A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility von Vecchione, Loredana, Gambino, Valentina, Raaijmakers, Jonne, Schlicker, Andreas, Fumagalli, Arianna, Russo, Mariangela, Villanueva, Alberto, Beerling, Evelyne, Bartolini, Alice, Mollevi, David G., El-Murr, Nizar, Chiron, Marielle, Calvet, Loreley, Nicolazzi, Céline, Combeau, Cécile, Henry, Christophe, Simon, Iris M., Tian, Sun, in ‘t Veld, Sjors, D’ario, Giovanni, Mainardi, Sara, Beijersbergen, Roderick L., Lieftink, Cor, Linn, Sabine, Rumpf-Kienzl, Cornelia, Delorenzi, Mauro, Wessels, Lodewyk, Salazar, Ramon, Di Nicolantonio, Federica, Bardelli, Alberto, van Rheenen, Jacco, Medema, René H., Tejpar, Sabine, Bernards, René

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Bioselection of a gain of function mutation that enhances adenovirus 5 release and improves its antitumoral potency von Gros, Alena, Martínez-Quintanilla, Jordi, Puig, Cristina, Guedan, Sonia, Molleví, David G, Alemany, Ramon, Cascallo, Manel

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Can medical imaging identify the histopathological growth patterns of liver metastases? von Latacz, Emily, van Dam, Pieter-Jan, Vanhove, Christian, Llado, Laura, Descamps, Benedicte, Ruiz, Núria, Joye, Ines, Grünhagen, Dirk, Van Laere, Steven, Dirix, Piet, Mollevi, David G., Verhoef, Cornelis, Dirix, Luc, Vermeulen, Peter

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Aberrant gene expression in mucosa adjacent to tumor reveals a molecular crosstalk in colon cancer von Sanz-Pamplona, Rebeca, Berenguer, Antoni, Cordero, David, Molleví, David G, Crous-Bou, Marta, Sole, Xavier, Paré-Brunet, Laia, Guino, Elisabet, Salazar, Ramón, Santos, Cristina, de Oca, Javier, Sanjuan, Xavier, Rodriguez-Moranta, Francisco, Moreno, Victor

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Differences between CAFs and their paired NCF from adjacent colonic mucosa reveal functional heterogeneity of CAFs, providing prognostic information von Berdiel-Acer, Mireia, Sanz-Pamplona, Rebeca, Calon, Alexandre, Cuadras, Daniel, Berenguer, Antoni, Sanjuan, Xavier, Paules, Maria José, Salazar, Ramon, Moreno, Victor, Batlle, Eduard, Villanueva, Alberto, Molleví, David G.

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Noncanonical TGFβ Pathway Relieves the Blockade of IL1β/TGFβ-Mediated Crosstalk between Tumor and Stroma: TGFBR1 and TAK1 Inhibition in Colorectal Cancer von Guillén Díaz-Maroto, Natalia, Sanz-Pamplona, Rebeca, Berdiel-Acer, Mireia, Cimas, Francisco J, García, Elena, Gonçalves-Ribeiro, Samuel, Albert, Nerea, Garcia-Vicién, Gemma, Capella, Gabriel, Moreno, Victor, Salazar, Ramon, Villanueva, Alberto, Molleví, David G

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The Blockade of Tumoral IL1 beta-Mediated Signaling in Normal Colonic Fibroblasts Sensitizes Tumor Cells to Chemotherapy and Prevents Inflammatory CAF Activation von Diaz-Maroto, Natalia Guillen, Garcia-Vicien, Gemma, Polcaro, Giovanna, Banuls, Maria, Albert, Nerea, Villanueva, Alberto, Mollevi, David G.

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The Tumor Microenvironment in Liver Metastases from Colorectal Carcinoma in the Context of the Histologic Growth Patterns von Garcia-Vicien, Gemma, Mezheyeuski, Artur, Banuls, Maria, Ruiz-Roig, Nuria, Mollevi, David G.

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Lurbinectedin (PM01183), a New DNA Minor Groove Binder, Inhibits Growth of Orthotopic Primary Graft of Cisplatin-Resistant Epithelial Ovarian Cancer von VIDAL, August, MUNOZ, Clara, PUJANA, Miguel A, SALAZAR, Ramon, GIL-MARTIN, Marta, MARTI, Lola, PONCE, Jordi, MOLLEVI, David G, CAPELLA, Gabriel, CONDOM, Enric, VINALS, Francesc, HUERTAS, Dori, GUILLEN, María-José, CUEVAS, Carmen, ESTELLER, Manel, AVILES, Pablo, VILLANUEVA, Alberto, MORETO, Jemina, PUERTAS, Sara, MARTINEZ-INIESTA, Maria, FIGUERAS, Agnes, PADULLES, Laura, GARCIA-RODRIGUEZ, Francisco J, BERDIEL-ACER, Mireia

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Stromal interaction molecule 2 (STIM2) is frequently overexpressed in colorectal tumors and confers a tumor cell growth suppressor phenotype von Aytes, Alvaro, Molleví, David G., Martinez-Iniesta, Maria, Nadal, Marga, Vidal, August, Morales, Albert, Salazar, Ramón, Capellà, Gabriel, Villanueva, Alberto

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Carcinoma-associated fibroblasts affect sensitivity to oxaliplatin and 5FU in colorectal cancer cells von Gonçalves-Ribeiro, Samuel, Díaz-Maroto, Natalia Guillen, Berdiel-Acer, Mireia, Soriano, Antonio, Guardiola, Jordi, Martínez-Villacampa, Mercedes, Salazar, Ramon, Capellà, Gabriel, Villanueva, Alberto, Martínez-Balibrea, Eva, Molleví, David G

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Spatial Immunology in Liver Metastases from Colorectal Carcinoma according to the Histologic Growth Pattern von Garcia-Vicién, Gemma, Mezheyeuski, Artur, Micke, Patrick, Ruiz, Núria, Ruffinelli, José Carlos, Mils, Kristel, Bañuls, María, Molina, Natàlia, Losa, Ferran, Lladó, Laura, Molleví, David G

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A 5-gene classifier from the carcinoma-associated fibroblast transcriptomic profile and clinical outcome in colorectal cancer von Berdiel-Acer, Mireia, Berenguer, Antoni, Sanz-Pamplona, Rebeca, Cuadras, Daniel, Sanjuan, Xavier, Paules, Maria José, Santos, Cristina, Salazar, Ramon, Moreno, Victor, Capella, Gabriel, Villanueva, Alberto, Molleví, David G

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A monotonic and prognostic genomic signature from fibroblasts for colorectal cancer initiation, progression, and metastasis von Berdiel-Acer, Mireia, Cuadras, Daniel, Díaz-Maroto, Natalia Guillén, Sanjuan, Xavier, Serrano, Teresa, Berenguer, Antoni, Moreno, Victor, Gonçalves-Ribeiro, Samuel, Salazar, Ramon, Villanueva, Alberto, Molleví, David G

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Tumor Thymidylate Synthase 1494del6 Genotype As a Prognostic Factor in Colorectal Cancer Patients Receiving Fluorouracil-Based Adjuvant Treatment von DOTOR, Emma, CUATRECASES, Miriam, DE OCA, Javier, PEINADO, Miguel A, MORENO, Victor, GERMA, Josep Ramon, CAPELLD, Gabriel, VILLANUEVA, Alberto, MARTINEZ-INIESTA, Maria, NAVARRO, Matilde, VILARDELL, Felip, GUINO, Elisabeth, PAREJA, Laura, FIGUERAS, Agnés, MOLLEVI, David G, SERRANO, Teresa

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Hepatic Carcinoma—Associated Fibroblasts Promote an Adaptative Response in Colorectal Cancer Cells That Inhibit Proliferation and Apoptosis: Nonresistant Cells Die by Nonapoptotic... von Berdiel-Acer, Mireia, Bohem, Monika E, López-Doriga, Adriana, Vidal, August, Salazar, Ramon, Martínez-Iniesta, Maria, Santos, Cristina, Sanjuan, Xavier, Villanueva, Alberto, Molleví, David G

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Mutations in TP53 are a prognostic factor in colorectal hepatic metastases undergoing surgical resection von Molleví, David G., Serrano, Teresa, Ginestà, Mireia M., Valls, Joan, Torras, Jaume, Navarro, Matilde, Ramos, Emilio, Germà, Josep R., Jaurrieta, Eduardo, Moreno, Víctor, Figueras, Joan, Capellà, Gabriel, Villanueva, Alberto

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Mutanome and expression of immune response genes in microsatellite stable colon cancer von Sanz-Pamplona, Rebeca, Gil-Hoyos, Raúl, López-Doriga, Adriana, Alonso, M Henar, Aussó, Susanna, Molleví, David G, Santos, Cristina, Sanjuán, Xavier, Salazar, Ramón, Alemany, Ramón, Moreno, Víctor

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Orthoxenografts of Testicular Germ Cell Tumors Demonstrate Genomic Changes Associated with Cisplatin Resistance and Identify PDMP as a Resensitizing Agent von Piulats, Josep M, Vidal, August, García-Rodríguez, Francisco J, Muñoz, Clara, Nadal, Marga, Moutinho, Catia, Martínez-Iniesta, María, Mora, Josefina, Figueras, Agnés, Guinó, Elisabet, Padullés, Laura, Aytés, Àlvaro, Molleví, David G, Puertas, Sara, Martínez-Fernández, Carmen, Castillo, Wilmar, Juliachs, Merce, Moreno, Victor, Muñoz, Purificación, Stefanovic, Milica, Pujana, Miguel A, Condom, Enric, Esteller, Manel, Germà, Josep R, Capella, Gabriel, Farré, Lourdes, Morales, Albert, Viñals, Francesc, García-Del-Muro, Xavier, Cerón, Julián, Villanueva, Alberto

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The prognostic impact of the tumour stroma fraction: A machine learning-based analysis in 16 human solid tumour types von Micke, Patrick, Strell, Carina, Mattsson, Johanna, Martín-Bernabé, Alfonso, Brunnström, Hans, Huvila, Jutta, Sund, Malin, Wärnberg, Fredrik, Ponten, Fredrik, Glimelius, Bengt, Hrynchyk, Ina, Mauchanski, Siarhei, Khelashvili, Salome, Garcia-Vicién, Gemma, Molleví, David G., Edqvist, Per-Henrik, O´Reilly, Aine, Corvigno, Sara, Dahlstrand, Hanna, Botling, Johan, Segersten, Ulrika, Krzyzanowska, Agnieszka, Bjartell, Anders, Elebro, Jacob, Heby, Margareta, Lundgren, Sebastian, Hedner, Charlotta, Borg, David, Brändstedt, Jenny, Sartor, Hanna, Malmström, Per-Uno, Johansson, Martin, Nodin, Björn, Backman, Max, Lindskog, Cecilia, Jirström, Karin, Mezheyeuski, Artur

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