Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity von Zhernakova, Alexandra, Kurilshikov, Alexander, Bonder, Marc Jan, Tigchelaar, Ettje F., Schirmer, Melanie, Vatanen, Tommi, Mujagic, Zlatan, Vila, Arnau Vich, Falony, Gwen, Vieira-Silva, Sara, Wang, Jun, Imhann, Floris, Brandsma, Eelke, Jankipersadsing, Soesma A., Joossens, Marie, Cenit, Maria Carmen, Deelen, Patrick, Swertz, Morris A., study, LifeLines cohort, Weersma, Rinse K., Feskens, Edith J. M., Netea, Mihai G., Gevers, Dirk, Jonkers, Daisy, Franke, Lude, Aulchenko, Yurii S., Huttenhower, Curtis, Raes, Jeroen, Hofker, Marten H., Xavier, Ramnik J., Wijmenga, Cisca, Fu, Jingyuan

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The effect of host genetics on the gut microbiome von Bonder, Marc Jan, Kurilshikov, Alexander, Tigchelaar, Ettje F, Mujagic, Zlatan, Imhann, Floris, Vila, Arnau Vich, Deelen, Patrick, Vatanen, Tommi, Schirmer, Melanie, Smeekens, Sanne P, Zhernakova, Daria V, Jankipersadsing, Soesma A, Jaeger, Martin, Oosting, Marije, Cenit, Maria Carmen, Masclee, Ad A M, Swertz, Morris A, Li, Yang, Kumar, Vinod, Joosten, Leo, Harmsen, Hermie, Weersma, Rinse K, Franke, Lude, Hofker, Marten H, Xavier, Ramnik J, Jonkers, Daisy, Netea, Mihai G, Wijmenga, Cisca, Fu, Jingyuan, Zhernakova, Alexandra

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Cohort Profile: LifeLines, a three-generation cohort study and biobank von Scholtens, Salome, Smidt, Nynke, Swertz, Morris A, Bakker, Stephan J L, Dotinga, Aafje, Vonk, Judith M, van Dijk, Freerk, van Zon, Sander K R, Wijmenga, Cisca, Wolffenbuttel, Bruce H R, Stolk, Ronald P

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PeakML/mzMatch: A File Format, Java Library, R Library, and Tool-Chain for Mass Spectrometry Data Analysis von Scheltema, Richard A, Jankevics, Andris, Jansen, Ritsert C, Swertz, Morris A, Breitling, Rainer

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Host and Environmental Factors Influencing Individual Human Cytokine Responses von ter Horst, Rob, Jaeger, Martin, Smeekens, Sanne P., Oosting, Marije, Swertz, Morris A., Li, Yang, Kumar, Vinod, Diavatopoulos, Dimitri A., Jansen, Anne F.M., Lemmers, Heidi, Toenhake-Dijkstra, Helga, van Herwaarden, Antonius E., Janssen, Matthijs, van der Molen, Renate G., Joosten, Irma, Sweep, Fred C.G.J., Smit, Johannes W., Netea-Maier, Romana T., Koenders, Mieke M.J.F., Xavier, Ramnik J., van der Meer, Jos W.M., Dinarello, Charles A., Pavelka, Norman, Wijmenga, Cisca, Notebaart, Richard A., Joosten, Leo A.B., Netea, Mihai G.

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A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans von Li, Yang, Oosting, Marije, Smeekens, Sanne P., Jaeger, Martin, Aguirre-Gamboa, Raul, Le, Kieu T.T., Deelen, Patrick, Ricaño-Ponce, Isis, Schoffelen, Teske, Jansen, Anne F.M., Swertz, Morris A., Withoff, Sebo, van de Vosse, Esther, van Deuren, Marcel, van de Veerdonk, Frank, Zhernakova, Alexandra, van der Meer, Jos W.M., Xavier, Ramnik J., Franke, Lude, Joosten, Leo A.B., Wijmenga, Cisca, Kumar, Vinod, Netea, Mihai G.

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The LifeCycle Project-EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents von Jaddoe, Vincent W. V., Felix, Janine F., Andersen, Anne-Marie Nybo, Charles, Marie-Aline, Chatzi, Leda, Corpeleijn, Eva, Donner, Nina, Elhakeem, Ahmed, Eriksson, Johan G., Foong, Rachel, Grote, Veit, Haakma, Sido, Hanson, Mark, Harris, Jennifer R., Heude, Barbara, Huang, Rae-Chi, Inskip, Hazel, Järvelin, Marjo-Riitta, Koletzko, Berthold, Lawlor, Deborah A., Lindeboom, Maarten, McEachan, Rosemary R. C., Mikkola, Tuija M., Nader, Johanna L. T., de Moira, Angela Pinot, Pizzi, Costanza, Richiardi, Lorenzo, Sebert, Sylvain, Schwalber, Ameli, Sunyer, Jordi, Swertz, Morris A., Vafeiadi, Marina, Vrijheid, Martine, Wright, John, Duijts, Liesbeth

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Position paper on management of personal data in environment and health research in Europe von Eva, Govarts, Liese, Gilles, Stephanie, Bopp, Petr, Holub, Leslie, Matalonga, Roel, Vermeulen, Martine, Vrijheid, Sergi, Beltran, Mette, Hartlev, Sarah, Jones, Laura, Rodriguez Martin, Arnout, Standaert, Morris A., Swertz, Jan, Theunis, Xenia, Trier, Nina, Vogel, Koert, Van Espen, Sylvie, Remy, Greet, Schoeters

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Leveraging European infrastructures to access 1 million human genomes by 2022 von Saunders, Gary, Baudis, Michael, Becker, Regina, Beltran, Sergi, Béroud, Christophe, Birney, Ewan, Brooksbank, Cath, Brunak, Søren, Van den Bulcke, Marc, Drysdale, Rachel, Capella-Gutierrez, Salvador, Flicek, Paul, Florindi, Francesco, Goodhand, Peter, Gut, Ivo, Heringa, Jaap, Holub, Petr, Hooyberghs, Jef, Juty, Nick, Keane, Thomas M., Korbel, Jan O., Lappalainen, Ilkka, Leskosek, Brane, Matthijs, Gert, Mayrhofer, Michaela Th, Metspalu, Andres, Navarro, Arcadi, Newhouse, Steven, Nyrönen, Tommi, Page, Angela, Persson, Bengt, Palotie, Aarno, Parkinson, Helen, Rambla, Jordi, Salgado, David, Steinfelder, Erik, Swertz, Morris A., Valencia, Alfonso, Varma, Susheel, Blomberg, Niklas, Scollen, Serena

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Improving the diagnostic yield of exome- sequencing by predicting gene–phenotype associations using large-scale gene expression analysis von Deelen, Patrick, van Dam, Sipko, Herkert, Johanna C., Karjalainen, Juha M., Brugge, Harm, Abbott, Kristin M., van Diemen, Cleo C., van der Zwaag, Paul A., Gerkes, Erica H., Zonneveld-Huijssoon, Evelien, Boer-Bergsma, Jelkje J., Folkertsma, Pytrik, Gillett, Tessa, van der Velde, K. Joeri, Kanninga, Roan, van den Akker, Peter C., Jan, Sabrina Z., Hoorntje, Edgar T., te Rijdt, Wouter P., Vos, Yvonne J., Jongbloed, Jan D. H., van Ravenswaaij-Arts, Conny M. A., Sinke, Richard, Sikkema-Raddatz, Birgit, Kerstjens-Frederikse, Wilhelmina S., Swertz, Morris A., Franke, Lude

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Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits von Aguirre-Gamboa, Raul, Joosten, Irma, Urbano, Paulo C.M., van der Molen, Renate G., van Rijssen, Esther, van Cranenbroek, Bram, Oosting, Marije, Smeekens, Sanne, Jaeger, Martin, Zorro, Maria, Withoff, Sebo, van Herwaarden, Antonius E., Sweep, Fred C.G.J., Netea, Romana T., Swertz, Morris A., Franke, Lude, Xavier, Ramnik J., Joosten, Leo A.B., Netea, Mihai G., Wijmenga, Cisca, Kumar, Vinod, Li, Yang, Koenen, Hans J.P.M.

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Mutation update on the CHD7 gene involved in CHARGE syndrome von Janssen, Nicole, Bergman, Jorieke E. H., Swertz, Morris A., Tranebjaerg, Lisbeth, Lodahl, Marianne, Schoots, Jeroen, Hofstra, Robert M. W., van Ravenswaaij-Arts, Conny M. A., Hoefsloot, Lies H.

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Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: study design and baseline characteristics von Tigchelaar, Ettje F, Zhernakova, Alexandra, Dekens, Jackie A M, Hermes, Gerben, Baranska, Agnieszka, Mujagic, Zlatan, Swertz, Morris A, Muñoz, Angélica M, Deelen, Patrick, Cénit, Maria C, Franke, Lude, Scholtens, Salome, Stolk, Ronald P, Wijmenga, Cisca, Feskens, Edith J M

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Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration von Noordam, Raymond, Wang, Heming, Bentley, Amy R., de Vries, Paul S., Sung, Yun Ju, Schwander, Karen, Richard, Melissa, Aslibekyan, Stella, Feitosa, Mary, Horimoto, Andrea R., Ilkov, Marjan, Kho, Minjung, Kraja, Aldi, Li, Changwei, Liu, Yongmei, Mook-Kanamori, Dennis O., Tajuddin, Salman M., van der Spek, Ashley, Laville, Vincent, Alver, Maris, Evangelou, Evangelos, Graff, Maria E., He, Meian, Kühnel, Brigitte, Lyytikäinen, Leo-Pekka, Marques-Vidal, Pedro, Palmer, Nicholette D., Rauramaa, Rainer, Shu, Xiao-Ou, Wen, Wanqing, Adolfo, Correa, Ballantyne, Christie, Bielak, Larry, Dimou, Niki, Eiriksdottir, Gudny, Gao, Chuan, Gharib, Sina A., Gottlieb, Daniel J., Haba-Rubio, José, Harris, Tamara B., Heikkinen, Sami, Heinzer, Raphaël, Hixson, James E., Homuth, Georg, Krieger, Jose E., Lohman, Kurt K., Luik, Annemarie I., Martin, Lisa W., Nalls, Mike A., O’Connell, Jeff, Raitakari, Olli T., Reiner, Alex P., Rensen, Patrick C. N., Rich, Stephen S., Roenneberg, Till, Schreiner, Pamela J., Shikany, James, Sidney, Stephen S., Sitlani, Colleen M., Strauch, Konstantin, Swertz, Morris A., Uitterlinden, André G., van Duijn, Cornelia M., Völzke, Henry, Waldenberger, Melanie, Wallance, Robert B., van Dijk, Ko Willems, Yu, Caizheng, Zonderman, Alan B., Becker, Diane M., Elliott, Paul, Esko, Tõnu, Gieger, Christian, Grabe, Hans J., Lakka, Timo A., North, Kari E., Penninx, Brenda W. J. H., Vollenweider, Peter, Wagenknecht, Lynne E., Wu, Tangchun, Arnett, Donna K., Bouchard, Claude, Evans, Michele K., Gudnason, Vilmundur, Kelly, Tanika N., Loos, Ruth J. F., Pereira, Alexandre C., Province, Mike, Psaty, Bruce M., Rotimi, Charles, Zhu, Xiaofeng, Amin, Najaf, Cupples, L. Adrienne, Fornage, Myriam, Fox, Ervin F., Guo, Xiuqing, Gauderman, W. James, Liu, Ching-Ti, Rao, Dabeeru C., Redline, Susan

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A high-quality human reference panel reveals the complexity and distribution of genomic structural variants von Hehir-Kwa, Jayne Y., Marschall, Tobias, Kloosterman, Wigard P., Francioli, Laurent C., Baaijens, Jasmijn A., Dijkstra, Louis J., Abdellaoui, Abdel, Koval, Vyacheslav, Thung, Djie Tjwan, Wardenaar, René, Renkens, Ivo, Coe, Bradley P., Deelen, Patrick, de Ligt, Joep, Lameijer, Eric-Wubbo, van Dijk, Freerk, Hormozdiari, Fereydoun, Uitterlinden, André G., van Duijn, Cornelia M., Eichler, Evan E., de Bakker, Paul I. W., Swertz, Morris A., Wijmenga, Cisca, van Ommen, Gert-Jan B., Slagboom, P. Eline, Boomsma, Dorret I., Schönhuth, Alexander, Ye, Kai, Guryev, Victor

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Characteristics of de novo structural changes in the human genome von Kloosterman, Wigard P, Francioli, Laurent C, Hormozdiari, Fereydoun, Marschall, Tobias, Hehir-Kwa, Jayne Y, Abdellaoui, Abdel, Lameijer, Eric-Wubbo, Moed, Matthijs H, Koval, Vyacheslav, Renkens, Ivo, van Roosmalen, Markus J, Arp, Pascal, Karssen, Lennart C, Coe, Bradley P, Handsaker, Robert E, Suchiman, Eka D, Cuppen, Edwin, Thung, Djie Tjwan, McVey, Mitch, Wendl, Michael C, Uitterlinden, André, van Duijn, Cornelia M, Swertz, Morris A, Wijmenga, Cisca, van Ommen, GertJan B, Slagboom, P Eline, Boomsma, Dorret I, Schönhuth, Alexander, Eichler, Evan E, de Bakker, Paul I W, Ye, Kai, Guryev, Victor

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Population-specific genotype imputations using minimac or IMPUTE2 von van Leeuwen, Elisabeth M, Kanterakis, Alexandros, Deelen, Patrick, Kattenberg, Mathijs V, Slagboom, P Eline, de Bakker, Paul I W, Wijmenga, Cisca, Swertz, Morris A, Boomsma, Dorret I, van Duijn, Cornelia M, Karssen, Lennart C, Hottenga, Jouke Jan

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GAVIN: Gene-Aware Variant INterpretation for medical sequencing von van der Velde, K Joeri, de Boer, Eddy N, van Diemen, Cleo C, Sikkema-Raddatz, Birgit, Abbott, Kristin M, Knopperts, Alain, Franke, Lude, Sijmons, Rolf H, de Koning, Tom J, Wijmenga, Cisca, Sinke, Richard J, Swertz, Morris A

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Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data von Li, Shuang, Schmid, Katharina T, de Vries, Dylan H, Korshevniuk, Maryna, Losert, Corinna, Oelen, Roy, van Blokland, Irene V, Groot, Hilde E, Swertz, Morris A, van der Harst, Pim, Westra, Harm-Jan, van der Wijst, Monique G P, Heinig, Matthias, Franke, Lude

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Towards FAIRification of sensitive and fragmented rare disease patient data: challenges and solutions in European reference network registries von Dos Santos Vieira, Bruna, Bernabé, César H, Zhang, Shuxin, Abaza, Haitham, Benis, Nirupama, Cámara, Alberto, Cornet, Ronald, Le Cornec, Clémence M A, 't Hoen, Peter A C, Schaefer, Franz, van der Velde, K Joeri, Swertz, Morris A, Wilkinson, Mark D, Jacobsen, Annika, Roos, Marco

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