Murine Models of Sepsis and Trauma: Can We Bridge the Gap? von Stortz, Julie A., Raymond, Steven L., Mira, Juan C., Moldawer, Lyle L., Mohr, Alicia M., Efron, Philip A.

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Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome von Mira, Juan C., Gentile, Lori F., Mathias, Brittany J., Efron, Philip A., Brakenridge, Scott C., Mohr, Alicia M., Moore, Frederick A., Moldawer, Lyle L.

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Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome von Hawkins, Russell B, Raymond, Steven L, Stortz, Julie A, Horiguchi, Hiroyuki, Brakenridge, Scott C, Gardner, Anna, Efron, Philip A, Bihorac, Azra, Segal, Mark, Moore, Frederick A, Moldawer, Lyle L

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Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab von Hotchkiss, Richard S., Colston, Elizabeth, Yende, Sachin, Crouser, Elliott D., Martin, Greg S., Albertson, Timothy, Bartz, Raquel R., Brakenridge, Scott C., Delano, Matthew J., Park, Pauline K., Donnino, Michael W., Tidswell, Mark, Mayr, Florian B., Angus, Derek C., Coopersmith, Craig M., Moldawer, Lyle L., Catlett, Ian M., Girgis, Ihab G., Ye, June, Grasela, Dennis M.

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Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis von Hollen, McKenzie K, Stortz, Julie A, Darden, Dijoia, Dirain, Marvin L, Nacionales, Dina C, Hawkins, Russell B, Cox, Michael C, Lopez, Maria-Cecilia, Rincon, Jaimar C, Ungaro, Ricardo, Wang, Zhongkai, Wu, Quran, Brumback, Babette, Gauthier, Marie-Pierre L, Kladde, Michael, Leeuwenburgh, Christiaan, Segal, Mark, Bihorac, Azra, Brakenridge, Scott, Moore, Frederick A, Baker, Henry V, Mohr, Alicia M, Moldawer, Lyle L, Efron, Philip A

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Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients von Stortz, Julie A, Mira, Juan C, Raymond, Steven L, Loftus, Tyler J, Ozrazgat-Baslanti, Tezcan, Wang, Zhongkai, Ghita, Gabriela L, Leeuwenburgh, Christiaan, Segal, Mark S, Bihorac, Azra, Brumback, Babette A, Mohr, Alicia M, Efron, Philip A, Moldawer, Lyle L, Moore, Frederick A, Brakenridge, Scott C

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Mice are not men von Warren, H. Shaw, Tompkins, Ronald G., Moldawer, Lyle L., Seok, Junhee, Xu, Weihong, Mindrinos, Michael N., Maier, Ronald V., Xiao, Wenzhong, Davis, Ronald W.

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The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical intensive care unit patients von Brakenridge, Scott C, Efron, Philip A, Stortz, Julie A, Ozrazgat-Baslanti, Teczan, Ghita, Gabriela, Wang, Zhongkai, Bihorac, Azra, Mohr, Alicia M, Brumback, Babette A, Moldawer, Lyle L, Moore, Frederick A

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Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy von Horiguchi, Hiroyuki, Loftus, Tyler J, Hawkins, Russell B, Raymond, Steven L, Stortz, Julie A, Hollen, McKenzie K, Weiss, Brett P, Miller, Elizabeth S, Bihorac, Azra, Larson, Shawn D, Mohr, Alicia M, Brakenridge, Scott C, Tsujimoto, Hironori, Ueno, Hideki, Moore, Frederick A, Moldawer, Lyle L, Efron, Philip A

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Defining critical illness using immunological endotypes in patients with and without sepsis: a cohort study von Balch, Jeremy A, Chen, Uan-I, Liesenfeld, Oliver, Starostik, Petr, Loftus, Tyler J, Efron, Philip A, Brakenridge, Scott C, Sweeney, Timothy E, Moldawer, Lyle L

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Unique transcriptomic response to sepsis is observed among patients of different age groups von Raymond, Steven L, López, María Cecilia, Baker, Henry V, Larson, Shawn D, Efron, Philip A, Sweeney, Timothy E, Khatri, Purvesh, Moldawer, Lyle L, Wynn, James L

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Phenotypic heterogeneity by site of infection in surgical sepsis: a prospective longitudinal study von Stortz, Julie A., Cox, Michael C., Hawkins, Russell B., Ghita, Gabriela L., Brumback, Babette A., Mohr, Alicia M., Moldawer, Lyle L., Efron, Philip A., Brakenridge, Scott C., Moore, Frederick A.

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DAMPs, PAMPs, and the origins of SIRS in bacterial sepsis von Gentile, Lori F, Moldawer, Lyle L

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Intravenously administered interleukin-7 to reverse lymphopenia in patients with septic shock: a double-blind, randomized, placebo-controlled trial von Daix, Thomas, Mathonnet, Armelle, Brakenridge, Scott, Dequin, Pierre-François, Mira, Jean-Paul, Berbille, Frederique, Morre, Michel, Jeannet, Robin, Blood, Teresa, Unsinger, Jacqueline, Blood, Jane, Walton, Andrew, Moldawer, Lyle L., Hotchkiss, Richard, François, Bruno

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Apoptosis in sepsis: a new target for therapeutic exploration von Oberholzer, C, Oberholzer, A, Clare-Salzler, M, Moldawer, L L

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The impact of sarcopenia and acute muscle mass loss on long‐term outcomes in critically ill patients with intra‐abdominal sepsis von Cox, Michael C., Booth, Matthew, Ghita, Gabriela, Wang, Zhongkai, Gardner, Anna, Hawkins, Russell B., Darden, Dijoia B., Leeuwenburgh, Christiaan, Moldawer, Lyle L., Moore, Frederick A., Efron, Philip A., Anton, Steven, Brakenridge, Scott C.

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Sepsis syndromes : Understanding the role of innate and acquired immunity von OBERHOLZER, Andreas, OBERHOLZER, Caroline, MOLDAWER, Lyle L

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B cells enhance early innate immune responses during bacterial sepsis von Kelly-Scumpia, Kindra M, Scumpia, Philip O, Weinstein, Jason S, Delano, Matthew J, Cuenca, Alex G, Nacionales, Dina C, Wynn, James L, Lee, Pui Y, Kumagai, Yutaro, Efron, Philip A, Akira, Shizuo, Wasserfall, Clive, Atkinson, Mark A, Moldawer, Lyle L

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Overlapping but Disparate Inflammatory and Immunosuppressive Responses to SARS-CoV-2 and Bacterial Sepsis: An Immunological Time Course Analysis von Loftus, Tyler J., Ungaro, Ricardo, Dirain, Marvin, Efron, Philip A., Mazer, Monty B., Remy, Kenneth E., Hotchkiss, Richard S., Zhong, Luer, Bacher, Rhonda, Starostik, Petr, Moldawer, Lyle L., Brakenridge, Scott C.

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Dysregulated Immunity and Immunotherapy after Sepsis von Darden, Dijoia B., Kelly, Lauren S., Fenner, Brittany P., Moldawer, Lyle L., Mohr, Alicia M., Efron, Philip A.

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