Magali, Trébaul, Annette, Cattaneo, Christophe, Eckert, Doriane, Garzotti, Marco, Sieber, Patrick, Segrestaa, Jérôme, Studer, Rolf, Groenen, Peter M. A., Nayler, Oliver

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Distinct ETA receptor binding mode of macitentan as determined by site directed mutagenesis von Gatfield, John, Mueller Grandjean, Celia, Bur, Daniel, Bolli, Martin H, Nayler, Oliver

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Desensitization by progressive up-titration prevents first-dose effects on the heart: guinea pig study with ponesimod, a selective S1P1 receptor modulator von Rey, Markus, Hess, Patrick, Clozel, Martine, Delahaye, Stéphane, Gatfield, John, Nayler, Oliver, Steiner, Beat

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Comparison of Macitentan and Bosentan on Right Ventricular Remodeling in a Rat Model of Non-vasoreactive Pulmonary Hypertension von Iglarz, Marc, Landskroner, Kyle, Bauer, Yasmina, Vercauteren, Magali, Rey, Markus, Renault, Berengère, Studer, Rolf, Vezzali, Enrico, Freti, Diego, Hadana, Hakim, Schläpfer, Manuela, Cattaneo, Christophe, Bortolamiol, Céline, Weber, Edgar, Whitby, Brian R, Delahaye, Stéphane, Wanner, Daniel, Steiner, Pauline, Nayler, Oliver, Hess, Patrick, Clozel, Martine

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NF-κB drives epithelial-mesenchymal mechanisms of lung fibrosis in a translational lung cell model von Sieber, Patrick, Schäfer, Anny, Lieberherr, Raphael, Caimi, Silvia L, Lüthi, Urs, Ryge, Jesper, Bergmann, Jan H, Le Goff, François, Stritt, Manuel, Blattmann, Peter, Renault, Bérengère, Rammelt, Patrick, Sempere, Bruno, Freti, Diego, Studer, Rolf, White, Eric S, Birker-Robaczewska, Magdalena, Boucher, Maxime, Nayler, Oliver

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Sphingosine 1-Phosphate (S1P) Receptor Agonists Mediate Pro-fibrotic Responses in Normal Human Lung Fibroblasts via S1P2 and S1P3 Receptors and Smad-independent Signaling von Sobel, Katrin, Menyhart, Katalin, Killer, Nina, Renault, Bérengère, Bauer, Yasmina, Studer, Rolf, Steiner, Beat, Bolli, Martin H., Nayler, Oliver, Gatfield, John

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The ER Repeat Protein YT521-B Localizes to a Novel Subnuclear Compartment von Nayler, Oliver, Hartmann, Annette M., Stamm, Stefan

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Characterization and comparison of four serine- and arginine-rich (SR) protein kinases von Nayler, O, Stamm, S, Ullrich, A

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Hereditary Pancreatitis Caused by a Novel PRSS1 Mutation (Arg-122 → Cys) That Alters Autoactivation and Autodegradation of Cationic Trypsinogen von Simon, Peter, Weiss, F Ulrich, Sahin-Toth, Miklos, Parry, Marina, Nayler, Oliver, Lenfers, Berthold, Schnekenburger, Jurgen, Mayerle, Julia, Domschke, Wolfram, Lerch, Markus M

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059 Daridorexant: A dual, equipotent, and insurmountable antagonist of both orexin-1 and orexin-2 receptors von Grandjean, Celia Mueller, Kiry, Manon, Vaillant, Catherine, Nayler, Oliver, Gatfield, John

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