Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells von Chiarle, Roberto, Zhang, Yu, Frock, Richard L., Lewis, Susanna M., Molinie, Benoit, Ho, Yu-Jui, Myers, Darienne R., Choi, Vivian W., Compagno, Mara, Malkin, Daniel J., Neuberg, Donna, Monti, Stefano, Giallourakis, Cosmas C., Gostissa, Monica, Alt, Frederick W.

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Tonic Signals: Why Do Lymphocytes Bother? von Myers, Darienne R., Zikherman, Julie, Roose, Jeroen P.

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mTOR and other effector kinase signals that impact T cell function and activity von Myers, Darienne R., Wheeler, Benjamin, Roose, Jeroen P.

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Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells von Myers, Darienne R., Norlin, Emilia, Vercoulen, Yvonne, Roose, Jeroen P.

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Allosteric Inhibition of SHP2 Stimulates Antitumor Immunity by Transforming the Immunosuppressive Environment von Quintana, Elsa, Schulze, Christopher J., Myers, Darienne R., Choy, Tiffany J., Mordec, Kasia, Wildes, David, Shifrin, Nataliya Tobvis, Belwafa, Amira, Koltun, Elena S., Gill, Adrian L., Singh, Mallika, Kelsey, Stephen, Goldsmith, Mark A., Nichols, Robert, Smith, Jacqueline A. M.

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Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity von Myers, Darienne R., Abram, Clare L., Wildes, David, Belwafa, Amira, Welsh, Alia M. N., Schulze, Christopher J., Choy, Tiffany J., Nguyen, Tram, Omaque, Neil, Hu, Yongmei, Singh, Mallika, Hansen, Rich, Goldsmith, Mark A., Quintana, Elsa, Smith, Jacqueline A. M., Lowell, Clifford A.

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The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates von Basu, Uttiya, Meng, Fei-Long, Keim, Celia, Grinstein, Veronika, Pefanis, Evangelos, Eccleston, Jennifer, Zhang, Tingting, Myers, Darienne, Wasserman, Caitlyn R., Wesemann, Duane R., Januszyk, Kurt, Gregory, Richard I., Deng, Haiteng, Lima, Christopher D., Alt, Frederick W.

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Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells von Myers, Darienne R., Lau, Tannia, Markegard, Evan, Lim, Hyung W., Kasler, Herbert, Zhu, Minghua, Barczak, Andrea, Huizar, John P., Zikherman, Julie, Erle, David J., Zhang, Weiguo, Verdin, Eric, Roose, Jeroen P.

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Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity von Baars, Matthijs J.D., Douma, Thera, Simeonov, Dimitre R., Myers, Darienne R., Kulhanek, Kayla, Banerjee, Saikat, Zwakenberg, Susan, Baltissen, Marijke P., Amini, Mojtaba, Roock, Sytze, Wijk, Femke, Vermeulen, Michiel, Marson, Alexander, Roose, Jeroen P., Vercoulen, Yvonne

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603 Autoreactivity drives increased metabolism in T cells from SLE patients? von Bahl, Kriti, Myers, Darienne, Roose, Jeroen

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Protocol for Barcoding T Cells Combined with Timed Stimulations von Kulhanek, Kayla R., Myers, Darienne R., Ksionda, Olga, Vercoulen, Yvonne, Romero-Moya, Damia, Roose, Jeroen P.

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Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies von Daley, Stephen R, Coakley, Kristen M, Hu, Daniel Y, Randall, Katrina L, Jenne, Craig N, Limnander, Andre, Myers, Darienne R, Polakos, Noelle K, Enders, Anselm, Roots, Carla, Balakishnan, Bhavani, Miosge, Lisa A, Sjollema, Geoff, Bertram, Edward M, Field, Matthew A, Shao, Yunli, Andrews, T Daniel, Whittle, Belinda, Barnes, S Whitney, Walker, John R, Cyster, Jason G, Goodnow, Christopher C, Roose, Jeroen P

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Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells von Chiarle, Roberto, Zhang, Yu, Frock, Richard L., Lewis, Susanna M., Molinie, Benoit, Ho, Yu-Jui, Myers, Darienne R., Choi, Vivian W., Compagno, Mara, Malkin, Daniel J., Neuberg, Donna, Monti, Stefano, Giallourakis, Cosmas C., Gostissa, Monica, Alt, Frederick W.

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Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells von Myers, Darienne R, Norlin, Emilia, Vercoulen, Yvonne, Roose, Jeroen P

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CTCF-binding elements mediate control of V(D)J recombination von Guo, Chunguang, Yoon, Hye Suk, Franklin, Andrew, Jain, Suvi, Ebert, Anja, Cheng, Hwei-Ling, Hansen, Erica, Despo, Orion, Bossen, Claudia, Vettermann, Christian, Bates, Jamie G., Richards, Nicholas, Myers, Darienne, Patel, Harin, Gallagher, Michael, Schlissel, Mark S., Murre, Cornelis, Busslinger, Meinrad, Giallourakis, Cosmas C., Alt, Frederick W.

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Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity von Baars, Matthijs J.D, Douma, Thera, Simeonov, Dimitre R, Myers, Darienne R, Kulhanek, Kayla, Banerjee, Saikat, Zwakenberg, Susan, Baltissen, Marijke P, Amini, Mojtaba, de Roock, Sytze, van Wijk, Femke, Vermeulen, Michiel, Marson, Alexander, Roose, Jeroen P, Vercoulen, Yvonne

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Abstract 5019: Allosteric inhibition of SHP2 suppresses CSF1R signaling and selectively reduces viability of M2 tumor associated macrophages contributing to anti-tumor immunity von Quintana, Elsa, Schulze, Chris J., Choy, Tiffany J., Myers, Darienne R., Mordec, Kasia, Daniel, Dylan, Goldsmith, Mark A., Smith, Jan A.

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Allosteric Inhibition of SHP2 Stimulates Antitumor Immunity by Transforming the Immunosuppressive Environment von Quintana, Elsa, Schulze, Christopher J., Myers, Darienne R., Choy, Tiffany J., Mordec, Kasia, Wildes, David, Shifrin, Nataliya Tobvis, Belwafa, Amira, Koltun, Elena S., Gill, Adrian L., Singh, Mallika, Kelsey, Stephen, Goldsmith, Mark A., Nichols, Robert, Smith, Jacqueline A. M.

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Protocol for Barcoding T Cells Combined with Timed Stimulations von Kulhanek, Kayla R, Myers, Darienne R, Ksionda, Olga, Vercoulen, Yvonne, Romero-Moya, Damia, Roose, Jeroen P

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Abstract A103: Allosteric inhibition of SHP2 induces antitumor immunity in PD-1-sensitive tumors through modulation of both innate and adaptive mechanisms von Quintana, Elsa, Mordec, Kasia, Nichols, Robert J., Wildes, David, Schulze, Chris J., Myers, Darienne R., Singh, Mallika, Koltun, Elena, Gill, Adrian, Kelsey, Stephen, Goldsmith, Mark A, Smith, Jan A.M.

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