721 Defining Bleeding Characteristics in Frostbite Patients Managed with tPA von Murphy, Jenna E, Winters, M Kenett, Rogers, Charlotte, Walter, Ellen, Neumann, Nichole, Weber, Lynn, Lacey, Alexandra M, Punjabi, Gopal, Endorf, Frederick W, Nygaard, Rachel M

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SASH3 variants cause a novel form of X-linked combined immunodeficiency with immune dysregulation von Delmonte, Ottavia M., Bergerson, Jenna R.E., Kawai, Tomoki, Kuehn, Hye Sun, McDermott, David H., Cortese, Irene, Zimmermann, Michael T., Dobbs, A. Kerry, Bosticardo, Marita, Fink, Danielle, Majumdar, Shamik, Palterer, Boaz, Pala, Francesca, Dsouza, Nikita R., Pouzolles, Marie, Taylor, Naomi, Calvo, Katherine R., Daley, Stephen R., Velez, Daniel, Agharahimi, Anahita, Myint-Hpu, Katherine, Dropulic, Lesia K., Lyons, Jonathan J., Holland, Steven M., Freeman, Alexandra F., Ghosh, Rajarshi, Similuk, Morgan B., Niemela, Julie E., Stoddard, Jennifer, Kuhns, Douglas B., Urrutia, Raul, Rosenzweig, Sergio D., Walkiewicz, Magdalena A., Murphy, Philip M., Notarangelo, Luigi D.

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Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial von Maughan, Timothy S, Prof, Adams, Richard A, FRCP, Smith, Christopher G, BSc, Meade, Angela M, DPhil, Seymour, Matthew T, Prof, Wilson, Richard H, MD, Idziaszczyk, Shelley, MPhil, Harris, Rebecca, MSc, Fisher, David, MSc, Kenny, Sarah L, MSc, Kay, Edward, BA, Mitchell, Jenna K, BHSc, Madi, Ayman, MRCP, Jasani, Bharat, Prof, James, Michelle D, BSc, Bridgewater, John, MD, Kennedy, M John, MD, Claes, Bart, MSc, Lambrechts, Diether, PhD, Kaplan, Richard, Prof, Cheadle, Jeremy P, Prof

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Strain specific differences in rates of Photosystem II repair in picocyanobacteria correlate to differences in FtsH protein levels and isoform expression patterns von Bonisteel, Erin M, Turner, Brooke E, Murphy, Cole D, Melanson, Jenna-Rose, Duff, Nicole M, Beardsall, Brian D, Xu, Kui, Campbell, Douglas A, Cockshutt, Amanda M

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Human skeletal muscle fiber type-specific responses to sprint interval and moderate-intensity continuous exercise: acute and training-induced changes von Skelly, Lauren E., Gillen, Jenna B., Frankish, Barnaby P., MacInnis, Martin J., Godkin, F. Elizabeth, Tarnopolsky, Mark A., Murphy, Robyn M., Gibala, Martin J.

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Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice von Collier, Jenna L, Pauken, Kristen E, Lee, Catherine A A, Patterson, Dillon G, Markson, Samuel C, Conway, Thomas S, Fung, Megan E, France, Joshua A, Mucciarone, Kyla N, Lian, Christine G, Murphy, George F, Sharpe, Arlene H

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Association of rs9939609 in FTO with BMI among Polynesian peoples living in Aotearoa New Zealand and other Pacific nations von Krishnan, Mohanraj, Phipps-Green, Amanda, Russell, Emily M, Major, Tanya J, Cadzow, Murray, Stamp, Lisa K, Dalbeth, Nicola, Hindmarsh, Jennie Harré, Qasim, Muhammad, Watson, Huti, Liu, Shuwei, Carlson, Jenna C, Minster, Ryan L, Hawley, Nicola L, Naseri, Take, Reupena, Muagututi'a Sefuiva, Deka, Ranjan, McGarvey, Stephen T, Merriman, Tony R, Murphy, Rinki, Weeks, Daniel E

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Perturbations of the T-cell receptor repertoire in response to SARS-CoV-2 in immunocompetent and immunocompromised individuals von Delmonte, Ottavia M., Oguz, Cihan, Dobbs, Kerry, Myint-Hpu, Katherine, Palterer, Boaz, Abers, Michael S., Draper, Deborah, Truong, Meng, Kaplan, Ian M., Gittelman, Rachel M., Zhang, Yu, Rosen, Lindsey B., Snow, Andrew L., Dalgard, Clifton L., Burbelo, Peter D., Imberti, Luisa, Sottini, Alessandra, Quiros-Roldan, Eugenia, Castelli, Francesco, Rossi, Camillo, Brugnoni, Duilio, Biondi, Andrea, Bettini, Laura Rachele, D’Angio, Mariella, Bonfanti, Paolo, Anderson, Megan V., Saracino, Annalisa, Chironna, Maria, Di Stefano, Mariantonietta, Fiore, Jose Ramon, Santantonio, Teresa, Castagnoli, Riccardo, Marseglia, Gian Luigi, Magliocco, Mary, Bosticardo, Marita, Pala, Francesca, Shaw, Elana, Matthews, Helen, Weber, Sarah E., Xirasagar, Sandhya, Barnett, Jason, Oler, Andrew J., Dimitrova, Dimana, Bergerson, Jenna R.E., McDermott, David H., Rao, V. Koneti, Murphy, Philip M., Holland, Steven M., Lisco, Andrea, Su, Helen C., Lionakis, Michail S., Cohen, Jeffrey I., Freeman, Alexandra F., Snyder, Thomas M., Lack, Justin, Notarangelo, Luigi D.

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Clinical exome sequencing of 1000 families with complex immune phenotypes: Toward comprehensive genomic evaluations von Similuk, Morgan N, Yan, Jia, Ghosh, Rajarshi, Oler, Andrew J, Franco, Luis M, Setzer, Michael R, Kamen, Michael, Jodarski, Colleen, DiMaggio, Thomas, Davis, Joie, Gore, Rachel, Jamal, Leila, Borges, Adrienne, Gentile, Nicole, Niemela, Julie, Lowe, Chenery, Jevtich, Kathleen, Yu, Yunting, Hullfish, Haley, Hsu, Amy P, Hong, Celine, Littel, Patricia, Seifert, Bryce A, Milner, Joshua, Johnston, Jennifer J, Cheng, Xi, Li, Zhiwen, Veltri, Daniel, Huang, Ke, Kaladi, Krishnaveni, Barnett, Jason, Zhang, Lingwen, Vlasenko, Nikita, Fan, Yongjie, Karlins, Eric, Ganakammal, Satishkumar Ranganathan, Gilmore, Robert, Tran, Emily, Yun, Alvin, Mackey, Joseph, Yazhuk, Svetlana, Lack, Justin, Kuram, Vasudev, Cao, Wenjia, Huse, Susan, Frank, Karen, Fahle, Gary, Rosenzweig, Sergio, Su, Yan, Hwang, SuJin, Bi, Weimin, Bennett, John, Myles, Ian A, De Ravin, Suk See, Fuss, Ivan, Strober, Warren, Bielekova, Bibiana, Almeida de Jesus, Adriana, Goldbach-Mansky, Raphaela, Williamson, Peter, Kumar, Kelly, Dempsy, Caeden, Frischmeyer-Guerrerio, Pamela, Fisch, Robin, Bolan, Hyejeong, Metcalfe, Dean D, Komarow, Hirsh, Carter, Melody, Druey, Kirk M, Sereti, Irini, Dropulic, Lesia, Klion, Amy D, Khoury, Paneez, O' Connell, Elise M, Holland-Thomas, Nicole C, Brown, Thomas, McDermott, David H, Murphy, Philip M, Bundy, Vanessa, Keller, Michael D, Peng, Christine, Kim, Helen, Norman, Stephanie, Delmonte, Ottavia M, Kang, Elizabeth, Su, Helen C, Malech, Harry, Freeman, Alexandra, Zerbe, Christa, Uzel, Gulbu, Bergerson, Jenna R E, Rao, V Koneti, Olivier, Kenneth N, Lyons, Jonathan J, Lisco, Andrea, Cohen, Jeffrey I, Lionakis, Michail S, Biesecker, Leslie G, Xirasagar, Sandhya, Notarangelo, Luigi D

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Comparative spatially explicit approach for testing effects of soil chemicals on terrestrial wildlife bioindicator demographics von Murphy, Sean M., Hathcock, Charles D., Espinoza, Tatiana N., Fresquez, Philip R., Berryhill, Jesse T., Stanek, Jenna E., Sutter, Benjamin J., Gaukler, Shannon M.

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Evolutionary constraint and innovation across hundreds of placental mammals von Christmas, Matthew J, Kaplow, Irene M, Genereux, Diane P, Dong, Michael X, Hughes, Graham M, Li, Xue, Sullivan, Patrick F, Hindle, Allyson G, Andrews, Gregory, Armstrong, Joel C, Bianchi, Matteo, Breit, Ana M, Diekhans, Mark, Fanter, Cornelia, Foley, Nicole M, Goodman, Daniel B, Goodman, Linda, Keough, Kathleen C, Kirilenko, Bogdan, Kowalczyk, Amanda, Lawless, Colleen, Lind, Abigail L, Meadows, Jennifer R S, Moreira, Lucas R, Redlich, Ruby W, Ryan, Louise, Swofford, Ross, Valenzuela, Alejandro, Wagner, Franziska, Wallerman, Ola, Brown, Ashley R, Damas, Joana, Fan, Kaili, Gatesy, John, Grimshaw, Jenna, Johnson, Jeremy, Kozyrev, Sergey V, Lawler, Alyssa J, Marinescu, Voichita D, Morrill, Kathleen M, Osmanski, Austin, Paulat, Nicole S, Phan, BaDoi N, Reilly, Steven K, Schäffer, Daniel E, Steiner, Cynthia, Supple, Megan A, Wilder, Aryn P, Wirthlin, Morgan E, Xue, James R, Birren, Bruce W, Gazal, Steven, Hubley, Robert M, Koepfli, Klaus-Peter, Marques-Bonet, Tomas, Meyer, Wynn K, Nweeia, Martin, Sabeti, Pardis C, Shapiro, Beth, Smit, Arian F A, Springer, Mark S, Teeling, Emma C, Weng, Zhiping, Hiller, Michael, Levesque, Danielle L, Lewin, Harris A, Murphy, William J, Navarro, Arcadi, Paten, Benedict, Pollard, Katherine S, Ray, David A, Ruf, Irina, Ryder, Oliver A, Pfenning, Andreas R, Lindblad-Toh, Kerstin, Karlsson, Elinor K

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Insights into mammalian TE diversity through the curation of 248 genome assemblies von Osmanski, Austin B, Paulat, Nicole S, Korstian, Jenny, Grimshaw, Jenna R, Halsey, Michaela, Sullivan, Kevin A M, Moreno-Santillán, Diana D, Crookshanks, Claudia, Roberts, Jacquelyn, Garcia, Carlos, Johnson, Matthew G, Densmore, Llewellyn D, Stevens, Richard D, Rosen, Jeb, Storer, Jessica M, Hubley, Robert, Smit, Arian F A, Dávalos, Liliana M, Karlsson, Elinor K, Lindblad-Toh, Kerstin, Ray, David A

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17β-Estradiol and Progesterone Regulate Expression of β-Amyloid Clearance Factors in Primary Neuron Cultures and Female Rat Brain von Jayaraman, Anusha, Carroll, Jenna C, Morgan, Todd E, Lin, Sharon, Zhao, Liqin, Arimoto, Jason M, Murphy, M. Paul, Beckett, Tina L, Finch, Caleb E, Brinton, Roberta Diaz, Pike, Christian J

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Effect of Depth and Duration of Cooling on Deaths in the NICU Among Neonates With Hypoxic Ischemic Encephalopathy: A Randomized Clinical Trial von Shankaran, Seetha, Laptook, Abbot R, Pappas, Athina, McDonald, Scott. A, Das, Abhik, Tyson, Jon E, Poindexter, Brenda B, Schibler, Kurt, Bell, Edward F, Heyne, Roy J, Pedroza, Claudia, Bara, Rebecca, Van Meurs, Krisa P, Grisby, Cathy, Petrie Huitema, Carolyn M, Garg, Meena, Ehrenkranz, Richard A, Shepherd, Edward G, Chalak, Lina F, Hamrick, Shannon E. G, Khan, Amir M, Reynolds, Anne Marie, Laughon, Matthew M, Truog, William E, Dysart, Kevin C, Carlo, Waldemar A, Walsh, Michele C, Watterberg, Kristi L, Higgins, Rosemary D

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Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and correlates of response von Rebhun, Robert B, York, Daniel, Cruz, Sylvia Margret, Judge, Sean J, Razmara, Aryana M, Farley, Lauren E, Brady, Rachel V, Johnson, Eric G, Burton, Jenna H, Willcox, Jennifer, Wittenburg, Luke A, Woolard, Kevin, Dunai, Cordelia, Stewart, Susan L, Sparger, Ellen E, Withers, Sita S, Gingrich, Alicia A, Skorupski, Katherine A, Al-Nadaf, Sami, LeJeune, Amandine T, Culp, William TN, Murphy, William J, Kent, Michael S, Canter, Robert J

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In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson’s Disease in Common Marmosets von Vermilyea, Scott C., Babinski, Alexander, Tran, Nina, To, Samantha, Guthrie, Scott, Kluss, Jillian H., Schmidt, Jenna Kropp, Wiepz, Gregory J., Meyer, Michael G., Murphy, Megan E., Cookson, Mark R., Emborg, Marina E., Golos, Thaddeus G.

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Appendectomy Versus Observation for Appendicitis in Neutropenic Children With Cancer von Many, Benjamin T., Lautz, Timothy B., Dobrozsi, Sarah, Wilkinson, Katheryn Hope, Rossoff, Jenna, Le-Nguyen, Annie, Dakhallah, Nawar, Piche, Nelson, Weinschenk, Whitney, Cooke-Barker, Jo, Goodhue, Catherine, Zamora, Abigail, Kim, Eugene S., Talbot, Lindsay J., Quevedo, Oswaldo Gomez, Murphy, Andrew J., Commander, Sarah J., Tracy, Elisabeth T., Short, Scott S., Meyers, Rebecka L., Rinehardt, Hannah N., Aldrink, Jennifer H., Heaton, Todd E., Ortiz, Michael, Baertschiger, Reto, Wong, Kaitlyn E., Lapidus-Krol, Eveline, Butter, Andreana, Davidson, Jacob, Stark, Rebecca, Ramaraj, Akila, Malek, Marcus, Mastropolo, Rosemarie, Morgan, Katrina, Murphy, Joseph T., Janek, Kevin, Le, Hau D., Dasgupta, Roshni, Lal, Dave R.

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Panaxynol, a bioactive component of American ginseng, targets macrophages and suppresses colitis in mice von Chaparala, Anusha, Poudyal, Deepak, Tashkandi, Hossam, Witalison, Erin E, Chumanevich, Alexander A, Hofseth, Jenna L, Nguyen, Ivy, Hardy, Olivia, Pittman, Douglas L, Wyatt, Michael D, Windust, Anthony, Murphy, Elizabeth A, Nagarkatti, Mitzi, Nagarkatti, Prakash, Hofseth, Lorne J

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Effects of Cardiac Sympathetic Neurodegeneration and PPARγ Activation on Rhesus Macaque Whole Blood miRNA and mRNA Expression Profiles von Vemuganti, Raghu, Murphy, Megan E., Schmidt, Jenna K., Lopez, Mary S., Metzger, Jeanette M., Emborg, Marina E.

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A genomic timescale for placental mammal evolution von Foley, Nicole M, Mason, Victor C, Harris, Andrew J, Bredemeyer, Kevin R, Damas, Joana, Lewin, Harris A, Eizirik, Eduardo, Gatesy, John, Karlsson, Elinor K, Lindblad-Toh, Kerstin, Springer, Mark S, Murphy, William J

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