Targeting PP2A in cancer: Combination therapies von Mazhar, Sahar, Taylor, Sarah E., Sangodkar, Jaya, Narla, Goutham

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Mistletoe extract Fraxini inhibits the proliferation of liver cancer by down-regulating c-Myc expression von Yang, Peiying, Jiang, Yan, Pan, Yong, Ding, Xiaoping, Rhea, Patrea, Ding, Jibin, Hawke, David H., Felsher, Dean, Narla, Goutham, Lu, Zhimin, Lee, Richard T.

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Kruppel-like Transcription Factor 6 Regulates Inflammatory Macrophage Polarization von Date, Dipali, Das, Riku, Narla, Goutham, Simon, Daniel I., Jain, Mukesh K., Mahabeleshwar, Ganapati H.

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Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex von He, Xuxiao, Li, Min, Yu, Hongming, Liu, Guijun, Wang, Ningning, Yin, Chunzhao, Tu, Qiaochu, Narla, Goutham, Tao, Yongzhen, Cheng, Shuqun, Yin, Huiyong

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Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth von Sangodkar, Jaya, Perl, Abbey, Tohme, Rita, Kiselar, Janna, Kastrinsky, David B, Zaware, Nilesh, Izadmehr, Sudeh, Mazhar, Sahar, Wiredja, Danica D, O'Connor, Caitlin M, Hoon, Divya, Dhawan, Neil S, Schlatzer, Daniela, Yao, Shen, Leonard, Daniel, Borczuk, Alain C, Gokulrangan, Giridharan, Wang, Lifu, Svenson, Elena, Farrington, Caroline C, Yuan, Eric, Avelar, Rita A, Stachnik, Agnes, Smith, Blake, Gidwani, Vickram, Giannini, Heather M, McQuaid, Daniel, McClinch, Kimberly, Wang, Zhizhi, Levine, Alice C, Sears, Rosalie C, Chen, Edward Y, Duan, Qiaonan, Datt, Manish, Haider, Shozeb, Ma'ayan, Avi, DiFeo, Analisa, Sharma, Neelesh, Galsky, Matthew D, Brautigan, David L, Ioannou, Yiannis A, Xu, Wenqing, Chance, Mark R, Ohlmeyer, Michael, Narla, Goutham

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PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells von Kauko, O, O'Connor, CM, Kulesskiy, E, Sangodkar, J, Aakula, A, Izadmehr, S, Yetukuri, L, Yadav, B, Padzik, A, Laajala, TD, Haapaniemi, P, Momeny, M, Varila, T, Ohlmeyer, M, Aittokallio, T, Wennerberg, K, Narla, G, Westermarck, J

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microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial–mesenchymal transition von Parikh, Aditya, Lee, Christine, Joseph, Peronne, Marchini, Sergio, Baccarini, Alessia, Kolev, Valentin, Romualdi, Chiara, Fruscio, Robert, Shah, Hardik, Wang, Feng, Mullokandov, Gavriel, Fishman, David, D’Incalci, Maurizio, Rahaman, Jamal, Kalir, Tamara, Redline, Raymond W., Brown, Brian D., Narla, Goutham, DiFeo, Analisa

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Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells von Coles, Garry L., Cristea, Sandra, Webber, James T., Levin, Rebecca S., Moss, Steven M., He, Andy, Sangodkar, Jaya, Hwang, Yeonjoo C., Arand, Julia, Drainas, Alexandros P., Mooney, Nancie A., Demeter, Janos, Spradlin, Jessica N., Mauch, Brandon, Le, Vicky, Shue, Yan Ting, Ko, Julie H., Lee, Myung Chang, Kong, Christina, Nomura, Daniel K., Ohlmeyer, Michael, Swaney, Danielle L., Krogan, Nevan J., Jackson, Peter K., Narla, Goutham, Gordan, John D., Shokat, Kevan M., Sage, Julien

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A Genome-Wide Pooled shRNA Screen Identifies PPP2R2A as a Predictive Biomarker for the Response to ATR and CHK1 Inhibitors von Qiu, Zhaojun, Fa, Pengyan, Liu, Tao, Prasad, Chandra B., Ma, Shanhuai, Hong, Zhipeng, Chan, Ernest R., Wang, Hongbing, Li, Zaibo, He, Kai, Wang, Qi-En, Williams, Terence M., Yan, Chunhong, Sizemore, Steven T., Narla, Goutham, Zhang, Junran

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Development and comparison of novel bioluminescent mouse models of pancreatic neuroendocrine neoplasm metastasis von Kaemmer, Courtney A., Umesalma, Shaikamjad, Maharjan, Chandra K., Moose, Devon L., Narla, Goutham, Mott, Sarah L., Zamba, Gideon K. D., Breheny, Patrick, Darbro, Benjamin W., Bellizzi, Andrew M., Henry, Michael D., Quelle, Dawn E.

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PP2A modulation overcomes multidrug resistance in chronic lymphocytic leukemia via mPTP-dependent apoptosis von Jayappa, Kallesh D, Tran, Brian, Gordon, Vicki L, Morris, Christopher, Saha, Shekhar, Farrington, Caroline C, O'Connor, Caitlin M, Zawacki, Kaitlin P, Isaac, Krista M, Kester, Mark, Bender, Timothy P, Williams, Michael E, Portell, Craig A, Weber, Michael J, Narla, Goutham

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Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors von O’Connor, Caitlin M., Leonard, Daniel, Wiredja, Danica, Avelar, Rita A., Wang, Zhizhi, Schlatzer, Daniela, Bryson, Benjamin, Tokala, Eesha, Taylor, Sarah E., Upadhyay, Aditya, Sangodkar, Jaya, Gingras, Anne-Claude, Westermarck, Jukka, Xu, Wenqing, DiFeo, Analisa, Brautigan, David L., Haider, Shozeb, Jackson, Mark, Narla, Goutham

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Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer von McClinch, Kimberly, Avelar, Rita A, Callejas, David, Izadmehr, Sudeh, Wiredja, Danica, Perl, Abbey, Sangodkar, Jaya, Kastrinsky, David B, Schlatzer, Daniela, Cooper, Maxwell, Kiselar, Janna, Stachnik, Agnes, Yao, Shen, Hoon, Divya, McQuaid, Daniel, Zaware, Nilesh, Gong, Yixuan, Brautigan, David L, Plymate, Stephen R, Sprenger, Cynthia C T, Oh, William K, Levine, Alice C, Kirschenbaum, Alexander, Sfakianos, John P, Sears, Rosalie, DiFeo, Analisa, Ioannou, Yiannis, Ohlmeyer, Michael, Narla, Goutham, Galsky, Matthew D

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Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance von Rasool, Reyaz ur, O’Connor, Caitlin M., Das, Chandan Kanta, Alhusayan, Mohammed, Verma, Brijesh Kumar, Islam, Sehbanul, Frohner, Ingrid E., Deng, Qu, Mitchell-Velasquez, Erick, Sangodkar, Jaya, Ahmed, Aqila, Linauer, Sarah, Mudrak, Ingrid, Rainey, Jessica, Zawacki, Kaitlin P., Suhan, Tahra K., Callahan, Catherine G., Rebernick, Ryan, Natesan, Ramakrishnan, Siddiqui, Javed, Sauter, Guido, Thomas, Dafydd, Wang, Shaomeng, Taylor, Derek J., Simon, Ronald, Cieslik, Marcin, Chinnaiyan, Arul M., Busino, Luca, Ogris, Egon, Narla, Goutham, Asangani, Irfan A.

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Food and science: Lessons learned from a great chef von Narla, Goutham

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Sprague Dawley Rag2 -Null Rats Created from Engineered Spermatogonial Stem Cells Are Immunodeficient and Permissive to Human Xenografts von Noto, Fallon K, Adjan-Steffey, Valeriya, Tong, Min, Ravichandran, Kameswaran, Zhang, Wei, Arey, Angela, McClain, Christopher B, Ostertag, Eric, Mazhar, Sahar, Sangodkar, Jaya, DiFeo, Analisa, Crawford, Jack, Narla, Goutham, Jamling, Tseten Y

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Challenges and Reinterpretation of Antibody-Based Research on Phosphorylation of Tyr307 on PP2Ac von Mazhar, Sahar, Leonard, Daniel, Sosa, Alejandro, Schlatzer, Daniela, Thomas, Dafydd, Narla, Goutham

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RABL6A inhibits tumor-suppressive PP2A/AKT signaling to drive pancreatic neuroendocrine tumor growth von Umesalma, Shaikamjad, Kaemmer, Courtney A, Kohlmeyer, Jordan L, Letney, Blake, Schab, Angela M, Reilly, Jacqueline A, Sheehy, Ryan M, Hagen, Jussara, Tiwari, Nitija, Zhan, Fenghuang, Leidinger, Mariah R, O'Dorisio, Thomas M, Dillon, Joseph, Merrill, Ronald A, Meyerholz, David K, Perl, Abbey L, Brown, Bart J, Braun, Terry A, Scott, Aaron T, Ginader, Timothy, Taghiyev, Agshin F, Zamba, Gideon K, Howe, James R, Strack, Stefan, Bellizzi, Andrew M, Narla, Goutham, Darbro, Benjamin W, Quelle, Frederick W, Quelle, Dawn E

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The SRG rat, a Sprague-Dawley Rag2/Il2rg double-knockout validated for human tumor oncology studies von Noto, Fallon K., Sangodkar, Jaya, Adedeji, Bisoye Towobola, Moody, Sam, McClain, Christopher B., Tong, Ming, Ostertag, Eric, Crawford, Jack, Gao, Xiaohua, Hurst, Lauren, O'Connor, Caitlin M., Hanson, Erika N., Izadmehr, Sudeh, Tohme, Rita, Narla, Jyothsna, LeSueur, Kristin, Bhattacharya, Kajari, Rupani, Amit, Tayeh, Marwan K., Innis, Jeffrey W., Galsky, Matthew D., Evers, B. Mark, DiFeo, Analisa, Narla, Goutham, Jamling, Tseten Y.

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Bisphosphonates inactivate human EGFRs to exert antitumor actions von Yuen, Tony, Stachnik, Agnes, Iqbal, Jameel, Sgobba, Miriam, Gupta, Yogesh, Lu, Ping, Colaianni, Graziana, Ji, Yaoting, Zhu, Ling-Ling, Kim, Se-Min, Li, Jianhua, Liu, Peng, Izadmehr, Sudeh, Sangodkar, Jaya, Bailey, Jack, Latif, Yathin, Mujtaba, Shiraz, Epstein, Solomon, Davies, Terry F., Bian, Zhuan, Zallone, Alberta, Aggarwal, Aneel K., Haider, Shozeb, New, Maria I., Sun, Li, Narla, Goutham, Zaidi, Mone

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