Discovery of Ruzasvir (MK-8408): A Potent, Pan-Genotype HCV NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Polymorphisms von Tong, Ling, Yu, Wensheng, Chen, Lei, Selyutin, Oleg, Dwyer, Michael P, Nair, Anilkumar G, Mazzola, Robert, Kim, Jae-Hun, Sha, Deyou, Yin, Jingjun, Ruck, Rebecca T, Davies, Ian W, Hu, Bin, Zhong, Bin, Hao, Jinglai, Ji, Tao, Zan, Shuai, Liu, Rong, Agrawal, Sony, Xia, Ellen, Curry, Stephanie, McMonagle, Patricia, Bystol, Karin, Lahser, Frederick, Carr, Donna, Rokosz, Laura, Ingravallo, Paul, Chen, Shiying, Feng, Kung-I, Cartwright, Mark, Asante-Appiah, Ernest, Kozlowski, Joseph A

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MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV von Nair, Anilkumar G., Zeng, Qingbei, Selyutin, Oleg, Rosenblum, Stuart B., Jiang, Yueheng, Yang, De-Yi, Keertikar, Kerry, Zhou, Guowei, Dwyer, Michael, Kim, Seong Heon, Shankar, Bandarpalle, Yu, Wensheng, Tong, Ling, Chen, Lei, Mazzola, Robert, Caldwell, John, Tang, Haiqun, Agrawal, Sony, Liu, Rong, Kong, Rong, Ingravallo, Paul, Xia, Ellen, Zhai, Ying, Nomeir, Amin, Asante-Appiah, Ernest, Kozlowski, Joseph A.

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Discovery of silyl proline containing HCV NS5A inhibitors with pan-genotype activity: SAR development von Nair, Anilkumar G., Zeng, Qingbei, Selyutin, Oleg, Rosenblum, Stuart B., Jiang, Yueheng, Yang, De-Yi, Keertikar, Kerry, Zhou, Guowei, Dwyer, Michael P., Kim, Seong Heon, Shankar, Bandarpalle, Yu, Wensheng, Tong, Ling, Chen, Lei, Mazzola, Robert, Caldwell, John, Tang, Haiqun, Allard, Melissa L., Buckle, Ronald N., Gauuan, Polivina Jolicia F., Holst, Christian L., Martin, Gregory S., Naicker, Kannan P., Vellekoop, Samuel, Agrawal, Sony, Liu, Rong, Kong, Rong, Ingravallo, Paul, Xia, Ellen, Zhai, Ying, Nomeir, Amin, Kozlowski, Joseph A.

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Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors von Dwyer, Michael P., Keertikar, Kerry M., Chen, Lei, Tong, Ling, Selyutin, Oleg, Nair, Anilkumar G., Yu, Wensheng, Zhou, Guowei, Lavey, Brian J., Yang, De-Yi, Wong, Michael, Kim, Seong Heon, Coburn, Craig A., Rosenblum, Stuart B., Zeng, Qingbei, Jiang, Yueheng, Shankar, Bandarpalle B., Rizvi, Razia, Nomeir, Amin A., Liu, Rong, Agrawal, Sony, Xia, Ellen, Kong, Rong, Zhai, Ying, Ingravallo, Paul, Asante-Appiah, Ernest, Kozlowski, Joseph A.

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Alkyl substituted aminal derivatives of HCV NS5A inhibitor MK-8742 von Yu, Wensheng, Coburn, Craig A., Nair, Anilkumar G., Wong, Michael, Tong, Ling, Dwyer, Michael P., Hu, Bin, Zhong, Bin, Hao, Jinglai, Yang, De-Yi, Selyutin, Oleg, Jiang, Yueheng, Rosenblum, Stuart B., Kim, Seong Heon, Lavey, Brian J., Zhou, Guowei, Rizvi, Razia, Shankar, Bandarpalle B., Zeng, Qingbei, Chen, Lei, Agrawal, Sony, Carr, Donna, Rokosz, Laura, Liu, Rong, Curry, Stephanie, McMonagle, Patricia, Ingravallo, Paul, Lahser, Fred, Asante-Appiah, Ernest, Nomeir, Amin, Kozlowski, Joseph A.

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Structure–activity relationships of proline modifications around the tetracyclic-indole class of NS5A inhibitors von Tong, Ling, Yu, Wensheng, Coburn, Craig A., Chen, Lei, Selyutin, Oleg, Zeng, Qingbei, Dwyer, Michael P., Nair, Anilkumar G., Shankar, Bandarpalle B., Kim, Seong Heon, Yang, De-Yi, Rosenblum, Stuart B., Ruck, Rebecca T., Davies, Ian W., Hu, Bin, Zhong, Bin, Hao, Jinglai, Ji, Tao, Zan, Shuai, Liu, Rong, Agrawal, Sony, Carr, Donna, Curry, Stephanie, McMonagle, Patricia, Bystol, Karin, Lahser, Frederick, Ingravallo, Paul, Chen, Shiying, Asante-Appiah, Ernest, Kozlowski, Joseph A.

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Substituted tetracyclic indole core derivatives of HCV NS5A inhibitor MK-8742 von Yu, Wensheng, Zhou, Guowei, Coburn, Craig A., Zeng, Qingbei, Tong, Ling, Dwyer, Michael P., Hu, Bin, Zhong, Bin, Hao, Jinglai, Ji, Tao, Zan, Shuai, Chen, Lei, Mazzola, Robert, Kim, Jae-Hun, Sha, Deyou, Selyutin, Oleg, Rosenblum, Stuart B., Lavey, Brian, Nair, Anilkumar G., Heon Kim, Seong, Keertikar, Kerry M., Rokosz, Laura, Agrawal, Sony, Liu, Rong, Xia, Ellen, Zhai, Ying, Curry, Stephanie, McMonagle, Patricia, Ingravallo, Paul, Asante-Appiah, Ernest, Chen, Shiying, Kozlowski, Joseph A.

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Optimization of potency and pharmacokinetics of tricyclic indole derived inhibitors of HCV NS5B polymerase. Identification of ester prodrugs with improved oral pharmacokinetics von Venkatraman, Srikanth, Velazquez, Francisco, Gavalas, Stephen, Wu, Wanli, Chen, Kevin X., Nair, Anilkumar G., Bennett, Frank, Huang, Yuhua, Pinto, Patrick, Jiang, Yueheng, Selyutin, Oleg, Vibulbhan, Bancha, Zeng, Qingbei, Lesburg, Charles, Duca, Jose, Heimark, Larry, Huang, Hsueh-Cheng, Agrawal, Sony, Jiang, Chuan-kui, Ferrari, Eric, Li, Cheng, Kozlowski, Joseph, Rosenblum, Stuart, Shih, Neng-Yang, Njoroge, F. George

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IV. Discovery of CXCR3 antagonists substituted with heterocycles as amide surrogates: improved PK, hERG and metabolic profiles von Nair, Anilkumar G, Wong, Michael K C, Shu, Youheng, Jiang, Yueheng, Jenh, Chung-Her, Kim, Seong Heon, Yang, De-Yi, Zeng, Qingbei, Shao, Yuefei, Zawacki, Lisa Guise, Duo, Jingqi, McGuinness, Brian F, Carroll, Carolyn Diianni, Hobbs, Doug W, Shih, Neng-Yang, Rosenblum, Stuart B, Kozlowski, Joseph A

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Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase von Venkatraman, Srikanth, Velazquez, Francisco, Gavalas, Stephen, Wu, Wanli, Chen, Kevin X., Nair, Anilkumar G., Bennett, Frank, Huang, Yuhua, Pinto, Patrick, Jiang, Yueheng, Selyutin, Oleg, Vibulbhan, Bancha, Zeng, Qingbei, Lesburg, Charles, Duca, Jose, Huang, Hsueh-Cheng, Agrawal, Sony, Jiang, Chuan-kui, Ferrari, Eric, Li, Cheng, Kozlowski, Joseph, Rosenblum, Stuart, Shih, Neng-Yang, Njoroge, F. George

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Discovery of an irreversible HCV NS5B polymerase inhibitor von Zeng, Qingbei, Nair, Anilkumar G., Rosenblum, Stuart B., Huang, Hsueh-Cheng, Lesburg, Charles A., Jiang, Yueheng, Selyutin, Oleg, Chan, Tin-Yau, Bennett, Frank, Chen, Kevin X., Venkatraman, Srikanth, Sannigrahi, Mousumi, Velazquez, Francisco, Duca, Jose S., Gavalas, Stephen, Huang, Yuhua, Pu, Haiyan, Wang, Li, Pinto, Patrick, Vibulbhan, Bancha, Agrawal, Sony, Ferrari, Eric, Jiang, Chuan-kui, Li, Cheng, Hesk, David, Gesell, Jennifer, Sorota, Steve, Shih, Neng-Yang, Njoroge, F. George, Kozlowski, Joseph A.

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Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor von Johns, Douglas G., Campeau, Louis-Charles, Banka, Puja, Bautmans, An, Bueters, Tjerk, Bianchi, Elisabetta, Branca, Danila, Bulger, Paul G., Crevecoeur, Inne, Ding, Fa-Xiang, Garbaccio, Robert M., Guetschow, Erik D., Guo, Yan, Ha, Sookhee N., Johnston, Jennifer M., Josien, Hubert, Kauh, Eunkyung A., Koeplinger, Kenneth A., Kuethe, Jeffrey T., Lai, Eseng, Lanning, Christine L., Lee, Anita Y.H., Li, Li, Nair, Anilkumar G., O’Neill, Edward A., Stoch, S. Aubrey, Thaisrivongs, David A., Tucker, Thomas J., Vachal, Petr, van Dyck, Kristien, Vanhoutte, Frederic P., Volckaert, Bram, Wolford, Dennis G., Xu, Andy, Zhao, Tian, Zhou, Dan, Zhou, Susan, Zhu, Xiaohong, Zokian, Hratch J., Walji, Abbas, Wood, Harold B.

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Periselective [4π+2π] Cycloaddition Reactions of 3-Ethoxy Carbonyl-2H-cyclohepta[b]furan-2-one with Aralkenes von Nair, Vijay, Nair, Anilkumar G, Rath, Nigam P, Eigendorf, Guenter K

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Diels-Alder Reactions of a 6-Arenyl Fulvene Participating both as Diene and Dienophile von Nair, Vijay, Nair, Anilkumar G., Radhakrishnan, K. V., Nandakumar, M. V., Rath, Nigam P.

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DIAMINOPYRIMIDINE CARBOXAMIDE INHIBITORS OF HPK1 von Achab, Abdelghani, Vara, Brandon A, Fradera, Xavier, Yu, Elsie C, Kawamura, Shuhei, Pasternak, Alexander, Candito, David A, Donofrio, Anthony, Nair, Anilkumar G, Levi, Samuel M, Li, Bing

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DIAMINOPYRIMIDINE CARBOXAMIDE INHIBITORS OF HPK1 von NAIR, Anilkumar G, VARA, Brandon A, CANDITO, David A, LI, Bing, ACHAB, Abdelghani, DONOFRIO, Anthony, YU, Elsie C, FRADERA, Xavier, KAWAMURA, Shuhei, PASTERNAK, Alexander, LEVI, Samuel M

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INDAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF HERPES VIRUSES von Jayne, Charles Lee, Tellers, David M, Cooke, Andrew John, Skudlarek, Jason W, Schubert, Jeffrey W, Nair, Anilkumar G, Yang, De-Yi, Cox, Christopher D, Edmondson, Scott D

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7-PHENYL SUBSTITUTED 2-AMINOQUINAZOLINE INHIBITORS OF HPK1 von VARA, Brandon, A, CANDITO, David, A, FULLER, Peter, H, FRADERA, Xavier, METHOT, Joey, L, PASTERNAK, Alexander, LI, Bing, NAIR, Anilkumar, G, LIM, Jongwon, DONOFRIO, Anthony, KAWAMURA, Shuhei, YU, Elsie, C, CHEN, Joanna, L, LIU, Ping

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PCSK9 antagonist compounds von NAIR, Anilkumar G, TONG, Ling, BRANCA, Danila, HA, Sookhee Nicole, JOSIEN, Hubert B, KEREKES, Angela Dawn, WOOD, Harold B, LIU, Jian, BIANCHI, Elisabetta, BOGA, Sobhana Babu, DING, Fa-Xiang, XIONG, Yusheng, WU, Chengwei, TUCKER, Thomas Joseph, WALJI, Abbas M

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PCSK9 antagonist compounds von Liu, Jian, Tucker, Thomas Joseph, Nair, Anilkumar G, Xiong, Yusheng, Wood, Harold B, Kerekes, Angela Dawn, Ding, Fa-Xiang, Wu, Chengwei, Bianchi, Elisabetta, Branca, Danila, Josien, Hubert B, Tong, Ling, Walji, Abbas M, Ha, Sookhee Nicole, Boga, Sobhana Babu

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