ROCK inhibitors 4: Structure-activity relationship studies of 7-azaindole-based rho kinase (ROCK) inhibitors von Bandarage, Upul K., Court, John, Gao, Huai, Nanthakumar, Suganthini, Come, Jon H., Giroux, Simon, Green, Jeremy

Volltext

APOL1 Inhibitors Reverse Established Proteinuria in an APOL1-Mediated Kidney Disease Mouse Model: TH-PO442 von Blasio, Angelo, Sullivan, Kelly E., Mann, James J., Wang, Guanyu, Kumar, Shyamesh, Bright, Franklin, Bouillez, Audrey, Daniel, Kevin, Nanthakumar, Suganthini, Rosario, Aldo A., Aragon Mejia, Monica A., Heighton, Thomas F., Nanou, Evanthia, Proctor, Jennifer, Furey, Brinley, Fortier, Anne, Senter, Timothy J., Dakin, Leslie, Zimmerman, Brandon

Volltext

Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1 von Come, Jon H, Senter, Timothy J, Clark, Michael P, Court, John J, Gale-Day, Zachary, Gu, Wenxin, Krueger, Elaine, Liang, Jianglin, Morris, Mark, Nanthakumar, Suganthini, O’Dowd, Hardwin, Maltais, Francois, Iyer, Ganesh, Andreassi, John, Boucher, Christina, Considine, Tony, Moody, Cameron S, Taylor, William, Mohanty, Arun K, Huang, Yulin, Zuccola, Harmon, Coll, Joyce, Bonanno, Kenneth C, Gagnon, Kevin J, Gan, Lu, Lu, Fan, Gao, Hong, Chakilam, Ananthisrinivas, Engtrakul, Juntyma, Song, Bin, Crawford, Dan, Doyle, Elisabeth, Kramer, Tal, Vought, Bryan, Phillips, Jonathan, Kemper, Raymond, Sanders, Martin, Swett, Rebecca, Furey, Brinley, Winquist, Ray, Bunnage, Mark E, Jackson, Katrina L, Charifson, Paul S, Magavi, Sanjay S

Volltext

Fragment-Based Discovery of Dual JC Virus and BK Virus Helicase Inhibitors von Bonafoux, Dominique, Nanthakumar, Suganthini, Bandarage, Upul K, Memmott, Christine, Lowe, Derek, Aronov, Alex M, Bhisetti, Govinda Rao, Bonanno, Kenneth C, Coll, Joyce, Leeman, Joshua, Lepre, Christopher A, Lu, Fan, Perola, Emanuele, Rijnbrand, Rene, Taylor, William P, Wilson, Dean, Zhou, Yi, Zwahlen, Jacque, ter Haar, Ernst

Volltext

Structure-Guided Design of Potent and Selective Pyrimidylpyrrole Inhibitors of Extracellular Signal-Regulated Kinase (ERK) Using Conformational Control von Aronov, Alex M, Tang, Qing, Martinez-Botella, Gabriel, Bemis, Guy W, Cao, Jingrong, Chen, Guanjing, Ewing, Nigel P, Ford, Pamella J, Germann, Ursula A, Green, Jeremy, Hale, Michael R, Jacobs, Marc, Janetka, James W, Maltais, Francois, Markland, William, Namchuk, Mark N, Nanthakumar, Suganthini, Poondru, Srinivasu, Straub, Judy, ter Haar, Ernst, Xie, Xiaoling

Volltext

Two General Routes to 1,4-Disubstituted-2,3,4,5-tetrahydro- 1H-3-benzazepines von Gerritz, Samuel W, Smith, Jennifer S, Nanthakumar, Suganthini S, Uehling, David E, Cobb, Jeffery E

Volltext

Synthesis, Topoisomerase I Inhibitory Activity, and in Vivo Evaluation of 11-Azacamptothecin Analogs von Uehling, David E, Nanthakumar, Suganthini S, Croom, Dallas, Emerson, David L, Leitner, Peter P, Luzzio, Michael J, McIntyre, Gordon, Morton, Bradley, Profeta, Salvadore

Volltext

Discovery of Novel Allosteric HCV NS5B Inhibitors. 2. Lactam-Containing Thiophene Carboxylates von Li, Pan, Dorsch, Warren, Lauffer, David J., Bilimoria, Darius, Chauret, Nathalie, Court, John J., Das, Sanjoy Kumar, Denis, Francois, Mani, Nagraj, Nanthakumar, Suganthini, Nicolas, Olivier, Rao, B. Govinda, Ronkin, Steven, Selliah, Subajini, Shawgo, Rebecca S., Stearns, Ralph, Tang, Qing, Waal, Nathan D., Green, Jeremy

Volltext

Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK) von FARMER, Luc J, BEMIS, Guy, TER HAAR, Ernst, JIAN WANG, ZHAVERI, Darshana, SALITURO, Francesco G, BRITT, Shawn D, COCHRAN, John, CONNORS, Martin, HARRINGTON, Edmund M, HOOCK, Thomas, MARKLAND, William, NANTHAKUMAR, Suganthini, TASLIMI, Paul

Volltext

2-Aminopyrazolo[1,5- a]pyrimidines as potent and selective inhibitors of JAK2 von Ledeboer, Mark W., Pierce, Albert C., Duffy, John P., Gao, Huai, Messersmith, David, Salituro, Francesco G., Nanthakumar, Suganthini, Come, Jon, Zuccola, Harmon J., Swenson, Lora, Shlyakter, Dina, Mahajan, Sudipta, Hoock, Thomas, Fan, Bin, Tsai, Wan-Jung, Kolaczkowski, Elaine, Carrier, Scott, Hogan, James K., Zessis, Richard, Pazhanisamy, S., Bennani, Youssef L.

Volltext

Functionalized 2,5-Disubstituted Benzazepines: Stereoselective Synthesis of 3-Methyl-5-phenyl-2,3,4,5-tetrahydro-1 H -3-benzazepine-2-carbonitrile and Related Derivatives von Cobb, Jeff E., Nanthakumar, Suganthini S., Rutkowske, Randy, Uehling, David E.

Volltext

Functionalized 2,5-Disubstituted Benzazepines: Stereoselective Synthesis of 3-Methyl-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-2-carbonitrile and Related Derivatives von Cobb, Jeff E., Nanthakumar, Suganthini S., Rutkowske, Randy, Uehling, David E.

Volltext

4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME von CAO, Jingrong, SENTER, Timothy J, WANG, Haoxuan, BRODNEY, Michael A, ANGLE, Samantha, OLSEN, Jessica H, STONE, Steven D, DOLGIKH, Elena, NANTHAKUMAR, Suganthini, KRUEGER, Elaine B, GALE-DAY, Zachary, COME, Jon, DAKIN, Leslie A, SHIMIZU, Akira J

Volltext bestellen

Two General Routes to 1,4-Disubstituted-2,3,4,5-tetrahydro- 1 H -3-benzazepines von Gerritz, Samuel W., Smith, Jennifer S., Nanthakumar, Suganthini S., Uehling, David E., Cobb, Jeffery E.

Volltext

INHIBITORS OF APOL1 AND METHODS OF USING SAME von CAO, Jingrong, MAXWELL, Brad D, BRODNEY, Michael Aaron, SENTER, Timothy J, WANG, Haoxuan, COCHRAN, John E, O'DOWD, Hardwin, OLSEN, Jessica Howard, ANGLE, Samantha, STONE, Steven David, DOLGIKH, Elena, COME, Jon H, SHIMIZU, Akira Joseph, NANTHAKUMAR, Suganthini S, DAKIN, Leslie A, AHN, Jun Myun

Volltext bestellen

Inhibitors of APOL1 and methods of using same von Sturino, Claudio, Szychowski, Janek, Nicolas, Olivier, Fortier, Anne, Hamel, Martine, Wang, Tiansheng, Sayegh, Camil E, Senter, Timothy J, Come, Jon H, Nanthakumar, Suganthini S, Krueger, Elaine B, Ledford, Brian, Fader, Lee, Dorsch, Warren A, Denis, Francois, Maltais, Francois, Cao, Jingrong, Dorich, Stephane, Dakin, Leslie A

Volltext bestellen

Inhibitors of APOL1 and methods of using same von Sayegh, Camil, Shi, Yi, Nicolas, Olivier, Fortier, Anne, Hamel, Martine, Wang, Tiansheng, Hu, Kan-Nian, Gagnon, Kevin, Witkos, Faith, Rose, Peter, Come, Jon H, Senter, Timothy J, Nanthakumar, Suganthini S, Krueger, Elaine B, Ledford, Brian, Dorsch, Warren A, Denis, Francois, Brodney, Michael, Cao, Jingrong, Shrestha, Muna, Medek, Ales, Dakin, Leslie A

Volltext bestellen

4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME von CAO, Jingrong, SENTER, Timothy J, WANG, Haoxuan, BRODNEY, Michael A, ANGLE, Samantha, OLSEN, Jessica H, STONE, Steven D, DOLGIKH, Elena, NANTHAKUMAR, Suganthini, KRUEGER, Elaine B, GALE-DAY, Zachary, COME, Jon, DAKIN, Leslie A, SHIMIZU, Akira J

Volltext bestellen

INHIBITORS OF APOL1 AND USE OF THE SAME von CAO, Jingrong, WANG, Tiansheng, LEDFORD, Brian, SENTER, Timothy J, SAYEGH, Camil E, DENIS, Francois, FORTIER, Anne, NICOLAS, Olivier, DORSCH, Warren A, COME, Jon H, KRUEGER, Elaine B, HAMEL, Martine, NANTHAKUMAR, Suganthini S, DAKIN, Leslie A, MALTAIS, Francois

Volltext bestellen

INHIBITORS OF APOL1 AND USE OF THE SAME von CAO, Jingrong, WANG, Tiansheng, LEDFORD, Brian, SENTER, Timothy J, SAYEGH, Camil E, DENIS, Francois, FORTIER, Anne, NICOLAS, Olivier, DORSCH, Warren A, COME, Jon H, KRUEGER, Elaine B, HAMEL, Martine, NANTHAKUMAR, Suganthini S, DAKIN, Leslie A, MALTAIS, Francois

Volltext bestellen