A Common Functional Regulatory Variant at a Type 2 Diabetes Locus Upregulates ARAP1 Expression in the Pancreatic Beta Cell von Kulzer, Jennifer R., Stitzel, Michael L., Morken, Mario A., Huyghe, Jeroen R., Fuchsberger, Christian, Kuusisto, Johanna, Laakso, Markku, Boehnke, Michael, Collins, Francis S., Mohlke, Karen L.

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Heritable Individual-Specific and Allele-Specific Chromatin Signatures in Humans von McDaniell, Ryan, Lee, Bum-Kyu, Song, Lingyun, Liu, Zheng, Boyle, Alan P., Erdos, Michael R., Scott, Laura J., Morken, Mario A., Kucera, Katerina S., Battenhouse, Anna, Keefe, Damian, Collins, Francis S., Willard, Huntington F., Lieb, Jason D., Furey, Terrence S., Crawford, Gregory E., lyer, Vishwanath R., Birney, Ewan

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Hyperglycemia and a Common Variant of GCKR Are Associated With the Levels of Eight Amino Acids in 9,369 Finnish Men von STANCAKOVA, Alena, CIVELEK, Mete, BOEHNKE, Michael, PAJUKANTA, Paivi, LUSIS, Aldons J, COLLINS, Francis S, KUUSISTO, Johanna, ALA-KORPELA, Mika, LAAKSO, Markku, SALEEM, Niyas K, SOININEN, Pasi, KANGAS, Antti J, CEDERBERG, Henna, PAANANEN, Jussi, PIHLAJAMÄKI, Jussi, BONNYCASTLE, Lori L, MORKEN, Mario A

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A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus von Roman, Tamara S, Cannon, Maren E, Vadlamudi, Swarooparani, Buchkovich, Martin L, Wolford, Brooke N, Welch, Ryan P, Morken, Mario A, Kwon, Grace J, Varshney, Arushi, Kursawe, Romy, Wu, Ying, Jackson, Anne U, Erdos, Michael R, Kuusisto, Johanna, Laakso, Markku, Scott, Laura J, Boehnke, Michael, Collins, Francis S, Parker, Stephen C J, Stitzel, Michael L, Mohlke, Karen L

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Association of Ketone Body Levels With Hyperglycemia and Type 2 Diabetes in 9,398 Finnish Men von MAHENDRAN, Yuvaraj, VANGIPURAPU, Jagadish, PAJUKANTA, Päivi, LUSIS, Aldons J, BONNYCASTLE, Lori L, MORKEN, Mario A, COLLINS, Francis S, MOHLKE, Karen L, BOEHNKE, Michael, ALA-KORPELA, Mika, KUUSISTO, Johanna, LAAKSO, Markku, CEDERBERG, Henna, STANCAKOVA, Alena, PIHLAJAMÄKI, Jussi, SOININEN, Pasi, KANGAS, Antti J, PAANANEN, Jussi, CIVELEK, Mete, SALEEM, Niyas K

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Newly identified loci that influence lipid concentrations and risk of coronary artery disease von Narisu, Narisu, Lakatta, Edward, Mohlke, Karen L, Willer, Cristen J, Shuldiner, Alan R, Najjar, Samer S, Davey-Smith, George, Scuteri, Angelo, Zelenika, Diana, Li, Yun, Galan, Pilar, Shen, Haiqing, Schlessinger, David, Lawlor, Debbie A, Collins, Francis S, Strait, James, Meneton, Pierre, Duren, William L, Clarke, Robert, Watanabe, Richard M, Ebrahim, Shah, Mulas, Antonella, Uda, Manuela, Swift, Amy J, Albai, Giuseppe, Bergman, Richard N, Maschio, Andrea, Collins, Rory, Tuomilehto, Jaakko, Scott, Laura J, Bonnycastle, Lori L, Hercberg, Serge, Busonero, Fabio, Boehnke, Michael, Nagaraja, Ramaiah, Jackson, Anne U, Ben-Shlomo, Yoav, Morken, Mario A, Heath, Simon C, Stringham, Heather M, Abecasis, Gonçalo R, Cao, Antonio, Scheet, Paul A, Lathrop, G Mark, Parish, Sarah, Bennett, Derrick, Chen, Wei-Min, Sundvall, Jouko, Timpson, Nicholas J, Sanna, Serena

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Effects of 34 Risk Loci for Type 2 Diabetes or Hyperglycemia on Lipoprotein Subclasses and Their Composition in 6,580 Nondiabetic Finnish Men von STANCAKOVA, Alena, PAANANEN, Jussi, ALA-KORPELA, Mika, LAAKSO, Markku, SOININEN, Pasi, KANGAS, Antti J, BONNYCASTLE, Lori L, MORKEN, Mario A, COLLINS, Francis S, JACKSON, Anne U, BOEHNKE, Michael L, KUUSISTO, Johanna

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Correlation of rare coding variants in the gene encoding human glucokinase regulatory protein with phenotypic, cellular, and kinetic outcomes von Rees, Matthew G, Ng, David, Ruppert, Sarah, Turner, Clesson, Beer, Nicola L, Swift, Amy J, Morken, Mario A, Below, Jennifer E, Blech, Ilana, Mullikin, James C, McCarthy, Mark I, Biesecker, Leslie G, Gloyn, Anna L, Collins, Francis S

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Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways von SORANZO, Nicole, SANNA, Serena, SANDHU, Manjinder S, HEENEY, Matthew M, DEVANEY, Joseph M, REILLY, Muredach P, RICKETTS, Sally L, WHEELER, Eleanor, GIEGER, Christian, RAKE, Dörte, DUPUIS, Josée, BOUATIA-NAJI, Nabila, LANGENBERG, Claudia, PROKOPENKO, Inga, STOLERMAN, Elliot

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Common variants at 30 loci contribute to polygenic dyslipidemia von Kooner, Jaspal S, Mohlke, Karen L, Groop, Leif, Schadt, Eric E, O'Donnell, Christopher J, Zelenika, Diana, Sanna, Serena, Bonnycastle, Lori L, Yang, Qiong, Hercberg, Serge, Schlessinger, David, Chambers, John C, Laakso, Markku, Li, Yun, Ordovas, Jose M, Ferrucci, Luigi, Orho-Melander, Marju, Surti, Aarti, de Bakker, Paul I W, Clarke, Robert, Kathiresan, Sekar, Tanaka, Toshiko, Stringham, Heather M, Salomaa, Veikko, Willer, Cristen J, Scott, Laura J, Tuomilehto, Jaakko, Swift, Amy J, Lathrop, G Mark, Melander, Olle, Collins, Rory, Dupuis, Josée, Collins, Francis S, Lunetta, Kathryn L, Jackson, Anne U, Galan, Pilar, Peltonen, Leena, Peloso, Gina M, Musunuru, Kiran, Kuusisto, Johanna, Sundvall, Jouko, Crawford, Gabriel, Guiducci, Candace, Meneton, Pierre, Lakatta, Edward G, Altshuler, David, Scheet, Paul, Burtt, Noel P, Kaplan, Lee, Abecasis, Gonçalo R, Parish, Sarah, Uda, Manuela, Kubalanza, Kari A, Scuteri, Angelo, Boehnke, Michael, Voight, Benjamin F, Cupples, L Adrienne, Demissie, Serkalem, Bennett, Derrick, Bergman, Richard N, Morken, Mario A

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FGFR testing and urine-based risk straticfication from matched tissue and urine samples within the prospective real-world clinicopathological register trial: BRIDGister von Wirtz, Ralph M., Watts, Richard, Kellner, Ronny, Ortmann, Reinhard, Horns, Torsten, Enderle, Daniel, Meyer, Lisa, Noerholm, Mikkel, Morken, Mario, Veltrup, Elke, Hake, Roland, Eidt, Sebastian, Roggisch, Jenny, Koch, Stefan, Ecke, Thorsten

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Common variants at 10 genomic loci influence hemoglobin [A.sub.1C] levels via glycemic and nonglycemic pathways von Soranzo, Nicole, Sanna, Serena, Wheeler, Eleanor, Gieger, Christian, Radke, Dorte, Dupuis, Josee, Bouatia-Naji, Nabila, Langenberg, Claudia, Prokopenko, Inga, Stolerman, Elliot, Sandhu, Manjinder S, Heeney, Matthew M, Devaney, Joseph M, Reilly, Muredach P, Ricketts, Sally L

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Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge von Saxena, Richa, Langenberg, Claudia, Tanaka, Toshiko, Vollenweider, Peter, Lyssenko, Valeriya, Bouatia-Naji, Nabila, Jackson, Anne U, Kao, W H Linda, Glazer, Nicole L, Manning, Alisa K, Luan, Jian'an, Stringham, Heather M, Prokopenko, Inga, Johnson, Toby, Grarup, Niels, Boesgaard, Trine W, Lecoeur, Cécile, Shrader, Peter, O'Connell, Jeffrey, Ingelsson, Erik, Couper, David J, Rice, Kenneth, Song, Kijoung, Andreasen, Camilla H, Köttgen, Anna, Le Bacquer, Olivier, Pattou, François, Taneera, Jalal, Steinthorsdottir, Valgerdur, Rybin, Denis, Ardlie, Kristin, Sampson, Michael, Qi, Lu, van Hoek, Mandy, Weedon, Michael N, Voight, Benjamin F, Grallert, Harald, Balkau, Beverley, Bergman, Richard N, Bielinski, Suzette J, Bonnefond, Amelie, Bonnycastle, Lori L, Borch-Johnsen, Knut, Böttcher, Yvonne, Brunner, Eric, Buchanan, Thomas A, Bumpstead, Suzannah J, Cavalcanti-Proença, Christine, Collins, Francis S, Cornelis, Marilyn, J Crawford, Gabriel, Delplanque, Jerome, Doney, Alex, Egan, Josephine M, Erdos, Michael R, Firmann, Mathieu, Forouhi, Nita G, Fox, Caroline S, Goodarzi, Mark O, Graessler, Jürgen, Hingorani, Aroon, Isomaa, Bo, Jørgensen, Torben, Kivimaki, Mika, Kovacs, Peter, Krohn, Knut, Kumari, Meena, Lauritzen, Torsten, Lévy-Marchal, Claire, Mayor, Vladimir, McAteer, Jarred B, Meyre, David, Mitchell, Braxton D, Mohlke, Karen L, Morken, Mario A, Narisu, Narisu, Palmer, Colin N A, Pakyz, Ruth, Pascoe, Laura, Payne, Felicity, Pearson, Daniel, Rathmann, Wolfgang, Sandbaek, Annelli, Sayer, Avan Aihie, Scott, Laura J, Sharp, Stephen J, Sijbrands, Eric, Singleton, Andrew, Siscovick, David S, Smith, Nicholas L, Sparsø, Thomas, Syddall, Holly, Thorleifsson, Gudmar, Tönjes, Anke, Tuomi, Tiinamaija, Tuomilehto, Jaakko, Valle, Timo T, Waeber, Gérard, Zeggini, Eleftheria, Zhao, Jing Hua

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Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma von Gartner, Jared J., Parker, Stephen C. J., Prickett, Todd D., Dutton-Regester, Ken, Stitzel, Michael L., Lin, Jimmy C., Davis, Sean, Simhadri, Vijaya L., Jha, Sujata, Katagiri, Nobuko, Gotea, Valer, Teer, Jamie K., Wei, Xiaomu, Morken, Mario A., Bhanot, Umesh K., Chen, Guo, Elnitski, Laura L., Davies, Michael A., Gershenwald, Jeffrey E., Carter, Hannah, Karchin, Rachel, Robinson, William, Robinson, Steven, Rosenberg, Steven A., Collins, Francis S., Parmigiani, Giovanni, Komar, Anton A., Kimchi-Sarfaty, Chava, Hayward, Nicholas K., Margulies, Elliott H., Samuels, Yardena

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FGFR testing from matched tissue and urine samples within the prospective real world clinico-pathological register trial BRIDGister von Wirtz, Ralph M., Watts, Richard, Kellner, Ronny, Ortmann, Reinhard, Horns, Torsten, Enderle, Daniel, Meyer, Lisa, Noerholm, Mikkel, Morken, Mario, Veltrup, Elke, Hake, Roland, Eidt, Sebastian, Roggisch, Jenny, Koch, Stefan, Ecke, Thorsten

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Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution von Lindgren, Cecilia M, Heid, Iris M, Randall, Joshua C, Lamina, Claudia, Steinthorsdottir, Valgerdur, Qi, Lu, Speliotes, Elizabeth K, Thorleifsson, Gudmar, Willer, Cristen J, Herrera, Blanca M, Jackson, Anne U, Lim, Noha, Scheet, Paul, Soranzo, Nicole, Amin, Najaf, Aulchenko, Yurii S, Chambers, John C, Drong, Alexander, Luan, Jian'an, Lyon, Helen N, Rivadeneira, Fernando, Sanna, Serena, Timpson, Nicholas J, Zillikens, M Carola, Zhao, Jing Hua, Almgren, Peter, Bandinelli, Stefania, Bennett, Amanda J, Bergman, Richard N, Bonnycastle, Lori L, Bumpstead, Suzannah J, Chanock, Stephen J, Cherkas, Lynn, Chines, Peter, Coin, Lachlan, Cooper, Cyrus, Crawford, Gabriel, Doering, Angela, Dominiczak, Anna, Doney, Alex S F, Ebrahim, Shah, Elliott, Paul, Erdos, Michael R, Estrada, Karol, Ferrucci, Luigi, Fischer, Guido, Forouhi, Nita G, Gieger, Christian, Grallert, Harald, Groves, Christopher J, Grundy, Scott, Guiducci, Candace, Hadley, David, Hamsten, Anders, Havulinna, Aki S, Hofman, Albert, Holle, Rolf, Holloway, John W, Illig, Thomas, Isomaa, Bo, Jacobs, Leonie C, Jameson, Karen, Jousilahti, Pekka, Karpe, Fredrik, Kuusisto, Johanna, Laitinen, Jaana, Lathrop, G Mark, Lawlor, Debbie A, Mangino, Massimo, McArdle, Wendy L, Meitinger, Thomas, Morken, Mario A, Morris, Andrew P, Munroe, Patricia, Narisu, Narisu, Nordström, Anna, Nordström, Peter, Oostra, Ben A, Palmer, Colin N A, Payne, Felicity, Peden, John F, Prokopenko, Inga, Renström, Frida, Ruokonen, Aimo, Salomaa, Veikko, Sandhu, Manjinder S, Scott, Laura J, Scuteri, Angelo, Silander, Kaisa, Song, Kijoung, Yuan, Xin, Stringham, Heather M, Swift, Amy J, Tuomi, Tiinamaija, Uda, Manuela, Vollenweider, Peter, Waeber, Gerard, Wallace, Chris, Walters, G Bragi, Weedon, Michael N

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Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes von Perry, John R.B., Weedon, Michael N., Langenberg, Claudia, Jackson, Anne U., Lyssenko, Valeriya, Sparsø, Thomas, Thorleifsson, Gudmar, Grallert, Harald, Ferrucci, Luigi, Maggio, Marcello, Paolisso, Giuseppe, Walker, Mark, Palmer, Colin N.A., Payne, Felicity, Young, Elizabeth, Herder, Christian, Narisu, Narisu, Morken, Mario A., Bonnycastle, Lori L., Owen, Katharine R., Shields, Beverley, Knight, Beatrice, Bennett, Amanda, Groves, Christopher J., Ruokonen, Aimo, Jarvelin, Marjo Riitta, Pearson, Ewan, Pascoe, Laura, Ferrannini, Ele, Bornstein, Stefan R., Stringham, Heather M., Scott, Laura J., Kuusisto, Johanna, Nilsson, Peter, Neptin, Malin, Gjesing, Anette P., Pisinger, Charlotta, Lauritzen, Torsten, Sandbaek, Annelli, Sampson, Mike, Zeggini, MAGIC, Ele, Lindgren, Cecilia M., Steinthorsdottir, Valgerdur, Thorsteinsdottir, Unnur, Hansen, Torben, Schwarz, Peter, Illig, Thomas, Laakso, Markku, Stefansson, Kari, Morris, Andrew D., Groop, Leif, Pedersen, Oluf, Boehnke, Michael, Barroso, Inês, Wareham, Nicholas J., Hattersley, Andrew T., McCarthy, Mark I., Frayling, Timothy M.

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Abstract LB-226: Exosomal liquid biopsy reveals mRNA and lincRNA biomarkers in early stage breast cancer patient plasma von Chakrabortty, Sudipto K., Kitchen, Robert R., Coticchia, Christine M., Tadigotla, Vasisht R., Eitan, Erez, Castellanos-Rizaldos, Elena, Bedford, Lisa, Badola, Sunita, Valentino, Michael D., Colafemina, Nicholas, Uchiyama, Hidefumi, Morken, Mario, Williams, Miguel, Vincent, Sylvie, Danaee, Hadi, Yu, Seth, Skog, Johan

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Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity von DIMAS, Antigone S, LAGOU, Vasiliki, CI SONG, FISCHER-ROSINSKY, Antje, BOESGAARD, Trine Welløv, GRARUP, Niels, ABBASI, Fahim A, ASSIMES, Themistocles L, KE HAO, XIA YANG, LECOEUR, Cécile, BARROSO, Inês, BARKER, Adam, BONNYCASTLE, Lori L, BÖTTCHER, Yvonne, BUMPSTEAD, Suzannah, CHINES, Peter S, ERDOS, Michael R, GRAESSLER, Jurgen, KOVACS, Peter, MORKEN, Mario A, NARISU, Narisu, PAYNE, Felicity, KNOWLES, Joshua W, STANCAKOVA, Alena, SWIFT, Amy J, TÖNJES, Anke, BORNSTEIN, Stefan R, CAUCHI, Stéphane, FROGUEL, Philippe, MEYRE, David, SCHWARZ, Peter E. H, HÄRING, Hans-Ulrich, SMITH, Ulf, MÄGI, Reedik, BOEHNKE, Michael, BERGMAN, Richard N, COLLINS, Francis S, MOHLKE, Karen L, TUOMILEHTO, Jaakko, QUERTEMOUS, Thomas, LIND, Lars, HANSEN, Torben, PEDERSEN, Oluf, WALKER, Mark, HIVERT, Marie-France, PFEIFFER, Andreas F. H, SPRANGER, Joachim, STUMVOLL, Michael, MEIGS, James B, WAREHAM, Nicholas J, KUUSISTO, Johanna, LAAKSO, Markku, LANGENBERG, Claudia, DUPUIS, Josée, BENAZZO, Andrea, RYBIN, Denis, JACKSON, Anne U, STRINGHAM, Heather M

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Clinical Meaningfulness in Alzheimer’s Disease Clinical Trials. A Report from the EU-US CTAD Task Force von Angioni, D., Cummings, J., Lansdall, C. J., Sampaio, C., Gauthier, S., Cohen, S., Petersen, R. C., Rentz, D. M., Wessels, A. M., Hendrix, S. B., Jessen, F., Carrillo, M. C., Doody, R. S., Irizarry, M., Andrews, J. S., Vellas, B., Aisen, P., Andrieu, Sandrine, Bateman, Randall, Batrla, Richard, Bell, Joanne, Bosson, Oskar, Brooks, Dawn, Haeberlein, Samantha Budd, Cho, Min, Crisitello, Darrin, Dangond, Fernando, de Santi, Susan, Dennehy, Ellen, Dhadda, Shobha, Dhillon, Harjeet, Dunn, Billy, Egan, Michael, Elwood, Fiona, Eriksson, Sven, Fillit, Howard, Gallagher, Diana, Granda, Carlos, Greeley, David, Gronblad, Anna-Kaija, Hampel, Harald, Hawthorne, Paul, Henley, David, Herring, Joe, Hersch, Steve, Holt, Bill, Jones, Daryl, Kahl, Anja, Kinney, Gene, Kolb, Hartmuth, Kramer, Lynn, Kulic, Luka, Kumar, Sanjay, Lannfelt, Lars, Lawson, John, Legrand, Valérie, Lenington, Rachel, Longo, Frank, Matthews, Brandy, Masterman, Donna, McLinden, Kristina, Mikels, Sarah, Miller, Michael, Monteiro, Cecilia, Murphy, Jennifer, Odergren, Tomas, Osswald, Gunilla, Parnas, Laura, Patru, Maria-Magdalena, Prazma, Charlene, Raman, Rema, Reyderman, Larisa, Rogers, Sharon, Roman, Lise, Romano, Gary, Roskey, Mark, Rubino, Ivana, Ryan, Laurie, Salloway, Stephen, Schindler, Rachel, Schneider, Lon, Scott, David, Sims, John, Soto, Marion, Steukers, Lennert, Stoops, Erik, Strittmatter, Stephen, Tahami, Amir, Tariot, Gilles, Toloue, Masoud, Touchon, Jacques, Vanmechelen, Eugeen, Walt, Len, Weiner, Michael, White, Anne, Wiesel, Iris, Wilson, David, Yarenis, Lisa, Zago, Wagner, Zhou, Jin

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