Design, Parallel Synthesis, and Crystal Structures of Pyrazinone Antithrombotics as Selective Inhibitors of the Tissue Factor VIIa Complex von Parlow, John J, Case, Brenda L, Dice, Thomas A, Fenton, Ricky L, Hayes, Michael J, Jones, Darin E, Neumann, William L, Wood, Rhonda S, Lachance, Rhonda M, Girard, Thomas J, Nicholson, Nancy S, Clare, Michael, Stegeman, Roderick A, Stevens, Anna M, Stallings, William C, Kurumbail, Ravi G, South, Michael S

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Potent in vitro and in vivo inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between th... von Zablocki, Jeffery A, Miyano, Masateru, Garland, Robert B, Pireh, Daisy, Schretzman, Lori, Rao, Shashidhar N, Lindmark, Richard J, Panzer-Knodle, Susan G, Nicholson, Nancy S

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The role of tissue factor/factor VIIa in the pathophysiology of acute thrombotic formation von Girard, Thomas J, Nicholson, Nancy S

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Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex von South, Michael S., Case, Brenda L., Wood, Rhonda S., Jones, Darin E., Hayes, Michael J., Girard, Thomas J., Lachance, Rhonda M., Nicholson, Nancy S., Clare, Michael, Stevens, Anna M., Stegeman, Roderick A., Stallings, William C., Kurumbail, Ravi G., Parlow, John J.

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Administration of a small molecule tissue factor/Factor VIIa inhibitor in a non-human primate thrombosis model of venous thrombosis: effects on thrombus formation and bleeding time von Szalony, James A, Suleymanov, Osman D, Salyers, Anita K, Panzer-Knodle, Susan G, Blom, Jason D, LaChance, Rhonda M, Case, Brenda L, Parlow, John J, South, Michael S, Wood, Rhonda S, Nicholson, Nancy S

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Pharmacological intervention at disparate sites in the coagulation cascade: Comparison of anti-thrombotic efficacy vs. bleeding propensity in a rat model of acute arterial thrombos... von SZALONY, James A, TAITE, Beatrice B, GIRARD, Thomas J, NICHOLSON, Nancy S, LACHANCE, Rhonda M

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Orbofiban: An orally active GPIIb/IIIa platelet receptor antagonist von Nicholson, Nancy S., Abood, Norman A., Panzer-Knodle, Susan G., Frederick, Leo G., Page, Jimmy D., Salyers, Anita K., Suleymanov, Osman D., Szalony, James A., Taite, Beatrice B., Anders, Robert J.

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Assessment of Bleeding Propensity in Non-Human Primates by Combination of Selective Tissue Factor/VIIa Inhibition and Aspirin Compared to Warfarin and Aspirin Treatment von Salyers, Anita K., Szalony, James A., Suleymanov, Osman D., Parlow, John J., Wood, Rhonda S., South, Michael S., Nicholson, Nancy S.

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SC-54684A : an orally active inhibitor of platelet aggregation von NICHOLSON, N. S, PANZER-KNODLE, S. G, ENGLEMAN, V. W, HERIN, M, JACQMIN, P, FEIGEN, L. P, SALYERS, A. K, TAITE, B. B, SZALONY, J. A, HAAS, N. F, KING, L. W, ZABLOCKI, J. A, KELLER, B. T, BROSCHAT, K

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A method for determining whether hypotension caused by novel compounds in preclinical development results from histamine release von Blom, Jason D., Yang, Po-Chang, Nicholson, Nancy S., Case, Brenda L., Parlow, John J., South, Michael S., Wegner, Craig D.

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Extended inhibition of platelet aggregation with the orally active platelet inhibitor SC-54684A von SZALONY, J. A, HAAS, N. F, SALYERS, A. K, TAITE, B. B, NICHOLSON, N. S, MEHROTRA, D. V, FEIGEN, L. P

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The protective dose of the potent GPIIb/IIIa antagonist SC-54701A is reduced when used in combination with aspirin and heparin in a canine model of coronary artery thrombosis von FREDERICK, L. G, SULEYMANOV, O. D, KING, L. W, SALYERS, A. K, NICHOLSON, N. S, FEIGEN, L. P

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Protective effect of oral xemilofiban in arterial thrombosis in dogs: Increased activity in combination with aspirin von FREDERICK, L. G, SULEYMANOV, O. D, SZALONY, J. A, TAITE, B. B, SALYERS, A. K, KING, L. W, FEIGEN, L. P, NICHOLSON, N. S

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Assessment of platelet function assays von Nicholson, Nancy S., Panzer-Knodle, Susan G., Haas, Neal F., Taite, Beatrice B., Szalony, James A., Page, Jimmy D., Feigen, Larry P., Lansky, David M., Salyers, Anita K.

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Species variation in the effect of glycoprotein IIb/IIIa antagonists on inhibition of platelet aggregation von Panzer-Knodle, Susan, Taite, Beatrice B., Mehrotra, Devan V., Nicholson, Nancy S., Feigen, Larry P.

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Potent in Vitro and in Vivo Inhibitors of Platelet Aggregation Based Upon the Arg-Gly-Asp Sequence of Fibrinogen. (Aminobenzamidino)succinyl (ABAS) Series of Orally Active Fibrinog... von Zablocki, Jeffery A, Rico, Joseph G, Garland, Robert B, Rogers, Thomas E, Williams, Kenneth, Schretzman, Lori A, Rao, Shashidhar A, Bovy, Philippe R, Tjoeng, Foe S

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Fibrinogen receptor antagonists von Zablocki, Jeffery A., Nicholson, Nancy S., Feigen, Larry P.

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A novel series of orally active antiplatelet agents von Zablocki, Jeffery A., Tjoeng, Foe S., Bovy, Philippe R., Miyano, Masateru, Garland, Robert B., Williams, Kenneth, Schretzman, Lori, Zupec, Mark E., Rico, Joseph G., Lindmark, Richard J., Toth, Mihaly V., McMackins, Dudley E., Adams, Steven P., Panzer-Knodle, Susan G., Nicholson, Nancy S., Taite, Beatrice B., Salyers, Anita K., King, Lucy W., Campion, James G., Feigen, Larry P.

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SC-49992-A potent and specific inhibitor of platelet aggregation von Nicholson, Nancy S., Panzer-Knodle, Susan G., King, Lucy W., Taite, Beatrice B., Keller, Brad T., Tjoeng, F.Siong, Engleman, V.Wayne, Giorgio, Todd D., Feigen, Larry P.

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A radioreceptor binding assay for measurement of platelet-activating factor synthesis by human neutrophils von Paulson, Susan K., Nicholson, Nancy S.

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