Engineering Glucose Responsiveness Into Insulin von Kaarsholm, Niels C, Lin, Songnian, Yan, Lin, Kelly, Theresa, van Heek, Margaret, Mu, James, Wu, Margaret, Dai, Ge, Cui, Yan, Zhu, Yonghua, Carballo-Jane, Ester, Reddy, Vijay, Zafian, Peter, Huo, Pei, Shi, Shuai, Antochshuk, Valentyn, Ogawa, Aimie, Liu, Franklin, Souza, Sandra C, Seghezzi, Wolfgang, Duffy, Joseph L, Erion, Mark, Nargund, Ravi P, Kelley, David E

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Discovery of Insulin/GLP-1/Glucagon Triagonists for the Treatment of Diabetes and Obesity von Huang, Chunhui, Palani, Anandan, Yang, Zhiqiang, Deng, Qiaolin, Reddy, Vijay, Nargund, Ravi P., Lin, Songnian, Altezza, Simona, Bianchi, Elisabetta, Orvieto, Federica, Carrington, Paul

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Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration von Dong, Shuzhi, Zhao, Zhiqiang, Tang, Haiqun, Li, Guoqing, Pan, Jianping, Gu, Xin, Jiang, Jinlong, Xiao, Li, Scapin, Giovanna, Hunter, David N., Yang, Dexi, Huang, Yuhua, Bennett, Frank, Yang, Shu-Wei, Mandal, Mihirbaran, Tang, Haifeng, Su, Jing, Tudge, Clare, deJesus, Reynalda Keh, Ding, Fa-Xiang, Lombardo, Matthew, Hicks, Jacqueline D., Fischmann, Thierry, Mirza, Asra, Dayananth, Priya, Painter, Ronald E., Villafania, Artjohn, Garlisi, Charles G., Zhang, Rumin, Mayhood, Todd W., Si, Qian, Li, Nianyu, Amin, Rupesh P., Bhatt, Bhavana, Chen, Feifei, Regan, Christopher P., Regan, Hillary, Lin, Xinjie, Wu, Jin, Leithead, Andrew, Pollack, Scott R., Scott, Jack D., Nargund, Ravi P., Therien, Alex G., Black, Todd, Young, Katherine, Pasternak, Alexander

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Discovery of Insulin Receptor Partial Agonists MK-5160 and MK-1092 as Novel Basal Insulins with Potential to Improve Therapeutic Index von Pissarnitski, Dmitri A, Kekec, Ahmet, Yan, Lin, Zhu, Yuping, Feng, Danqing D, Huo, Pei, Madsen-Duggan, Christina, Moyes, Christopher R, Nargund, Ravi P, Kelly, Terri, Zhang, Xiaoping, Carballo-Jane, Ester, Gorski, Judith, Zafian, Peter, Qatanani, Mo, Kaarsholm, Niels, Meng, Fanyu, Jia, Xiujuan, Lee, Keun-Joong, Wang, Weixun, Xu, Sherrie, Hohn, Michael J, Iammarino, Michael J, McCoy, Mark A, Okoh, Grace A, Liang, Yingkai, Hollingsworth, Scott A, Erion, Mark D, Kelley, David E, Garbaccio, Robert M, Zhang, Amy, Mu, James, Lin, Songnian

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Design and evaluation of novel tetracyclic benzofurans as palm site allosteric inhibitors of HCV NS5B polymerase von Liu, Hong, Dai, Xing, He, Shuwen, Brockunier, Linda, Marcantonio, Karen, Ludmerer, Steven W., Li, Fangbiao, Feng, Kung-I, Nargund, Ravi P., Palani, Anandan

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Discovery of a potent and selective small molecule hGPR91 antagonist von Bhuniya, Debnath, Umrani, Dhananjay, Dave, Bhavesh, Salunke, Deepak, Kukreja, Gagan, Gundu, Jayasagar, Naykodi, Minakshi, Shaikh, Nadim S., Shitole, Prasad, Kurhade, Santosh, De, Siddhartha, Majumdar, Sreemita, Reddy, Srinivasa B., Tambe, Suhas, Shejul, Yogesh, Chugh, Anita, Palle, Venkata P., Mookhtiar, Kasim A., Cully, Doris, Vacca, Joseph, Chakravarty, Prasun K., Nargund, Ravi P., Wright, Samuel D., Graziano, Michael P., Singh, Sheo B., Roy, Sophie, Cai, Tian-Quan

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Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC) von Yu, Yang, Wu, Zhicai, Shi, Zhi-Cai, He, Shuwen, Lai, Zhong, Cernak, Timothy A., Vachal, Petr, Liu, Min, Liu, Jian, Hong, Qingmei, Jian, Tianying, Guiadeen, Deodial, Krikorian, Arto, Sperbeck, Donald M., Verras, Andreas, Sonatore, Lisa M., Murphy, Beth A., Wiltsie, Judyann, Chung, Christine C., Gorski, Judith N., Liu, Jinqi, Xiao, Jianying, Wolff, Michael, Tong, Sharon X., Madeira, Maria, Karanam, Bindhu V., Shen, Dong-Ming, Balkovec, James M., De Vita, Robert J., Pinto, Shirly, Nargund, Ravi P.

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Orphan G-protein-coupled receptors and natural ligand discovery von Howard, Andrew D, McAllister, George, Feighner, Scott D, Liu, Qingyun, Nargund, Ravi P, Van der Ploeg, Lex H.T, Patchett, Arthur A

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Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes von Wilson, Jonathan E., Kurukulasuriya, Ravi, Sinz, Christopher, Lombardo, Matthew, Bender, Kate, Parker, Dann, Sherer, Edward C., Costa, Melissa, Dingley, Karen, Li, Xiaofang, Mitelman, Stanley, Tong, Sharon, Bugianesi, Randal, Ehrhardt, Anka, Priest, Birgit, Ratliff, Kevin, Ujjainwalla, Feroze, Nargund, Ravi, Hagmann, William K., Edmondson, Scott

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Erratum. Engineering Glucose Responsiveness Into Insulin. Diabetes 2018;67:299-308 von Kaarsholm, Niels C, Lin, Songnian, Yan, Lin, Kelly, Theresa, van Heek, Margaret, Mu, James, Wu, Margaret, Dai, Ge, Cui, Yan, Zhu, Yonghua, Carballo-Jane, Ester, Reddy, Vijay, Zafian, Peter, Huo, Pei, Shi, Shuai, Antochshuk, Valentyn, Ogawa, Aimie, Liu, Franklin, Souza, Sandra C, Seghezzi, Wolfgang, Duffy, Joseph L, Erion, Mark, Nargund, Ravi P, Kelley, David E

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A Role for the Melanocortin 4 Receptor in Sexual Function von Lex H. T. Van der Ploeg, Martin, William J., Howard, Andrew D., Nargund, Ravi P., Austin, Christopher P., Guan, Xiaoming, Drisko, Jennifer, Cashen, Doreen, Sebhat, Iyassu, Patchett, Arthur A., Figueroa, David J., DiLella, Anthony G., Connolly, Brett M., Weinberg, David H., Tan, Carina P., Palyha, Oksana C., Pong, Sheng-Shung, MacNeil, Tanya, Rosenblum, Charles, Vongs, Aurawan, Tang, Rui, Yu, Hong, Sailer, Andreas W., Fong, Tung Ming, Huang, Cathy, Tota, Michael R., Chang, Ray S., Stearns, Ralph, Tamvakopoulos, Constantin, Christ, George, Drazen, Deborah L., Spar, Brian D., Nelson, Randy J., MacIntyre, D. Euan

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Melanocortin-4 Receptor (MC4R) Agonists for the Treatment of Obesity von Nargund, Ravi P, Strack, Alison M, Fong, Tung M

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Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety von He, Shuwen, Lai, Zhong, Hong, Qingmei, Shang, Jackie, Reibarkh, Mikhail, Kuethe, Jeffrey T., Liu, Jian, Guiadeen, Deodial, Krikorian, Arto D., Cernak, Timothy A., Dykstra, Kevin D., Sperbeck, Donald M., Wu, Zhicai, Yu, Yang, Yang, Ginger X., Jian, Tianying, Verras, Andreas, Sonatore, Lisa M., Wiltsie, Judyann, Chung, Christine C., Murphy, Beth A., Gorski, Judith N., Liu, Jinqi, Xiao, Jianying, Wolff, Michael, Tong, Sharon X., Madeira, Maria, Karanam, Bindhu V., Shen, Dong-Ming, Balkovec, James M., Pinto, Shirly, Nargund, Ravi P., DeVita, Robert J.

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Regulation of Energy Homeostasis by Bombesin Receptor Subtype-3: Selective Receptor Agonists for the Treatment of Obesity von Guan, Xiao-Ming, Chen, Howard, Dobbelaar, Peter H., Dong, Yan, Fong, Tung M., Gagen, Karen, Gorski, Judith, He, Shuwen, Howard, Andrew D., Jian, Tianying, Jiang, Michael, Kan, Yanqing, Kelly, Theresa M., Kosinski, Jennifer, Lin, Linus S., Liu, Jian, Marsh, Donald J., Metzger, Joseph M., Miller, Randy, Nargund, Ravi P., Palyha, Oksana, Shearman, Lauren, Shen, Zhu, Stearns, Ralph, Strack, Alison M., Stribling, Sloan, Tang, Yui Sing, Wang, Sheng-Ping, White, Amanda, Yu, Hong, Reitman, Marc L.

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A glucose-responsive insulin therapy protects animals against hypoglycemia von Yang, Ruojing, Wu, Margaret, Lin, Songnian, Nargund, Ravi P, Li, Xinghai, Kelly, Theresa, Yan, Lin, Dai, Ge, Qian, Ying, Dallas-Yang, Qing, Fischer, Paul A, Cui, Yan, Shen, Xiaolan, Huo, Pei, Feng, Danqing Dennis, Erion, Mark D, Kelley, David E, Mu, James

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Discovery of phenyl acetamides as potent and selective GPR119 agonists von Zhu, Cheng, Wang, Liping, Zhu, Yuping, Guo, Zack Zhiqiang, Liu, Ping, Hu, Zhiyong, Szewczyk, Jason W., Kang, Ling, Chicchi, Gary, Ehrhardt, Anka, Woods, Andrea, Seo, Toru, Woods, Morgan, van Heek, Margaret, Dingley, Karen H., Pang, Jianmei, Salituro, Gino M., Powell, Joyce, Terebetski, Jenna L., Hornak, Viktor, Campeau, Louis-Charles, Orr, Robert K., Ujjainwalla, Feroze, Miller, Michael, Stamford, Andrew, Wood, Harold B., Kowalski, Timothy, Nargund, Ravi P., Edmondson, Scott D.

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Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist von Guan, Xiao-Ming, Metzger, Joseph M, Yang, Liming, Raustad, Kate A, Wang, Sheng-Ping, Spann, Stephanie K, Kosinski, Jennifer A, Yu, Hong, Shearman, Lauren P, Faidley, Terry D, Palyha, Oksana, Kan, Yanqing, Kelly, Theresa M, Sebhat, Iyassu, Lin, Linus S, Dragovic, Jasminka, Lyons, Kathy A, Craw, Stephanie, Nargund, Ravi P, Marsh, Donald J, Strack, Alison M, Reitman, Marc L

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SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists von He, Shuwen, Dobbelaar, Peter H., Guo, Liangqin, Ye, Zhixiong, Liu, Jian, Jian, Tianying, Truong, Quang, Shah, Shrenik K., Du, Wu, Qi, Hongbo, Bakshi, Raman K., Hong, Qingmei, Dellureficio, James D., Sherer, Edward, Pasternak, Alexander, Feng, Zhe, Reibarkh, Mikhail, Lin, Melissa, Samuel, Koppara, Reddy, Vijay B., Mitelman, Stan, Tong, Sharon X., Chicchi, Gary G., Tsao, Kwei-Lan, Trusca, Dorina, Wu, Margaret, Shao, Qing, Trujillo, Maria E., Fernandez, Guillermo, Nelson, Donald, Bunting, Patricia, Kerr, Janet, Fitzgerald, Patrick, Morissette, Pierre, Volksdorf, Sylvia, Eiermann, George J., Li, Cai, Zhang, Bei B., Howard, Andrew D., Zhou, Yun-Ping, Nargund, Ravi P., Hagmann, William K.

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Late-stage lipidation of fully elaborated tryptophan-containing peptides for improved pharmacokinetics von Huang, Chunhui, Wille, Cannon B., He, Huaibing, Reddy, Vijay Bhasker Gangula, Nargund, Ravi P., Lin, Songnian, Palani, Anandan

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Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase von Liu, Ping, Hamill, Terence G, Chioda, Marc, Chobanian, Harry, Fung, Selena, Guo, Yan, Chang, Linda, Bakshi, Raman, Hong, Qingmei, Dellureficio, James, Lin, Linus S, Abbadie, Catherine, Alexander, Jessica, Jin, Hong, Mandala, Suzanne, Shiao, Lin-Lin, Li, Wenping, Sanabria, Sandra, Williams, David, Zeng, Zhizhen, Hajdu, Richard, Jochnowitz, Nina, Rosenbach, Mark, Karanam, Bindhu, Madeira, Maria, Salituro, Gino, Powell, Joyce, Xu, Ling, Terebetski, Jenna L, Leone, Joseph F, Miller, Patricia, Cook, Jacquelynn, Holahan, Marie, Joshi, Aniket, O’Malley, Stacey, Purcell, Mona, Posavec, Diane, Chen, Tsing-Bau, Riffel, Kerry, Williams, Mangay, Hargreaves, Richard, Sullivan, Kathleen A, Nargund, Ravi P, DeVita, Robert J

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