p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade von Molkentine, David P, Molkentine, Jessica M, Bridges, Kathleen A, Valdecanas, David R, Dhawan, Annika, Bahri, Reshub, Hefner, Andrew J, Kumar, Manish, Yang, Liangpeng, Abdelhakiem, Mohamed, Pifer, Phillip M, Sandulache, Vlad, Sheth, Aakash, Beadle, Beth M, Thames, Howard D, Mason, Kathryn A, Pickering, Curtis R, Meyn, Raymond E, Skinner, Heath D

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Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function von Kumar, Manish, Molkentine, David, Molkentine, Jessica, Bridges, Kathleen, Xie, Tongxin, Yang, Liangpeng, Hefner, Andrew, Gao, Meng, Bahri, Reshub, Dhawan, Annika, Frederick, Mitchell J., Seth, Sahil, Abdelhakiem, Mohamed, Beadle, Beth M., Johnson, Faye, Wang, Jing, Shen, Li, Heffernan, Timothy, Sheth, Aakash, Ferris, Robert L., Myers, Jeffrey N., Pickering, Curtis R., Skinner, Heath D.

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Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment von Garcia Garcia, Carolina J., Huang, Yanqing, Fuentes, Natividad R., Turner, Madeleine C., Monberg, Maria E., Lin, Daniel, Nguyen, Nicholas D., Fujimoto, Tara N., Zhao, Jun, Lee, Jaewon J., Bernard, Vincent, Yu, Meifang, Delahoussaye, Abagail M., Jimenez Sacarello, Iancarlos, Caggiano, Emily G., Phan, Jae L., Deorukhkar, Amit, Molkentine, Jessica M., Saur, Dieter, Maitra, Anirban, Taniguchi, Cullen M.

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MK-1775, a Novel Wee1 Kinase Inhibitor, Radiosensitizes p53-Defective Human Tumor Cells von BRIDGES, Kathleen A, HIRAI, Hiroshi, BUSER, Carolyn A, BROOKS, Colin, HUIFENG LIU, BUCHHOLZ, Thomas A, MOLKENTINE, Jessica M, MASON, Kathryn A, MEYN, Raymond E

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Tumor-Associated Fatigue in Cancer Patients Develops Independently of IL1 Signaling von Grossberg, Aaron J, Vichaya, Elisabeth G, Christian, Diana L, Molkentine, Jessica M, Vermeer, Daniel W, Gross, Phillip S, Vermeer, Paola D, Lee, John H, Dantzer, Robert

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Mitochondrial fusion exploits a therapeutic vulnerability of pancreatic cancer von Yu, Meifang, Nguyen, Nicholas D, Huang, Yanqing, Lin, Daniel, Fujimoto, Tara N, Molkentine, Jessica M, Deorukhkar, Amit, Kang, Ya'an, San Lucas, F Anthony, Fernandes, Conrad J, Koay, Eugene J, Gupta, Sonal, Ying, Haoqiang, Koong, Albert C, Herman, Joseph M, Fleming, Jason B, Maitra, Anirban, Taniguchi, Cullen M

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Neuroimmune mechanisms of behavioral alterations in a syngeneic murine model of human papilloma virus-related head and neck cancer von Vichaya, Elisabeth G, Vermeer, Daniel W, Christian, Diana L, Molkentine, Jessica M, Mason, Kathy A, Lee, John H, Dantzer, Robert

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Dasatinib, a multi-kinase inhibitor increased radiation sensitivity by interfering with nuclear localization of epidermal growth factor receptor and by blocking DNA repair pathways von Raju, Uma, Riesterer, Oliver, Wang, Zhi-Qiang, Molkentine, David P, Molkentine, Jessica M, Johnson, Faye M, Glisson, Bonnie, Milas, Luka, Ang, K. Kian

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Associative learning contributes to the persistence of fatigue-like behavior in male mice in a model of cancer survivorship von Vichaya, Elisabeth G., Darpolor, Josephine K., Gross, Phillip S., Molkentine, Jessica M., Vermeer, Daniel W., Vermeer, Paola D., Lee, John H., Taniguchi, Cullen M., Dantzer, Robert

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Enteral Activation of WR-2721 Mediates Radioprotection and Improved Survival from Lethal Fractionated Radiation von Molkentine, Jessica M., Fujimoto, Tara N., Horvath, Thomas D., Grossberg, Aaron J., Garcia, Carolina J. Garcia, Deorukhkar, Amit, de la Cruz Bonilla, Marimar, Lin, Daniel, Samuel, Errol L. G., Chan, Wai Kin, Lorenzi, Philip L., Piwnica-Worms, Helen, Dantzer, Robert, Tour, James M., Mason, Kathryn A., Taniguchi, Cullen M.

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Selective EGLN Inhibition Enables Ablative Radiotherapy and Improves Survival in Unresectable Pancreatic Cancer von Fujimoto, Tara N, Colbert, Lauren E, Huang, Yanqing, Molkentine, Jessica M, Deorukhkar, Amit, Baseler, Laura, de la Cruz Bonilla, Marimar, Yu, Meifang, Lin, Daniel, Gupta, Sonal, Cabeceiras, Peter K, Kingsley, Charles V, Tailor, Ramesh C, Sawakuchi, Gabriel O, Koay, Eugene J, Piwnica-Worms, Helen, Maitra, Anirban, Taniguchi, Cullen M

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Feasibility of administering human pancreatic cancer chemotherapy in a spontaneous pancreatic cancer mouse model von Delahoussaye, Abagail M, Abi Jaoude, Joseph, Green, Morgan, Fujimoto, Tara N, Molkentine, Jessica, Garcia Garcia, Carolina J, Gay, Jason P, Feng, Ningping, Marszalek, Joseph, Fowlkes, Natalie, Taniguchi, Cullen M

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Sickness behavior induced by cisplatin chemotherapy and radiotherapy in a murine head and neck cancer model is associated with altered mitochondrial gene expression von Vichaya, Elisabeth G., Molkentine, Jessica M., Vermeer, Daniel W., Walker, Adam K., Feng, Rebekah, Holder, Gerard, Luu, Katherine, Mason, Ryan M., Saligan, Leo, Heijnen, Cobi J., Kavelaars, Annemieke, Mason, Kathy A., Lee, John H., Dantzer, Robert

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Inhibition of P-TEFb by DRB suppresses SIRT1/CK2α pathway and enhances radiosensitivity of human cancer cells von Wang, Zhi-Qiang, Johnson, Casey L, Kumar, Amit, Molkentine, David P, Molkentine, Jessica M, Rabin, Tatiana, Mason, Kathryn A, Milas, Luka, Raju, Uma

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Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance von Thatikonda, Venu, Lyu, Hengyu, Jurado, Sabine, Kostyrko, Kaja, Bristow, Christopher A., Albrecht, Christoph, Alpar, Donat, Arnhof, Heribert, Bergner, Oliver, Bosch, Karin, Feng, Ningping, Gao, Sisi, Gerlach, Daniel, Gmachl, Michael, Hinkel, Melanie, Lieb, Simone, Jeschko, Astrid, Machado, Annette A., Madensky, Thomas, Marszalek, Ethan D., Mahendra, Mikhila, Melo-Zainzinger, Gabriella, Molkentine, Jessica M., Jaeger, Philipp A., Peng, David H., Schenk, Robyn L., Sorokin, Alexey, Strauss, Sandra, Trapani, Francesca, Kopetz, Scott, Vellano, Christopher P., Petronczki, Mark, Kraut, Norbert, Heffernan, Timothy P., Marszalek, Joseph R., Pearson, Mark, Waizenegger, Irene C., Hofmann, Marco H.

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(S033) Questioning the Role of Inflammation in Tumor-Induced Fatigue von Grossberg, Aaron, MD, PhD, Vichaya, Elisabeth, PhD, Christian, Diana, BS, Molkentine, Jessica M., BS, Heijnen, Cobi J., PhD, Kavelaars, Annemieke, PhD, Vermeer, Daniel, BS, Lee, John H., MD, Dantzer, Robert, DVM, PhD

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TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects von Wang, L, Zhang, P, Molkentine, D P, Chen, C, Molkentine, J M, Piao, H, Raju, U, Zhang, J, Valdecanas, D R, Tailor, R C, Thames, H D, Buchholz, T A, Chen, J, Ma, L, Mason, K A, Ang, K-K, Meyn, R E, Skinner, H D

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FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner von Pifer, Phillip M, Yang, Liangpeng, Kumar, Manish, Xie, Tongxin, Frederick, Mitchell, Hefner, Andrew, Beadle, Beth, Molkentine, David, Molkentine, Jessica, Dhawan, Annika, Abdelhakiem, Mohamed, Osman, Abdullah A, Leibowitz, Brian J, Myers, Jeffrey N, Pickering, Curtis R, Sandulache, Vlad C, Heymach, John, Skinner, Heath D

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Fasting Reduces Intestinal Radiotoxicity, Enabling Dose-Escalated Radiation Therapy for Pancreatic Cancer von de la Cruz Bonilla, Marimar, Stemler, Kristina M., Jeter-Jones, Sabrina, Fujimoto, Tara N., Molkentine, Jessica, Asencio Torres, Gabriela M., Zhang, Xiaomei, Broaddus, Russell R., Taniguchi, Cullen M., Piwnica-Worms, Helen

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Effect of stereotactic radiation (SBRT) on survival in a preclinical model of spontaneous pancreatic cancer with induction gemcitabine/nab-paclitaxel von Taniguchi, Cullen M., Molkentine, Jessica, Fujimoto, Tara N, Colbert, Lauren Elizabeth, Deorukhkar, Amit, Herman, Joseph M.

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