Glycosphingolipid metabolism and polycystic kidney disease von Natoli, Thomas A., Modur, Vijay, Ibraghimov-Beskrovnaya, Oxana

Volltext

mTOR signaling in polycystic kidney disease von Ibraghimov-Beskrovnaya, Oxana, Natoli, Thomas A

Volltext

Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models von Leonard, John P, Natoli, Thomas A, Rogers, Kelly A, Russo, Ryan J, Ibraghimov-Beskrovnaya, Oxana, Husson, Hervé, Budman, Yeva, Wang, Bing, Bukanov, Nikolay O, Smith, Laurie A, Belenky, Alexei, Komarnitsky, Svetlana, Shayman, James A, Ledbetter, Steven R, Dackowski, William R

Volltext

CaMKII as a pathological mediator of ER stress, oxidative stress, and mitochondrial dysfunction in a murine model of nephronophthisis von Bracken, Christina, Beauverger, Philippe, Duclos, Olivier, Russo, Ryan J, Rogers, Kelly A, Husson, Hervé, Natoli, Thomas A, Ledbetter, Steven R, Janiak, Philip, Ibraghimov-Beskrovnaya, Oxana, Bukanov, Nikolay O

Volltext

Correction of cilia structure and function alleviates multi-organ pathology in Bardet–Biedl syndrome mice von Husson, Hervé, Bukanov, Nikolay O, Moreno, Sarah, Smith, Mandy M, Richards, Brenda, Zhu, Cheng, Picariello, Tyler, Park, Hyejung, Wang, Bing, Natoli, Thomas A, Smith, Laurie A, Zanotti, Stefano, Russo, Ryan J, Madden, Stephen L, Klinger, Katherine W, Modur, Vijay, Ibraghimov-Beskrovnaya, Oxana

Volltext

VEPTP inhibition with an extracellular domain targeting antibody did not restore albuminuria in a mouse model of diabetic kidney disease von Rana, Rajashree, Natoli, Thomas A., Khandelwal, Puneet, Pissios, Pavlos, Muhammad, Abdul Bari, Chipashvili, Vaja, Farrington, Krista P., Zhou, Wen, Zheng, Gang, Bukanov, Nikolay O., Pocai, Alessandro, Magnone, Maria Chiara

Volltext

CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD von Bukanov, Nikolay O., Moreno, Sarah E., Natoli, Thomas A., Rogers, Kelly A., Smith, Laurie A., Ledbetter, Steven R., Oumata, Nassima, Galons, Hervé, Meijer, Laurent, Ibraghimov-Beskrovnaya, Oxana

Volltext

Glucosylceramide synthase modulation ameliorates murine renal pathologies and promotes macrophage effector function in vitro von Cheong, Agnes, Craciun, Florin, Husson, Hervé, Gans, Joseph, Escobedo, Javier, Chang, Yi-Chien, Guo, Lilu, Goncalves, Mariana, Kaplan, Nathan, Smith, Laurie A., Moreno, Sarah, Boulanger, Joseph, Liu, Shiguang, Saleh, Jacqueline, Zhang, Mindy, Blazier, Anna S., Qiu, Weiliang, Macklin, Andrew, Iyyanki, Tejaswi, Chatelain, Clément, Khader, Shameer, Natoli, Thomas A., Ibraghimov-Beskrovnaya, Oxana, Ofengeim, Dimitry, Proto, Jonathan D.

Volltext

Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease von NATOLI, Thomas A, HUSSON, Hervé, IBRAGHIMOV-BESKROVNAYA, Oxana, ROGERS, Kelly A, SMITH, Laurie A, BING WANG, BUDMAN, Yeva, BUKANOV, Nikolay O, LEDBETTER, Steven R, KLINGER, Katherine W, LEONARD, John P

Volltext

Pkd1 and Nek8 mutations affect cell-cell adhesion and cilia in cysts formed in kidney organ cultures von Natoli, Thomas A, Gareski, Tiffany C, Dackowski, William R, Smith, Laurie, Bukanov, Nikolay O, Russo, Ryan J, Husson, Herve, Matthews, Douglas, Piepenhagen, Peter, Ibraghimov-Beskrovnaya, Oxana

Volltext

Differences in the timing and magnitude of Pkd1 gene deletion determine the severity of polycystic kidney disease in an orthologous mouse model of ADPKD von Rogers, Kelly A., Moreno, Sarah E., Smith, Laurie A., Husson, Hervé, Bukanov, Nikolay O., Ledbetter, Steven R., Budman, Yeva, Lu, Yuefeng, Wang, Bing, Ibraghimov‐Beskrovnaya, Oxana, Natoli, Thomas A.

Volltext

A Mammal-Specific Exon of WT1 Is Not Required for Development or Fertility von Natoli, Thomas A., McDonald, Alice, Alberta, Julia A., Taglienti, Mary E., Housman, David E., Kreidberg, Jordan A.

Volltext

Role of the WT1 tumor suppressor in murine hematopoiesis von Alberta, Julia A., Springett, Gregory M., Rayburn, Helen, Natoli, Thomas A., Loring, Janet, Kreidberg, Jordan A., Housman, David

Volltext

Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis von Natoli, Thomas A, Alberta, Julia A, Bortvin, Alex, Taglienti, Mary E, Menke, Douglas B, Loring, Jan, Jaenisch, Rudolf, Page, David C, Housman, David E, Kreidberg, Jordan A

Volltext

Effects of a Vascular Endothelial Protein Tyrosine Phosphatase (VE-PTP) Blocking Antibody in a Mouse Model of Severe Diabetic Kidney Disease: FR-PO334 von Rana, Rajashree, Natoli, Thomas A., Khandelwal, Puneet, Pissios, Pavlos, Muhammad, Abdul Bari, Chipashvili, Vaja, Farrington, Krista P., Zhou, Wen, Zheng, Gang, Bukanov, Nikolay O., Magnone, Maria Chiara

Volltext

A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary development von NATOLI, Thomas A, JING LIU, KREIDBERG, Jordan A, EREMINA, Vera, HODGENS, Karen, CONG LI, HAMANO, Yuki, MUNDEL, Peter, KALLURI, Raghu, MINER, Jeffrey H, QUAGGIN, Susan E

Volltext

Effects of KCNN4 Blockade With Senicapoc in Kidney Cell-Based Assays and a Mouse Model of Renal Inflammation and Fibrosis: FR-PO237 von Zhou, Peng, Hinke, Simon A., Cavanaugh, Cassandre, Ma, Li-Jun, Myshkin, Eugene, Shukla, Neetu, Natoli, Thomas A., Silva, Jose M., Magnone, Maria chiara, Yang, Zhiyong

Volltext

P0029GLUCOSYLCERAMIDE SYNTHASE INHIBITION PRESERVES MITOCHONDRIAL FUNCTION AND REDUCES REACTIVE OXYGEN DAMAGE IN THE JCK MOUSE MODEL OF POLYCYSTIC KIDNEY DISEASE von Picariello, Tyler, Rogers, Kelly, Smith, Laurie, Bracken, Christina, Bukanov, Nickolay, Ibraghimov-Beskrovnaya, Oxana, Natoli, Thomas

Volltext

Integrin α3β1 as a Potential Target for Diabetic Kidney Disease (DKD): SA-PO1006 von Bukanov, Nikolay O., Natoli, Thomas A., Chipashvili, Vaja, Zhou, Wen, Rana, Rajashree, Pissios, Pavlos, Zheng, Gang, Nchaw, Gladys A., Lutnick, Brendon R., Yip, Stephen S., Lin, Fu-Yang, Moy, Terence, Leloup, Nadia, Habte, Habtom, Tobin, James F., Magnone, Maria Chiara

Volltext

Glucosylceramide Synthase Inhibition Preserves Mitochondrial Function and Reduces Reactive Oxygen Damage in the Jck Mouse Model of Polycystic Kidney Disease: PO1561 von Picariello, Tyler, Rogers, Kelly A., Smith, Laurie A., Bracken, Christina M., Bukanov, Nikolay O., Beskrovnaya, Oxana, Natoli, Thomas A.

Volltext