352: PPI ADMINISTRATION INDUCED COLONIC TIGHT JUNCTION BARRIER DYSFUNCTION IS ASSOCIATED WITH INCREASE IN PH, MLCK AND ENETROCOCCUS FECALIS von Morris, Nathan M., Saha, Kushal, Ganapathy, Ashwinkumar Subramenium, Nighot, Prashant K., Clarke, Kofi, Ma, Thomas Y., Nighot, Meghali T.

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664 INTESTINAL EPITHELIA-SPECIFIC DELETION OF ARYL HYDROCARBON RECEPTOR (AHR) REDUCES PARACELLULAR TIGHT JUNCTION PERMEABILITY AND HINDERS IMMUNOGENIC TOLERANCE von Venkatesh, Anirudh, Saha, Kushal, Ganapathy, Ashwinkumar Subramenium, Wang, Alexandra, Morris, Nathan M., Nighot, Meghali T., Ma, Thomas Y., Nighot, Prashant K.

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955 ALPHA-TOCOPHERYLQUINONE (TQ) REDUCES INTESTINAL INFLAMMATION BY INHIBITING NFkB AND STAT3 SIGNALING IN AN ARYL HYDROCARBON RECEPTOR (AHR) DEPENDENT MECHANISM von Saha, Kushal, Ganapathy, Ashwinkumar Subramenium, Wang, Alexandra, Morris, Nathan M., Harris, Leonard, Yochum, Gregory S., Koltun, Walter, Nighot, Meghali T., Ma, Thomas Y., Nighot, Prashant K.

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599: AUTOPHAGY ENHANCES INTESTINAL TIGHT JUNCTION BARRIER BY INCREASING THE LEVELS AND MEMBRANE LOCALIZATION OF OCCLUDIN, AND PROTECTS AGAINST INFLAMMATION INDUCED BARRIER LOSS, IN... von Saha, Kushal, Ganapathy, Ashwinkumar Subramenium, Wang, Alexandra, Morris, Nathan M., Nighot, Meghali T., Yochum, Gregory S., Koltun, Walter, Ma, Thomas Y., Nighot, Prashant K.

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Imaging Activity in Neurons and Glia with a Polr2a-Based and Cre-Dependent GCaMP5G-IRES-tdTomato Reporter Mouse von Gee, J. Michael, Smith, Nathan A., Fernandez, Fernando R., Economo, Michael N., Brunert, Daniela, Rothermel, Markus, Morris, S. Craig, Talbot, Amy, Palumbos, Sierra, Ichida, Jennifer M., Shepherd, Jason D., West, Peter J., Wachowiak, Matt, Capecchi, Mario R., Wilcox, Karen S., White, John A., Tvrdik, Petr

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Bottom‐up when it is not top‐down: Predators and plants control biomass of grassland arthropods von Welti, Ellen A. R., Prather, Rebecca M., Sanders, Nathan J., de Beurs, Kirsten M., Kaspari, Michael, Morris, Rebecca

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Mirikizumab as Induction and Maintenance Therapy for Ulcerative Colitis von D’Haens, Geert, Dubinsky, Marla, Kobayashi, Taku, Irving, Peter M., Howaldt, Stefanie, Pokrotnieks, Juris, Krueger, Kathryn, Laskowski, Janelle, Li, Xingyuan, Lissoos, Trevor, Milata, Joe, Morris, Nathan, Arora, Vipin, Milch, Catherine, Sandborn, William, Sands, Bruce E.

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Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition von Corey, Lawrence, Gilbert, Peter B, Juraska, Michal, Montefiori, David C, Morris, Lynn, Karuna, Shelly T, Edupuganti, Srilatha, Mgodi, Nyaradzo M, deCamp, Allan C, Rudnicki, Erika, Huang, Yunda, Gonzales, Pedro, Cabello, Robinson, Orrell, Catherine, Lama, Javier R, Laher, Fatima, Lazarus, Erica M, Sanchez, Jorge, Frank, Ian, Hinojosa, Juan, Sobieszczyk, Magdalena E, Marshall, Kyle E, Mukwekwerere, Pamela G, Makhema, Joseph, Baden, Lindsey R, Mullins, James I, Williamson, Carolyn, Hural, John, McElrath, M. Juliana, Bentley, Carter, Takuva, Simbarashe, Gomez Lorenzo, Margarita M, Burns, David N, Espy, Nicole, Randhawa, April K, Kochar, Nidhi, Piwowar-Manning, Estelle, Donnell, Deborah J, Sista, Nirupama, Andrew, Philip, Kublin, James G, Gray, Glenda, Ledgerwood, Julie E, Mascola, John R, Cohen, Myron S

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Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders von Võsa, Urmo, Stathopoulou, Maria G., de Vries, Paul S., Tanaka, Toshiko, Wu, Ying, Karlsson, Robert, Pool, René, Kemp, John P., Verweij, Niek, Smith, Albert V., Huq, Mahmudul, Deelen, Joris, Alizadeh, Behrooz Z., van der Harst, Pim, Navis, Gerjan, Snieder, Harold, Chasman, Daniel I., Meigs, James, Ligthart, Symen, Bis, Josh, Gross, Myron, Koenig, Wolfgang, Uher, Rudolf, Ward-Caviness, Cavin, Boerwinkle, Eric, Stacey, David, Eriksson, Johan, Lahti, Jari, Schraut, Katharina E., Suktitipat, Bhoom, Nutile, Teresa, Schork, Nicholas, Thiering, Elisabeth, Mahajan, Anubha, Aslibekyan, Stella, Yengo, Loïc, Rajan, Kumar B., Timpson, Nicholas, Huang, Hongyan, Uh, Hae-Won, Yanek, Lisa R., Verbanck, Marie, Magnusson, Patrik K.E., Ballantyne, Christie M., Montgomery, Grant W., Rueedi, Rico, Steri, Maristella, Stott, David J., Felix, Stephan B., Kraft, Peter, Seppälä, Ilkka, Williams, Stephen R., Moed, Matthijs, Langenberg, Claudia, Räikkönen, Katri, Sale, Michele M., Chen, Yii-Der I., James, Alan L., Soranzo, Nicole, Berenson, Gerald S., Liewald, David, Beilby, John, Ryan, Kathleen A., Balkau, Beverly, Paternoster, Lavinia, Kähönen, Mika, Sattar, Naveed, van Heemst, Diana, Gambaro, Giovanni, Ferrucci, Luigi, Karlsson, Magnus, Lind, Lars, Mori, Trevor A., Buckley, Brendan M., de Craen, Anton J.M., Scott, Rodney J., Strachan, David P., Jarvelin, Marjo-Riitta, Jukema, J. Wouter, Hamsten, Anders, Gudnason, Vilmundur, Qi, Lu, März, Winfried, Penninx, Brenda W.J.H., Worrall, Bradford B., Gibson, Greg, Oldehinkel, Albertine J., Murray, Sarah S., Pramstaller, Peter P., Deary, Ian J., Desch, Karl C., Hayward, Caroline, Arnett, Donna K., Jess, Tine, Psaty, Bruce M., Tracy, Russell P., Nolte, Ilja M., Visvikis-Siest, Sophie, Franke, Lude, Franco, Oscar H.

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Xpert MTB/RIF Ultra for the diagnosis of HIV-associated tuberculous meningitis: a prospective validation study von Cresswell, Fiona V, Tugume, Lillian, Bahr, Nathan C, Kwizera, Richard, Bangdiwala, Ananta S, Musubire, Abdu K, Rutakingirwa, Morris, Kagimu, Enock, Nuwagira, Edwin, Mpoza, Edward, Rhein, Joshua, Williams, Darlisha A, Muzoora, Conrad, Grint, Daniel, Elliott, Alison M, Meya, David B, Boulware, David R

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Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions von Thyme, Summer B., Pieper, Lindsey M., Li, Eric H., Pandey, Shristi, Wang, Yiqun, Morris, Nathan S., Sha, Carrie, Choi, Joo Won, Herrera, Kristian J., Soucy, Edward R., Zimmerman, Steve, Randlett, Owen, Greenwood, Joel, McCarroll, Steven A., Schier, Alexander F.

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Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer von Wei, Shuo, Kozono, Shingo, Kats, Lev, Nechama, Morris, Li, Wenzong, Guarnerio, Jlenia, Luo, Manli, You, Mi-Hyeon, Yao, Yandan, Kondo, Asami, Hu, Hai, Bozkurt, Gunes, Moerke, Nathan J, Cao, Shugeng, Reschke, Markus, Chen, Chun-Hau, Rego, Eduardo M, Lo-Coco, Francesco, Cantley, Lewis C, Lee, Tae Ho, Wu, Hao, Zhang, Yan, Pandolfi, Pier Paolo, Zhou, Xiao Zhen, Lu, Kun Ping

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Clinical criteria for COVID-19-associated hyperinflammatory syndrome: a cohort study von Webb, Brandon J, Peltan, Ithan D, Jensen, Paul, Hoda, Daanish, Hunter, Bradley, Silver, Aaron, Starr, Nathan, Buckel, Whitney, Grisel, Nancy, Hummel, Erika, Snow, Gregory, Morris, Dave, Stenehjem, Eddie, Srivastava, Rajendu, Brown, Samuel M

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Late Pleistocene Human Skull from Hofmeyr, South Africa, and Modern Human Origins von Grine, F.E, Bailey, R.M, Harvati, K, Nathan, R.P, Morris, A.G, Henderson, G.M, Ribot, I, Pike, A.W.G

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The novel and transferable erm(51) gene confers macrolides, lincosamides and streptogramins B (MLSB) resistance to clonal Rhodococcus equi in the environment von Huber, Laura, Giguère, Steeve, Slovis, Nathan M., Álvarez‐Narváez, Sonsiray, Hart, Kelsey A., Greiter, Maggie, Morris, Ellen Ruth A., Cohen, Noah D.

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Global epidemiology of drug resistance after failure of WHO recommended first-line regimens for adult HIV-1 infection: a multicentre retrospective cohort study von Gregson, John, Tang, Michele, Ndembi, Nicaise, Hamers, Raph L, Rhee, Soo-Yon, Marconi, Vincent C, Diero, Lameck, Brooks, Katherine A, Theys, Kristof, Rinke de Wit, Tobias, Arruda, Monica, Garcia, Frederico, Monge, Susana, Günthard, Huldrych F, Hoffmann, Christopher J, Kanki, Phyllis J, Kumarasamy, Nagalingeshwaran, Kerschberger, Bernard, Mor, Orna, Charpentier, Charlotte, Todesco, Eva, Rokx, Casper, Gras, Luuk, Helvas, Elias K, Sunpath, Henry, Di Carlo, Domenico, Antinori, Antonio, Andreoni, Massimo, Latini, Alessandra, Mussini, Cristina, Aghokeng, Avelin, Sonnerborg, Anders, Neogi, Ujjwal, Fessel, William J, Agolory, Simon, Yang, Chunfu, Blanco, Jose L, Juma, James M, Smit, Erasmus, Schmidt, Daniel, Watera, Christine, Asio, Juliet, Kurungi, Wilford, Tostevin, Anna, El-Hay, Tal, Clumeck, Nathan, Goedhals, Dominique, Van Vuuren, Cloete, Bester, Philip A, Sabin, Caroline, Mukui, Irene, Santoro, MARIA M, Perno, Carlo F, Hunt, Gillian, Morris, Lynn, Camacho, Ricardo, De Oliveira, Tulio, Pillay, Deenan, Schulter, Eugene, Murakami-Ogasawara, Akio, Reyes-Terán, Gustavo, Romero, Karla, Avila-Rios, Santiago, Sirivichayakul, Sunee, Ruxrungtham, Kiat, Mekprasan, Suwanna, Dunn, David, Kaleebu, Pontiano, Raizes, Elliot, Kantor, Rami, Shafer, Robert W, Gupta, Ravindra K

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Medical instrument for accessing a breast duct for performing a medical procedure and its method von SAKAL ROBERT,BRENNAN MEGAN,FURNISH GREG R.,WHATLEY CHARLES H.,MORRIS BEN E.,WOOD NATHAN,MC CARTHY DOUGLAS,HALL TODD A.,FURNISH SIMON,SHEETS ELLEN,GUNASKERA INDI,SMITH ARTHUR L

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Leukocyte Esterase Reagent Strips for the Rapid Diagnosis of Periprosthetic Joint Infection von Wetters, Nathan G., BS, Berend, Keith R., MD, Lombardi, Adolph V., MD, Morris, Michael J., MD, Tucker, Tawnya L., MT, Della Valle, Craig J., MD

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Multiplex Surveillance Kit Using Sweetened Solid Support to Detect Arboviruses Isothermally in Mosquito Saliva from the Field von Yaren, Ozlem, McCarter, Jacquelyn, Morris, Andrew R., Bradley, Kevin M., Karalkar, Nilesh B., McLendon, Daniel C., Kim, Dongmin, Eastmond, Bradley H., Burkett-Cadena, Nathan D., Alto, Barry W., Benner, Steven A.

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Accuracy and Precision of the Computed Tomographic Angiography Perforator Localization Technique for Virtual Surgical Planning of Composite Osteocutaneous Fibular Free Flaps in Hea... von Ettinger, Kyle S., Morris, Jonathan M., Alexander, Amy E., Nathan, John M., Arce, Kevin

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