Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors von Donnelly‐Roberts, Diana L, Namovic, Marian T, Han, Ping, Jarvis, Michael F

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Monocytes/Macrophages play a pathogenic role in IL-23 mediated psoriasis-like skin inflammation von Wang, Yibing, Edelmayer, Rebecca, Wetter, Joe, Salte, Katherine, Gauvin, Donna, Leys, Laura, Paulsboe, Stephanie, Su, Zhi, Weinberg, Isaac, Namovic, Marian, Gauld, Stephen B., Honore, Prisca, Scott, Victoria E., McGaraughty, Steve

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ACT1 Is Required for Murine IL-23–Induced Psoriasiform Inflammation Potentially Independent of E3 Ligase Activity von Lipovsky, Alex, Slivka, Peter F., Su, Zhi, Wang, Yibing, Paulsboe, Stephanie, Wetter, Joseph, Namovic, Marian T., Gauvin, Donna, Perron, Denise, Gauld, Stephen B., McGaraughty, Steven, Goedken, Eric R.

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[3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors von Donnelly-Roberts, Diana L., Namovic, Marian T., Surber, Bruce, Vaidyanathan, Srirajan X., Perez-Medrano, Arturo, Wang, Ying, Carroll, William A., Jarvis, Michael F.

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A non-clinical comparative study of IL-23 antibodies in psoriasis von Zhou, Li, Wang, Yibing, Wan, Qi, Wu, Fei, Barbon, Jeffrey, Dunstan, Robert, Gauld, Stephen, Konrad, Mark, Leys, Laura, McCarthy, Richard, Namovic, Marian, Nelson, Christine, Overmeyer, Gary, Perron, Denise, Su, Zhi, Wang, Leyu, Westmoreland, Susan, Zhang, Jun, Zhu, Rui, Veldman, Geertruida

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Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design von Hobson, Adrian D, Judge, Russell A, Aguirre, Ana L, Brown, Brian S, Cui, Yifang, Ding, Ping, Dominguez, Eric, DiGiammarino, Enrico, Egan, David A, Freiberg, Gail M, Gopalakrishnan, Sujatha M, Harris, Christopher M, Honore, Marie P, Kage, Karen L, Kapecki, Nicolas J, Ling, Christopher, Ma, Junli, Mack, Helmut, Mamo, Mulugeta, Maurus, Stefan, McRae, Bradford, Moore, Nigel S, Mueller, Bernhard K, Mueller, Reinhold, Namovic, Marian T, Patel, Kaushal, Pratt, Steve D, Putman, C. Brent, Queeney, Kara L, Sarris, Kathy K, Schaffter, Lisa M, Stoll, Vincent, Vasudevan, Anil, Wang, Lei, Wang, Lu, Wirthl, William, Yach, Kimberly

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Short-term oral gavage administration of adenine induces a model of fibrotic kidney disease in rats von Zhu, Chang Z., Doyle, Kelly J., Nikkel, Arthur L., Olsen, Lauren, Namovic, Marian T., Salte, Katherine, Widomski, Deborah, Su, Zhi, Donnelly-Roberts, Diana L., Gopalakrishnan, Murali M., McGaraughty, Steve

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Structure−Activity Relationship Studies on a Series of Novel, Substituted 1-Benzyl-5-phenyltetrazole P2X7 Antagonists von Nelson, Derek W, Gregg, Robert J, Kort, Michael E, Perez-Medrano, Arturo, Voight, Eric A, Wang, Ying, Grayson, George, Namovic, Marian T, Donnelly-Roberts, Diana L, Niforatos, Wende, Honore, Prisca, Jarvis, Michael F, Faltynek, Connie R, Carroll, William A

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Small Molecule and Pooled CRISPR Screens Investigating IL17 Signaling Identify BRD2 as a Novel Contributor to Keratinocyte Inflammatory Responses von Slivka, Peter F, Hsieh, Chen-Lin, Lipovsky, Alex, Pratt, Steven D, Locklear, John, Namovic, Marian T, McDonald, Heath A, Wetter, Joseph, Edelmayer, Rebecca, Hu, Min, Murphy, Erin, Domanus, Marc, Lu, Charles, Duggan, Ryan, King, Jacob, Scott, Victoria E, Donnelly-Roberts, Diana, Slavin, Anthony, Gopalakrishnan, Sujatha, Chung, Namjin, Goedken, Eric R

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Characterization of psoriasiform dermatitis induced by systemic injection of interleukin‐23 minicircles in mice von Leys, Laura, Wang, Yibing, Paulsboe, Stephanie, Edelmayer, Rebecca, Salte, Katie, Wetter, Joseph, Namovic, Marian, Phillips, Lucy, Dunstan, Robert, Gauvin, Donna, Donnelly‐Roberts, Diana, Su, Zhi, Honore, Prisca, McGaraughty, Steve

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Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate von Judge, Russell A., Vasudevan, Anil, Scott, Victoria E., Simler, Gricelda H., Pratt, Steve D., Namovic, Marian T., Putman, C. Brent, Aguirre, Ana, Stoll, Vincent S., Mamo, Mulugeta, Swann, Steven I., Cassar, Steven C., Faltynek, Connie R., Kage, Karen L., Boyce‐Rustay, Janel M., Hobson, Adrian D.

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NRF2 activator A-1396076 ameliorates inflammation in autoimmune disease models by inhibiting antigen dependent T cell activation von Goess, Christian, Terrillon, Sonia, Mayo, Martha, Bousquet, Peter, Wallace, Craig, Hart, Michelle, Mathieu, Suzanne, Twomey, Rachel, Donnelly-Roberts, Diana, Namovic, Marian, Jung, Paul, Hu, Min, Richardson, Paul, Esbenshade, Tim, Cuff, Carolyn A.

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Corrigendum: Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate von Judge, Russell A., Vasudevan, Anil, Scott, Victoria E., Simler, Gricelda H., Pratt, Steve D., Namovic, Marian T., Putman, C. Brent, Aguirre, Ana, Stoll, Vincent S., Mamo, Mulugeta, Swann, Steven I., Cassar, Steven C., Faltynek, Connie R., Kage, Karen L., Boyce‐Rustay, Janel M., Hobson, Adrian D.

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Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain von Perez-Medrano, Arturo, Donnelly-Roberts, Diana L, Honore, Prisca, Hsieh, Gin C, Namovic, Marian T, Peddi, Sridhar, Shuai, Qi, Wang, Ying, Faltynek, Connie R, Jarvis, Michael F, Carroll, William A

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Discovery and Biological Evaluation of Novel Cyanoguanidine P2X7 Antagonists with Analgesic Activity in a Rat Model of Neuropathic Pain von Perez-Medrano, Arturo, Donnelly-Roberts, Diana L, Honore, Prisca, Hsieh, Gin C, Namovic, Marian T, Peddi, Sridhar, Shuai, Qi, Wang, Ying, Faltynek, Connie R, Jarvis, Michael F, Carroll, William A

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Structure−Activity Relationship Studies on N′-Aryl Carbohydrazide P2X7 Antagonists von Nelson, Derek W, Sarris, Kathy, Kalvin, Douglas M, Namovic, Marian T, Grayson, George, Donnelly-Roberts, Diana L, Harris, Richard, Honore, Prisca, Jarvis, Michael F, Faltynek, Connie R, Carroll, William A

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Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine P2X(7) antagonists von Perez-Medrano, Arturo, Donnelly-Roberts, Diana L, Florjancic, Alan S, Nelson, Derek W, Li, Tongmei, Namovic, Marian T, Peddi, Sridhar, Faltynek, Connie R, Jarvis, Michael F, Carroll, William A

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Novel and potent 3-(2,3-dichlorophenyl)-4-(benzyl)-4H-1,2,4-triazole P2X7 antagonists von CARROLL, William A, KALVIN, Douglas M, PEREZ MEDRANO, Arturo, FLORJANCIC, Alan S, YING WANG, DONNELLY-ROBERTS, Diana L, NAMOVIC, Marian T, GRAYSON, George, HONORE, Prisca, JARVIS, Michael F

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Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine... von Florjancic, Alan S, Peddi, Sridhar, Perez-Medrano, Arturo, Li, Biqin, Namovic, Marian T, Grayson, George, Donnelly-Roberts, Diana L, Jarvis, Michael F, Carroll, William A

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High Throughput Functional Assays for P2X Receptors von Namovic, Marian T., Jarvis, Michael F., Donnelly‐Roberts, Diana

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