Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies von Sveen, Anita, Bruun, Jarle, Eide, Peter W, Eilertsen, Ina A, Ramirez, Lorena, Murumägi, Astrid, Arjama, Mariliina, Danielsen, Stine A, Kryeziu, Kushtrim, Elez, Elena, Tabernero, Josep, Guinney, Justin, Palmer, Hector G, Nesbakken, Arild, Kallioniemi, Olli, Dienstmann, Rodrigo, Lothe, Ragnhild A

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Wnt5a and ROR1 activate non-canonical Wnt signaling via RhoA in TCF3-PBX1 acute lymphoblastic leukemia and highlight new treatment strategies via Bcl-2 co-targeting von Karvonen, Hanna, Perttilä, Robert, Niininen, Wilhelmiina, Hautanen, Veera, Barker, Harlan, Murumägi, Astrid, Heckman, Caroline A., Ungureanu, Daniela

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KIT pathway upregulation predicts dasatinib efficacy in acute myeloid leukemia von Malani, Disha, Yadav, Bhagwan, Kumar, Ashwini, Potdar, Swapnil, Kontro, Mika, Kankainen, Matti, Javarappa, Komal K., Porkka, Kimmo, Wolf, Maija, Aittokallio, Tero, Wennerberg, Krister, Heckman, Caroline A., Murumägi, Astrid, Kallioniemi, Olli

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Reanalysis of RNA-sequencing data reveals several additional fusion genes with multiple isoforms von Kangaspeska, Sara, Hultsch, Susanne, Edgren, Henrik, Nicorici, Daniel, Murumägi, Astrid, Kallioniemi, Olli

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Anagrelide for Gastrointestinal Stromal Tumor von Pulkka, Olli-Pekka, Gebreyohannes, Yemarshet K, Wozniak, Agnieszka, Mpindi, John-Patrick, Tynninen, Olli, Icay, Katherine, Cervera, Alejandra, Keskitalo, Salla, Murumägi, Astrid, Kulesskiy, Evgeny, Laaksonen, Maria, Wennerberg, Krister, Varjosalo, Markku, Laakkonen, Pirjo, Lehtonen, Rainer, Hautaniemi, Sampsa, Kallioniemi, Olli, Schöffski, Patrick, Sihto, Harri, Joensuu, Heikki

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Multiomics characterization implicates PTK7 in ovarian cancer EMT and cell plasticity and offers strategies for therapeutic intervention von Raivola, Juuli, Dini, Alice, Karvonen, Hanna, Piki, Emilia, Salokas, Kari, Niininen, Wilhelmiina, Kaleva, Laura, Zhang, Kaiyang, Arjama, Mariliina, Gudoityte, Greta, Seashore-Ludlow, Brinton, Varjosalo, Markku, Kallioniemi, Olli, Hautaniemi, Sampsa, Murumägi, Astrid, Ungureanu, Daniela

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Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia von Pemovska, Tea, Kontro, Mika, Yadav, Bhagwan, Edgren, Henrik, Eldfors, Samuli, Szwajda, Agnieszka, Almusa, Henrikki, Bespalov, Maxim M, Ellonen, Pekka, Elonen, Erkki, Gjertsen, Bjørn T, Karjalainen, Riikka, Kulesskiy, Evgeny, Lagström, Sonja, Lehto, Anna, Lepistö, Maija, Lundán, Tuija, Majumder, Muntasir Mamun, Marti, Jesus M Lopez, Mattila, Pirkko, Murumägi, Astrid, Mustjoki, Satu, Palva, Aino, Parsons, Alun, Pirttinen, Tero, Rämet, Maria E, Suvela, Minna, Turunen, Laura, Västrik, Imre, Wolf, Maija, Knowles, Jonathan, Aittokallio, Tero, Heckman, Caroline A, Porkka, Kimmo, Kallioniemi, Olli, Wennerberg, Krister

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Drug response profiles in patient-derived cancer cells across histological subtypes of ovarian cancer: real-time therapy tailoring for a patient with low-grade serous carcinoma von Murumägi, Astrid, Ungureanu, Daniela, Khan, Suleiman, Arjama, Mariliina, Välimäki, Katja, Ianevski, Aleksandr, Ianevski, Philipp, Bergström, Rebecka, Dini, Alice, Kanerva, Anna, Koivisto-Korander, Riitta, Tapper, Johanna, Lassus, Heini, Loukovaara, Mikko, Mägi, Andrus, Hirasawa, Akira, Aoki, Daisuke, Pietiäinen, Vilja, Pellinen, Teijo, Bützow, Ralf, Aittokallio, Tero, Kallioniemi, Olli

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Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies von Yadav, Bhagwan, Pemovska, Tea, Szwajda, Agnieszka, Kulesskiy, Evgeny, Kontro, Mika, Karjalainen, Riikka, Majumder, Muntasir Mamun, Malani, Disha, Murumägi, Astrid, Knowles, Jonathan, Porkka, Kimmo, Heckman, Caroline, Kallioniemi, Olli, Wennerberg, Krister, Aittokallio, Tero

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A multiplex single-cell RNA-Seq pharmacotranscriptomics pipeline for drug discovery von Dini, Alice, Barker, Harlan, Piki, Emilia, Sharma, Subodh, Raivola, Juuli, Murumägi, Astrid, Ungureanu, Daniela

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Glucocorticoids induce differentiation and chemoresistance in ovarian cancer by promoting ROR1-mediated stemness von Karvonen, Hanna, Arjama, Mariliina, Kaleva, Laura, Niininen, Wilhelmiina, Barker, Harlan, Koivisto-Korander, Riitta, Tapper, Johanna, Pakarinen, Päivi, Lassus, Heini, Loukovaara, Mikko, Bützow, Ralf, Kallioniemi, Olli, Murumägi, Astrid, Ungureanu, Daniela

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Drug response prediction by inferring pathway-response associations with kernelized Bayesian matrix factorization von Ammad-Ud-Din, Muhammad, Khan, Suleiman A, Malani, Disha, Murumägi, Astrid, Kallioniemi, Olli, Aittokallio, Tero, Kaski, Samuel

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Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1 von Meager, Anthony, Visvalingam, Kumuthini, Peterson, Pärt, Möll, Kaidi, Murumägi, Astrid, Krohn, Kai, Eskelin, Petra, Perheentupa, Jaakko, Husebye, Eystein, Kadota, Yoshihisa, Willcox, Nick

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Interferon autoantibodies associated with AIRE deficiency decrease the expression of IFN-stimulated genes von Kisand, Kai, Link, Maire, Wolff, Anette S.B., Meager, Anthony, Tserel, Liina, Org, Tõnis, Murumägi, Astrid, Uibo, Raivo, Willcox, Nick, Trebušak Podkrajšek, Katarina, Battelino, Tadej, Lobell, Anna, Kämpe, Olle, Lima, Kari, Meloni, Antonella, Ergun-Longmire, Berrin, Maclaren, Noel K., Perheentupa, Jaakko, Krohn, Kai J.E., Scott, Hamish S., Husebye, Eystein S., Peterson, Pärt

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Crosstalk between ROR1 and BCR pathways defines novel treatment strategies in mantle cell lymphoma von Karvonen, Hanna, Chiron, David, Niininen, Wilhelmiina, Ek, Sara, Jerkeman, Mats, Moradi, Elaheh, Nykter, Matti, Heckman, Caroline A., Kallioniemi, Olli, Murumägi, Astrid, Ungureanu, Daniela

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Consistency in drug response profiling von Mpindi, John Patrick, Yadav, Bhagwan, Östling, Päivi, Gautam, Prson, Malani, Disha, Murumägi, Astrid, Hirasawa, Akira, Kangaspeska, Sara, Wennerberg, Krister, Kallioniemi, Olli, Aittokallio, Tero

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Ets transcription factors regulate AIRE gene promoter von Murumägi, Astrid, Silvennoinen, Olli, Peterson, Pärt

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STRN-ALK rearranged pediatric malignant peritoneal mesothelioma – Functional testing of 527 cancer drugs in patient-derived cancer cells von Murumägi, Astrid, Ungureanu, Daniela, Arjama, Mariliina, Bützow, Ralf, Lohi, Jouko, Sariola, Hannu, Kanerva, Jukka, Koskenvuo, Minna, Kallioniemi, Olli

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Drug-Sensitivity Screening and Genomic Characterization of 45 HPV-Negative Head and Neck Carcinoma Cell Lines for Novel Biomarkers of Drug Efficacy von Lepikhova, Tatiana, Karhemo, Piia-Riitta, Louhimo, Riku, Yadav, Bhagwan, Murumägi, Astrid, Kulesskiy, Evgeny, Kivento, Mikko, Sihto, Harri, Grénman, Reidar, Syrjänen, Stina M, Kallioniemi, Olli, Aittokallio, Tero, Wennerberg, Krister, Joensuu, Heikki, Monni, Outi

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Comparison of two supporting matrices for patient-derived cancer cells in 3D drug sensitivity and resistance testing assay (3D-DSRT) von Feodoroff, Michaela, Mikkonen, Piia, Turunen, Laura, Hassinen, Antti, Paasonen, Lauri, Paavolainen, Lassi, Potdar, Swapnil, Murumägi, Astrid, Kallioniemi, Olli, Pietiäinen, Vilja

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