Elucidation of Tumor-Stromal Heterogeneity and the Ligand-Receptor Interactome by Single-Cell Transcriptomics in Real-world Pancreatic Cancer Biopsies von Lee, Jaewon J, Bernard, Vincent, Semaan, Alexander, Monberg, Maria E, Huang, Jonathan, Stephens, Bret M, Lin, Daniel, Rajapakshe, Kimal I, Weston, Brian R, Bhutani, Manoop S, Haymaker, Cara L, Bernatchez, Chantale, Taniguchi, Cullen M, Maitra, Anirban, Guerrero, Paola A

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Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution von Monberg, Maria E., Geiger, Heather, Lee, Jaewon J., Sharma, Roshan, Semaan, Alexander, Bernard, Vincent, Wong, Justin, Wang, Fang, Liang, Shaoheng, Swartzlander, Daniel B., Stephens, Bret M., Katz, Matthew H. G., Chen, Ken, Robine, Nicolas, Guerrero, Paola A., Maitra, Anirban

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Defining the Comprehensive Genomic Landscapes of Pancreatic Ductal Adenocarcinoma Using Real-World Endoscopic Aspiration Samples von Semaan, Alexander, Bernard, Vincent, Lee, Jaewon J, Wong, Justin W, Huang, Jonathan, Swartzlander, Daniel B, Stephens, Bret M, Monberg, Maria E, Weston, Brian R, Bhutani, Manoop S, Chang, Kyle, Scheet, Paul A, Maitra, Anirban, Jakubek, Yasminka A, Guerrero, Paola A

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Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment von Garcia Garcia, Carolina J., Huang, Yanqing, Fuentes, Natividad R., Turner, Madeleine C., Monberg, Maria E., Lin, Daniel, Nguyen, Nicholas D., Fujimoto, Tara N., Zhao, Jun, Lee, Jaewon J., Bernard, Vincent, Yu, Meifang, Delahoussaye, Abagail M., Jimenez Sacarello, Iancarlos, Caggiano, Emily G., Phan, Jae L., Deorukhkar, Amit, Molkentine, Jessica M., Saur, Dieter, Maitra, Anirban, Taniguchi, Cullen M.

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Abstract PO-010: Elucidating intratumoral heterogeneity and predicting effective combination regimens in PDAC PDOs using scRNA-seq and snATAC-seq von Guerrero, Paola A., Maitra, Anirban, Monberg, Maria E., Lee, Jaewon J, Bernard-Pagan, Vincent, Muthuswamy, Senthil

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Abstract A33: Single-cell profiling reveals subclonal vulnerabilities to therapy in patient-derived 2D and organoid models von Monberg, Maria E., Pagan, Vincent B., Semaan, Alexander, Lee, Jaewon J., Guerrero, Paola A., Muthuswamy, Senthil K., Maitra, Anirban

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