Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1 von KORTUM, Steven W, BENSON, Timothy E, BIENKOWSKI, Michael J, EMMONS, Thomas L, PRINCE, D. Bryan, PADDOCK, Donna J, TOMASSELLI, Alfredo G, MOON, Joseph B, LABORDE, Alice, TENBRINK, Ruth E

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Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human β-Secretase von Maillard, Michel C, Hom, Roy K, Benson, Timothy E, Moon, Joseph B, Mamo, Shumeye, Bienkowski, Michael, Tomasselli, Alfredo G, Woods, Danielle D, Prince, D. Bryan, Paddock, Donna J, Emmons, Thomas L, Tucker, John A, Dappen, Michael S, Brogley, Louis, Thorsett, Eugene D, Jewett, Nancy, Sinha, Sukanto, John, Varghese

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Design and Synthesis of Hydroxyethylene-Based Peptidomimetic Inhibitors of Human β-Secretase von Hom, Roy K, Gailunas, Andrea F, Mamo, Shumeye, Fang, Larry Y, Tung, Jay S, Walker, Donald E, Davis, David, Thorsett, Eugene D, Jewett, Nancy E, Moon, Joseph B, John, Varghese

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Design of potent inhibitors of human β-secretase. Part 1 von Freskos, John N., Fobian, Yvette M., Benson, Timothy E., Bienkowski, Michael J., Brown, David L., Emmons, Thomas L., Heintz, Robert, Laborde, Alice, McDonald, Joseph J., Mischke, Brent V., Molyneaux, John M., Moon, Joseph B., Mullins, Patrick B., Bryan Prince, D., Paddock, Donna J., Tomasselli, Alfredo G., Winterrowd, Gregory

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Design, Synthesis, and Biological Evaluation of 3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a Potent, Orally Ac... von Hughes, Robert O, Rogier, D. Joseph, Jacobsen, E. Jon, Walker, John K, MacInnes, Alan, Bond, Brian R, Zhang, Lena L, Yu, Ying, Zheng, Yi, Rumsey, Jeanne M, Walgren, Jennie L, Curtiss, Sandra W, Fobian, Yvette M, Heasley, Steven E, Cubbage, Jerry W, Moon, Joseph B, Brown, David L, Acker, Brad A, Maddux, Todd M, Tollefson, Mike B, Mischke, Brent V, Owen, Dafydd R, Freskos, John N, Molyneaux, John M, Benson, Alan G, Blevis-Bal, Rhadika M

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Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system von Hughes, Robert O., Walker, John K., Cubbage, Jerry W., Fobian, Yvette M., Rogier, D. Joseph, Heasley, Steve E., Blevis-Bal, Rhadika M., Benson, Alan G., Owen, Dafydd R., Jacobsen, E. Jon, Freskos, John N., Molyneaux, John M., Brown, David L., Stallings, William C., Acker, Brad A., Maddux, Todd M., Tollefson, Mike B., Williams, Jennifer M., Moon, Joseph B., Mischke, Brent V., Rumsey, Jeanne M., Zheng, Yi, MacInnes, Alan, Bond, Brian R., Yu, Ying

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Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors von Owen, Dafydd R., Walker, John K., Jon Jacobsen, E., Freskos, John N., Hughes, Robert O., Brown, David L., Bell, Andrew S., Brown, David G., Phillips, Christopher, Mischke, Brent V., Molyneaux, John M., Fobian, Yvette M., Heasley, Steve E., Moon, Joseph B., Stallings, William C., Joseph Rogier, D., Fox, David N.A., Palmer, Michael J., Ringer, Tracy, Rodriquez-Lens, Margarita, Cubbage, Jerry W., Blevis-Bal, Radhika M., Benson, Alan G., Acker, Brad A., Maddux, Todd M., Tollefson, Michael B., Bond, Brian R., MacInnes, Alan, Yu, Yung

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Design of potent inhibitors of human β-secretase. Part 2 von Freskos, John N., Fobian, Yvette M., Benson, Timothy E., Moon, Joseph B., Bienkowski, Michael J., Brown, David L., Emmons, Thomas L., Heintz, Robert, Laborde, Alice, McDonald, Joseph J., Mischke, Brent V., Molyneaux, John M., Mullins, Patrick B., Bryan Prince, D., Paddock, Donna J., Tomasselli, Alfredo G., Winterrowd, Greg

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Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: Discovery of 3-[( trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4- b]py... von Hughes, Robert O., Walker, John K., Joseph Rogier, D., Heasley, Steve E., Blevis-Bal, Rhadika M., Benson, Alan G., Jon Jacobsen, E., Cubbage, Jerry W., Fobian, Yvette M., Owen, Dafydd R., Freskos, John N., Molyneaux, John M., Brown, David L., Acker, Brad A., Maddux, Todd M., Tollefson, Mike B., Moon, Joseph B., Mischke, Brent V., Rumsey, Jeanne M., Zheng, Yi, MacInnes, Alan, Bond, Brian R., Yu, Ying

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Computer design of bioactive molecules: A method for receptor-based de novo ligand design von Moon, Joseph B., Howe, W. Jeffrey

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Cation binding to the integrin CD11b I domain and activation model assessment von Baldwin, Eric T, Sarver, Ronald W, Bryant, Garold L, Curry, Kimberly A, Fairbanks, Michael B, Finzel, Barry C, Garlick, Robert L, Heinrikson, Robert L, Horton, Nancy C, Kelley, Laura-Lee C, Mildner, Ana M, Moon, Joseph B, Mott, John E, Mutchler, Veronica T, Tomich, Che-Shen C, Watenpaugh, Keith D, Wiley, Veronica H

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Primary and secondary kinetic deuterium isotope effects and transition-state structures for benzylic chlorination and bromination of toluene von Hanzlik, Robert P, Schaefer, Angela R, Moon, Joseph B, Judson, Charles M

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Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effect... von Thaisrivongs, Suvit, Tomasselli, Alfredo G, Moon, Joseph B, Hui, John, McQuade, Thomas J, Turner, Steve R, Strohbach, Joseph W, Howe, W. Jeffrey, Tarpley, W. Gary, Heinrikson, Robert L

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Potent and selective isophthalamide S 2 hydroxyethylamine inhibitors of BACE1 von Kortum, Steven W., Benson, Timothy E., Bienkowski, Michael J., Emmons, Thomas L., Prince, D. Bryan, Paddock, Donna J., Tomasselli, Alfredo G., Moon, Joseph B., LaBorde, Alice, TenBrink, Ruth E.

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Potent and selective isophthalamide S sub(2) hydroxyethylamine inhibitors of BACE1 von Kortum, Steven W, Benson, Timothy E, Bienkowski, Michael J, Emmons, Thomas L, Prince, DBryan, Paddock, Donna J, Tomasselli, Alfredo G, Moon, Joseph B, LaBorde, Alice, TenBrink, Ruth E

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Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS) von Carron, Chris P, Trujillo, John I, Olson, Kirk L, Huang, Wei, Hamper, Bruce C, Dice, Tom, Neal, Bradley E, Pelc, Matthew J, Day, Jacqueline E, Rohrer, Douglas C, Kiefer, James R, Moon, Joseph B, Schweitzer, Barbara A, Blake, Tanisha D, Turner, Steve R, Woerndle, Rhonda, Case, Brenda L, Bono, Christine P, Dilworth, Vickie M, Funckes-Shippy, Christie L, Hood, Becky L, Jerome, Gina M, Kornmeier, Christine M, Radabaugh, Melissa R, Williams, Melanie L, Davies, Michael S, Wegner, Craig D, Welsch, Dean J, Abraham, William M, Warren, Chad J, Dowty, Martin E, Hua, Fengmei, Zutshi, Anup, Yang, Jerry Z, Thorarensen, Atli

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Structure-Based Design of HIV Protease Inhibitors: 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Non-peptidic Inhibitors von Thaisrivongs, Suvit, Tomich, Paul K, Watenpaugh, Keith D, Chong, Kong-Teck, Howe, W. Jeffrey, Yang, Chih-Ping, Strohbach, Joseph W, Turner, Steve R, McGrath, James P

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Intramolecular kinetic deuterium isotope effects on microsomal hydroxylation and chemical chlorination of toluene-.alpha.-d1 and toluene-.alpha.,.alpha.-d2 von Hanzlik, Robert P, Hogberg, Kerstin, Moon, Joseph B, Judson, Charles M

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Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors von Thaisrivongs, Suvit, Watenpaugh, Keith D, Howe, W. Jeffrey, Tomich, Paul K, Dolak, Lester A, Chong, Kong-Teck, Tomich, Che-Shen C, Tomasselli, Alfredo G, Turner, Steve R

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Reversible covalent inhibition of papain by a peptide nitrile. Carbon-13 NMR evidence for a thioimidate ester adduct von Moon, Joseph B, Coleman, Robert S, Hanzlik, Robert P

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