MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate von Beshore, Douglas C., N. Di Marco, Christina, Chang, Ronald K., Greshock, Thomas J., Ma, Lei, Wittmann, Marion, Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Fuerst, Joy, Hartman, George D., Bilodeau, Mark T., Ray, William J., Kuduk, Scott D.

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Design and synthesis of aminopyridine containing biaryls reducing c-MYC protein levels in cells von Di Marco, Christina N., Terrell, Lamont, Sanchez, Robert, Rueda, Lourdes, Shuster, Leanna, Nartey, Eldridge N., McHugh, Charles, Mack, James F., Shu, Arthur, Tian, Xinrong, Medina, Jesus R., Rivero, Ralph, Manetsch, Roman, Heerding, Dirk, Mangatt, Biju

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MK-7622: A First-in-Class M 1 Positive Allosteric Modulator Development Candidate von Beshore, Douglas C, N Di Marco, Christina, Chang, Ronald K, Greshock, Thomas J, Ma, Lei, Wittmann, Marion, Seager, Matthew A, Koeplinger, Kenneth A, Thompson, Charles D, Fuerst, Joy, Hartman, George D, Bilodeau, Mark T, Ray, William J, Kuduk, Scott D

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Discovery of MK-8970: An Acetal Carbonate Prodrug of Raltegravir with Enhanced Colonic Absorption von Walji, Abbas M., Sanchez, Rosa I., Clas, Sophie-Dorothee, Nofsinger, Rebecca, de Lera Ruiz, Manuel, Li, Jing, Bennet, Amrithraj, John, Christopher, Bennett, David Jonathan, Sanders, John M., Di Marco, Christina N., Kim, Somang Hope, Balsells, Jaume, Ceglia, Scott S., Dang, Qun, Manser, Kimberly, Nissley, Becky, Wai, John S., Hafey, Michael, Wang, Junying, Chessen, Gene, Templeton, Allen, Higgins, John, Smith, Ronald, Wu, Yunhui, Grobler, Jay, Coleman, Paul J.

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Discovery of a Selective Allosteric M1 Receptor Modulator with Suitable Development Properties Based on a Quinolizidinone Carboxylic Acid Scaffold von Kuduk, Scott D, Chang, Ronald K, Di Marco, Christina N, Pitts, Daniel R, Greshock, Thomas J, Ma, Lei, Wittmann, Marion, Seager, Matthew A, Koeplinger, Kenneth A, Thompson, Charles D, Hartman, George D, Bilodeau, Mark T, Ray, William J

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N-Heterocyclic derived M 1 positive allosteric modulators von Kuduk, Scott D., Marco, Christina N. Di, Cofre, Victoria, Pitts, Daniel R., Ray, William J., Ma, Lei, Wittmann, Marion, Veng, Lone, Seager, Matthew A., Koeplinger, Kenneth, Thompson, Charles D., Hartman, George D., Bilodeau, Mark T.

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Synthesis and evaluation of carbon-linked analogs of dual orexin receptor antagonist filorexant von Kuduk, Scott D., Skudlarek, Jason W., Di Marco, Christina N., Bruno, Joseph G., Pausch, Mark A., O’Brien, Julie A., Cabalu, Tamara D., Stevens, Joanne, Brunner, Joseph, Tannenbaum, Pamela L., Gotter, Anthony L., Winrow, Christopher J., Renger, John J., Coleman, Paul J.

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Quinolizidinone Carboxylic Acids as CNS Penetrant, Selective M1 Allosteric Muscarinic Receptor Modulators von Kuduk, Scott D, Chang, Ronald K, Di Marco, Christina N, Ray, William J, Ma, Lei, Wittmann, Marion, Seager, Matthew A, Koeplinger, Kenneth A, Thompson, Charles D, Hartman, George D, Bilodeau, Mark T

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Fused heterocyclic M₁ positive allosteric modulators von Kuduk, Scott D, Di Marco, Christina N, Cofre, Victoria, Ray, William J, Ma, Lei, Wittmann, Marion, Seager, Matthew A, Koeplinger, Kenneth A, Thompson, Charles D, Hartman, George D, Bilodeau, Mark T

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Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series von Kuduk, Scott D., Chang, Ronald K., Di Marco, Christina N., Ray, William J., Ma, Lei, Wittmann, Marion, Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Hartman, George D., Bilodeau, Mark T.

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Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3) von Kuduk, Scott D., Di Marco, Christina N., Chang, Ronald K., DiPardo, Robert M., Cook, Sean P., Cato, Matthew J., Jovanovska, Aneta, Urban, Mark O., Leitl, Michael, Spencer, Robert H., Kane, Stefanie A., Bilodeau, Mark T., Hartman, George D., Bock, Mark G.

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Preparation of 4-heteroaryl-4-cyanopiperidines via SNAr substitution reactions von Chang, Ronald K., Di Marco, Christina N., Pitts, Daniel R., Greshock, Thomas J., Kuduk, Scott D.

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Identification of non-amidine inhibitors of acid-sensing ion channel-3 (ASIC3) von Kuduk, Scott D., Chang, Ronald K., Di Marco, Christina N., DiPardo, Robert M., Cook, Sean P., Cato, Matthew J., Jovanovska, Aneta, Urban, Mark O., Leitl, Michael, Spencer, Robert H., Kane, Stefanie A., Hartman, George D., Bilodeau, Mark T.

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Development of Orally Bioavailable and CNS Penetrant Biphenylaminocyclopropane Carboxamide Bradykinin B1 Receptor Antagonists von Kuduk, Scott D., Di Marco, Christina N., Chang, Ronald K., Wood, Michael R., Schirripa, Kathy M., Kim, June J., Wai, Jenny M. C., DiPardo, Robert M., Murphy, Kathy L., Ransom, Richard W., Harrell, C. Meacham, Reiss, Duane R., Holahan, Marie A., Cook, Jacquelynn, Hess, J. Fred, Sain, Nova, Urban, Mark O., Tang, Cuyue, Prueksaritanont, Thomayant, Pettibone, Douglas J., Bock, Mark G.

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N-Heterocyclic derived M1 positive allosteric modulators von KUDUK, Scott D, DI MARCO, Christina N, THOMPSON, Charles D, HARTMAN, George D, BILODEAU, Mark T, COFRE, Victoria, PITTS, Daniel R, RAY, William J, LEI MA, WITTMANN, Marion, VENG, Lone, SEAGER, Matthew A, KOEPLINGER, Kenneth

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Synthesis, Structure−Activity Relationship, and Pharmacological Profile of Analogs of The ASIC-3 Inhibitor A-317567 von Kuduk, Scott D, Di Marco, Christina N, Bodmer-Narkevitch, Vera, Cook, Sean P, Cato, Matthew J, Jovanovska, Aneta, Urban, Mark O, Leitl, Michael, Sain, Nova, Liang, Annie, Spencer, Robert H, Kane, Stefanie A, Hartman, George D, Bilodeau, Mark T

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Pyridine containing M1 positive allosteric modulators with reduced plasma protein binding von KUDUK, Scott D, DI MARCO, Christina N, HARTMAN, George D, BILODEAU, Mark T, COFRE, Victoria, PITTS, Daniel R, RAY, William J, LEI MA, WITTMANN, Marion, SEAGER, Matthew, KOEPLINGER, Kenneth, THOMPSON, Chuck D

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Heterocyclic fused pyridone carboxylic acid M1 positive allosteric modulators von KUDUK, Scott D, DI MARCO, Christina N, BILODEAU, Mark T, CHANG, Ronald K, RAY, William J, LEI MA, WITTMANN, Marion, SEAGER, Matthew A, KOEPLINGER, Kenneth A, THOMPSON, Charles D, HARTMAN, George D

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Bradykinin B1 receptor antagonists : An α-hydroxy amide with an improved metabolism profile von KUDUK, Scott D, CHANG, Ronald K, BOCK, Mark G, DIPARDO, Robert M, DI MARCO, Christina N, MURPHY, Kathy L, RANSOM, Richard W, REISS, Duane R, TANG, Cuyue, PRUEKSARITANONT, Thomayant, PETTIBONE, Douglas J

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Bradykinin B1 antagonists : Biphenyl SAR studies in the cyclopropanecarboxamide series von KUDUK, Scott D, DIPARDO, Robert M, BOCK, Mark G, CHANG, Ronald K, DI MARCO, Christina N, MURPHY, Kathy L, RANSOM, Richard W, REISS, Duane R, TANG, Cuyue, PRUEKSARITANONT, Thomayant, PETTIBONE, Douglas J

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