Modulation of glutamatergic synaptic transmission and neuronal excitability in the prelimbic medial prefrontal cortex via delta-opioid receptors in mice von Yamada, Daisuke, Takahashi, Junpei, Iio, Keita, Nagase, Hiroshi, Saitoh, Akiyoshi

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Delta Opioid Receptor Agonists Ameliorate Colonic Inflammation by Modulating Immune Responses von Nagata, Kazuki, Nagase, Hiroshi, Okuzumi, Ayumi, Nishiyama, Chiharu

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Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models von Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Tominaga, Hiromu, Ishikawa, Yukiko, Hosokawa, Naoto, Ambai, Shinobu, Kawabe, Yuki, Uchida, Shuntaro, Nakajima, Ryo, Saitoh, Tsuyoshi, Kanda, Takeshi, Vogt, Kaspar, Sakurai, Takeshi, Nagase, Hiroshi, Yanagisawa, Masashi

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KNT-127, a selective delta opioid receptor agonist, shows beneficial effects in the hippocampal dentate gyrus of a chronic vicarious social defeat stress mouse model von Yoshioka, Toshinori, Yamada, Daisuke, Segi-Nishida, Eri, Nagase, Hiroshi, Saitoh, Akiyoshi

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Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord von Kardon, Adam P., Polgár, Erika, Hachisuka, Junichi, Snyder, Lindsey M., Cameron, Darren, Savage, Sinead, Cai, Xiaoyun, Karnup, Sergei, Fan, Christopher R., Hemenway, Gregory M., Bernard, Carcha S., Schwartz, Erica S., Nagase, Hiroshi, Schwarzer, Christoph, Watanabe, Masahiko, Furuta, Takahiro, Kaneko, Takeshi, Koerber, H. Richard, Todd, Andrew J., Ross, Sarah E.

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Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists von Nagahara, Takashi, Saitoh, Tsuyoshi, Kutsumura, Noriki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Kuroda, Daisuke, Gouda, Hiroaki, Kumagai, Hidetoshi, Fujii, Hideaki, Yanagisawa, Masashi, Nagase, Hiroshi

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Possibility of uncoupling protein 1 expression in bovine fast-twitch muscle fibers von DIAO, Zhicheng, SHIMOKAWA, Fumie, YOSHIOKA, Hidetsugu, ITOYAMA, Erina, MATSUMURA, Manami, MURAKAMI, Masaru, KITAMURA, Shoko, NAGASE, Hiroshi, MATSUI, Tohru, FUNABA, Masayuki

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OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy von Yamamoto, Hikari, Nagumo, Yasuyuki, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Namekawa, Yukiko, Nemoto, Tsuyoshi, Tanaka, Hiromu, Takahashi, Genki, Tokuda, Akihisa, Saitoh, Tsuyoshi, Nagase, Hiroshi, Funato, Hiromasa, Yanagisawa, Masashi

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Design and Synthesis of Orexin 1 Receptor-Selective Agonists von Iio, Keita, Hashimoto, Kao, Nagumo, Yasuyuki, Amezawa, Mao, Hasegawa, Taisei, Yamamoto, Naoshi, Kutsumura, Noriki, Takeuchi, Katsuhiko, Ishikawa, Yukiko, Yamamoto, Hikari, Tokuda, Akihisa, Sato, Tetsu, Uchida, Yasuo, Inoue, Asuka, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi, Saitoh, Tsuyoshi

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Role for μ-opioid receptor in antidepressant effects of δ-opioid receptor agonist KNT-127 von Moriya, Yuki, Kasahara, Yoshiyuki, Shimada, Masafumi, Sakakibara, Yasufumi, Fujii, Hideaki, Nagase, Hiroshi, Ide, Soichiro, Ikeda, Kazutaka, Hall, F. Scott, Uhl, George R., Sora, Ichiro

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Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation von Shokirova, Hurramhon, Inomata, Takenori, Saitoh, Tsuyoshi, Zhu, Jun, Fujio, Kenta, Okumura, Yuichi, Yanagawa, Ai, Fujimoto, Keiichi, Sung, Jaemyoung, Eguchi, Atsuko, Miura, Maria, Nagino, Ken, Hirosawa, Kunihiko, Kuwahara, Mizu, Akasaki, Yasutsugu, Nagase, Hiroshi, Murakami, Akira

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Cold-Restraint Stress-Induced Ultrasonic Vocalization as a Novel Tool to Measure Anxiety in Mice von Yamauchi, Tsugumi, Yoshioka, Toshinori, Yamada, Daisuke, Hamano, Takumi, Ohashi, Misaki, Matsumoto, Maki, Iio, Keita, Ikeda, Maika, Kamei, Masato, Otsuki, Takaya, Sato, Yasuo, Nii, Kyoko, Suzuki, Masashi, Ichikawa, Hiroko, Nagase, Hiroshi, Iriyama, Satoshi, Yoshizawa, Kazumi, Nishino, Shoichi, Miyazaki, Satoru, Saitoh, Akiyoshi

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Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function von Korkutata, Mustafa, Saitoh, Tsuyoshi, Cherasse, Yoan, Ioka, Shuji, Duo, Feng, Qin, Rujie, Murakoshi, Nobuyuki, Fujii, Shinya, Zhou, Xuzhao, Sugiyama, Fumihiro, Chen, Jiang-Fan, Kumagai, Hidetoshi, Nagase, Hiroshi, Lazarus, Michael

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Selective δ-Opioid Receptor Agonist, KNT-127, Facilitates Contextual Fear Extinction via Infralimbic Cortex and Amygdala in Mice von Kawaminami, Ayako, Yamada, Daisuke, Yanagisawa, Shoko, Shirakata, Motoki, Iio, Keita, Nagase, Hiroshi, Saitoh, Akiyoshi

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Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring von Iio, Keita, Saitoh, Tsuyoshi, Ohshita, Ryuichiro, Hino, Tsubasa, Amezawa, Mao, Takayama, Yoshiaki, Nagumo, Yasuyuki, Yamamoto, Naoshi, Kutsumura, Noriki, Irukayama-Tomobe, Yoko, Ishikawa, Yukiko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi

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Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton von Hino, Tsubasa, Saitoh, Tsuyoshi, Nagumo, Yasuyuki, Yamamoto, Naoshi, Kutsumura, Noriki, Irukayama-Tomobe, Yoko, Ishikawa, Yukiko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi

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Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors von Wang, Yibing, Cao, Liqin, Lee, Chia-Ying, Matsuo, Tomohiko, Wu, Kejia, Asher, Greg, Tang, Lijun, Saitoh, Tsuyoshi, Russell, Jamie, Klewe-Nebenius, Daniela, Wang, Li, Soya, Shingo, Hasegawa, Emi, Chérasse, Yoan, Zhou, Jiamin, Li, Yuwenbin, Wang, Tao, Zhan, Xiaowei, Miyoshi, Chika, Irukayama, Yoko, Cao, Jie, Meeks, Julian P., Gautron, Laurent, Wang, Zhiqiang, Sakurai, Katsuyasu, Funato, Hiromasa, Sakurai, Takeshi, Yanagisawa, Masashi, Nagase, Hiroshi, Kobayakawa, Reiko, Kobayakawa, Ko, Beutler, Bruce, Liu, Qinghua

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Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats von Toyama, Satoshi, Shimoyama, Naohito, Tagaito, Yugo, Nagase, Hiroshi, Saitoh, Tsuyoshi, Yanagisawa, Masashi, Shimoyama, Megumi

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Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives von Katoh, Koki, Kutsumura, Noriki, Yamamoto, Naoshi, Nagumo, Yasuyuki, Saitoh, Tsuyoshi, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi

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Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands von Iio, Keita, Kutsumura, Noriki, Nagumo, Yasuyuki, Saitoh, Tsuyoshi, Tokuda, Akihisa, Hashimoto, Kao, Yamamoto, Naoshi, Kise, Ryoji, Inoue, Asuka, Mizoguchi, Hirokazu, Nagase, Hiroshi

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