PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication von LAM, Angela M, MURAKAMI, Eisuke, MORREY, John D, SMEE, Donald F, FRICK, David N, HECK, Julie A, PEIYUAN WANG, NAGARATHNAM, Dhanapalan, ROSS, Bruce S, SOFIA, Michael J, OTTO, Michael J, FURMAN, Phillip A, ESPIRITU, Christine, MICOLOCHICK STEUER, Holly M, NIU, Congrong, KEILMAN, Meg, HAIYING BAO, ZENNOU, Veronique, BOURNE, Nigel, JULANDER, Justin G

Volltext

Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine von LAM, Angela M, ESPIRITU, Christine, VESELENAK, Ronald L, GANAPATI REDDY, P, CHANG, Wonsuk, JINFA DU, NAGARATHNAM, Dhanapalan, SOFIA, Michael J, OTTO, Michael J, FURMAN, Phillip A, MURAKAMI, Eisuke, ZENNOU, Veronique, BANSAL, Shalini, MICOLOCHICK STEUER, Holly M, CONGRONG NIU, KEILMAN, Meg, HAIYING BAO, BOURNE, Nigel

Volltext

Pre-Clinical Efficacy of RP6503 in PI3Kδ/γ Mediated Airway Disorders von Vakkalanka, Swaroop, PhD, Govandarajulu, Babu, PhD, Routhu, Kasiviswanath, PhD, Veeraraghavan, Sridhar, M.Pharm, Viswanadha, Srikant, PhD, Nagarathnam, Dhanapalan, PhD

Volltext

Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection von Chang, Wonsuk, Bao, Donghui, Chun, Byoung-Kwon, Naduthambi, Devan, Nagarathnam, Dhanapalan, Rachakonda, Suguna, Reddy, P. Ganapati, Ross, Bruce S, Zhang, Hai-Ren, Bansal, Shalini, Espiritu, Christine L, Keilman, Meg, Lam, Angela M, Niu, Congrong, Steuer, Holly Micolochick, Furman, Phillip A, Otto, Michael J, Sofia, Michael J

Volltext

Identification of novel small molecule inhibitors against NS2B/NS3 serine protease from Zika virus von Lee, Hyun, Ren, Jinhong, Nocadello, Salvatore, Rice, Amy J., Ojeda, Isabel, Light, Samuel, Minasov, George, Vargas, Jason, Nagarathnam, Dhanapalan, Anderson, Wayne F., Johnson, Michael E.

Volltext

Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus von Sofia, Michael J, Bao, Donghui, Chang, Wonsuk, Du, Jinfa, Nagarathnam, Dhanapalan, Rachakonda, Suguna, Reddy, P. Ganapati, Ross, Bruce S, Wang, Peiyuan, Zhang, Hai-Ren, Bansal, Shalini, Espiritu, Christine, Keilman, Meg, Lam, Angela M, Steuer, Holly M. Micolochick, Niu, Congrong, Otto, Michael J, Furman, Phillip A

Volltext

Synthesis and evaluation of analogs of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents von Cushman, Mark, Nagarathnam, Dhanapalan, Gopal, D, He, Hu Ming, Lin, Chii M, Hamel, Ernest

Volltext

Cytotoxicities of Some Flavonoid Analogues von Cushman, Mark, Nagarathnam, Dhanapalan

Volltext

Pre-clinical efficacy of dual PI3K δ/γ inhibitors in airway inflammation (64.2) von Nagarathnam, Dhanapalan, Govindarajulu, Babu, Routhu, Kasiviswanath, Rajagopalan, Prasanna, Veeraraghavan, Sridhar, Viswanadha, Srikant, Vakkalanka, Swaroop

Volltext

Abstract 3741: Inhibition of PI3Kα kinase by a selective small molecule inhibitor suppresses B-cell proliferation and leukemic cell growth von Vakkalanka, Swaroop, Viswanadha, Srikant, R, Prasanna, Muthuppalaniappan, Meyyappan, Govindarajulu, Babu, Veeraraghavan, Sridhar, Varanasi, Kanthikiran, Dhanapalan, Nagarathnam

Volltext

2′-Deoxy-2′-α-fluoro-2′-β- C-methyl 3′,5′-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: Discovery of PSI-352938 von Reddy, P. Ganapati, Bao, Donghui, Chang, Wonsuk, Chun, Byoung-Kwon, Du, Jinfa, Nagarathnam, Dhanapalan, Rachakonda, Suguna, Ross, Bruce S., Zhang, Hai-Ren, Bansal, Shalini, Espiritu, Christine L., Keilman, Meg, Lam, Angela M., Niu, Congrong, Steuer, Holly Micolochick, Furman, Phillip A., Otto, Michael J., Sofia, Michael J.

Volltext

Abstract 1789: Preclinical profile of novel and potent c-Met kinase inhibitors von Vakkalanka, Swaroop, Muthuppalaniappan, Meyyappan, Govindarajulu, Babu, Varanasi, Kanthikiran, Veeraraghavan, Sridhar, Kuppireddi, Sumalatha, Viswanadha, Srikant, Dhanapalan, Nagarathnam, Bhavar, Prashant

Volltext

A short and facile synthetic route to hydroxylated flavones. New syntheses of apigenin, tricin, and luteolin von Nagarathnam, Dhanapalan, Cushman, Mark

Volltext

A practical synthesis of flavones from methyl salicylate von Nagarathnam, Dhanapalan, Cushman, Mark

Volltext

In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia von Barrow, J C, Nantermet, P G, Selnick, H G, Glass, K L, Rittle, K E, Gilbert, K F, Steele, T G, Homnick, C F, Freidinger, R M, Ransom, R W, Kling, P, Reiss, D, Broten, T P, Schorn, T W, Chang, R S, O'Malley, S S, Olah, T V, Ellis, J D, Barrish, A, Kassahun, K, Leppert, P, Nagarathnam, D, Forray, C

Volltext

A novel dimerization of ethyl 3-cyanomethyl-2-indolecarboxylate von Nagarathnam, Dhanapalan, Johnson, Michael E.

Volltext

In Vitro and in Vivo Evaluation of Dihydropyrimidinone C-5 Amides as Potent and Selective α1A Receptor Antagonists for the Treatment of Benign Prostatic Hyperplasia von Barrow, James C, Nantermet, Philippe G, Selnick, Harold G, Glass, Kristen L, Rittle, Kenneth E, Gilbert, Kevin F, Steele, Thomas G, Homnick, Carl F, Freidinger, Roger M, Ransom, Rick W, Kling, Paul, Reiss, Duane, Broten, Theodore P, Schorn, Terry W, Chang, Raymond S. L, O'Malley, Stacey S, Olah, Timothy V, Ellis, Joan D, Barrish, Andrea, Kassahun, Kelem, Leppert, Paula, Nagarathnam, Dhanapalan, Forray, Carlos

Volltext

Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones von Nagarathnam, D, Miao, S W, Lagu, B, Chiu, G, Fang, J, Murali Dhar, T G, Zhang, J, Tyagarajan, S, Marzabadi, M R, Zhang, F, Wong, W C, Sun, W, Tian, D, Wetzel, J M, Forray, C, Chang, R S, Broten, T P, Ransom, R W, Schorn, T W, Chen, T B, O'Malley, S, Kling, P, Schneck, K, Bendesky, R, Harrell, C M

Volltext

GABAB receptors function as a heteromeric assembly of the subunits GABABR1 and GABABR2 von Jones, Kenneth A., Borowsky, Beth, Tamm, Joe A., Craig, Douglas A., Durkin, Margaret M., Dai, Meng, Yao, Wen-Jeng, Johnson, Mary, Gunwaldsen, Caryn, Huang, Ling-Yan, Tang, Cheng, Shen, Quanrong, Salon, John A., Morse, Kelley, Laz, Thomas, Smith, Kelli E., Nagarathnam, Dhanapalan, Noble, Stewart A., Branchek, Theresa A., Gerald, Christophe

Volltext

Design and Synthesis of Novel α1a Adrenoceptor-Selective Dihydropyridine Antagonists for the Treatment of Benign Prostatic Hyperplasia von Nagarathnam, Dhanapalan, Wetzel, John M, Miao, Shou Wu, Marzabadi, Mohammad R, Chiu, George, Wong, Wai C, Hong, Xingfang, Fang, James, Forray, Carlos, Branchek, Theresa A, Heydorn, William E, Chang, Raymond S. L, Broten, Theodore, Schorn, Terry W, Gluchowski, Charles

Volltext