RIPK1- and RIPK3-induced cell death mode is determined by target availability von Cook, W D, Moujalled, D M, Ralph, T J, Lock, P, Young, S N, Murphy, J M, Vaux, D L

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Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1 von Teh, T-C, Nguyen, N-Y, Moujalled, D M, Segal, D, Pomilio, G, Rijal, S, Jabbour, A, Cummins, K, Lackovic, K, Blombery, P, Thompson, E, Ekert, P G, Lessene, G, Glaser, S P, Huang, D C S, Roberts, A W, Guthridge, M A, Wei, A H

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TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1 von Moujalled, D M, Cook, W D, Okamoto, T, Murphy, J, Lawlor, K E, Vince, J E, Vaux, D L

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Necroptosis induced by RIPK3 requires MLKL but not Drp1 von Moujalled, D M, Cook, W D, Murphy, J M, Vaux, D L

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In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-κB, but caspase-8 is required for TNF to cause ce... von Moujalled, D M, Cook, W D, Lluis, J M, Khan, N R, Ahmed, A U, Callus, B A, Vaux, D L

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Targeting p38 or MK2 enhances the anti-leukemic activity of smac-mimetics von Lalaoui, N, Hänggi, K, Brumatti, G, Chau, D, Nguyen, N Y N, Vasilikos, L, Spilgies, L M, Heckmann, D A, Ma, C, Ghisi, M, Salmon, J M, Matthews, G M, de Valle, E, Moujalled, D M, Menon, M B, Spall, S K, Glaser, S P, Richmond, J, Lock, R B, Condon, S M, Gugasyan, R, Gaestel, M, Guthridge, M, Johnstone, R W, Munoz, L, Wei, A, Ekert, P G, Vaux, D L, Wong, W Wei-Lynn, Silke, J

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In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-[kappa]B, but caspase-8 is required for TNF to ca... von Moujalled, D M, Cook, W D, Lluis, J M, Khan, N R, Ahmed, A U, Callus, B A, Vaux, D L

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In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8 von Gentle, I E, Wong, W W L, Evans, J M, Bankovacki, A, Cook, W D, Khan, N R, Nachbur, U, Rickard, J, Anderton, H, Moulin, M, Lluis, J M, Moujalled, D M, Silke, J, Vaux, D L

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Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43 von Moujalled, Diane, James, Janine L, Yang, Shu, Zhang, Katharine, Duncan, Clare, Moujalled, Donia M, Parker, Sarah J, Caragounis, Aphrodite, Lidgerwood, Grace, Turner, Bradley J, Atkin, Julie D, Grubman, Alexandra, Liddell, Jeffrey R, Proepper, Christian, Boeckers, Tobias M, Kanninen, Katja M, Blair, Ian, Crouch, Peter J, White, Anthony R

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TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway von Moujalled, Diane, Grubman, Alexandra, Acevedo, Karla, Yang, Shu, Ke, Yazi D, Moujalled, Donia M, Duncan, Clare, Caragounis, Aphrodite, Perera, Nirma D, Turner, Bradley J, Prudencio, Mercedes, Petrucelli, Leonard, Blair, Ian, Ittner, Lars M, Crouch, Peter J, Liddell, Jeffrey R, White, Anthony R

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Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming von Allam, Ramanjaneyulu, Lawlor, Kate E, Yu, Eric Chi-Wang, Mildenhall, Alison L, Moujalled, Donia M, Lewis, Rowena S, Ke, Francine, Mason, Kylie D, White, Michael J, Stacey, Katryn J, Strasser, Andreas, O'Reilly, Lorraine A, Alexander, Warren, Kile, Benjamin T, Vaux, David L, Vince, James E

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The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models von Kotschy, András, Szlavik, Zoltán, Murray, James, Davidson, James, Maragno, Ana Leticia, Le Toumelin-Braizat, Gaëtane, Chanrion, Maïa, Kelly, Gemma L., Gong, Jia-Nan, Moujalled, Donia M., Bruno, Alain, Csekei, Márton, Paczal, Attila, Szabo, Zoltán B., Sipos, Szabolcs, Radics, Gábor, Proszenyak, Agnes, Balint, Balázs, Ondi, Levente, Blasko, Gábor, Robertson, Alan, Surgenor, Allan, Dokurno, Pawel, Chen, Ijen, Matassova, Natalia, Smith, Julia, Pedder, Christopher, Graham, Christopher, Studeny, Aurélie, Lysiak-Auvity, Gaëlle, Girard, Anne-Marie, Gravé, Fabienne, Segal, David, Riffkin, Chris D., Pomilio, Giovanna, Galbraith, Laura C. A., Aubrey, Brandon J., Brennan, Margs S., Herold, Marco J., Chang, Catherine, Guasconi, Ghislaine, Cauquil, Nicolas, Melchiore, Fabien, Guigal-Stephan, Nolwen, Lockhart, Brian, Colland, Frédéric, Hickman, John A., Roberts, Andrew W., Huang, David C. S., Wei, Andrew H., Strasser, Andreas, Lessene, Guillaume, Geneste, Olivier

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Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias von Thijssen, Rachel, Diepstraten, Sarah T., Moujalled, Donia, Chew, Edward, Flensburg, Christoffer, Shi, Melissa X., Dengler, Michael A., Litalien, Veronique, MacRaild, Sarah, Chen, Maoshan, Anstee, Natasha S., Reljić, Boris, Gabriel, Sarah S., Djajawi, Tirta M., Riffkin, Chris D., Aubrey, Brandon J., Chang, Catherine, Tai, Lin, Xu, Zhen, Morley, Thomas, Pomilio, Giovanna, Bruedigam, Claudia, Kallies, Axel, Stroud, David A., Bajel, Ashish, Kluck, Ruth M., Lane, Steven W., Schoumacher, Marie, Banquet, Sébastien, Majewski, Ian J., Strasser, Andreas, Roberts, Andrew W., Huang, David C.S., Brown, Fiona C., Kelly, Gemma L., Wei, Andrew H.

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CREB-binding protein (CBP) regulates β-adrenoceptor (β-AR)−mediated apoptosis von Lee, Y Y, Moujalled, D, Doerflinger, M, Gangoda, L, Weston, R, Rahimi, A, de Alboran, I, Herold, M, Bouillet, P, Xu, Q, Gao, X, Du, X-J, Puthalakath, H

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In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8 von Gentle, Ian E., Wong, W. Wei-Lynn, Evans, Joseph M., Bankovacki, Alexandra, Cook, Wendy D., Khan, Nufail R., Nachbur, Ulrich, Rickard, James, Anderton, Holly, Moulin, Maryline, Lluis, Josep Maria, Moujalled, Donia M., Silke, John, Vaux, David L.

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Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling von Au, Amanda E., Lebois, Marion, Sim, Starling A., Cannon, Ping, Corbin, Jason, Gangatirkar, Pradnya, Hyland, Craig D., Moujalled, Diane, Rutgersson, Angelika, Yassinson, Fatme, Kile, Benjamin T., Mason, Kylie D., Ng, Ashley P., Alexander, Warren S., Josefsson, Emma C.

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Proinflammatory microenvironment promotes lymphoma progression in mice with high megakaryocyte and TPO levels von Au, Amanda E., Corbin, Jason, Lebois, Marion, Gangatirkar, Pradnya, Yassinson, Fatme, Hyslop, Stephanie R., Cannon, Ping, Mason, Kylie D., Li-Wai-Suen, Connie S. N., Garnham, Alexandra L., Moujalled, Diane, Cimmino, Luisa, Alexander, Warren S., Josefsson, Emma C.

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In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-κB and Activation of Caspase-8 von Gentle, Ian E., Wong, W. Wei-Lynn, Evans, Joseph M., Bankovacki, Alexandra, Cook, Wendy D., Khan, Nufail R., Nachbur, Ulrich, Rickard, James, Anderton, Holly, Moulin, Maryline, Lluis, Josep Maria, Moujalled, Donia M., Silke, John, Vaux, David L.

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Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models von Morrish, Emma, Copeland, Anthony, Moujalled, Donia M., Powell, Jason A., Silke, Natasha, Lin, Ann, Jarman, Kate E., Sandow, Jarrod J., Ebert, Gregor, Mackiewicz, Liana, Beach, Jessica A., Christie, Elizabeth L., Lewis, Alexander C., Pomilio, Giovanna, Fischer, Karla C., MacPherson, Laura, Bowtell, David D.L., Webb, Andrew I., Pellegrini, Marc, Dawson, Mark A., Pitson, Stuart M., Wei, Andrew H., Silke, John, Brumatti, Gabriela

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CREB-binding protein (CBP) regulates [beta]-adrenoceptor ([beta]-AR)-mediated apoptosis von Lee, Y Y, Moujalled, D, Doerflinger, M, Gangoda, L, Weston, R, Rahimi, A, De Alboran, I, Herold, M, Bouillet, P, Xu, Q, Gao, X, Du, X-j, Puthalakath, H

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