Combined Therapy of AXL and HDAC Inhibition Reverses Mesenchymal Transition in Diffuse Intrinsic Pontine Glioma von Meel, Michaël H, de Gooijer, Mark C, Metselaar, Dennis S, Sewing, A Charlotte P, Zwaan, Kenn, Waranecki, Piotr, Breur, Marjolein, Buil, Levi C M, Lagerweij, Tonny, Wedekind, Laurine E, Twisk, Jos W R, Koster, Jan, Hashizume, Rintaro, Raabe, Eric H, Montero Carcaboso, Ángel, Bugiani, Marianna, Phoenix, Timothy N, van Tellingen, Olaf, van Vuurden, Dannis G, Kaspers, Gertjan J L, Hulleman, Esther

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PDX-Derived Ewing's Sarcoma Cells Retain High Viability and Disease Phenotype in Alginate Encapsulated Spheroid Cultures von Domenici, Giacomo, Eduardo, Rodrigo, Castillo-Ecija, Helena, Orive, Gorka, Montero Carcaboso, Ángel, Brito, Catarina

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Efficacy of systemic temozolomide‐activated phage‐targeted gene therapy in human glioblastoma von Przystal, Justyna Magdalena, Waramit, Sajee, Pranjol, Md Zahidul Islam, Yan, Wenqing, Chu, Grace, Chongchai, Aitthiphon, Samarth, Gargi, Olaciregui, Nagore Gene, Tabatabai, Ghazaleh, Carcaboso, Angel Montero, Aboagye, Eric Ofori, Suwan, Keittisak, Hajitou, Amin

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ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma von Carvalho, Diana, Taylor, Kathryn R., Olaciregui, Nagore Gene, Molinari, Valeria, Clarke, Matthew, Mackay, Alan, Ruddle, Ruth, Henley, Alan, Valenti, Melanie, Hayes, Angela, Brandon, Alexis De Haven, Eccles, Suzanne A., Raynaud, Florence, Boudhar, Aicha, Monje, Michelle, Popov, Sergey, Moore, Andrew S., Mora, Jaume, Cruz, Ofelia, Vinci, Mara, Brennan, Paul E., Bullock, Alex N., Carcaboso, Angel Montero, Jones, Chris

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Genomic and Transcriptomic Tumor Heterogeneity in Bilateral Retinoblastoma von Winter, Ursula, Ganiewich, Daiana, Ottaviani, Daniela, Zugbi, Santiago, Aschero, Rosario, Sendoya, Juan Martin, Cafferata, Eduardo G, Mena, Marcela, Sgroi, Mariana, Sampor, Claudia, Lubieniecki, Fabiana, Fandiño, Adriana, Abba, Martin C, Doz, François, Podhjacer, Osvaldo, Carcaboso, Angel Montero, Letouzé, Eric, Radvanyi, François, Chantada, Guillermo L, Llera, Andrea S, Schaiquevich, Paula

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MELK Inhibition in Diffuse Intrinsic Pontine Glioma von Meel, Michaël H, de Gooijer, Mark C, Guillén Navarro, Miriam, Waranecki, Piotr, Breur, Marjolein, Buil, Levi C M, Wedekind, Laurine E, Twisk, Jos W R, Koster, Jan, Hashizume, Rintaro, Raabe, Eric H, Montero Carcaboso, Angel, Bugiani, Marianna, van Tellingen, Olaf, van Vuurden, Dannis G, Kaspers, Gertjan J L, Hulleman, Esther

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Treatment of Retinoblastoma: What Is the Latest and What Is the Future von Schaiquevich, Paula, Francis, Jasmine H, Cancela, María Belén, Carcaboso, Angel Montero, Chantada, Guillermo L, Abramson, David H

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BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomas von Huchede, Paul, Meyer, Swann, Berthelot, Clement, Hamadou, Maud, Bertrand-Chapel, Adrien, Rakotomalala, Andria, Manceau, Line, Tomine, Julia, Lespinasse, Nicolas, Lewandowski, Paul, Cordier-Bussat, Martine, Broutier, Laura, Dutour, Aurelie, Rochet, Isabelle, Blay, Jean-Yves, Degletagne, Cyril, Attignon, Valery, Montero-Carcaboso, Angel, Le Grand, Marion, Pasquier, Eddy, Vasiljevic, Alexandre, Gilardi-Hebenstreit, Pascale, Meignan, Samuel, Leblond, Pierre, Ribes, Vanessa, Cosset, Erika, Castets, Marie

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Evofosfamide Is Effective against Pediatric Aggressive Glioma Cell Lines in Hypoxic Conditions and Potentiates the Effect of Cytotoxic Chemotherapy and Ionizing Radiations von Bailleul, Quentin, Navarin, Pauline, Arcicasa, Mélanie, Bal-Mahieu, Christine, Carcaboso, Angel Montero, Le Bourhis, Xuefen, Furlan, Alessandro, Meignan, Samuel, Leblond, Pierre

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An Integrated In Vitro and In Vivo High-Throughput Screen Identifies Treatment Leads for Ependymoma von Atkinson, Jennifer M., Shelat, Anang A., Carcaboso, Angel Montero, Kranenburg, Tanya A., Arnold, Leggy A., Boulos, Nidal, Wright, Karen, Johnson, Robert A., Poppleton, Helen, Mohankumar, Kumarasamypet M., Féau, Clementine, Phoenix, Timothy, Gibson, Paul, Zhu, Liqin, Tong, Yiai, Eden, Chris, Ellison, David W., Priebe, Waldemar, Koul, Dimpy, Yung, W. K. Alfred, Gajjar, Amar, Stewart, Clinton F., Guy, R. Kiplin, Gilbertson, Richard J.

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SN-38-loaded nanofiber matrices for local control of pediatric solid tumors after subtotal resection surgery von Monterrubio, Carles, Pascual-Pasto, Guillem, Cano, Francisco, Vila-Ubach, Monica, Manzanares, Alejandro, Schaiquevich, Paula, Tornero, Jose A, Sosnik, Alejandro, Mora, Jaume, Carcaboso, Angel M

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INSP-15. ITCC-P4: A sustainable platform of molecularly well-characterized PDX models of pediatric cancers for high throughput in vivo testing von Kool, Marcel, Federico, Aniello, Surdez, Didier, Gopisetty, Apurva, Saberi-Ansari, Elnaz, Saint-Charles, Alexandra, Iddir, Yasmine, Waterfall, Joshua, Wierzbinska, Justyna, Schlicker, Andreas, Bhalsankar, Jaydutt, Mack, Norman, Schwalm, Benjamin, Böttcher, Anna-Lisa, Sill, Martin, Westermann, Frank, Jones, David T W, Volckmann, Richard, Zwijnenburg, Danny, Gürgen, Dennis, Inderise, Emilie, Schulte, Johannes, Eggert, Angelika, Molenaar, Jan J, Delattre, Olivier, Colombetti, Sara, Heidenreich, Olaf, Jeremias, Irmela, Scotlandi, Katia, Manara, Maria Cristina, Gojo, Johannes, Berger, Walter, Iradier, Fatima, Geoerger, Birgit, Costa, Jenny, Schäfer, Beat, Wachtel, Marco, Chesler, Louis, Jones, Chris, Kovar, Heinrich, Carcaboso, Ángel Montero, Klusmann, Jan-Henning, Debatin, Klaus-Michael, Bomken, Simon, Guttke, Christina, Hamerlik, Petra, Hattersley, Maureen, Garcia, Michelle, Colland, Frédéric, Strougo, Ashley, Witt, Olaf, Vassal, Gilles, Caron, Hubert, Shields, David J, Stancato, Lou F, Aviles, Pablo M, Hoffmann, Jens, Cairo, Stefano, Schueler, Julia, Jäger, Natalie, Koster, Jan, Schleiermacher, Gudrun, Pfister, Stefan M

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Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. “Alive, with good vision and no comorbidity” von Munier, Francis L., Beck-Popovic, Maja, Chantada, Guillermo L., Cobrinik, David, Kivelä, Tero T., Lohmann, Dietmar, Maeder, Philippe, Moll, Annette C., Carcaboso, Angel Montero, Moulin, Alexandre, Schaiquevich, Paula, Bergin, Ciara, Dyson, Paul J., Houghton, Susan, Puccinelli, Francesco, Vial, Yvan, Gaillard, Marie-Claire, Stathopoulos, Christina

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DIPG-05. PRECLINICAL EFFICACY OF MELK INHIBITION IN DIFFUSE INTRINSIC PONTINE GLIOMA von Meel, Michaël, de Gooijer, Mark, Navarro, Miriam Guillén, Waranecki, Piotr, Breur, Marjolein, Buil, Levi, Wedekind, Laurine, Twisk, Jos, Koster, Jan, Hashizume, Rintaro, Raabe, Eric, Carcaboso, Ángel Montero, Bugiani, Marianna, van Tellingen, Olaf, van Vuurden, Dannis, Kaspers, Gertjan, Hulleman, Esther

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DIPG-04. INHIBITION OF AXL SENSITIZES DIFFUSE INTRINSIC PONTINE GLIOMA TO CYTOTOXIC THERAPIES von Meel, Michaël, de Gooijer, Mark, Zwaan, Kenn, Waranecki, Piotr, Breur, Marjolein, Buil, Levi, Lagerweij, Tonny, Wedekind, Laurine, Twisk, Jos, Koster, Jan, Hashizume, Rintaro, Raabe, Eric, Carcaboso, Ángel Montero, Bugiani, Marianna, van Tellingen, Olaf, van Vuurden, Dannis, Kaspers, Gertjan, Hulleman, Esther

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Tissue Compatibility of SN‐38‐Loaded Anticancer Nanofiber Matrices von Manzanares, Alejandro, Restrepo‐Perdomo, Camilo A., Botteri, Gaia, Castillo‐Ecija, Helena, Pascual‐Pasto, Guillem, Cano, Francesc, Garcia‐Alvarez, Laura, Monterrubio, Carles, Ruiz, Bonaventura, Vazquez‐Carrera, Manuel, Suñol, Mariona, Mora, Jaume, Tornero, Jose A., Sosnik, Alejandro, Carcaboso, Angel M.

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Abstract 3571: The ITCC-P4 sustainable platform of fully characterized PDXs supports the preclinical proof-of-concept drug testing of high-risk pediatric tumor models von Federico, Aniello, Gopisetty, Apurva, Surdez, Didier, Iddir, Yasmine, Saint-Charles, Alexandra, Wierzbinska, Justyna, Schlicker, Andreas, Volckmann, Richard, Zwijnenburg, Danny, Colombetti, Sara, Heidenreich, Olaf, Iradier, Fatima, Kovar, Heinrich, Klusmann, Jan-Henning, Debatin, Klaus-Michael, Bomken, Simon, Guttke, Christina, Hattersley, Maureen M., Colland, Frédéric, Strougo, Ashley, Guillén, María José, Chesler, Louis, Jones, Chris, da Costa, Maria Eugénia Marques, Scotlandi, Katia, Moro, Massimo, Schäfer, Beat, Wachtel, Marco, Gojo, Johannes, Berger, Walter, Carcaboso, Ángel Montero, Gürgen, Dennis, Hoffmann, Jens, Indersie, Emilie, Cairo, Stefano, Schueler, Julia, Huebener, Nicole, Schulte, Johannes H., Molenaar, Jan J., Geoerger, Birgit, Shields, David J., Caron, Hubert N., Vassal, Gilles, Stancato, Lou F., Pfister, Stefan M., Jäger, Natalie, Koster, Jan, Kool, Marcel, Schleiermacher, Gudrun

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RONC-21. IDENTIFICATION OF EPIGENETIC DRUGS AS RADIOSENSITIZERS IN PEDIATRIC HIGH-GRADE GLIOMAS von Metselaar, Dennis, ter Huizen, Giovanna, Meel, Michaël Hananja, Goulding, Joshua, Waranecki, Piotr, Carcaboso, Angel Montero, Kaspers, Gertjan, Hulleman, Esther

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Abstract 5416: Positioning the NQO1-bioactivatable drug isobutyl-deoxynyboquinone in diffuse intrinsic pontine glioma (DIPG): an exceptional therapeutic opportunity in pediatric br... von Janin, Maxime Henri, Barahona, Vanessa Ortiz, Arias, Pere Llinas, De La Torre, Carolina, Carcaboso, Angel Montero, La Madrid, Andres Morales, Hergenrother, Paul, Esteller, Manel

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HGG-46. Inter and Intra-tumor Heterogeneity of Pediatric-type Diffuse High-Grade Glioma Revealed by High-Dimensional Single-Cell Proteomics von Petrilli, Lucia Lisa, Fuoco, Claudia, Pasquini, Luca, Palma, Alessandro, Pericoli, Giulia, Grabovska, Yura, Mackay, Alan, Rossi, Sabrina, Camassei, Francesca Diomedi, Carcaboso, Angel Montero, Carai, Andrea, Mastronuzzi, Angela, Jones, Chris, Cesareni, Gianni, Locatelli, Franco, Vinci, Maria

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