Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia von Paris, Jasmin, Morgan, Marcos, Campos, Joana, Spencer, Gary J., Shmakova, Alena, Ivanova, Ivayla, Mapperley, Christopher, Lawson, Hannah, Wotherspoon, David A., Sepulveda, Catarina, Vukovic, Milica, Allen, Lewis, Sarapuu, Annika, Tavosanis, Andrea, Guitart, Amelie V., Villacreces, Arnaud, Much, Christian, Choe, Junho, Azar, Ali, van de Lagemaat, Louie N., Vernimmen, Douglas, Nehme, Ali, Mazurier, Frederic, Somervaille, Tim C.P., Gregory, Richard I., O’Carroll, Dónal, Kranc, Kamil R.

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mRNA 3′ uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome von Morgan, Marcos, Much, Christian, DiGiacomo, Monica, Azzi, Chiara, Ivanova, Ivayla, Vitsios, Dimitrios M., Pistolic, Jelena, Collier, Paul, Moreira, Pedro N., Benes, Vladimir, Enright, Anton J., O’Carroll, Dónal

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A transit-amplifying population underpins the efficient regenerative capacity of the testis von Carrieri, Claudia, Comazzetto, Stefano, Grover, Amit, Morgan, Marcos, Buness, Andreas, Nerlov, Claus, O'Carroll, Dónal

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Oligoasthenoteratozoospermia and infertility in mice deficient for miR-34b/c and miR-449 loci von Comazzetto, Stefano, Di Giacomo, Monica, Rasmussen, Kasper Dindler, Much, Christian, Azzi, Chiara, Perlas, Emerald, Morgan, Marcos, O'Carroll, Dónal

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Multiple Epigenetic Mechanisms and the piRNA Pathway Enforce LINE1 Silencing during Adult Spermatogenesis von Di Giacomo, Monica, Comazzetto, Stefano, Saini, Harpreet, De Fazio, Serena, Carrieri, Claudia, Morgan, Marcos, Vasiliauskaite, Lina, Benes, Vladimir, Enright, Anton J., O’Carroll, Dónal

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Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions von Guitart, Amelie V, Panagopoulou, Theano I, Villacreces, Arnaud, Vukovic, Milica, Sepulveda, Catarina, Allen, Lewis, Carter, Roderick N, van de Lagemaat, Louie N, Morgan, Marcos, Giles, Peter, Sas, Zuzanna, Gonzalez, Marta Vila, Lawson, Hannah, Paris, Jasmin, Edwards-Hicks, Joy, Schaak, Katrin, Subramani, Chithra, Gezer, Deniz, Armesilla-Diaz, Alejandro, Wills, Jimi, Easterbrook, Aaron, Coman, David, So, Chi Wai Eric, O'Carroll, Donal, Vernimmen, Douglas, Rodrigues, Neil P, Pollard, Patrick J, Morton, Nicholas M, Finch, Andrew, Kranc, Kamil R

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TUT4/7-mediated uridylation of a coronavirus subgenomic RNAs delays viral replication von Gupta, Ankit, Li, Yin, Chen, Shih-Heng, Papas, Brian N., Martin, Negin P., Morgan, Marcos

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A unique poly(A) tail profile uncovers the stability and translational activation of TOP transcripts during neuronal differentiation von Baptissart, Marine, Papas, Brian N., Chi, Ru-pin Alicia, Li, Yin, Lee, Dongwon, Puviindran, Bhairavy, Morgan, Marcos

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WNK1 is required during male pachynema to sustain fertility von Chi, Ru-pin Alicia, Xu, Xiaojiang, Li, Jian-Liang, Xu, Xin, Hu, Guang, Brown, Paula, Willson, Cynthia, Kirsanov, Oleksandr, Geyer, Christopher, Huang, Chou-Long, Morgan, Marcos, DeMayo, Francesco

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The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses von Kozlowski, Elyse, Wasserman, Gregory A, Morgan, Marcos, O'Carroll, Dónal, Ramirez, Nora-Guadalupe P, Gummuluru, Suryaram, Rah, Jasmine Y, Gower, Adam C, Ieong, Michael, Quinton, Lee J, Mizgerd, Joseph P, Jones, Matthew R

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The RNA m 6 A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence von Ivanova, Ivayla, Much, Christian, Di Giacomo, Monica, Azzi, Chiara, Morgan, Marcos, Moreira, Pedro N, Monahan, Jack, Carrieri, Claudia, Enright, Anton J, O'Carroll, Dónal

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NANOS2 is a sequence-specific mRNA-binding protein that promotes transcript degradation in spermatogonial stem cells von Codino, Azzurra, Turowski, Tomasz, van de Lagemaat, Louie N., Ivanova, Ivayla, Tavosanis, Andrea, Much, Christian, Auchynnikava, Tania, Vasiliauskaitė, Lina, Morgan, Marcos, Rappsilber, Juri, Allshire, Robin C., Kranc, Kamil R., Tollervey, David, O'Carroll, Dónal

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Identification of 3' gene ends using transcriptional and genomic conservation across vertebrates von Morgan, Marcos, Iaconcig, Alessandra, Muro, Andrés Fernando

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Post-transcriptional regulation in spermatogenesis: all RNA pathways lead to healthy sperm von Morgan, Marcos, Kumar, Lokesh, Li, Yin, Baptissart, Marine

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The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function von Mapperley, Christopher, van de Lagemaat, Louie N., Lawson, Hannah, Tavosanis, Andrea, Paris, Jasmin, Campos, Joana, Wotherspoon, David, Durko, Jozef, Sarapuu, Annika, Choe, Junho, Ivanova, Ivayla, Krause, Daniela S., von Kriegsheim, Alex, Much, Christian, Morgan, Marcos, Gregory, Richard I., Mead, Adam J., O'Carroll, Donal, Kranc, Kamil R.

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Quantification of Poly(A) Tail Length and Terminal Modifications Using Direct RNA Sequencing von Gupta, Ankit, Papas, Brian N., Baptissart, Marine, Morgan, Marcos

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A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis von Morgan, Marcos, Kabayama, Yuka, Much, Christian, Ivanova, Ivayla, Di Giacomo, Monica, Auchynnikava, Tatsiana, Monahan, Jack Michael, Vitsios, Dimitrios Michael, Vasiliauskaitė, Lina, Comazzetto, Stefano, Rappsilber, Juri, Allshire, Robin Campbell, Porse, Bo Torben, Enright, Anton James, O’Carroll, Dónal

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3009 – THERAPEUTIC TARGETING OF RNA DEGRADATION PATHWAYS- NEW AVENUES FOR INTERVENTION IN ACUTE MYELOID LEUKAEMIA von Mapperley, Christopher, Lawson, Hannah, Kabayama, Yuka, Georges, Elise, Azar, Ali, Van der Lagemaat, Louie, Paris, Jasmin, Morgan, Marcos, Vernimmen, Douglas, O'Carroll, Donal, Kranc, Kamil

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CPEB2, CPEB3 and CPEB4 are coordinately regulated by miRNAs recognizing conserved binding sites in paralog positions of their 3'-UTRs von Morgan, Marcos, Iaconcig, Alessandra, Muro, Andrés Fernando

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Identification of 3 super(') gene ends using transcriptional and genomic conservation across vertebrates von Morgan, Marcos, Iaconcig, Alessandra, Muro, Andres Fernando

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