Applications of microbial cytochrome P450 enzymes in biotechnology and synthetic biology von Girvan, Hazel M, Munro, Andrew W

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Unusual Cytochrome P450 Enzymes and Reactions von Guengerich, F. Peter, Munro, Andrew W.

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Effect of DMSO on Protein Structure and Interactions Assessed by Collision-Induced Dissociation and Unfolding von Chan, Daniel S.-H, Kavanagh, Madeline E, McLean, Kirsty J, Munro, Andrew. W, Matak-Vinković, Dijana, Coyne, Anthony G, Abell, Chris

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Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE: Involvement of a Ferric-Peroxynitrite Intermediate von Louka, Savvas, Barry, Sarah M, Heyes, Derren J, Mubarak, M. Qadri E, Ali, Hafiz Saqib, Alkhalaf, Lona M, Munro, Andrew W, Scrutton, Nigel S, Challis, Gregory L, de Visser, Sam P

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P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping von Acevedo-Rocha, Carlos G, Gamble, Charles G, Lonsdale, Richard, Li, Aitao, Nett, Nathalie, Hoebenreich, Sabrina, Lingnau, Julia B, Wirtz, Cornelia, Fares, Christophe, Hinrichs, Heike, Deege, Alfred, Mulholland, Adrian J, Nov, Yuval, Leys, David, McLean, Kirsty J, Munro, Andrew W, Reetz, Manfred T

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Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5 von Wright, William C, Chenge, Jude, Wang, Jingheng, Girvan, Hazel M, Yang, Lei, Chai, Sergio C, Huber, Andrew D, Wu, Jing, Oladimeji, Peter O, Munro, Andrew W, Chen, Taosheng

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A Promiscuous Bacterial P450: The Unparalleled Diversity of BM3 in Pharmaceutical Metabolism von Thistlethwaite, Sian, Jeffreys, Laura N., Girvan, Hazel M., McLean, Kirsty J., Munro, Andrew W.

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Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleTJE von Matthews, Sarah, Belcher, James D., Tee, Kang Lan, Girvan, Hazel M., McLean, Kirsty J., Rigby, Stephen E.J., Levy, Colin W., Leys, David, Parker, David A., Blankley, Richard T., Munro, Andrew W.

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Structure and Biochemical Properties of the Alkene Producing Cytochrome P450 OleTJE (CYP152L1) from the Jeotgalicoccus sp. 8456 Bacterium von Belcher, James, McLean, Kirsty J., Matthews, Sarah, Woodward, Laura S., Fisher, Karl, Rigby, Stephen E.J., Nelson, David R., Potts, Donna, Baynham, Michael T., Parker, David A., Leys, David, Munro, Andrew W.

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Variations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamily von Munro, Andrew W, Girvan, Hazel M, McLean, Kirsty J

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Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum von McLean, Kirsty J, Hans, Marcus, Meijrink, Ben, van Scheppingen, Wibo B, Vollebregt, Aad, Tee, Kang Lan, van der Laan, Jan-Metske, Leys, David, Munro, Andrew W, van den Berg, Marco A

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Key Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate Bias von Butler, Christopher F., Peet, Caroline, Mason, Amy E., Voice, Michael W., Leys, David, Munro, Andrew W.

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Application of Fragment Screening and Merging to the Discovery of Inhibitors of the Mycobacterium tuberculosis Cytochrome P450 CYP121 von Hudson, Sean A., McLean, Kirsty J., Surade, Sachin, Yang, Yong-Qing, Leys, David, Ciulli, Alessio, Munro, Andrew W., Abell, Chris

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Characterization of Active Site Structure in CYP121: A Cytochrome P450 Essential for Viability of Mycobacterium Tuberculosis H37Rv von McLean, Kirsty J., Carroll, Paul, Lewis, D. Geraint, Dunford, Adrian J., Seward, Harriet E., Neeli, Rajasekhar, Cheesman, Myles R., Marsollier, Laurent, Douglas, Philip, Smith, W. Ewen, Rosenkrands, Ida, Cole, Stewart T., Leys, David, Parish, Tanya, Munro, Andrew W.

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Cytochrome P450 1A1 opens up to new substrates von Munro, Andrew W.

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Crystal Structure of the Mycobacterium tuberculosis P450 CYP121-Fluconazole Complex Reveals New Azole Drug-P450 Binding Mode von Seward, Harriet E., Roujeinikova, Anna, McLean, Kirsty J., Munro, Andrew W., Leys, David

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Human P450-like oxidation of diverse proton pump inhibitor drugs by 'gatekeeper' mutants of flavocytochrome P450 BM3 von Butler, Christopher F, Peet, Caroline, McLean, Kirsty J, Baynham, Michael T, Blankley, Richard T, Fisher, Karl, Rigby, Stephen E J, Leys, David, Voice, Michael W, Munro, Andrew W

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Biochemical and Structural Insights into Bacterial Organelle Form and Biogenesis von Parsons, Joshua B., Dinesh, Sriramulu D., Deery, Evelyne, Leech, Helen K., Brindley, Amanda A., Heldt, Dana, Frank, Steffanie, Smales, C. Mark, Lünsdorf, Heinrich, Rambach, Alain, Gass, Mhairi H., Bleloch, Andrew, McClean, Kirsty J., Munro, Andrew W., Rigby, Stephen E.J., Warren, Martin J., Prentice, Michael B.

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Analysis of Heme Iron Coordination in DGCR8: The Heme-Binding Component of the Microprocessor Complex von Girvan, Hazel M, Bradley, Justin M, Cheesman, Myles R, Kincaid, James R, Liu, Yilin, Czarnecki, Kazimierz, Fisher, Karl, Leys, David, Rigby, Stephen E. J, Munro, Andrew W

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Heme Sensor Proteins von Girvan, Hazel M., Munro, Andrew W.

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