Targeting Prostate Cancer Subtype 1 by Forkhead Box M1 Pathway Inhibition von Ketola, Kirsi, Munuganti, Ravi S N, Davies, Alastair, Nip, Ka Mun, Bishop, Jennifer L, Zoubeidi, Amina

Volltext

Discovery of 1H‑Indole-2-carboxamides as Novel Inhibitors of the Androgen Receptor Binding Function 3 (BF3) von Ban, Fuqiang, Leblanc, Eric, Li, Huifang, Munuganti, Ravi S. N, Frewin, Kate, Rennie, Paul S, Cherkasov, Artem

Volltext

Benzothiophenone Derivatives Targeting Mutant Forms of Estrogen Receptor-α in Hormone-Resistant Breast Cancers von Singh, Kriti, Munuganti, Ravi S N, Lallous, Nada, Dalal, Kush, Yoon, Ji Soo, Sharma, Aishwariya, Yamazaki, Takeshi, Cherkasov, Artem, Rennie, Paul S

Volltext

Discovery of 1 H -Indole-2-carboxamides as Novel Inhibitors of the Androgen Receptor Binding Function 3 (BF3) von Ban, Fuqiang, Leblanc, Eric, Li, Huifang, Munuganti, Ravi S. N., Frewin, Kate, Rennie, Paul S., Cherkasov, Artem

Volltext

Targeting Binding Function-3 of the Androgen Receptor Blocks Its Co-Chaperone Interactions, Nuclear Translocation, and Activation von Lallous, Nada, Leblanc, Eric, Munuganti, Ravi S N, Hassona, Mohamed D H, Nakouzi, Nader Al, Awrey, Shannon, Morin, Helene, Roshan-Moniri, Mani, Singh, Kriti, Lawn, Sam, Yamazaki, Takeshi, Adomat, Hans H, Andre, Christophe, Daugaard, Mads, Young, Robert N, Guns, Emma S Tomlinson, Rennie, Paul S, Cherkasov, Artem

Volltext

Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells von Johnson, Fraser D., Ferrarone, John, Liu, Alvin, Brandstädter, Christina, Munuganti, Ravi, Farnsworth, Dylan A., Lu, Daniel, Luu, Jennifer, Sihota, Tianna, Jansen, Sophie, Nagelberg, Amy, Shi, Rocky, Forcina, Giovanni C., Zhang, Xu, Cheng, Grace S.W., Spencer Miko, Sandra E., de Rappard-Yuswack, Georgia, Sorensen, Poul H., Dixon, Scott J., Guha, Udayan, Becker, Katja, Djaballah, Hakim, Somwar, Romel, Varmus, Harold, Morin, Gregg B., Lockwood, William W.

Volltext

Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy von Pan, Mengwu, Solozobova, Valeria, Kuznik, Nane C, Jung, Nicole, Gräßle, Simone, Gourain, Victor, Heneka, Yvonne M, Cramer von Clausbruch, Christina A, Fuhr, Olaf, Munuganti, Ravi S N, Maddalo, Danilo, Blattner, Christine, Neeb, Antje, Sharp, Adam, Cato, Laura, Weiss, Carsten, Jeselsohn, Rinath M, Orian-Rousseau, Veronique, Bräse, Stefan, Cato, Andrew C B

Volltext

In silico discovery and validation of potent small-molecule inhibitors targeting the activation function 2 site of human oestrogen receptor α von Singh, Kriti, Munuganti, Ravi Shashi Nayana, Leblanc, Eric, Lin, Yu Lun, Leung, Euphemia, Lallous, Nada, Butler, Miriam, Cherkasov, Artem, Rennie, Paul S

Volltext

Drug-Discovery Pipeline for Novel Inhibitors of the Androgen Receptor von Dalal, Kush, Munuganti, Ravi, Morin, Hélène, Lallous, Nada, Rennie, Paul S., Cherkasov, Artem

Volltext

Targeting the Binding Function 3 (BF3) Site of the Androgen Receptor Through Virtual Screening. 2. Development of 2‑((2-phenoxyethyl) thio)‑1H‑benzimidazole Derivatives von Munuganti, Ravi Shashi Nayana, Leblanc, Eric, Axerio-Cilies, Peter, Labriere, Christophe, Frewin, Kate, Singh, Kriti, Hassona, Mohamed D. H, Lack, Nathan A, Li, Huifang, Ban, Fuqiang, Tomlinson Guns, Emma, Young, Robert, Rennie, Paul S, Cherkasov, Artem

Volltext

Abstract A029: Targeting neural transcription factor BRN2 in neuroendocrine prostate tumors von Munuganti, Ravi Shashi Nayana, Thaper, Daksh, Zoubeidi, Amina

Volltext

Abstract 14: Computer-aided discovery of small-molecule inhibitors targeting neural transcription factor BRN2 in neuroendocrine prostate tumors von Munuganti, Ravi, Thaper, Daksh, Aguda, Adeleke, Kim, Soojin, Sivak, Olena, Zoubeidi, Amina

Volltext

Identification of a Potent Antiandrogen that Targets the BF3 Site of the Androgen Receptor and Inhibits Enzalutamide-Resistant Prostate Cancer von Munuganti, Ravi S.N., Hassona, Mohamed D.H., Leblanc, Eric, Frewin, Kate, Singh, Kriti, Ma, Dennis, Ban, Fuqiang, Hsing, Michael, Adomat, Hans, Lallous, Nada, Andre, Christophe, Jonadass, Jon Paul Selvam, Zoubeidi, Amina, Young, Robert N., Tomlinson Guns, Emma, Rennie, Paul S., Cherkasov, Artem

Volltext

Abstract 3083: Selective inhibition of transcription factor BRN2 as a treatment strategy for Small Cell Prostate Cancer von Thaper, Daksh, Munuganti, Ravi, Aguda, Adeleke, Kim, Soojin, Ku, Shungyu, Kumar, Sahil, Vahid, Sepideh, Nouruzi, Shaghayegh, Sivak, Olena, Ganguli, Dwaiyapan, Morrissey, Colm, Corey, Eva, Beltran, Himisha, Zoubeidi, Amina

Volltext

Abstract 1931: Targeting master neuronal transcription factor BRN2 in neuroendocrine prostate cancer von Thaper, Daksh, Munuganti, Ravi, Norouzi, Shaghayegh, Kumar, Sahil, Kim, Soojin, Singh, Kriti, Vahid, Sepideh, Bishop, Jennifer, Zoubeidi, Amina

Volltext

Abstract 1295: First-in-field small molecule inhibitors targeting BRN2 as a therapeutic strategy for small cell prostate cancer von Thaper, Daksh, Munuganti, Ravi, Nouruzi, Shaghayegh, Kumar, Sahil, Kim, Soojin, Sivak, Olena, Aguda, Adeleke, Ganguli, Dwaipayan, Vahid, Sepideh, Puca, Loredana, Beltran, Himisha, Zoubeidi, Amina

Volltext

First-in-field small molecule inhibitors targeting BRN2 as a therapeutic strategy for small cell prostate cancer von Thaper, Daksh L., Munuganti, Ravi, Nouruzi, Shaghayegh, Kumar, Sahil, Kim, Soojin, Vahid, Sepideh, Sivak, Olena, Aguda, Adeleke, Puca, Loredana, Beltran, Himisha, Zoubeidi, Amina

Volltext

Development of a Benzothiazole Scaffold-Based Androgen Receptor N‑Terminal Inhibitor for Treating Androgen-Responsive Prostate Cancer von Kuznik, Nane C, Solozobova, Valeria, Jung, Nicole, Gräßle, Simone, Lei, Qing, Lewandowski, Eric M, Munuganti, Ravi, Zoubeidi, Amina, Chen, Yu, Bräse, Stefan, Cato, Andrew C. B

Volltext

Abstract 3651: The development of anti-estrogens targeting the activation function 2 site of estrogen receptor alpha for treatment of Tamoxifen resistant breast cancer von Singh, Kriti, Munuganti, Ravi Shashi Nayana, Leblanc, Eric, Cherkasov, Artem, Rennie, Paul S.

Volltext

Abstract PD6-7: In-silico discovery of novel estrogen receptor-α inhibitors as potential therapeutics for tamoxifen resistant breast cancer von Singh, Kriti, Munuganti, Ravi SN, Butler, Miriam, Cherkasov, Artem, Rennie, Paul S

Volltext