Tipping the Balance: Hepatotoxicity and the 4 Apical Key Events of Hepatic Steatosis von Angrish, Michelle M, Kaiser, Jonathan Phillip, McQueen, Charlene A, Chorley, Brian N

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Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop von Buesen, Roland, Chorley, Brian N., da Silva Lima, Beatriz, Daston, George, Deferme, Lize, Ebbels, Timothy, Gant, Timothy W., Goetz, Amber, Greally, John, Gribaldo, Laura, Hackermüller, Jörg, Hubesch, Bruno, Jennen, Danyel, Johnson, Kamin, Kanno, Jun, Kauffmann, Hans-Martin, Laffont, Madeleine, McMullen, Patrick, Meehan, Richard, Pemberton, Mark, Perdichizzi, Stefania, Piersma, Aldert H., Sauer, Ursula G., Schmidt, Kerstin, Seitz, Hervé, Sumida, Kayo, Tollefsen, Knut E., Tong, Weida, Tralau, Tewes, van Ravenzwaay, Ben, Weber, Ralf J.M., Worth, Andrew, Yauk, Carole, Poole, Alan

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Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor von Rooney, John, Oshida, Keiyu, Vasani, Naresh, Vallanat, Beena, Ryan, Natalia, Chorley, Brian N, Wang, Xuting, Bell, Douglas A, Wu, Kai C, Aleksunes, Lauren M, Klaassen, Curtis D, Kensler, Thomas W, Corton, J Christopher

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MicroRNA Biomarkers of Toxicity in Biological Matrices von Harrill, Alison H, McCullough, Shaun D, Wood, Charles E, Kahle, Juliette J, Chorley, Brian N

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Persistent gene expression and DNA methylation alterations linked to carcinogenic effects of dichloroacetic acid von Carswell, Gleta, Chamberlin, John, Bennett, Brian D, Bushel, Pierre R, Chorley, Brian N

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Transplacental arsenic exposure produced 5-methylcytosine methylation changes and aberrant microRNA expressions in livers of male fetal mice von Liu, Jie, Gunewardena, Sumedha, Yue Cui, Julia, Klaassen, Curtis D., Chorley, Brian N., Corton, J. Christopher

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Epigenetic Applications in Adverse Outcome Pathways and Environmental Risk Evaluation von Angrish, Michelle M, Allard, Patrick, McCullough, Shaun D, Druwe, Ingrid L, Helbling Chadwick, Lisa, Hines, Erin, Chorley, Brian N

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Enhanced Quality Metrics for Assessing RNA Derived From Archival Formalin-Fixed Paraffin-Embedded Tissue Samples von Wehmas, Leah C, Wood, Charles E, Chorley, Brian N, Yauk, Carole L, Nelson, Gail M, Hester, Susan D

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A Polymorphic Antioxidant Response Element Links NRF2/sMAF Binding to Enhanced MAPT Expression and Reduced Risk of Parkinsonian Disorders von Wang, Xuting, Campbell, Michelle R., Lacher, Sarah E., Cho, Hye-Youn, Wan, Ma, Crowl, Christopher L., Chorley, Brian N., Bond, Gareth L., Kleeberger, Steven R., Slattery, Matthew, Bell, Douglas A.

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A generic Transcriptomics Reporting Framework (TRF) for ‘omics data processing and analysis von Gant, Timothy W., Sauer, Ursula G., Zhang, Shu-Dong, Chorley, Brian N., Hackermüller, Jörg, Perdichizzi, Stefania, Tollefsen, Knut E., van Ravenzwaay, Ben, Yauk, Carole, Tong, Weida, Poole, Alan

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Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer von Wang, Xuting, Chorley, Brian N, Pittman, Gary S, Kleeberger, Steven R, Brothers, 2nd, John, Liu, Gang, Spira, Avrum, Bell, Douglas A

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Framework for the quality assurance of ’omics technologies considering GLP requirements von Kauffmann, Hans-Martin, Kamp, Hennicke, Fuchs, Regine, Chorley, Brian N., Deferme, Lize, Ebbels, Timothy, Hackermüller, Jörg, Perdichizzi, Stefania, Poole, Alan, Sauer, Ursula G., Tollefsen, Knut E., Tralau, Tewes, Yauk, Carole, van Ravenzwaay, Ben

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Novel Hematopoietic Target Genes in the NRF2-Mediated Transcriptional Pathway von Adamski, Kelly N., Campbell, Michelle R., Bell, Douglas A., Wang, Xuting, Chorley, Brian N., Karaca, Mehmet

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Identification of polymorphic antioxidant response elements in the human genome von Wang, Xuting, Tomso, Daniel J., Chorley, Brian N., Cho, Hye-Youn, Cheung, Vivian G., Kleeberger, Steven R., Bell, Douglas A.

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Developing a Gene Biomarker at the Tipping Point of Adaptive and Adverse Responses in Human Bronchial Epithelial Cells von Currier, Jenna M, Cheng, Wan-Yun, Menendez, Daniel, Conolly, Rory, Chorley, Brian N

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Ozone-induced fetal growth restriction in rats is associated with sexually dimorphic placental and fetal metabolic adaptation von Miller, Colette N., Dye, Janice A., Henriquez, Andres R., Stewart, Erica J., Lavrich, Katelyn S., Carswell, Gleta K., Ren, Hongzu, Freeborn, Danielle L., Snow, Samantha J., Schladweiler, Mette C., Richards, Judy H., Kodavanti, Prasada R.S., Fisher, Anna, Chorley, Brian N., Kodavanti, Urmila P.

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Early microRNA indicators of PPARα pathway activation in the liver von Chorley, Brian N., Carswell, Gleta K., Nelson, Gail, Bhat, Virunya S., Wood, Charles E.

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Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha von Chorley, Brian N, Campbell, Michelle R, Wang, Xuting, Karaca, Mehmet, Sambandan, Deepa, Bangura, Fatu, Xue, Peng, Pi, Jingbo, Kleeberger, Steven R, Bell, Douglas A

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Editor's Highlight: Dose-Response Analysis of RNA-Seq Profiles in Archival Formalin-Fixed Paraffin-Embedded Samples von Hester, Susan D, Bhat, Virunya, Chorley, Brian N, Carswell, Gleta, Jones, Wendell, Wehmas, Leah C, Wood, Charles E

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Progress towards an OECD reporting framework for transcriptomics and metabolomics in regulatory toxicology von Harrill, Joshua A., Viant, Mark R., Yauk, Carole L., Sachana, Magdalini, Gant, Timothy W., Auerbach, Scott S., Beger, Richard D., Bouhifd, Mounir, O'Brien, Jason, Burgoon, Lyle, Caiment, Florian, Carpi, Donatella, Chen, Tao, Chorley, Brian N., Colbourne, John, Corvi, Raffaella, Debrauwer, Laurent, O'Donovan, Claire, Ebbels, Timothy M.D., Ekman, Drew R., Faulhammer, Frank, Gribaldo, Laura, Hilton, Gina M., Jones, Stephanie P., Kende, Aniko, Lawson, Thomas N., Leite, Sofia B., Leonards, Pim E.G., Luijten, Mirjam, Martin, Alberto, Moussa, Laura, Rudaz, Serge, Schmitz, Oliver, Sobanski, Tomasz, Strauss, Volker, Vaccari, Monica, Vijay, Vikrant, Weber, Ralf J.M., Williams, Antony J., Williams, Andrew, Thomas, Russell S., Whelan, Maurice

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