Preventive and Therapeutic Efficacy of ONO-4641, a Selective Agonist for Sphingosine 1-Phosphate Receptor 1 and 5, in Preclinical Models of Type 1 Diabetes Mellitus von Shioya, Hiroki, Inagaki, Yuichi, Hiraizumi, Kenji, Hoshino, Tomohiro, Kurata, Haruto, Habashita, Hiromu, Sato, Kazutoyo, Nakade, Shinji

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Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1 von Chrencik, Jill E., Roth, Christopher B., Terakado, Masahiko, Kurata, Haruto, Omi, Rie, Kihara, Yasuyuki, Warshaviak, Dora, Nakade, Shinji, Asmar-Rovira, Guillermo, Mileni, Mauro, Mizuno, Hirotaka, Griffith, Mark T., Rodgers, Caroline, Han, Gye Won, Velasquez, Jeffrey, Chun, Jerold, Stevens, Raymond C., Hanson, Michael A.

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A novel highly potent autotaxin/ENPP2 inhibitor produces prolonged decreases in plasma lysophosphatidic acid formation in vivo and regulates urethral tension von Saga, Hiroshi, Ohhata, Akira, Hayashi, Akio, Katoh, Makoto, Maeda, Tatsuo, Mizuno, Hirotaka, Takada, Yuka, Komichi, Yuka, Ota, Hiroto, Matsumura, Naoya, Shibaya, Masami, Sugiyama, Tetsuya, Nakade, Shinji, Kishikawa, Katsuya

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Discovery of a 1‑Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P1 and S1P5 Selective Agonist for the Treatment of A... von Kurata, Haruto, Kusumi, Kensuke, Otsuki, Kazuhiro, Suzuki, Ryo, Kurono, Masakuni, Komiya, Takaki, Hagiya, Hiroshi, Mizuno, Hirotaka, Shioya, Hiroki, Ono, Takeji, Takada, Yuka, Maeda, Tatsuo, Matsunaga, Norikazu, Kondo, Tetsu, Tominaga, Sachiko, Nunoya, Ken-ici, Kiyoshi, Hidekazu, Komeno, Masaharu, Nakade, Shinji, Habashita, Hiromu

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Effects of ONO-6950, a novel dual cysteinyl leukotriene 1 and 2 receptors antagonist, in a guinea pig model of asthma von Yonetomi, Yasuo, Sekioka, Tomohiko, Kadode, Michiaki, Kitamine, Tetsuya, Kamiya, Akihiro, inoue, Atsuto, Nakao, Takafumi, Nomura, Hiroaki, Murata, Masayuki, Nakao, Shintaro, Nambu, Fumio, Fujita, Manabu, Nakade, Shinji, Kawabata, Kazuhito

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A new CysLT1 and CysLT2 receptors-mediated anaphylaxis guinea pig model von Sekioka, Tomohiko, Kadode, Michiaki, Osakada, Noriko, Fujita, Manabu, Matsumura, Naoya, Yamaura, Yoshiyuki, Nakade, Shinji, Nabe, Takeshi, Kawabata, Kazuhito

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Discovery of ONO-7300243 from a Novel Class of Lysophosphatidic Acid Receptor 1 Antagonists: From Hit to Lead von Terakado, Masahiko, Suzuki, Hidehiro, Hashimura, Kazuya, Tanaka, Motoyuki, Ueda, Hideyuki, Kohno, Hiroshi, Fujimoto, Taku, Saga, Hiroshi, Nakade, Shinji, Habashita, Hiromu, Takaoka, Yoshikazu, Seko, Takuya

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Block of Ca2+ wave and Ca2+ oscillation by antibody to the inositol 1,4,5-trisphosphate receptor in fertilized hamster eggs von MIAZAKI, S.-I, YUZAKI, M, NAKADA, K, SHIRAKAWA, H, NAKANISHI, S, NAKADE, S, MIKOSHIBA, K

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The Xenopus IP3 receptor : structure, function, and localization in oocytes and eggs von KUME, S, MUTO, A, ARUGA, J, NAKAGAWA, T, MICHIKAWA, T, FURUICHI, T, NAKADE, S, OKANO, H, MIKOSHIBA, K

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A Novel Animal Model of Dysphagia Following Stroke von Sugiyama, Naoto, Nishiyama, Eiji, Nishikawa, Yukitoshi, Sasamura, Takashi, Nakade, Shinji, Okawa, Katsumasa, Nagasawa, Tadashi, Yuki, Akane

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Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P 1 and S1P 5 Selective Agonist for the Treatment of... von Kurata, Haruto, Kusumi, Kensuke, Otsuki, Kazuhiro, Suzuki, Ryo, Kurono, Masakuni, Komiya, Takaki, Hagiya, Hiroshi, Mizuno, Hirotaka, Shioya, Hiroki, Ono, Takeji, Takada, Yuka, Maeda, Tatsuo, Matsunaga, Norikazu, Kondo, Tetsu, Tominaga, Sachiko, Nunoya, Ken-Ici, Kiyoshi, Hidekazu, Komeno, Masaharu, Nakade, Shinji, Habashita, Hiromu

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Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia von Terakado, Masahiko, Suzuki, Hidehiro, Hashimura, Kazuya, Tanaka, Motoyuki, Ueda, Hideyuki, Hirai, Keisuke, Asada, Masaki, Ikura, Masahiro, Matsunaga, Naoki, Saga, Hiroshi, Shinozaki, Koji, Karakawa, Naoko, Takada, Yuka, Minami, Masashi, Egashira, Hiromu, Sugiura, Yoshihiro, Yamada, Masanori, Nakade, Shinji, Takaoka, Yoshikazu

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Tu1370 Effects of Ono-2952, a Novel Translocator Protein 18kda Antagonist, on Stress-Induced Rectal Hyperalgesia and Defecation in Rats von Mitsui, Katsukuni, Sasamura, Takashi, Katsumata, Seishi, Niwa, Tomohiro, Kawahara, Yuji, Morimoto, Noriko, Yoshikawa, Ken, Nakade, Shinji

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Structure–activity relationship studies of S1P agonists with a dihydronaphthalene scaffold von Kurata, Haruto, Kusumi, Kensuke, Otsuki, Kazuhiro, Suzuki, Ryo, Kurono, Masakuni, Tokuda, Natsuko, Takada, Yuka, Shioya, Hiroki, Mizuno, Hirotaka, Komiya, Takaki, Ono, Takeji, Hagiya, Hiroshi, Minami, Masashi, Nakade, Shinji, Habashita, Hiromu

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Discovery of S1P agonists with a dihydronaphthalene scaffold von Kurata, Haruto, Kusumi, Kensuke, Otsuki, Kazuhiro, Suzuki, Ryo, Kurono, Masakuni, Takada, Yuka, Shioya, Hiroki, Komiya, Takaki, Mizuno, Hirotaka, Ono, Takeji, Hagiya, Hiroshi, Minami, Masashi, Nakade, Shinji, Habashita, Hiromu

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A new CysLT 1 and CysLT 2 receptors-mediated anaphylaxis guinea pig model von Sekioka, Tomohiko, Kadode, Michiaki, Osakada, Noriko, Fujita, Manabu, Matsumura, Naoya, Yamaura, Yoshiyuki, Nakade, Shinji, Nabe, Takeshi, Kawabata, Kazuhito

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Structure–activity relationship studies of sphingosine-1-phosphate receptor agonists with N-cinnamyl-β-alanine moiety von Kurata, Haruto, Otsuki, Kazuhiro, Kusumi, Kensuke, Kurono, Masakuni, Terakado, Masahiko, Seko, Takuya, Mizuno, Hirotaka, Ono, Takeji, Hagiya, Hiroshi, Minami, Masashi, Nakade, Shinji, Habashita, Hiromu

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Block of Ca$^{2+}$ Wave and Ca$^{2+}$ Oscillation by Antibody to the Inositol 1,4,5-Trisphosphate Receptor in Fertilized Hamster Eggs von Miyazaki, Shun-ichi, Yuzaki, Michisuke, Nakada, Ken, Shirakawa, Hideki, Nakanishi, Setsuko, Nakade, Shinji, Mikoshiba, Katsuhiko

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Localization of Inositol 1,4,5-Trisphosphate Receptor-Like Protein in Plasmalemmal Caveolae von Fujimoto, Toyoshi, Nakade, Shinji, Miyawaki, Atsushi, Mikoshiba, Katsuhiko, Ogawa, Kazuo

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Structural and functional characterization of inositol 1,4,5-trisphosphate receptor channel from mouse cerebellum von Maeda, N, Kawasaki, T, Nakade, S, Yokota, N, Taguchi, T, Kasai, M, Mikoshiba, K

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