Stem cell signature in glioblastoma: therapeutic development for a moving target von Nakano, Ichiro

Volltext

The AMPK inhibitor compound C is a potent AMPK-independent antiglioma agent von Liu, Xiaona, Chhipa, Rishi Raj, Nakano, Ichiro, Dasgupta, Biplab

Volltext

Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy von Bastola, Soniya, Pavlyukov, Marat S., Yamashita, Daisuke, Ghosh, Sadashib, Cho, Heejin, Kagaya, Noritaka, Zhang, Zhuo, Minata, Mutsuko, Lee, Yeri, Sadahiro, Hirokazu, Yamaguchi, Shinobu, Komarova, Svetlana, Yang, Eddy, Markert, James, Nabors, Louis B., Bhat, Krishna, Lee, James, Chen, Qin, Crossman, David K., Shin-Ya, Kazuo, Nam, Do-Hyun, Nakano, Ichiro

Volltext

Enhanced fatty acid oxidation provides glioblastoma cells metabolic plasticity to accommodate to its dynamic nutrient microenvironment von Kant, Shiva, Kesarwani, Pravin, Prabhu, Antony, Graham, Stewart F., Buelow, Katie L., Nakano, Ichiro, Chinnaiyan, Prakash

Volltext

Activation of the Receptor Tyrosine Kinase AXL Regulates the Immune Microenvironment in Glioblastoma von Sadahiro, Hirokazu, Kang, Kyung-Don, Gibson, Justin T, Minata, Mutsuko, Yu, Hai, Shi, Junfeng, Chhipa, Rishi, Chen, Zhihong, Lu, Songjian, Simoni, Yannick, Furuta, Takuya, Sabit, Hemragul, Zhang, Suojun, Bastola, Soniya, Yamaguchi, Shinobu, Alsheikh, Hebaallah, Komarova, Svetlana, Wang, Jun, Kim, Sung-Hak, Hambardzumyan, Dolores, Lu, Xinghua, Newell, Evan W, DasGupta, Biplab, Nakada, Mitsutoshi, Lee, L James, Nabors, Burt, Norian, Lyse A, Nakano, Ichiro

Volltext

Angiocrine extracellular vesicles impose mesenchymal reprogramming upon proneural glioma stem cells von Adnani, Lata, Kassouf, Jordan, Meehan, Brian, Spinelli, Cristiana, Tawil, Nadim, Nakano, Ichiro, Rak, Janusz

Volltext

Molecular and cellular intratumoral heterogeneity in primary glioblastoma: clinical and translational implications von Bernstock, Joshua D, Mooney, James H, Ilyas, Adeel, Chagoya, Gustavo, Estevez-Ordonez, Dagoberto, Ibrahim, Ahmed, Nakano, Ichiro

Volltext

Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells von Kim, Eunhee, Kim, Misuk, Woo, Dong-Hun, Shin, Yongjae, Shin, Jihye, Chang, Nakho, Oh, Young Taek, Kim, Hong, Rheey, Jingeun, Nakano, Ichiro, Lee, Cheolju, Joo, Kyeung Min, Rich, Jeremy N., Nam, Do-Hyun, Lee, Jeongwu

Volltext

Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis von Geng, Feng, Cheng, Xiang, Wu, Xiaoning, Yoo, Ji Young, Cheng, Chunming, Guo, Jeffrey Yunhua, Mo, Xiaokui, Ru, Peng, Hurwitz, Brian, Kim, Sung-Hak, Otero, Jose, Puduvalli, Vinay, Lefai, Etienne, Ma, Jianjie, Nakano, Ichiro, Horbinski, Craig, Kaur, Balveen, Chakravarti, Arnab, Guo, Deliang

Volltext

Combined PI3Kα-mTOR Targeting of Glioma Stem Cells von Eckerdt, Frank D., Bell, Jonathan B., Gonzalez, Christopher, Oh, Michael S., Perez, Ricardo E., Mazewski, Candice, Fischietti, Mariafausta, Goldman, Stewart, Nakano, Ichiro, Platanias, Leonidas C.

Volltext

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3 von Mao, Ping, Joshi, Kaushal, Li, Jianfeng, Kim, Sung-Hak, Li, Peipei, Santana-Santos, Lucas, Luthra, Soumya, Chandran, Uma R., Benos, Panayiotis V., Smith, Luke, Wang, Maode, Hu, Bo, Cheng, Shi-Yuan, Sobol, Robert W., Nakano, Ichiro

Volltext

MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma von Huang, Tianzhi, Kim, Chung Kwon, Alvarez, Angel A., Pangeni, Rajendra P., Wan, Xuechao, Song, Xiao, Shi, Taiping, Yang, Yongyong, Sastry, Namratha, Horbinski, Craig M., Lu, Songjian, Stupp, Roger, Kessler, John A., Nishikawa, Ryo, Nakano, Ichiro, Sulman, Erik P., Lu, Xinghua, James, Charles David, Yin, Xiao-Ming, Hu, Bo, Cheng, Shi-Yuan

Volltext

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake von Flavahan, William A, Wu, Qiulian, Hitomi, Masahiro, Rahim, Nasiha, Kim, Youngmi, Sloan, Andrew E, Weil, Robert J, Nakano, Ichiro, Sarkaria, Jann N, Stringer, Brett W, Day, Bryan W, Li, Meizhang, Lathia, Justin D, Rich, Jeremy N, Hjelmeland, Anita B

Volltext

Combined c-Met/Trk Inhibition Overcomes Resistance to CDK4/6 Inhibitors in Glioblastoma von Olmez, Inan, Zhang, Ying, Manigat, Laryssa, Benamar, Mouadh, Brenneman, Breanna, Nakano, Ichiro, Godlewski, Jakub, Bronisz, Agnieszka, Lee, Jeongwu, Abbas, Tarek, Abounader, Roger, Purow, Benjamin

Volltext

CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells von Han, Jianfeng, Chu, Jianhong, Keung Chan, Wing, Zhang, Jianying, Wang, Youwei, Cohen, Justus B., Victor, Aaron, Meisen, Walter H., Kim, Sung-hak, Grandi, Paola, Wang, Qi-En, He, Xiaoming, Nakano, Ichiro, Chiocca, E. Antonio, Glorioso III, Joseph C., Kaur, Balveen, Caligiuri, Michael A., Yu, Jianhua

Volltext

Combined CDK4/6 and mTOR Inhibition Is Synergistic against Glioblastoma via Multiple Mechanisms von Olmez, Inan, Brenneman, Breanna, Xiao, Aizhen, Serbulea, Vlad, Benamar, Mouadh, Zhang, Ying, Manigat, Laryssa, Abbas, Tarek, Lee, Jeongwu, Nakano, Ichiro, Godlewski, Jakub, Bronisz, Agnieszka, Abounader, Roger, Leitinger, Norbert, Purow, Benjamin

Volltext

Toxicity and Efficacy of a Novel GADD34-expressing Oncolytic HSV-1 for the Treatment of Experimental Glioblastoma von Nakashima, Hiroshi, Nguyen, Tran, Kasai, Kazue, Passaro, Carmela, Ito, Hirotaka, Goins, William F, Shaikh, Imran, Erdelyi, Ronald, Nishihara, Reiko, Nakano, Ichiro, Reardon, David A, Anderson, Ana C, Kuchroo, Vijay, Chiocca, E Antonio

Volltext

FOXD1-ALDH1A3 Signaling Is a Determinant for the Self-Renewal and Tumorigenicity of Mesenchymal Glioma Stem Cells von Cheng, Peng, Wang, Jia, Waghmare, Indrayani, Sartini, Stefania, Coviello, Vito, Zhang, Zhuo, Kim, Sung-Hak, Mohyeldin, Ahmed, Pavlyukov, Marat S, Minata, Mutsuko, Valentim, Claudia L L, Chhipa, Rishi Raj, Bhat, Krishna P L, Dasgupta, Biplab, La Motta, Concettina, Kango-Singh, Madhuri, Nakano, Ichiro

Volltext

The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches von Mineo, Marco, Ricklefs, Franz, Rooj, Arun K., Lyons, Shawn M., Ivanov, Pavel, Ansari, Khairul I., Nakano, Ichiro, Chiocca, E. Antonio, Godlewski, Jakub, Bronisz, Agnieszka

Volltext

MiR-21 in the extracellular vesicles (EVs) of cerebrospinal fluid (CSF): a platform for glioblastoma biomarker development von Akers, Johnny C, Ramakrishnan, Valya, Kim, Ryan, Skog, Johan, Nakano, Ichiro, Pingle, Sandeep, Kalinina, Juliya, Hua, Wei, Kesari, Santosh, Mao, Ying, Breakefield, Xandra O, Hochberg, Fred H, Van Meir, Erwin G, Carter, Bob S, Chen, Clark C

Volltext