Higher prevalence of cerebral white matter hyperintensities in homozygous APOE-ɛ4 allele carriers aged 45–75: Results from the ALFA study von Rojas, Santiago, Brugulat-Serrat, Anna, Bargalló, Nuria, Minguillón, Carolina, Tucholka, Alan, Falcon, Carles, Carvalho, Andreia, Morán, Sebastian, Esteller, Manel, Gramunt, Nina, Fauria, Karine, Camí, Jordi, Molinuevo, José L, Gispert, Juan D

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Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer von Heyn, Holger, Vidal, Enrique, Ferreira, Humberto J, Vizoso, Miguel, Sayols, Sergi, Gomez, Antonio, Moran, Sebastian, Boque-Sastre, Raquel, Guil, Sonia, Martinez-Cardus, Anna, Lin, Charles Y, Royo, Romina, Sanchez-Mut, Jose V, Martinez, Ramon, Gut, Marta, Torrents, David, Orozco, Modesto, Gut, Ivo, Young, Richard A, Esteller, Manel

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DNA Methylation Map of Human Atherosclerosis von Zaina, Silvio, Heyn, Holger, Carmona, F Javier, Varol, Nuray, Sayols, Sergi, Condom, Enric, Ramírez-Ruz, José, Gomez, Antonio, Gonçalves, Isabel, Moran, Sebastian, Esteller, Manel

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A Prognostic DNA Methylation Signature for Stage I Non–Small-Cell Lung Cancer von SANDOVAL, Juan, MENDEZ-GONZALEZ, Jesus, SANCHEZ-CESPEDES, Montse, ASSENOV, Yassen, MÜLLER, Fabian, BOCK, Christoph, TARON, Miquel, MORA, Josefina, MUSCARELLA, Lucia A, LILOGLOU, Triantafillos, DAVIES, Michael, POLLAN, Marina, NADAL, Ernest, PAJARES, Maria J, TORRE, Wenceslao, MONTUENGA, Luis M, BRAMBILLA, Elisabeth, FIELD, John K, ROZ, Luca, IACONO, Marco Lo, SCAGLIOTTI, Giorgio V, ROSELL, Rafael, BEER, David G, GUOAN CHEN, ESTELLER, Manel, CARMONA, F. Javier, SAYOLS, Sergi, MORAN, Sebastian, HEYN, Holger, VIZOSO, Miguel, GOMEZ, Antonio

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Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs von Nogales, Vanesa, Reinhold, William C, Varma, Sudhir, Martinez-Cardus, Anna, Moutinho, Catia, Moran, Sebastian, Heyn, Holger, Sebio, Ana, Barnadas, Agusti, Pommier, Yves, Esteller, Manel

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A DNA methylation-based definition of biologically distinct breast cancer subtypes von Stefansson, Olafur A., Moran, Sebastian, Gomez, Antonio, Sayols, Sergi, Arribas-Jorba, Carlos, Sandoval, Juan, Hilmarsdottir, Holmfridur, Olafsdottir, Elinborg, Tryggvadottir, Laufey, Jonasson, Jon G., Eyfjord, Jorunn, Esteller, Manel

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Aberrant DNA methylation in non-small cell lung cancer-associated fibroblasts von Vizoso, Miguel, Puig, Marta, Carmona, F Javier, Maqueda, María, Velásquez, Adriana, Gómez, Antonio, Labernadie, Anna, Lugo, Roberto, Gabasa, Marta, Rigat-Brugarolas, Luis G, Trepat, Xavier, Ramírez, Josep, Moran, Sebastian, Vidal, Enrique, Reguart, Noemí, Perera, Alexandre, Esteller, Manel, Alcaraz, Jordi

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Targeted Exome Sequencing of Krebs Cycle Genes Reveals Candidate Cancer-Predisposing Mutations in Pheochromocytomas and Paragangliomas von Remacha, Laura, Comino-Méndez, Iñaki, Richter, Susan, Contreras, Laura, Currás-Freixes, María, Pita, Guillermo, Letón, Rocío, Galarreta, Antonio, Torres-Pérez, Rafael, Honrado, Emiliano, Jiménez, Scherezade, Maestre, Lorena, Moran, Sebastian, Esteller, Manel, Satrústegui, Jorgina, Eisenhofer, Graeme, Robledo, Mercedes, Cascón, Alberto

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Prenatal adverse environment is associated with epigenetic age deceleration at birth and hypomethylation at the hypoxia-responsive EP300 gene von Palma-Gudiel, Helena, Eixarch, Elisenda, Crispi, Fátima, Morán, Sebastián, Zannas, Anthony S, Fañanás, Lourdes

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Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors von Martin-Trujillo, Alex, Vidal, Enrique, Monteagudo-Sánchez, Ana, Sanchez-Delgado, Marta, Moran, Sebastian, Hernandez Mora, Jose Ramon, Heyn, Holger, Guitart, Miriam, Esteller, Manel, Monk, David

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An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma von Davalos, Veronica, Lovell, Claudia D., Von Itter, Richard, Dolgalev, Igor, Agrawal, Praveen, Baptiste, Gillian, Kahler, David J., Sokolova, Elena, Moran, Sebastian, Piqué, Laia, Vega-Saenz de Miera, Eleazar, Fontanals-Cirera, Barbara, Karz, Alcida, Tsirigos, Aristotelis, Yun, Chi, Darvishian, Farbod, Etchevers, Heather C., Osman, Iman, Esteller, Manel, Schober, Markus, Hernando, Eva

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A comprehensive DNA methylation profile of epithelial-to-mesenchymal transition von Carmona, F Javier, Davalos, Veronica, Vidal, Enrique, Gomez, Antonio, Heyn, Holger, Hashimoto, Yutaka, Vizoso, Miguel, Martinez-Cardus, Anna, Sayols, Sergi, Ferreira, Humberto J, Sánchez-Mut, Jose V, Morán, Sebastián, Margelí, Mireia, Castella, Eva, Berdasco, Maria, Stefansson, Olafur A, Eyfjord, Jorunn E, Gonzalez-Suarez, Eva, Dopazo, Joaquín, Orozco, Modesto, Gut, Ivo G, Esteller, Manel

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Identification of 20 novel loci associated with ischaemic stroke. Epigenome-wide association study von Soriano-Tárraga, Carolina, Lazcano, Uxue, Giralt-Steinhauer, Eva, Avellaneda-Gómez, Carla, Ois, Ángel, Rodríguez-Campello, Ana, Cuadrado-Godia, Elisa, Gómez-González, Alejandra, Fernández-Sanlés, Alba, Elosua, Roberto, Fernández-Cadenas, Israel, Cullell, Natalia, Montaner, Joan, Moran, Sebastian, Esteller, Manel, Jiménez-Conde, Jordi, Roquer, Jaume

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EGLN2 DNA methylation and expression interact with HIF1A to affect survival of early-stage NSCLC von Zhang, Ruyang, Lai, Linjing, He, Jieyu, Chen, Chao, You, Dongfang, Duan, Weiwei, Dong, Xuesi, Zhu, Ying, Lin, Lijuan, Shen, Sipeng, Guo, Yichen, Su, Li, Shafer, Andrea, Moran, Sebastian, Fleischer, Thomas, Bjaanæs, Maria Moksnes, Karlsson, Anna, Planck, Maria, Staaf, Johan, Helland, Åslaug, Esteller, Manel, Wei, Yongyue, Chen, Feng, Christiani, David C.

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White matter microstructure is altered in cognitively normal middle-aged APOE-ε4 homozygotes von Operto, Grégory, Cacciaglia, Raffaele, Grau-Rivera, Oriol, Falcon, Carles, Brugulat-Serrat, Anna, Ródenas, Pablo, Ramos, Rubén, Morán, Sebastián, Esteller, Manel, Bargalló, Nuria, Molinuevo, José Luis, Gispert, Juan Domingo

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Serum methylation of GALNT9, UPF3A, WARS, and LDB2 as noninvasive biomarkers for the early detection of colorectal cancer and advanced adenomas von Gallardo-Gómez, María, Rodríguez-Girondo, Mar, Planell, Núria, Moran, Sebastian, Bujanda, Luis, Etxart, Ane, Castells, Antoni, Balaguer, Francesc, Jover, Rodrigo, Esteller, Manel, Cubiella, Joaquín, Gómez-Cabrero, David, De Chiara, Loretta

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Distinct Associations of BMI and Fatty Acids With DNA Methylation in Fasting and Postprandial States in Men von Pescador-Tapia, Azucena, Silva-Martinez, Guillermo A., Fragoso-Bargas, Nicolas, Rodriguez-Rios, Dalia, Esteller, Manel, Moran, Sebastian, Zaina, Silvio, Lund, Gertrud

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A multi‐omic study reveals BTG2 as a reliable prognostic marker for early‐stage non‐small cell lung cancer von Shen, Sipeng, Zhang, Ruyang, Guo, Yichen, Loehrer, Elizabeth, Wei, Yongyue, Zhu, Ying, Yuan, Qianyu, Moran, Sebastian, Fleischer, Thomas, Bjaanæs, Maria M., Karlsson, Anna, Planck, Maria, Staaf, Johan, Helland, Åslaug, Esteller, Manel, Su, Li, Chen, Feng, Christiani, David C.

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Precision medicine based on epigenomics: the paradigm of carcinoma of unknown primary von Moran, Sebastián, Martinez-Cardús, Anna, Boussios, Stergios, Esteller, Manel

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SIPA1L3 methylation modifies the benefit of smoking cessation on lung adenocarcinoma survival: an epigenomic–smoking interaction analysis von Zhang, Ruyang, Lai, Linjing, Dong, Xuesi, He, Jieyu, You, Dongfang, Chen, Chao, Lin, Lijuan, Zhu, Ying, Huang, Hui, Shen, Sipeng, Wei, Liangmin, Chen, Xin, Guo, Yichen, Liu, Liya, Su, Li, Shafer, Andrea, Moran, Sebastian, Fleischer, Thomas, Bjaanæs, Maria Moksnes, Karlsson, Anna, Planck, Maria, Staaf, Johan, Helland, Åslaug, Esteller, Manel, Wei, Yongyue, Chen, Feng, Christiani, David C.

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