MK-5108, a Highly Selective Aurora-A Kinase Inhibitor, Shows Antitumor Activity Alone and in Combination with Docetaxel von Shimomura, Toshiyasu, Hasako, Shinichi, Nakatsuru, Yoko, Mita, Takashi, Ichikawa, Koji, Kodera, Tsutomu, Sakai, Takumi, Nambu, Tadahiro, Miyamoto, Mayu, Takahashi, Ikuko, Miki, Satomi, Kawanishi, Nobuhiko, Ohkubo, Mitsuru, Kotani, Hidehito, Iwasawa, Yoshikazu

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Benzo[a]pyrene Carcinogenicity Is Lost in Mice Lacking the Aryl Hydrocarbon Receptor von Shimizu, Yasuhito, Nakatsuru, Yoko, Ichinose, Masao, Takahashi, Yoshihisa, Kume, Haruki, Mimura, Junsei, Fujii-Kuriyama, Yoshiaki, Ishikawa, Takatoshi

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Aryl Hydrocarbon Receptor Plays a Significant Role in Mediating Airborne Particulate-Induced Carcinogenesis in Mice von Matsumoto, Yutaka, Ide, Fumio, Kishi, Reiko, Akutagawa, Tomoko, Sakai, Shigekatsu, Nakamura, Masafumi, Ishikawa, Toshitaka, Fujii-Kuriyama, Yoshiaki, Nakatsuru, Yoko

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Base Excision Repair as a Therapeutic Target in Colon Cancer von Liu, Lili, Nakatsuru, Yoko, Gerson, Stanton L

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Spontaneous Tumorigenesis in Mice Defective in the MTH1 Gene Encoding 8-Oxo-dGTPase von Tsuzuki, Teruhisa, Egashira, Akinori, Igarashi, Hisato, Iwakuma, Tomoo, Nakatsuru, Yoko, Tominaga, Yohei, Kawate, Hisaya, Nakao, Kazuki, Nakamura, Kenji, Ide, Fumio, Kura, Shinobu, Nakabeppu, Yusaku, Katsuki, Motoya, Ishikawa, Takatoshi, Sekiguchi, Mutsuo

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DNA repair and cancer: Lessons from mutant mouse models von Ishikawa, Takatoshi, Zhang, Samuel S.‐M., Qin, Xiusheng, Takahashi, Yoshihisa, Oda, Hideaki, Nakatsuru, Yoko, Ide, Fumio

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Evaluating Chemical CDK Inhibitors as Cell Death Inducers von Hirai, Hiroshi, Nakatsuru, Yoko

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MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo von Hirai, Hiroshi, Sootome, Hiroshi, Nakatsuru, Yoko, Miyama, Katsuyoshi, Taguchi, Shunsuke, Tsujioka, Kyoko, Ueno, Yoko, Hatch, Harold, Majumder, Pradip K, Pan, Bo-Sheng, Kotani, Hidehito

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Dibenzo[A,L]pyrene‐induced genotoxic and carcinogenic responses are dramatically suppressed in aryl hydrocarbon receptor‐deficient mice von Nakatsuru, Yoko, Wakabayashi, Keiji, Fujii‐Kuriyama, Yoshiaki, Ishikawa, Takatoshi, Kusama, Kaoru, Ide, Fumio

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Biological characterization of 2-aminothiazole-derived Cdk4/6 selective inhibitor in vitro and in vivo von Hirai, Hiroshi, Shimomura, Toshiyasu, Kobayashi, Makiko, Eguchi, Tomohiro, Taniguchi, Eri, Fukasawa, Kazuhiro, Machida, Takumitsu, Oki, Hiroko, Arai, Tsuyoshi, Ichikawa, Koji, Hasako, Shinichi, Haze, Kyosuke, Kodera, Tsutomu, Kawanishi, Nobuhiko, Takahashi-Suziki, Ikuko, Nakatsuru, Yoko, Kotani, Hidehito, Iwasawa, Yoshikazu

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Separation of Killing and Tumorigenic Effects of an Alkylating Agent in Mice Defective in two of the DNA Repair Genes von Kawate, Hisaya, Sakumi, Kunihiko, Tsuzuki, Teruhisa, Nakatsuru, Yoko, Ishikawa, Takatoshi, Takahashi, Seiichi, Takano, Hiroshi, Noda, Tetsuo, Sekiguchi, Mutsuo

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Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase‑2 (SHP2) von Day, James E. H., Berdini, Valerio, Castro, Joan, Chessari, Gianni, Davies, Thomas G., Day, Philip J., St. Denis, Jeffrey D., Fujiwara, Hideto, Fukaya, Satoshi, Hamlett, Christopher C. F., Hearn, Keisha, Hiscock, Steven D., Holvey, Rhian S., Ito, Satoru, Kandola, Navrohit, Kodama, Yasuo, Liebeschuetz, John W., Martins, Vanessa, Matsuo, Kenichi, Mortenson, Paul N., Muench, Sandra, Nakatsuru, Yoko, Ochiiwa, Hiroaki, Palmer, Nicholas, Peakman, Torren, Price, Amanda, Reader, Michael, Rees, David C., Rich, Sharna J., Shah, Alpesh, Shibata, Yoshihiro, Smyth, Tomoko, Twigg, David G., Wallis, Nicola G., Williams, Glyn, Wilsher, Nicola E., Woodhead, Andrew, Shimamura, Tadashi, Johnson, Christopher N.

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Abstract 1287: The dual IAP antagonist, ASTX660, increases the anti-tumor activity of paclitaxel in preclinical models of triple-negative breast cancer in vivo von Smyth, Tomoko, Nakatsuru, Yoko, Fujita, Ryoto, Ward, George, Bevan, Luke, Lewis, Jon, Wallis, Nicola, Lyons, John

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Xeroderma pigmentosum group A gene action as a protection factor against 4-nitroquinoline 1-oxide-induced tongue carcinogenesis von Ide, Fumio, Oda, Hideaki, Nakatsuru, Yoko, Kusama, Kaoru, Sakashita, Hideaki, Tanaka, Kiyoji, Ishikawa, Takatoshi

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Mice deficient in the nucleotide excision repair gene XPA have elevated sensitivity to benzo[a]pyrene induction of lung tumors von Ide, Fumio, Iida, Naoko, Nakatsuru, Yoko, Oda, Hideaki, Tanaka, Kiyoji, Ishikawa, Takatoshi

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Abstract 1039: Fragment-based drug discovery to identify small molecule allosteric inhibitors of SHP2 von Day, Philip J., Berdini, Valerio, Castro, Juan, Chessari, Gianni, Davies, Thomas G., Day, James E., Fukaya, Satoshi, Hamlett, Chris, Hearn, Keisha, Hiscock, Steve, Holvey, Rhian, Ito, Satoru, Kodama, Yasuo, Matsuo, Kenichi, Nakatsuru, Yoko, Palmer, Nick, Price, Amanda, Shimamura, Tadashi, Denis, Jeffrey D.St, Wallis, Nicola G., Williams, Glyn, Johnson, Christopher N.

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Abstract 3365: Transcriptomics-based stratification of response to MAPK inhibition in vitro better predicts sensitivity to single agent and combination treatment than MAPK genomic... von Brothwood, Jessica, Biondo, Andrea, Dao, Kim-Hien, Hearn, Keisha, Hindley, Chris, Kandola, Navrohit, Keer, Harold, Lyons, John, Nakatsuru, Yoko, O'Reilly, Marc, Wallis, Nicola, Saini, Harpreet

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Frequent Somatic Mutations of the APC and p53 Genes in Sporadic Ampullary Carcinomas von Imai, Yasuo, Oda, Hideaki, Tsurutani, Naomi, Nakatsuru, Yoko, Inoue, Tohru, Ishikawa, Takatoshi

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Morphological and Physiological Restorations of Hereditary Form of Dilated Cardiomyopathy by Somatic Gene Therapy von Kawada, Tomie, Sakamoto, Aiji, Nakazawa, Mikio, Urabe, Masashi, Masuda, Fujiko, Hemmi, Chieko, Wang, Yue, Soo Shin, Wee, Nakatsuru, Yoko, Sato, Hiroshi, Ozawa, Keiya, Toyo-oka, Teruhiko

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Abstract A33: ASTX660, a dual XIAP and cIAP antagonist, potentiates the anti-PD-L1 antibody therapy in mouse tumor models von Smyth, Tomoko, Tsuji, Shingo, Tanaka, Gotaro, Nakatsuru, Yoko, Lyons, John, Thompson, Neil

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