New clinical trials regulation in Spain: analysis of royal decree 1090/2015 von Martin Jimenez, M., Calvo Ferrandiz, A., Aparicio Urtasun, J., Garcia-Campelo, R., Gonzalez-Flores, E., Lazaro Quintela, M., Muñoz Mateu, M., Rodriguez Sanchez, C. A., Santaballa Bertran, A., Sepulveda Sanchez, J. M., Vera Garcia, R., Virizuela Echaburu, J. A., Segui Palmer, M. A.

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203P Randomized study of single-agent metronomic versus weekly oral vinorelbine (VNR) as first-line chemotherapy in patients with HR+/HER2- advanced breast cancer von Cazzaniga, M.E., Martinez Jañez, N., Kukielka-Budny, B.D., Ulanska, M., Bourgeois, H., Muñoz Mateu, M., Morales Murillo, S., Bayo, J., Cortesi, L., Pinter, T., Palacova, M., Cherciu, N., Petru, E., Ettl, J., De Almeida, C., Raymond, R., Villanova, G.R., Thanh Minh, C. Ta, Rodrigues, A.C.F., Freyer, G.

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116P Real-world and in silico incidence of fibroblast growth factor receptor (FGFR) 1-4 molecular alterations across multiple cancer types von Angelats, L., Indacochea, A., Ruiz, I. Victoria, Moreno, D., Bentz, P. Sole, Mellado, B., Pineda, E., Garcia, L. Gaba, Mateu, M. Muñoz, Vidal, M., Saurí, T., Esposito, F.M., Ferrer, L., Martínez-Sáez, O., Basté, N., Ortega, V., Jolis, L., Mezquita, L., Prat, A., Garcia-Corbacho, J.

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275O Impact of tucatinib on health-related quality of life (HRQoL) in patients with HER2+ metastatic breast cancer (MBC) with and without brain metastases (BM) von Mueller, V., Paplomata, E., Hamilton, E.P., Zelnak, A., Fehrenbacher, L., Jakobsen, E.H., Curtit, E., Boyle, F., Brix, E.H., Brenner, A.J., Ferrario, C., Munoz-Mateu, M., Arkenau, T., Gelmon, K.A., Cameron, D., Curigliano, G., DeBusk, K., Ramos, J., An, X., Wardley, A.M.

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548P Molecular pre-screening using comprehensive gene panels offered by clinical trials (CT) von Ruiz, I. Victoria, Moreno, D., Sole, P., Gonzalez, B. Mellado, Pineda, E., Gaba, L., Sauri, T., Mileo, L. Ferrer, Orrillo, M., Maurel, J., Oliveres, H., Munoz-Mateu, M., Losada, M.J. Vidal, Saez, O. Martinez, Chic, N., Baste, N., Segarra, N. Vinolas, Reyes, R., Prat, A., Garcia-Corbacho, J.

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HER2-positive breast cancer cells percentage and progression to trastuzumab treatment in metastatic patients von García-García, Y., Martínez-Fernández, A., Muñoz Mateu, M., Fernández-Ruiz, P., García-Albéniz, X., Mármol-Casas, M., Domingo-Doménech, J., Pineda-Losada, E., Visa-Turmo, L., Gascón Vilaplana, P.

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Preservation of quality of life in patients with human epidermal growth factor receptor 2–positive metastatic breast cancer treated with tucatinib or placebo when added to trastuzu... von Mueller, V, Wardley, A, Paplomata, E, Hamilton, E, Zelnak, A, Fehrenbacher, L, Jakobsen, E, Curtit, E, Boyle, F, Harder Brix, E, Brenner, A, Crouzet, L, Ferrario, C, Muñoz-Mateu, M, Arkenau, HT, Iqbal, N, Aithal, S, Block, M, Cold, S, Cancel, M, Hahn, O, Poosarla, T, Stringer-Reasor, E, Colleoni, M, Cameron, D, Curigliano, G, Siadak, M, DeBusk, K, Ramos, J, Feng, W, Gelmon, K

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Randomized, phase II trial comparing continuous versus intermittent capecitabine (X) monotherapy for metastatic breast cancer (MBC): Results from the GEICAM 2009−05 study von Martin, M., Martinez, N., Ramos, M., Calvo, L., Lluch, A., Zamora, P., Munoz-Mateu, M., Caronia, D., Carrasco, E. M., Garcia Saenz, J. Á., Casado, A., Chacón, I., Hernando, B., Ruiz-Borrego, M., Gonzalez-Neira, A.

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Trastuzumab plus capecitabine with or without pertuzumab in patients with HER2-positive MBC whose disease has progressed during or following trastuzumab-based therapy for first-lin... von Munoz-Mateu, M., Urruticoechea, A., Separovic, R., Erfán, J., Bachelot, T. D., Canon, J., Kovalenko, N., Staroslawska, E., Pikó, B., Veyret, C., Pribylova, O., Ciule, D. L., Ratnayake, J., Das, S., Mayne, K., Ross, G.

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Multicentric, observational, transversal study to describe the clinical profile of patients with metastatic breast cancer (MBC) treated with first-line bevacizumab (TRANSBREAST): P... von Guirado-Risueño, M., Perez Manga, G., Rifa, J., Perez Carrion, R. M., García López, M. J., Velasco, A., Oltra Ferrando, A., Barrajon, E., Lopez-Vivanco, G., Munoz-Mateu, M.

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A Cluster-Randomized Trial of Hydroxychloroquine for Prevention of Covid-19 von Mitjà, Oriol, Corbacho-Monné, Marc, Ubals, Maria, Alemany, Andrea, Suñer, Clara, Tebé, Cristian, Tobias, Aurelio, Peñafiel, Judith, Ballana, Ester, Pérez, Carla A, Admella, Pol, Riera-Martí, Núria, Laporte, Pep, Mitjà, Jordi, Clua, Mireia, Bertran, Laia, Sarquella, Maria, Gavilán, Sergi, Ara, Jordi, Argimon, Josep M, Cuatrecasas, Gabriel, Cañadas, Paz, Elizalde-Torrent, Aleix, Fabregat, Robert, Farré, Magí, Forcada, Anna, Flores-Mateo, Gemma, López, Cristina, Muntada, Esteve, Nadal, Núria, Narejos, Silvia, Nieto, Aroa, Prat, Nuria, Puig, Jordi, Quiñones, Carles, Ramírez-Viaplana, Ferran, Reyes-Urueña, Juliana, Riveira-Muñoz, Eva, Ruiz, Lidia, Sanz, Sergi, Sentís, Alexis, Sierra, Alba, Velasco, César, Vivanco-Hidalgo, Rosa M, Zamora, Juani, Casabona, Jordi, Vall-Mayans, Martí, González-Beiras, Camila, Clotet, Bonaventura

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Evidence of possible SARS‐CoV‐2 vertical transmission according to World Health Organization criteria in asymptomatic pregnant women von Sevilla‐Montoya, R., Hidalgo‐Bravo, A., Estrada‐Gutiérrez, G., Villavicencio‐Carrisoza, O., Leon‐Juarez, M., Villegas‐Mota, I., Espino‐y‐Sosa, S., Monroy‐Muñoz, I. E., Martinez‐Portilla, R. J., Poon, L. C., Cardona‐Pérez, J. A., Helguera‐Repetto, A. C., Gonzalez‐García, L. D., Mora‐Vargas, C. D., Mateu‐Rogell, P., Rodriguez‐Bosch, M., Coronado‐Zarco, I., Acevedo‐Gallegos, S., Aguinaga‐Ríos, M., Ramirez‐Santes, V. H., Ortiz‐Ramirez, M. A., Valdes‐Flores, M., Cortes‐Bonilla, M.

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Nirmatrelvir/ritonavir as a possible treatment for Long-COVID von Pérez Catalán, I, Gascón Buj, A, García Muñoz, S, Gómez Alfaro, I, Roig Martí, C, Torres García, M, Reig Valero, R, Ferrando Piqueres, R, Mateu Campos, L, Ramos Rincón, J M, Usó Blasco, J

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Nirmatrelvir/ritonavir as a potential treatment for prolonged SARS-CoV-2 infection in immunocompromised patients von Pérez Catalán, I, García Muñoz, S, Roig Martí, C, Gómez Alfaro, I, Serrano Picazo, L, Torres García, M, Reig Valero, R, Ferrando Piqueres, R, Mateu Campos, L, Ramos Rincón, J M, Usó Blasco, J

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Graphene-encapsulated magnetic nanoparticles for safe and steady delivery of ferulic acid in diabetic mice von Zhong, Baihua, Mateu-Roldán, Adán, Fanarraga, Mónica L., Han, Wei, Muñoz-Guerra, Débora, González, Jesús, Tao Weng, Lu, Ricardo Ibarra, M., Marquina, Clara, Lun Yeung, King

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Baseline mutations and ctDNA dynamics as prognostic and predictive factors in ER-positive/HER2-negative metastatic breast cancer patients von Pascual, Javier, Gil-Gil, Miguel, Proszek, Paula, Zielinski, Christoph, Reay, Alistair, Ruiz-Borrego, Manuel, Cutts, Rosalind, Ciruelos Gil, Eva M, Feber, Andrew, Muñoz-Mateu, Montserrat, Swift, Claire, Bermejo, Begoña, Herranz, Jesus, Margeli Vila, Mireia, Antón, Antonio, Kahan, Zsuzsanna, Csöszi, Tibor, Liu, Yuan, Fernandez Garcia, Daniel, Garcia-Murillas, Isaac, Hubank, Michael, Turner, Nicholas C, Martín, Miguel

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Activation of pro- and anti-inflammatory responses in lung tissue injury during the acute phase of PRRSV-1 infection with the virulent strain Lena von Sánchez-Carvajal, J.M., Rodríguez-Gómez, I.M., Ruedas-Torres, I., Larenas-Muñoz, F., Díaz, I., Revilla, C., Mateu, E., Domínguez, J., Martín-Valls, G., Barranco, I., Pallarés, F.J., Carrasco, L., Gómez-Laguna, J.

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Hyperimmune immunoglobulin for hospitalised patients with COVID-19 (ITAC): a double-blind, placebo-controlled, phase 3, randomised trial von Polizzotto, Mark N., Nordwall, Jacqueline, Babiker, Abdel G., Phillips, Andrew, Vock, David M., Eriobu, Nnakelu, Kwaghe, Vivian, Paredes, Roger, Mateu, Lourdes, Ramachandruni, Srikanth, Narang, Rajeev, Jain, Mamta K., Lazarte, Susana M., Baker, Jason V., Frosch, Anne E.P., Poulakou, Garyfallia, Syrigos, Konstantinos N., Arnoczy, Gretchen S., McBride, Natalie A., Robinson, Philip A., Sarafian, Farjad, Bhagani, Sanjay, Taha, Hassan S., Benfield, Thomas, Liu, Sean T.H., Antoniadou, Anastasia, Jensen, Jens Ulrik Stæhr, Kalomenidis, Ioannis, Susilo, Adityo, Hariadi, Prasetyo, Jensen MD, Tomas O., Morales-Rull, Jose Luis, Helleberg, Marie, Meegada, Sreenath, Johansen, Isik S., Canario, Daniel, Fernández-Cruz, Eduardo, Metallidis, Simeon, Shah, Amish, Sakurai, Aki, Koulouris, Nikolaos G., Trotman, Robin, Weintrob, Amy C., Podlekareva, Daria, Hadi, Usman, Lloyd, Kathryn M., Røge, Birgit Thorup, Saito, Sho, Sweerus, Kelly, Malin, Jakob J., Lübbert, Christoph, Muñoz, Jose, Cummings, Matthew J., Losso, Marcelo H., Turner, Dan, Shaw-Saliba, Kathryn, Dewar, Robin, Highbarger, Helene, Lallemand, Perrine, Rehman, Tauseef, Gerry, Norman, Arlinda, Dona, Chang, Christina C., Grund, Birgit, Holbrook, Michael R., Holley, Horace P., Hudson, Fleur, McNay, Laura A., Murray, Daniel D., Pett, Sarah L., Shaughnessy, Megan, Smolskis, Mary C., Touloumi, Giota, Wright, Mary E., Doyle, Mittie K., Popik, Sharon, Hall, Christine, Ramanathan, Roshan, Cao, Huyen, Mondou, Elsa, Willis, Todd, Thakuria, Joseph V., Yel, Leman, Higgs, Elizabeth, Kan, Virginia L., Lundgren, Jens D., Neaton, James D., Lane, H. Clifford

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Food groups associated with immune-mediated inflammatory diseases: a Mendelian randomization and disease severity study von Julià, Antonio, Martínez-Mateu, Sergio H., Domènech, Eugeni, Cañete, Juan D., Ferrándiz, Carlos, Tornero, Jesús, Gisbert, Javier P., Fernández-Nebro, Antonio, Daudén, Esteban, Barreiro-de Acosta, Manuel, Pérez, Carolina, Queiró, Rubén, López-Longo, Francisco Javier, Carazo, José Luís Sánchez, Mendoza, Juan Luís, Alpéri, Mercedes, Montilla, Carlos, Venegas, José Javier Pérez, Muñoz, Fernando, Castañeda, Santos, Aterido, Adrià, Lasanta, María López, Marsal, Sara

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Long‐term benefit of ustekinumab in ulcerative colitis in clinical practice: ULISES study von Chaparro, María, Hermida, Sandra, Acosta, Diana, Fernández‐Clotet, Agnès, Barreiro‐de Acosta, Manuel, Hernández Martínez, Álvaro, Arroyo, Maite, Bosca‐Watts, Marta Maia, Diz‐Lois Palomares, M. Teresa, Menchén, Luis, Martínez Cadilla, Jesús, Leo‐Carnerero, Eduardo, Muñoz Villafranca, Carmen, Sierra‐Ausín, Mónica, González‐Lama, Yago, Riestra, Sabino, Sendra Rumbeu, Pau, Cabello Tapia, M. José, García de la Filia, Irene, Vicente, Raquel, Ceballos, Daniel, Pajares Villarroya, Ramón, Ramírez de la Piscina, Patricia, Martín‐Arranz, María Dolores, Ramos, Laura, Ruiz‐Cerulla, Alexandra, Martínez‐Pérez, Teresa de Jesús, San Miguel Amelivia, Elena, Calvet, Xavier, Huguet, José María, Keco‐Huerga, Alma, Lorente Poyatos, Rufo H., Muñoz, José Fernando, Ponferrada‐Díaz, Ángel, Sicilia, Beatriz, Delgado‐Guillena, Pedro, Gómez Delgado, Elena, Rancel‐Medina, Francisco J., Alonso‐Galán, Horacio, Herreros, Belén, Rivero, Montserrat, Varela, Pilar, Bermejo, Fernando, García Sepulcre, Marifé, Gimeno‐Pitarch, Leticia, Kolle‐Casso, Lilyan, Márquez‐Mosquera, Lucía, Martínez Tirado, Pilar, Ramírez, Cynthia, Sesé Abizanda, Eva, Dueñas Sadornil, Carmen, Fernández Rosáenz, Hipólito, Gutiérrez Casbas, Ana, Madrigal Domínguez, Rosa Eva, Nantes Castillejo, Óscar, Ber Nieto, Yolanda, Botella Mateu, Belén, Frago Larramona, Santiago, López Serrano, Pilar, Rubio Mateos, José María, Torrá Alsina, Sandra, Iyo, Eduardo, Fernández Forcelledo, José Luis, Hernández, Luis, Rodríguez‐Grau, María Carmen, Monfort Miquel, David, Van Domselaar, Manuel, López Ramos, Carmen, Ruiz Barcia, M. Jesús, Gisbert, Javier P.

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