The 'rule of three' for fragment-based drug discovery: where are we now? von Jhoti, Harren, Williams, Glyn, Rees, David C., Murray, Christopher W.

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Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor von Perera, Timothy P S, Jovcheva, Eleonora, Mevellec, Laurence, Vialard, Jorge, De Lange, Desiree, Verhulst, Tinne, Paulussen, Caroline, Van De Ven, Kelly, King, Peter, Freyne, Eddy, Rees, David C, Squires, Matthew, Saxty, Gordon, Page, Martin, Murray, Christopher W, Gilissen, Ron, Ward, George, Thompson, Neil T, Newell, David R, Cheng, Na, Xie, Liang, Yang, Jennifer, Platero, Suso J, Karkera, Jayaprakash D, Moy, Christopher, Angibaud, Patrick, Laquerre, Sylvie, Lorenzi, Matthew V

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Towards quantitative and multiplexed in vivo functional cancer genomics von Winters, Ian P., Murray, Christopher W., Winslow, Monte M.

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The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D von Chaikovsky, Andrea C., Li, Chuan, Jeng, Edwin E., Loebell, Samuel, Lee, Myung Chang, Murray, Christopher W., Cheng, Ran, Demeter, Janos, Swaney, Danielle L., Chen, Si-Han, Newton, Billy W., Johnson, Jeffrey R., Drainas, Alexandros P., Shue, Yan Ting, Seoane, Jose A., Srinivasan, Preethi, He, Andy, Yoshida, Akihiro, Hipkins, Susan Q., McCrea, Edel, Poltorack, Carson D., Krogan, Nevan J., Diehl, J. Alan, Kong, Christina, Jackson, Peter K., Curtis, Christina, Petrov, Dmitri A., Bassik, Michael C., Winslow, Monte M., Sage, Julien

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Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design von O’Reilly, Marc, Cleasby, Anne, Davies, Thomas G., Hall, Richard J., Ludlow, R. Frederick, Murray, Christopher W., Tisi, Dominic, Jhoti, Harren

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Associations between Patient Global Assessment scores and pain, physical function, and fatigue in rheumatoid arthritis: a post hoc analysis of data from phase 3 trials of tofacitin... von Strand, Vibeke, Kaine, Jeffrey, Alten, Rieke, Wallenstein, Gene, Diehl, Annette, Shi, Harry, Germino, Rebecca, Murray, Christopher W.

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An Arntl2-Driven Secretome Enables Lung Adenocarcinoma Metastatic Self-Sufficiency von Brady, Jennifer J., Chuang, Chen-Hua, Greenside, Peyton G., Rogers, Zoë N., Murray, Christopher W., Caswell, Deborah R., Hartmann, Ursula, Connolly, Andrew J., Sweet-Cordero, E. Alejandro, Kundaje, Anshul, Winslow, Monte M.

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Improved protein-ligand docking using GOLD von Verdonk, Marcel L., Cole, Jason C., Hartshorn, Michael J., Murray, Christopher W., Taylor, Richard D.

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Multiplexed screens identify RAS paralogues HRAS and NRAS as suppressors of KRAS-driven lung cancer growth von Tang, Rui, Shuldiner, Emily G., Kelly, Marcus, Murray, Christopher W., Hebert, Jess D., Andrejka, Laura, Tsai, Min K., Hughes, Nicholas W., Parker, Mitchell I., Cai, Hongchen, Li, Yao-Cheng, Wahl, Geoffrey M., Dunbrack, Roland L., Jackson, Peter K., Petrov, Dmitri A., Winslow, Monte M.

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Diverse, High-Quality Test Set for the Validation of Protein−Ligand Docking Performance von Hartshorn, Michael J, Verdonk, Marcel L, Chessari, Gianni, Brewerton, Suzanne C, Mooij, Wijnand T. M, Mortenson, Paul N, Murray, Christopher W

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A versatile system to record cell-cell interactions von Tang, Rui, Murray, Christopher W, Linde, Ian L, Kramer, Nicholas J, Lyu, Zhonglin, Tsai, Min K, Chen, Leo C, Cai, Hongchen, Gitler, Aaron D, Engleman, Edgar, Lee, Wonjae, Winslow, Monte M

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Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by... von Woodhead, Andrew J, Angove, Hayley, Carr, Maria G, Chessari, Gianni, Congreve, Miles, Coyle, Joseph E, Cosme, Jose, Graham, Brent, Day, Philip J, Downham, Robert, Fazal, Lynsey, Feltell, Ruth, Figueroa, Eva, Frederickson, Martyn, Lewis, Jonathan, McMenamin, Rachel, Murray, Christopher W, O’Brien, M. Alistair, Parra, Lina, Patel, Sahil, Phillips, Theresa, Rees, David C, Rich, Sharna, Smith, Donna-Michelle, Trewartha, Gary, Vinkovic, Mladen, Williams, Brian, Woolford, Alison J.-A

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LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer von Murray, Christopher W., Brady, Jennifer J., Han, Mingqi, Cai, Hongchen, Tsai, Min K., Pierce, Sarah E., Cheng, Ran, Demeter, Janos, Feldser, David M., Jackson, Peter K., Shackelford, David B., Winslow, Monte M.

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A multiplexed in vivo approach to identify driver genes in small cell lung cancer von Lee, Myung Chang, Cai, Hongchen, Murray, Christopher W., Li, Chuan, Shue, Yan Ting, Andrejka, Laura, He, Andy L., Holzem, Alessandra M.E., Drainas, Alexandros P., Ko, Julie H., Coles, Garry L., Kong, Christina, Zhu, Shirley, Zhu, ChunFang, Wang, Jason, van de Rijn, Matt, Petrov, Dmitri A., Winslow, Monte M., Sage, Julien

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Comparing protein-ligand docking programs is difficult von Cole, Jason C., Murray, Christopher W., Nissink, J. Willem M., Taylor, Richard D., Taylor, Robin

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Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function von Saalau-Bethell, Susanne M, Woodhead, Andrew J, Chessari, Gianni, Carr, Maria G, Coyle, Joseph, Graham, Brent, Hiscock, Steven D, Murray, Christopher W, Pathuri, Puja, Rich, Sharna J, Richardson, Caroline J, Williams, Pamela A, Jhoti, Harren

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Opportunity Knocks: Organic Chemistry for Fragment-Based Drug Discovery (FBDD) von Murray, Christopher W., Rees, David C.

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Apo and Inhibitor Complex Structures of BACE (β-secretase) von Patel, Sahil, Vuillard, Laurent, Cleasby, Anne, Murray, Christopher W., Yon, Jeff

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Protein−Ligand Docking against Non-Native Protein Conformers von Verdonk, Marcel L, Mortenson, Paul N, Hall, Richard J, Hartshorn, Michael J, Murray, Christopher W

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The rise of fragment-based drug discovery von Murray, Christopher W., Rees, David C.

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