Expandable Megakaryocyte Cell Lines Enable Clinically Applicable Generation of Platelets from Human Induced Pluripotent Stem Cells von Nakamura, Sou, Takayama, Naoya, Hirata, Shinji, Seo, Hideya, Endo, Hiroshi, Ochi, Kiyosumi, Fujita, Ken-ichi, Koike, Tomo, Harimoto, Ken-ichi, Dohda, Takeaki, Watanabe, Akira, Okita, Keisuke, Takahashi, Nobuyasu, Sawaguchi, Akira, Yamanaka, Shinya, Nakauchi, Hiromitsu, Nishimura, Satoshi, Eto, Koji

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iPLAT1: the first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study von Sugimoto, Naoshi, Kanda, Junya, Nakamura, Sou, Kitano, Toshiyuki, Hishizawa, Masakatsu, Kondo, Tadakazu, Shimizu, Shin, Shigemasa, Akiko, Hirai, Hideyo, Arai, Yasuyuki, Minami, Manabu, Tada, Harue, Momose, Dai, Koh, Ki-Ryang, Nogawa, Masayuki, Watanabe, Naohide, Okamoto, Shinichiro, Handa, Makoto, Sawaguchi, Akira, Matsuyama, Nobuki, Tanaka, Mitsunobu, Hayashi, Tomoya, Fuchizaki, Akihiro, Tani, Yoshihiko, Takaori-Kondo, Akifumi, Eto, Koji

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Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells von Takayama, Naoya, Nishimura, Satoshi, Nakamura, Sou, Shimizu, Takafumi, Ohnishi, Ryoko, Endo, Hiroshi, Yamaguchi, Tomoyuki, Otsu, Makoto, Nishimura, Ken, Nakanishi, Mahito, Sawaguchi, Akira, Nagai, Ryozo, Takahashi, Kazutoshi, Yamanaka, Shinya, Nakauchi, Hiromitsu, Eto, Koji

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Ex vivo generation of platelet products from human iPS cells von Nakamura, Sou, Sugimoto, Naoshi, Eto, Koji

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Three-dimensional microchannel reflecting cell size distribution for on-chip production of platelet-like particles von Sakuma, Shinya, Kumon, Hiroki, Nakamura, Sou, Kasai, Yusuke, Eto, Koji, Arai, Fumihito

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A let-7 microRNA-RALB axis links the immune properties of iPSC-derived megakaryocytes with platelet producibility von Chen, Si Jing, Hashimoto, Kazuya, Fujio, Kosuke, Hayashi, Karin, Paul, Sudip Kumar, Yuzuriha, Akinori, Qiu, Wei-Yin, Nakamura, Emiri, Kanashiro, Maria Alejandra, Kabata, Mio, Nakamura, Sou, Sugimoto, Naoshi, Kaneda, Atsushi, Yamamoto, Takuya, Saito, Hirohide, Takayama, Naoya, Eto, Koji

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Two differential flows in a bioreactor promoted platelet generation from human pluripotent stem cell–derived megakaryocytes von Nakagawa, Yosuke, Nakamura, Sou, Nakajima, Masahiro, Endo, Hiroshi, Dohda, Takeaki, Takayama, Naoya, Nakauchi, Hiromitsu, Arai, Fumihito, Fukuda, Toshio, Eto, Koji

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Development of platelet replacement therapy using human induced pluripotent stem cells von Nakamura, Sou, Sugimoto, Naoshi, Eto, Koji

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iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity von Suzuki, Daisuke, Flahou, Charlotte, Yoshikawa, Norihide, Stirblyte, Ieva, Hayashi, Yoshikazu, Sawaguchi, Akira, Akasaka, Marina, Nakamura, Sou, Higashi, Natsumi, Xu, Huaigeng, Matsumoto, Takuya, Fujio, Kosuke, Manz, Markus G., Hotta, Akitsu, Takizawa, Hitoshi, Eto, Koji, Sugimoto, Naoshi

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Microfluidic Bioreactor Made of Cyclo-Olefin Polymer for Observing On-Chip Platelet Production von Kumon, Hiroki, Sakuma, Shinya, Nakamura, Sou, Maruyama, Hisataka, Eto, Koji, Arai, Fumihito

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Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling von Hirata, Shinji, Takayama, Naoya, Jono-Ohnishi, Ryoko, Endo, Hiroshi, Nakamura, Sou, Dohda, Takeaki, Nishi, Masanori, Hamazaki, Yuhei, Ishii, Ei-ichi, Kaneko, Shin, Otsu, Makoto, Nakauchi, Hiromitsu, Kunishima, Shinji, Eto, Koji

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Extracellular laminin regulates hematopoietic potential of pluripotent stem cells through integrin β1-ILK-β-catenin-JUN axis von Yuzuriha, Akinori, Nakamura, Sou, Sugimoto, Naoshi, Kihara, Shunsuke, Nakagawa, Masato, Yamamoto, Takuya, Sekiguchi, Kiyotoshi, Eto, Koji

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Natural Killer Cell Activities Against iPSCs-Derived HLA-Knockout Platelets and Megakaryocytes Reveal Perfect Rejection Profiles for Allotransfusion von Suzuki, Daisuke, Sugimoto, Naoshi, Yoshikawa, Norihide, Endo, Hiroshi, Nakamura, Sou, Hotta, Akitsu, Eto, Koji

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Suppressive effects of anagrelide on cell cycle progression and the maturation of megakaryocyte progenitor cell lines in human induced pluripotent stem cells von Takaishi, Koji, Takeuchi, Masahiro, Tsukamoto, Shokichi, Takayama, Naoya, Oshima, Motohiko, Kimura, Kenji, Isshiki, Yusuke, Kayamori, Kensuke, Hino, Yutaro, Oshima-Hasegawa, Nagisa, Mitsukawa, Shio, Takeda, Yusuke, Mimura, Naoya, Ohwada, Chikako, Iseki, Tohru, Nakamura, Sou, Eto, Koji, Iwama, Atsushi, Yokote, Koutaro, Nakaseko, Chiaki, Sakaida, Emiko

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Production and nonclinical evaluation of an autologous iPSC–derived platelet product for the iPLAT1 clinical trial von Sugimoto, Naoshi, Nakamura, Sou, Shimizu, Shin, Shigemasa, Akiko, Kanda, Junya, Matsuyama, Nobuki, Tanaka, Mitsunobu, Hayashi, Tomoya, Fuchizaki, Akihiro, Nogawa, Masayuki, Watanabe, Naohide, Okamoto, Shinichiro, Handa, Makoto, Sawaguchi, Akira, Momose, Dai, Koh, Ki-Ryang, Tani, Yoshihiko, Takaori-Kondo, Akifumi, Eto, Koji

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Osteogenic effects and safety of human induced pluripotent stem cell-derived megakaryocytes and platelets produced on a clinical scale von Arai, Takahito, Shiga, Yasuhiro, Mukai, Michiaki, Takayama, Naoya, Tashiro, Susumu, Tajiri, Ikuko, Kosaka, Kentaro, Sato, Masashi, Nakamura, Sou, Okamoto, Haruki, Kimura, Seiji, Inage, Kazuhide, Suzuki-Narita, Miyako, Eguchi, Yawara, Orita, Sumihisa, Eto, Koji, Ohtori, Seiji

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Immortalization of Erythroblasts by c-MYC and BCL-XL Enables Large-Scale Erythrocyte Production from Human Pluripotent Stem Cells von Hirose, Sho-ichi, Takayama, Naoya, Nakamura, Sou, Nagasawa, Kazumichi, Ochi, Kiyosumi, Hirata, Shinji, Yamazaki, Satoshi, Yamaguchi, Tomoyuki, Otsu, Makoto, Sano, Shinya, Takahashi, Nobuyasu, Sawaguchi, Akira, Ito, Mamoru, Kato, Takashi, Nakauchi, Hiromitsu, Eto, Koji

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Defective flow space limits the scaling up of turbulence bioreactors for platelet generation von Okamoto, Haruki, Fujio, Kosuke, Nakamura, Sou, Harada, Yasuo, Hayashi, Hideki, Higashi, Natsumi, Ninomiya, Atsushi, Tanaka, Ryota, Sugimoto, Naoshi, Takayama, Naoya, Kaneda, Atsushi, Sawaguchi, Akira, Kato, Yoshikazu, Eto, Koji

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Novel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells von Aihara, Ayako, Koike, Tomo, Abe, Natsuki, Nakamura, Sou, Sawaguchi, Akira, Nakamura, Takanori, Sugimoto, Naoshi, Nakauchi, Hiromitsu, Nishino, Taito, Eto, Koji

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Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production von Ito, Yukitaka, Nakamura, Sou, Sugimoto, Naoshi, Shigemori, Tomohiro, Kato, Yoshikazu, Ohno, Mikiko, Sakuma, Shinya, Ito, Keitaro, Kumon, Hiroki, Hirose, Hidenori, Okamoto, Haruki, Nogawa, Masayuki, Iwasaki, Mio, Kihara, Shunsuke, Fujio, Kosuke, Matsumoto, Takuya, Higashi, Natsumi, Hashimoto, Kazuya, Sawaguchi, Akira, Harimoto, Ken-ichi, Nakagawa, Masato, Yamamoto, Takuya, Handa, Makoto, Watanabe, Naohide, Nishi, Eiichiro, Arai, Fumihito, Nishimura, Satoshi, Eto, Koji

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