Translocation of Sphingosine Kinase 1 to the Plasma Membrane Is Mediated by Calcium- and Integrin-binding Protein 1 von Jarman, Kate E., Moretti, Paul A.B., Zebol, Julia R., Pitson, Stuart M.

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The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism von Pitman, Melissa R., Lewis, Alexander C., Davies, Lorena T., Moretti, Paul A. B., Anderson, Dovile, Creek, Darren J., Powell, Jason A., Pitson, Stuart M.

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Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia von Lewis, Alexander C., Pope, Victoria S., Tea, Melinda N., Li, Manjun, Nwosu, Gus O., Nguyen, Thao M., Wallington-Beddoe, Craig T., Moretti, Paul A.B., Anderson, Dovile, Creek, Darren J., Costabile, Maurizio, Ali, Saira R., Thompson-Peach, Chloe A.L., Dredge, B. Kate, Bert, Andrew G., Goodall, Gregory J., Ekert, Paul G., Brown, Anna L., D'Andrea, Richard, Robinson, Nirmal, Pitman, Melissa R., Thomas, Daniel, Ross, David M., Gliddon, Briony L., Powell, Jason A., Pitson, Stuart M.

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Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia von Powell, Jason A., Lewis, Alexander C., Zhu, Wenying, Toubia, John, Pitman, Melissa R., Wallington-Beddoe, Craig T., Moretti, Paul A.B., Iarossi, Diana, Samaraweera, Saumya E., Cummings, Nik, Ramshaw, Hayley S., Thomas, Daniel, Wei, Andrew H., Lopez, Angel F., D'Andrea, Richard J., Lewis, Ian D., Pitson, Stuart M.

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Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma von Neubauer, Heidi A., Tea, Melinda N., Zebol, Julia R., Gliddon, Briony L., Stefanidis, Cassandra, Moretti, Paul A. B., Pitman, Melissa R., Costabile, Maurizio, Kular, Jasreen, Stringer, Brett W., Day, Bryan W., Samuel, Michael S., Bonder, Claudine S., Powell, Jason A., Pitson, Stuart M.

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CIB2 Negatively Regulates Oncogenic Signaling in Ovarian Cancer via Sphingosine Kinase 1 von Zhu, Wenying, Jarman, Kate E, Lokman, Noor A, Neubauer, Heidi A, Davies, Lorena T, Gliddon, Briony L, Taing, Houng, Moretti, Paul A B, Oehler, Martin K, Pitman, Melissa R, Pitson, Stuart M

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A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis von Kular, Jasreen, Scheer, Kaitlin G., Pyne, Natasha T., Allam, Amr H., Pollard, Anthony N., Magenau, Astrid, Wright, Rebecca L., Kolesnikoff, Natasha, Moretti, Paul A., Wullkopf, Lena, Stomski, Frank C., Cowin, Allison J., Woodcock, Joanna M., Grimbaldeston, Michele A., Pitson, Stuart M., Timpson, Paul, Ramshaw, Hayley S., Lopez, Angel F., Samuel, Michael S.

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Eukaryotic Elongation Factor 1A Interacts with Sphingosine Kinase and Directly Enhances Its Catalytic Activity von Leclercq, Tamara M., Moretti, Paul A.B., Vadas, Mathew A., Pitson, Stuart M.

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The Calmodulin-binding Site of Sphingosine Kinase and Its Role in Agonist-dependent Translocation of Sphingosine Kinase 1 to the Plasma Membrane von Sutherland, Catherine M., Moretti, Paul A.B., Hewitt, Niamh M., Bagley, Christopher J., Vadas, Mathew A., Pitson, Stuart M.

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Deactivation of Sphingosine Kinase 1 by Protein Phosphatase 2A von Barr, Renae K., Lynn, Helen E., Moretti, Paul A.B., Khew-Goodall, Yeesim, Pitson, Stuart M.

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Targeting human CALR‐mutated MPN progenitors with a neoepitope‐directed monoclonal antibody von Tvorogov, Denis, Thompson‐Peach, Chloe A L, Foßelteder, Johannes, Dottore, Mara, Stomski, Frank, Onnesha, Suraiya A, Lim, Kelly, Moretti, Paul A B, Pitson, Stuart M, Ross, David M, Reinisch, Andreas, Thomas, Daniel, Lopez, Angel F

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Sphingosine 1‐phosphate is a ligand for peroxisome proliferator‐activated receptor‐γ that regulates neoangiogenesis von Parham, Kate A., Zebol, Julia R., Tooley, Katie L., Sun, Wai Y., Moldenhauer, Lachlan M., Cockshell, Michaelia P., Gliddon, Briony L., Moretti, Paul A., Tigyi, Gabor, Pitson, Stuart M., Bonder, Claudine S.

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Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal degradation of sphingosine kinase 1 von Powell, Jason A., Pitman, Melissa R., Zebol, Julia R., Moretti, Paul A.B., Neubauer, Heidi A., Davies, Lorena T., Lewis, Alexander C., Dagley, Laura F., Webb, Andrew I., Costabile, Maurizio, Pitson, Stuart M.

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Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress von Wallington-Beddoe, Craig T, Bennett, Melissa K, Vandyke, Kate, Davies, Lorena, Zebol, Julia R, Moretti, Paul A B, Pitman, Melissa R, Hewett, Duncan R, Zannettino, Andrew C W, Pitson, Stuart M

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Attenuation of leakiness in doxycycline-inducible expression via incorporation of 3′ AU-rich mRNA destabilizing elements von Pham, Duyen H, Moretti, Paul A.B, Goodall, Gregory J, Pitson, Stuart M

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A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties von Pitman, Melissa R, Powell, Jason A, Coolen, Carl, Moretti, Paul A B, Zebol, Julia R, Pham, Duyen H, Finnie, John W, Don, Anthony S, Ebert, Lisa M, Bonder, Claudine S, Gliddon, Briony L, Pitson, Stuart M

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An oncogenic role for sphingosine kinase 2 von Neubauer, Heidi A, Pham, Duyen H, Zebol, Julia R, Moretti, Paul A B, Peterson, Amanda L, Leclercq, Tamara M, Chan, Huasheng, Powell, Jason A, Pitman, Melissa R, Samuel, Michael S, Bonder, Claudine S, Creek, Darren J, Gliddon, Briony L, Pitson, Stuart M

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A critical role for the protein phosphatase 2A B′α regulatory subunit in dephosphorylation of sphingosine kinase 1 von Pitman, Melissa R., Barr, Renae K., Gliddon, Briony L., Magarey, Angus M., Moretti, Paul A.B., Pitson, Stuart M.

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The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1 von Zebol, Julia R., Hewitt, Niamh M., Moretti, Paul A.B., Lynn, Helen E., Lake, Julie A., Li, Peng, Vadas, Mathew A., Wattenberg, Binks W., Pitson, Stuart M.

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Over-Expression of Sphingosine Kinase-1 Enhances a Progenitor Phenotype in Human Endothelial Cells von BARRETT, JEFFREY M., PARHAM, KATE A., PIPPAL, JYOTSNA B., COCKSHELL, MICHAELIA P., MORETTI, PAUL A. B., BRICE, SARAH L., PITSON, STUART M., BONDER, CLAUDINE S.

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