Antitumor activity of an allosteric inhibitor of centromere-associated protein-E von Wood, Kenneth W, Lad, Latesh, Luo, Lusong, Qian, Xiangping, Knight, Steven D, Nevins, Neysa, Brejc, Katjusa, Sutton, David, Gilmartin, Aidan G, Chua, Penelope R, Desai, Radhika, Schauer, Stephen P, McNulty, Dean E, Annan, Roland S, Belmont, Lisa D, Garcia, Carlos, Lee, Yan, Diamond, Melody A, Faucette, Leo F, Giardiniere, Michele, Zhang, ShuYun, Sun, Chiu-Mei, Vidal, Justin D, Lichtsteiner, Serge, Cornwell, William D, Greshock, Joel D, Wooster, Richard F, Finer, Jeffrey T, Copeland, Robert A, Huang, Pearl S, Morgans, David J. Jr, Dhanak, Dashyant, Bergnes, Gustave, Sakowicz, Roman, Jackson, Jeffrey R

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Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF von Decaris, Martin L., Schaub, Johanna R., Chen, Chun, Cha, Jacob, Lee, Gail G., Rexhepaj, Megi, Ho, Steve S., Rao, Vikram, Marlow, Megan M., Kotak, Prerna, Budi, Erine H., Hooi, Lisa, Wu, Jianfeng, Fridlib, Marina, Martin, Shamra P., Huang, Shaoyi, Chen, Ming, Muñoz, Manuel, Hom, Timothy F., Wolters, Paul J., Desai, Tushar J., Rock, Fernando, Leftheris, Katerina, Morgans, David J., Lepist, Eve-Irene, Andre, Patrick, Lefebvre, Eric A., Turner, Scott M.

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Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model von Hwee, Darren T, Kennedy, Adam, Ryans, Julie, Russell, Alan J, Jia, Zhiheng, Hinken, Aaron C, Morgans, David J, Malik, Fady I, Jasper, Jeffrey R

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Discovery of Omecamtiv Mecarbil the First, Selective, Small Molecule Activator of Cardiac Myosin von Morgan, Bradley P, Muci, Alexander, Lu, Pu-Ping, Qian, Xiangping, Tochimoto, Todd, Smith, Whitney W, Garard, Marc, Kraynack, Erica, Collibee, Scott, Suehiro, Ion, Tomasi, Adam, Valdez, S. Corey, Wang, Wenyue, Jiang, Hong, Hartman, James, Rodriguez, Hector M, Kawas, Raja, Sylvester, Sheila, Elias, Kathleen A, Godinez, Guillermo, Lee, Kenneth, Anderson, Robert, Sueoka, Sandra, Xu, Donghong, Wang, Zhengping, Djordjevic, Nebojsa, Malik, Fady I, Morgans, David J

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Discovery of Tirasemtiv, the First Direct Fast Skeletal Muscle Troponin Activator von Collibee, Scott E, Bergnes, Gustave, Muci, Alexander, Browne, William F, Garard, Marc, Hinken, Aaron C, Russell, Alan J, Suehiro, Ion, Hartman, James, Kawas, Raja, Lu, Pu-Ping, Lee, Kenneth H, Marquez, David, Tomlinson, Matthew, Xu, Donghong, Kennedy, Adam, Hwee, Darren, Schaletzky, Julia, Leung, Kwan, Malik, Fady I, Morgans, David J, Morgan, Bradley P

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Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure von Malik, Fady I., Hartman, James J., Elias, Kathleen A., Morgan, Bradley P., Rodriguez, Hector, Brejc, Katjuša, Anderson, Robert L., Sueoka, Sandra H., Lee, Kenneth H., Finer, Jeffrey T., Sakowicz, Roman, Baliga, Ramesh, Cox, David R., Garard, Marc, Godinez, Guillermo, Kawas, Raja, Kraynack, Erica, Lenzi, David, Lu, Pu Ping, Muci, Alexander, Niu, Congrong, Qian, Xiangping, Pierce, Daniel W., Pokrovskii, Maria, Suehiro, Ion, Sylvester, Sheila, Tochimoto, Todd, Valdez, Corey, Wang, Wenyue, Katori, Tatsuo, Kass, David A., Shen, You-Tang, Vatner, Stephen F., Morgans, David J.

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Smooth muscle myosin inhibition: a novel therapeutic approach for pulmonary hypertension von Ho, David, Chen, Li, Zhao, Xin, Durham, Nicquanna, Pannirselvam, Malar, Vatner, Dorothy E, Morgans, David J, Malik, Fady I, Vatner, Stephen F, Shen, You-Tang

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Inhibition of smooth muscle myosin as a novel therapeutic target for hypertension von Zhao, Xin, Ho, David, Abarzúa, Patricio, Dhar, Sunil K, Wang, Xi, Jia, Zhiheng, Pannirselvam, Malar, Morgans, David J, Malik, Fady I, Vatner, Stephen F

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Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases von Russell, Alan J, Hartman, James J, Hinken, Aaron C, Muci, Alexander R, Kawas, Raja, Driscoll, Lena, Godinez, Guillermo, Lee, Kenneth H, Marquez, David, Browne, William F, Chen, Michael M, Clarke, David, Collibee, Scott E, Garard, Marc, Hansen, Richard, Jia, Zhiheng, Lu, Pu-Ping, Rodriguez, Hector, Saikali, Khalil G, Schaletzky, Julia, Vijayakumar, Vipin, Albertus, Daniel L, Claflin, Dennis R, Morgans, David J, Morgan, Bradley P, Malik, Fady I

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Improvement of cardiac function by a cardiac Myosin activator in conscious dogs with systolic heart failure von Shen, You-Tang, Malik, Fady I, Zhao, Xin, Depre, Christophe, Dhar, Sunil K, Abarzúa, Patricio, Morgans, David J, Vatner, Stephen F

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Tirasemtiv amplifies skeletal muscle response to nerve activation in humans von Hansen, Richard, Saikali, Khalil G., Chou, Willis, Russell, Alan J., Chen, Michael M., Vijayakumar, Vipin, Stoltz, Randall R., Baudry, Stephane, Enoka, Roger M., Morgans, David J., Wolff, Andrew A., Malik, Fady I.

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Leading the way to the next generation of anti-mitotics von Wood, Kenneth W, Jackson, Jeffrey R, Morgans, David J, Elliott, John D, Sabry, James H, Huang, Pearl S

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MZ-301 Is a Small Molecule Inhibitor of APOL1 Pore Function That Attenuates Albuminuria in a Mouse Model of APOL1-Mediated Kidney Disease: FR-PO318 von Assimon, Victoria, Bronner, Sarah, Yu, Cecile, Zha, Weibin, Hoek, Maarten, Sinz, Christopher, Green, Eric, Morgans, David J.

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Asymmetric Synthesis and Stereochemical Assignment of RS-97613, a Potent Immunosuppressive and Antiinflammatory Agent von Smith, David B, Waltos, Ann Marie, Loughhead, David G, Weikert, Robert J, Morgans, David J, Rohloff, John C, Link, John O, Zhu, Rong-rong

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Small Molecule Inhibition of APOL1 Reverses Albuminuria in a Chronic Mouse Model of APOL1-Mediated Kidney Disease: SA-PO788 von Assimon, Victoria, Bronner, Sarah, Yu, Cecile, Chan, Helen, Crasta, Sheela, Lee, Patrick S., Lin, Baiwei, Luo, Yunqi, Octaviani, Angela, Reid, Adam, Sanman, Laura, Shi, Licheng, Situ, Eva, Tep, Sam, Zhang, Birong, Beattie, David T., Sinz, Christopher, Hoek, Maarten, Bernstein, Harold S., Morgans, David J., Green, Eric

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Small molecule inhibition of glycogen synthase 1 restores autophagolysosomal and metabolic pathway dysfunction in a mouse model of Pompe disease von Ullman, Julie C., Xi, Yannan, Mellem, Kevin T., Merritt, Hanne, Choy, Rebeca, Gujral, Taru, Blake, Kerrigan, Tep, Samnang, O'Regan, Adam, Wong, Perryn, Wong, Casper, Pang, Lisa, Satterfield, Terrence F., Lin, Baiwei, Situ, Eva, Hoek, Maarten, Chandriani, Sanjay J., Bainer, Russell, Sinz, Christopher, Dick, Ryan, Noonberg, Sarah B., Beattie, David, Morgans, David J., Green, Eric M.

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An investigation of the palladium-catalyzed, formate-mediated hydroxycarbonylation of optically active 1-arylethyl esters von Baird, Jeff M, Kern, John R, Lee, Gary R, Morgans, David J, Sparacino, Mark L

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Substrate reduction therapy for Pompe disease: Small molecule inhibition of glycogen synthase 1 in preclinical models von Ullman, Julie C., Mellem, Kevin T., Xi, Yannan, Satterfield, Terrence F., Gujral, Tarunmeet, Choy, Rebeca, Homburger, Julian R., Merritt, Hanne, Reiton, Daniel, Tep, Samnang, Lin, Baiwei, Yu, Cecile, Situ, Eva, Won, Walter, Powers, Hannah, Ramanan, Vyas, Hoek, Maarten, Graham, Robert, Chandriani, Sanjay J., Sinz, Christopher, Dick, Ryan A., Noonberg, Sarah B., Beattie, David T., Morgans, David J., Jr, Green, Eric M.

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Pharmacology of small molecule inhibitors of GYS1 in a mouse model of Pompe disease von Xi, Yannan, Satterfield, Terrence F., Choy, Rebeca, Gujral, Tarunmeet, Situ, Eva, Tep, Samnang, Morton, Vivian, Yu, Cecile, Reiton, Daniel, Lin, Baiwei, Merritt, Hanne, Santiago, Pam, Espanol, Bryan, Dick, Ryan A., Ullman, Julie C., Mellem, Kevin T., Noonberg, Sarah B., Green, Eric M., Morgans, David J., Chandriani, Sanjay J., Beattie, David T.

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Dual inhibition of alpha(v)beta(6) and alpha(v)beta(1) reduces fibrogenesis in lung tissue explants from patients with IPF von Decaris, Martin L., Schaub, Johanna R., Chen, Chun, Cha, Jacob, Lee, Gail G., Rexhepaj, Megi, Ho, Steve S., Rao, Vikram, Marlow, Megan M., Kotak, Prerna, Budi, Erine H., Hooi, Lisa, Wu, Jianfeng, Fridlib, Marina, Martin, Shamra P., Huang, Shaoyi, Chen, Ming, Munoz, Manuel, Hom, Timothy F., Wolters, Paul J., Desai, Tushar J., Rock, Fernando, Leftheris, Katerina, Morgans, David J., Lepist, Eve-Irene, Andre, Patrick, Lefebvre, Eric A., Turner, Scott M.

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