Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition von Safina, Brian S, Baker, Stewart, Baumgardner, Matt, Blaney, Paul M, Chan, Bryan K, Chen, Yung-Hsiang, Cartwright, Matthew W, Castanedo, Georgette, Chabot, Christine, Cheguillaume, Arnaud J, Goldsmith, Paul, Goldstein, David M, Goyal, Bindu, Hancox, Timothy, Handa, Raj K, Iyer, Pravin S, Kaur, Jasmit, Kondru, Rama, Kenny, Jane R, Krintel, Sussie L, Li, Jun, Lesnick, John, Lucas, Matthew C, Lewis, Cristina, Mukadam, Sophie, Murray, Jeremy, Nadin, Alan J, Nonomiya, Jim, Padilla, Fernando, Palmer, Wylie S, Pang, Jodie, Pegg, Neil, Price, Steve, Reif, Karin, Salphati, Laurent, Savy, Pascal A, Seward, Eileen M, Shuttleworth, Stephen, Sohal, Sukhjit, Sweeney, Zachary K, Tay, Suzanne, Tivitmahaisoon, Parcharee, Waszkowycz, Bohdan, Wei, Binqing, Yue, Qin, Zhang, Chenghong, Sutherlin, Daniel P

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Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf von Sutherlin, Daniel P., Baker, Stewart, Bisconte, Angelina, Blaney, Paul M., Brown, Anthony, Chan, Bryan K., Chantry, David, Castanedo, Georgette, DePledge, Paul, Goldsmith, Paul, Goldstein, David M., Hancox, Timothy, Kaur, Jasmit, Knowles, David, Kondru, Rama, Lesnick, John, Lucas, Matthew C., Lewis, Cristina, Murray, Jeremy, Nadin, Alan J., Nonomiya, Jim, Pang, Jodie, Pegg, Neil, Price, Steve, Reif, Karin, Safina, Brian S., Salphati, Laurent, Staben, Steven, Seward, Eileen M., Shuttleworth, Stephen, Sohal, Sukhjit, Sweeney, Zachary K., Ultsch, Mark, Waszkowycz, Bohdan, Wei, Binqing

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Potent and selective inhibitors of PI3KI': Obtaining isoform selectivity from the affinity pocket and tryptophan shelf von Sutherlin, Daniel P, Baker, Stewart, Bisconte, Angelina, Blaney, Paul M, Brown, Anthony, Chan, Bryan K, Chantry, David, Castanedo, Georgette, DePledge, Paul, Goldsmith, Paul, Goldstein, David M, Hancox, Timothy, Kaur, Jasmit, Knowles, David, Kondru, Rama, Lesnick, John, Lucas, Matthew C, Lewis, Cristina, Murray, Jeremy, Nadin, Alan J, Nonomiya, Jim, Pang, Jodie, Pegg, Neil, Price, Steve, Reif, Karin, Safina, Brian S, Salphati, Laurent, Staben, Steven, Seward, Eileen M, Shuttleworth, Stephen, Sohal, Sukhjit, Sweeney, Zachary K, Ultsch, Mark, Waszkowycz, Bohdan, Wei, Binqing

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Cyclic sulfonamides for inhibition of gamma-secretase von NADIN ALAN J, SHAW DUNCAN E, WILLIAMS BRIAN J, DINNELL KEVIN, OWENS ANDREW P, HARRISON TIMOTHY

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Novel cyclohexyl sulphones von CHURCHER IAN, NADIN ALAN J, SHAW DUNCAN E, WILLIAMS BRIAN J, WILLIAMS SUSANNAH, DINNELL KEVIN, KERRAD SONIA, HARRISON TIMOTHY, OAKLEY PAUL J, TEALL MARTIN R

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Novel cyclohexyl sulphones von CHURCHER IAN, NADIN ALAN J, SHAW DUNCAN E, WILLIAMS BRIAN J, WILLIAMS SUSANNAH, DINNELL KEVIN, KERRAD SONIA, HARRISON TIMOTHY, OAKLEY PAUL J, TEALL MARTIN R

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Sulphones which modulate the action of gammasecretase von CHURCHER IAN, NADIN ALAN J, SHAW DUNCAN E, WILLIAMS BRIAN J, CASTRO PINEIRO JOSE L, WILLIAMS SUSANNAH, DINNELL KEVIN, OWENS ANDREW P, KERRAD SONIA, HARRISON TIMOTHY, OAKLEY PAUL J, TEALL MARTIN R

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Reconstructing Prehistoric African Population Structure von Skoglund, Pontus, Thompson, Jessica C., Prendergast, Mary E., Mittnik, Alissa, Sirak, Kendra, Hajdinjak, Mateja, Salie, Tasneem, Rohland, Nadin, Mallick, Swapan, Peltzer, Alexander, Heinze, Anja, Olalde, Iñigo, Ferry, Matthew, Harney, Eadaoin, Michel, Megan, Stewardson, Kristin, Cerezo-Román, Jessica I., Chiumia, Chrissy, Crowther, Alison, Gomani-Chindebvu, Elizabeth, Gidna, Agness O., Grillo, Katherine M., Helenius, I. Taneli, Hellenthal, Garrett, Helm, Richard, Horton, Mark, López, Saioa, Mabulla, Audax Z.P., Parkington, John, Shipton, Ceri, Thomas, Mark G., Tibesasa, Ruth, Welling, Menno, Hayes, Vanessa M., Kennett, Douglas J., Ramesar, Raj, Meyer, Matthias, Pääbo, Svante, Patterson, Nick, Morris, Alan G., Boivin, Nicole, Pinhasi, Ron, Krause, Johannes, Reich, David

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The genetic legacy of African Americans from Catoctin Furnace von Harney, Éadaoin, Micheletti, Steven, Bruwelheide, Karin S, Freyman, William A, Bryc, Katarzyna, Akbari, Ali, Jewett, Ethan, Comer, Elizabeth, Gates, Jr, Henry Louis, Heywood, Linda, Thornton, John, Curry, Roslyn, Esselmann, Samantha Ancona, Barca, Kathryn G, Sedig, Jakob, Sirak, Kendra, Olalde, Iñigo, Adamski, Nicole, Bernardos, Rebecca, Broomandkhoshbacht, Nasreen, Ferry, Matthew, Qiu, Lijun, Stewardson, Kristin, Workman, J Noah, Zalzala, Fatma, Mallick, Shop, Micco, Adam, Mah, Matthew, Zhang, Zhao, Rohland, Nadin, Mountain, Joanna L, Owsley, Douglas W, Reich, David

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Ancient human genomes suggest three ancestral populations for present-day Europeans von Lazaridis, Iosif, Patterson, Nick, Mittnik, Alissa, Mallick, Swapan, Kirsanow, Karola, Sudmant, Peter H., Castellano, Sergi, Lipson, Mark, Berger, Bonnie, Economou, Christos, Bollongino, Ruth, Fu, Qiaomei, Bos, Kirsten I., Nordenfelt, Susanne, de Filippo, Cesare, Sawyer, Susanna, Posth, Cosimo, Haak, Wolfgang, Hallgren, Fredrik, Fornander, Elin, Rohland, Nadin, Francken, Michael, Guinet, Jean-Michel, Wahl, Joachim, Ayodo, George, Babiker, Hamza A., Bailliet, Graciela, Balanovska, Elena, Balanovsky, Oleg, Barrantes, Ramiro, Bedoya, Gabriel, Bene, Judit, Berrada, Fouad, Bravi, Claudio M., Brisighelli, Francesca, Busby, George B. J., Cole, David E. C., Corach, Daniel, Damba, Larissa, van Driem, George, Dugoujon, Jean-Michel, Fedorova, Sardana A., Gallego Romero, Irene, Gubina, Marina, Hammer, Michael, Henn, Brenna M., Hervig, Tor, Hodoglugil, Ugur, Jha, Aashish R., Karachanak-Yankova, Sena, Khusainova, Rita, Khusnutdinova, Elza, Kittles, Rick, Kivisild, Toomas, Klitz, William, Kučinskas, Vaidutis, Kushniarevich, Alena, Litvinov, Sergey, Loukidis, Theologos, Mahley, Robert W., Melegh, Béla, Metspalu, Ene, Molina, Julio, Mountain, Joanna, Nesheva, Desislava, Nyambo, Thomas, Parik, Jüri, Platonov, Fedor, Rothhammer, Francisco, Rudan, Igor, Ruizbakiev, Ruslan, Sajantila, Antti, Salas, Antonio, Tarekegn, Ayele, Toncheva, Draga, Turdikulova, Shahlo, Uktveryte, Ingrida, Utevska, Olga, Villena, Mercedes, Voevoda, Mikhail, Winkler, Cheryl A., Zemunik, Tatijana, Cooper, Alan, Capelli, Cristian, Thomas, Mark G., Ruiz-Linares, Andres, Tishkoff, Sarah A., Singh, Lalji, Thangaraj, Kumarasamy, Villems, Richard, Comas, David, Sukernik, Rem, Metspalu, Mait, Meyer, Matthias, Eichler, Evan E., Burger, Joachim, Slatkin, Montgomery, Pääbo, Svante, Kelso, Janet, Krause, Johannes

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A Paleogenomic Reconstruction of the Deep Population History of the Andes von Nakatsuka, Nathan, Lazaridis, Iosif, Barbieri, Chiara, Skoglund, Pontus, Rohland, Nadin, Mallick, Swapan, Posth, Cosimo, Harkins-Kinkaid, Kelly, Ferry, Matthew, Harney, Éadaoin, Michel, Megan, Stewardson, Kristin, Novak-Forst, Jannine, Capriles, José M., Durruty, Marta Alfonso, Álvarez, Karina Aranda, Beresford-Jones, David, Burger, Richard, Cadwallader, Lauren, Fujita, Ricardo, Isla, Johny, Lau, George, Aguirre, Carlos Lémuz, LeBlanc, Steven, Maldonado, Sergio Calla, Meddens, Frank, Messineo, Pablo G., Culleton, Brendan J., Harper, Thomas K., Quilter, Jeffrey, Politis, Gustavo, Rademaker, Kurt, Reindel, Markus, Rivera, Mario, Salazar, Lucy, Sandoval, José R., Santoro, Calogero M., Scheifler, Nahuel, Standen, Vivien, Barreto, Maria Ines, Espinoza, Isabel Flores, Tomasto-Cagigao, Elsa, Valverde, Guido, Kennett, Douglas J., Cooper, Alan, Krause, Johannes, Haak, Wolfgang, Llamas, Bastien, Reich, David, Fehren-Schmitz, Lars

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Ancient DNA and deep population structure in sub-Saharan African foragers von Lipson, Mark, Sawchuk, Elizabeth A., Thompson, Jessica C., Oppenheimer, Jonas, Tryon, Christian A., Ranhorn, Kathryn L., de Luna, Kathryn M., Sirak, Kendra A., Olalde, Iñigo, Ambrose, Stanley H., Arthur, John W., Arthur, Kathryn J. W., Ayodo, George, Bertacchi, Alex, Cerezo-Román, Jessica I., Culleton, Brendan J., Curtis, Matthew C., Davis, Jacob, Gidna, Agness O., Hanson, Annalys, Kaliba, Potiphar, Katongo, Maggie, Kwekason, Amandus, Laird, Myra F., Lewis, Jason, Mabulla, Audax Z. P., Mapemba, Fredrick, Morris, Alan, Mudenda, George, Mwafulirwa, Raphael, Mwangomba, Daudi, Ndiema, Emmanuel, Ogola, Christine, Schilt, Flora, Willoughby, Pamela R., Wright, David K., Zipkin, Andrew, Pinhasi, Ron, Kennett, Douglas J., Manthi, Fredrick Kyalo, Rohland, Nadin, Patterson, Nick, Reich, David, Prendergast, Mary E.

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The Anglo-Saxon migration and the formation of the early English gene pool von Gretzinger, Joscha, Sayer, Duncan, Justeau, Pierre, Altena, Eveline, Pala, Maria, Dulias, Katharina, Edwards, Ceiridwen J., Jodoin, Susanne, Lacher, Laura, Sabin, Susanna, Vågene, Åshild J., Haak, Wolfgang, Ebenesersdóttir, S. Sunna, Moore, Kristjan H. S., Radzeviciute, Rita, Schmidt, Kara, Brace, Selina, Bager, Martina Abenhus, Patterson, Nick, Papac, Luka, Broomandkhoshbacht, Nasreen, Callan, Kimberly, Harney, Éadaoin, Iliev, Lora, Lawson, Ann Marie, Michel, Megan, Stewardson, Kristin, Zalzala, Fatma, Rohland, Nadin, Kappelhoff-Beckmann, Stefanie, Both, Frank, Winger, Daniel, Neumann, Daniel, Saalow, Lars, Krabath, Stefan, Beckett, Sophie, Van Twest, Melanie, Faulkner, Neil, Read, Chris, Barton, Tabatha, Caruth, Joanna, Hines, John, Krause-Kyora, Ben, Warnke, Ursula, Schuenemann, Verena J., Barnes, Ian, Dahlström, Hanna, Clausen, Jane Jark, Richardson, Andrew, Popescu, Elizabeth, Dodwell, Natasha, Ladd, Stuart, Phillips, Tom, Mortimer, Richard, Sayer, Faye, Swales, Diana, Stewart, Allison, Powlesland, Dominic, Kenyon, Robert, Ladle, Lilian, Peek, Christina, Grefen-Peters, Silke, Ponce, Paola, Daniels, Robin, Spall, Cecily, Woolcock, Jennifer, Jones, Andy M., Roberts, Amy V., Symmons, Robert, Rawden, Anooshka C., Cooper, Alan, Bos, Kirsten I., Booth, Tom, Schroeder, Hannes, Thomas, Mark G., Helgason, Agnar, Richards, Martin B., Reich, David, Krause, Johannes, Schiffels, Stephan

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A Turing Test for Molecular Generators von Bush, Jacob T, Pogany, Peter, Pickett, Stephen D, Barker, Mike, Baxter, Andrew, Campos, Sebastien, Cooper, Anthony W. J, Hirst, David, Inglis, Graham, Nadin, Alan, Patel, Vipulkumar K, Poole, Darren, Pritchard, John, Washio, Yoshiaki, White, Gemma, Green, Darren V. S

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L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity von Shearman, Mark S, Beher, Dirk, Clarke, Earl E, Lewis, Huw D, Harrison, Tim, Hunt, Peter, Nadin, Alan, Smith, Adrian L, Stevenson, Graeme, Castro, José L

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Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism von Beher, Dirk, Clarke, Earl E, Wrigley, Jonathan D J, Martin, Agnes C L, Nadin, Alan, Churcher, Ian, Shearman, Mark S

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Author Correction: The Anglo-Saxon migration and the formation of the early English gene pool von Gretzinger, Joscha, Sayer, Duncan, Justeau, Pierre, Altena, Eveline, Pala, Maria, Dulias, Katharina, Edwards, Ceiridwen J., Jodoin, Susanne, Lacher, Laura, Sabin, Susanna, Vågene, Åshild J., Haak, Wolfgang, Ebenesersdóttir, S. Sunna, Moore, Kristjan H. S., Radzeviciute, Rita, Schmidt, Kara, Brace, Selina, Bager, Martina Abenhus, Patterson, Nick, Papac, Luka, Broomandkhoshbacht, Nasreen, Callan, Kimberly, Harney, Éadaoin, Iliev, Lora, Lawson, Ann Marie, Michel, Megan, Stewardson, Kristin, Zalzala, Fatma, Rohland, Nadin, Kappelhoff-Beckmann, Stefanie, Both, Frank, Winger, Daniel, Neumann, Daniel, Saalow, Lars, Krabath, Stefan, Beckett, Sophie, Van Twest, Melanie, Faulkner, Neil, Read, Chris, Barton, Tabatha, Caruth, Joanna, Hines, John, Krause-Kyora, Ben, Warnke, Ursula, Schuenemann, Verena J., Barnes, Ian, Dahlström, Hanna, Clausen, Jane Jark, Richardson, Andrew, Popescu, Elizabeth, Dodwell, Natasha, Ladd, Stuart, Phillips, Tom, Mortimer, Richard, Sayer, Faye, Swales, Diana, Stewart, Allison, Powlesland, Dominic, Kenyon, Robert, Ladle, Lilian, Peek, Christina, Grefen-Peters, Silke, Ponce, Paola, Daniels, Robin, Spall, Cecily, Woolcock, Jennifer, Jones, Andy M., Roberts, Amy V., Symmons, Robert, Rawden, Anooshka C., Cooper, Alan, Bos, Kirsten I., Booth, Tom, Schroeder, Hannes, Thomas, Mark G., Helgason, Agnar, Richards, Martin B., Reich, David, Krause, Johannes, Schiffels, Stephan

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Substitutions in woolly mammoth hemoglobin confer biochemical properties adaptive for cold tolerance von Austin, Jeremy J, Signore, Anthony V, Hofreiter, Michael, Ho, Chien, Weber, Roy E, Watson, Laura N, Cooper, Alan, Shen, Tong-Jian, Tame, Jeremy R H, Stetefeld, Jörg, Howatt, Jesse W, Rohland, Nadin, Roberts, Jason E E, Campbell, Kevin L, Sloan, Angela M

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Catalytic Site-Directed γ-Secretase Complex Inhibitors Do Not Discriminate Pharmacologically between Notch S3 and β-APP Cleavages von Lewis, Huw D, Pérez Revuelta, Blanca I, Nadin, Alan, Neduvelil, Joe G, Harrison, Timothy, Pollack, Scott J, Shearman, Mark S

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Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology von Beher, D, Wrigley, J D, Nadin, A, Evin, G, Masters, C L, Harrison, T, Castro, J L, Shearman, M S

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