Critical role for Syk in responses to vascular injury von Andre, Patrick, Morooka, Toshifumi, Sim, Derek, Abe, Keith, Lowell, Clifford, Nanda, Nisha, Delaney, Suzanne, Siu, Gail, Yan, Yibing, Hollenbach, Stan, Pandey, Anjali, Gao, Huiyun, Wang, Yunmei, Nakajima, Kohsuke, Parikh, Sahil A., Shi, Can, Phillips, David, Owen, Whyte, Sinha, Uma, Simon, Daniel I.

Volltext

Platelet Endothelial Aggregation Receptor 1 (PEAR1), a Novel Epidermal Growth Factor Repeat-containing Transmembrane Receptor, Participates in Platelet Contact-induced Activation von Nanda, Nisha, Bao, Ming, Lin, Hanna, Clauser, Karl, Komuves, Laszlo, Quertermous, Thomas, Conley, Pamela B., Phillips, David R., Hart, Matthew J.

Volltext

Targeted Inactivation of Gh/Tissue Transglutaminase II von Nanda, Nisha, Iismaa, Siiri E., Owens, W. Andrew, Husain, Ahsan, Mackay, Fabienne, Graham, Robert M.

Volltext

Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling von Nanda, Nisha, Andre, Patrick, Bao, Ming, Clauser, Karl, Deguzman, Francis, Howie, Duncan, Conley, Pamela B., Terhorst, Cox, Phillips, David R.

Volltext

Distinct Transglutaminase 2-independent and Transglutaminase 2-dependent Pathways Mediate Articular Chondrocyte Hypertrophy von Johnson, Kristen A., van Etten, Deborah, Nanda, Nisha, Graham, Robert M., Terkeltaub, Robert A.

Volltext

An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101 von Doebele, Robert C, Davis, Lara E, Vaishnavi, Aria, Le, Anh T, Estrada-Bernal, Adriana, Keysar, Stephen, Jimeno, Antonio, Varella-Garcia, Marileila, Aisner, Dara L, Li, Yali, Stephens, Philip J, Morosini, Deborah, Tuch, Brian B, Fernandes, Michele, Nanda, Nisha, Low, Jennifer A

Volltext

Identification of tropomyosin kinase receptor (TRK) mutations in cancer von Nanda, Nisha, Fennell, Tim, Low, Jennifer A.

Volltext

Phase 2 study of subcutaneous omacetaxine mepesuccinate after TKI failure in patients with chronic-phase CML with T315I mutation von Cortes, Jorge, Lipton, Jeff H., Rea, Delphine, Digumarti, Raghunadharao, Chuah, Charles, Nanda, Nisha, Benichou, Annie-Claude, Craig, Adam R., Michallet, Mauricette, Nicolini, Franck E., Kantarjian, Hagop

Volltext

PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model von Reilly, Michael P., Sinha, Uma, André, Pierrette, Taylor, Scott M., Pak, Yvonne, DeGuzman, Francis R., Nanda, Nisha, Pandey, Anjali, Stolla, Moritz, Bergmeier, Wolfgang, McKenzie, Steven E.

Volltext

Genetic Modeling and Therapeutic Targeting of ETV6-NTRK3 with Loxo-101in Acute Lymphoblastic Leukemia von Roberts, Kathryn G., Bridges, Olga, Janke, Laura J., Ebata, Kevin, Tuch, Brian B, Nanda, Nisha, Mullighan, Charles

Volltext

761: Maternal magnesium supplementation reduces placental infarction and apoptosis in a rat model of intrauterine growth restriction von Roman, Amanda, Gupta, Madhu, Carreon, Chrystalle, Nanda, Nisha, Xue, Xiangying, Williamson, Alex, Rochelson, Burton, Metz, Christine

Volltext

Pharmacokinetic study of omacetaxine mepesuccinate administered subcutaneously to patients with advanced solid and hematologic tumors von Nemunaitis, John, Mita, Alain, Stephenson, Joe, Mita, Monica M., Sarantopoulos, John, Padmanabhan-Iyer, Swami, Nanda, Nisha, Gleich, Lyon, Benichou, Annie-Claude, Craig, Adam

Volltext

Abstract 4529: Pharmacokinetics (PK) of LOXO-101 during the first-in-human Phase I study in patients with advanced solid tumors: Interim update von Burris, Howard A., Shaw, Alice T., Bauer, Todd M., Farago, Anna F., Doebele, Robert C., Smith, Steven, Nanda, Nisha, Cruickshank, Scott, Low, Jennifer A., Brose, Marcia S.

Volltext

Abstract CT008: Clinical safety and activity from a phase I study of LOXO-101, a selective TRKA/B/C inhibitor, in solid-tumor patients with NTRK gene fusions von Hong, David S., Farago, Anna F., Brose, Marcia S., Burris, Howard A., Dowlati, Afshin, Bauer, Todd M., Taylor, Matthew, Shaw, Alice T., Estrada-Bernal, Adriana, Lee, Anh T., Nanda, Nisha, Cox, Michael C., Doebele, Robert C.

Volltext

Abstract CT008: Clinical safety and activity from a phase I study of LOXO-101, a selective TRKABC inhibitor, in solid-tumor patients with NTRK gene fusions von Hong, David S, Farago, Anna F, Brose, Marcia S, Burris, Howard A, Dowlati, Afshin, Bauer, Todd M, Taylor, Matthew, Shaw, Alice T, Estrada-Bernal, Adriana, Lee, Anh T, Nanda, Nisha, Cox, Michael C, Doebele, Robert C

Volltext

Abstract C196: Identification of first-in-class, highly potent FGFR kinase inhibitors that spare FGFR1 von Winski, Shannon, Nanda, Nisha, Brown, Eric, Tang, Tony, Brandhuber, Barbara, Hamor, Robyn, Tuch, Brian, Ebata, Kevin, Low, Jennifer, Sullivan, Francis, Smith, Darin, Vigers, Guy, Strough, Megan, Rieger, Rob, Blake, James, Moreno, David, Chantry, David, Rothenberg, S. Michael, Andrews, Steven

Volltext

Abstract PR13: Clinical safety and activity from a phase 1 study of LOXO-101, a selective TRKA/B/C inhibitor, in solid-tumor patients with NTRK gene fusions von Hong, David S., Brose, Marcia S., Doebele, Robert C., Shaw, Alice T., Dowlati, Afshin, Bauer, Todd M., Farago, Anna F., Estrada-Bernal, Adriana, Lee, Anh T., Cox, Michael C., Nanda, Nisha, Low, Jennifer A., Burris, Howard A.

Volltext

Subcutaneous Omacetaxine Mepesuccinate in Patients With Chronic-Phase Chronic Myeloid Leukemia Previously Treated With 2 or More Tyrosine Kinase Inhibitors Including Imatinib von Cortes, Jorge E, Nicolini, Franck E, Wetzler, Meir, Lipton, Jeffrey H, Akard, Luke, Craig, Adam, Nanda, Nisha, Benichou, Annie-Claude, Leonoudakis, Janis, Khoury, H. Jean, Hochhaus, Andreas, Baccarani, Michele, Kantarjian, Hagop M

Volltext

Abstract B192: Identification and characterization of highly potent and selective RET kinase inhibitors for the treatment of RET-driven cancers von Brandhuber, Barbara J., Nanda, Nisha, Haas, Julia, Bouhana, Karyn, Williams, Lance, Winski, Shannon, Burkard, Michael, Tuch, Brian, Ebata, Kevin, Low, Jennifer, Sullivan, Francis, Hanson, Lauren, Morales, Tony, Vigers, Guy, Gaffney, Jessica, Wallace, Ross D., Blake, James, Jiang, Yutong, Rothenberg, S. Michael, Andrews, Steven

Volltext

An oncogenic NTRK fusion in a soft tissue sarcoma patient with response to the tropomyosin-related kinase (TRK) inhibitor LOXO-101 von Doebele, Robert C., Davis, Lara E., Vaishnavi, Aria, Le, Anh T., Estrada-Bernal, Adriana, Keysar, Stephen, Jimeno, Antonio, Varella-Garcia, Marileila, Aisner, Dara L., Li, Yali, Stephens, Philip J., Morosini, Deborah, Tuch, Brian B., Fernandes, Michele, Nanda, Nisha, Low, Jennifer A.

Volltext