Development and Manufacturing GMP Scale-Up of a Continuous Ir-Catalyzed Homogeneous Reductive Amination Reaction von May, Scott A, Johnson, Martin D, Buser, Jonas Y, Campbell, Alison N, Frank, Scott A, Haeberle, Brian D, Hoffman, Philip C, Lambertus, Gordon R, McFarland, Adam D, Moher, Eric D, White, Timothy D, Hurley, D. Declan, Corrigan, Aoife P, Gowran, Olivia, Kerrigan, Niall G, Kissane, Marie G, Lynch, Regina R, Sheehan, Paul, Spencer, Richard D, Pulley, Shon R, Stout, James R

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Synthesis of Methyl 7,9-Dimethyl-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carboxylate and Its Analogues von Vaid, Radhe K., Boini, Sathish K., Alt, Charles A., Spitler, Jeremy T., Hadden, Chad E., Frank, Scott A., Moher, Eric D.

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Leveraging an Industrial–Academic Partnership To Optimize Small Molecule Process Development within the Pharmaceutical Industry von Deasy, Rebecca E, Slattery, Catherine N, Kissane, Marie, McNamara, Orla A, Lynch, Denis, Maguire, Anita R, Moynihan, Humphrey A, O’Keeffe, Sarah, Kopach, Michael E, Mitchell, David, Magnus, Nicholas A, Kjell, Douglas P, Moher, Eric D

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Catalytic Regioselective Sulfonylation of α-Chelatable Alcohols:  Scope and Mechanistic Insight von Martinelli, Michael J, Vaidyanathan, Rajappa, Pawlak, Joseph M, Nayyar, Naresh K, Dhokte, Ulhas P, Doecke, Christopher W, Zollars, Lisa M. H, Moher, Eric D, Khau, Vien Van, Košmrlj, Berta

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Dibutyltin Oxide Catalyzed Selective Sulfonylation of α-Chelatable Primary Alcohols von Martinelli, Michael J, Nayyar, Naresh K, Moher, Eric D, Dhokte, Ulhas P, Pawlak, Joseph M, Vaidyanathan, Rajappa

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Mechanistic investigation of a Ru-catalyzed direct asymmetric reductive amination reaction for a batch or continuous process scale-up: an industrial perspective von Changi, Shujauddin M., Yokozawa, Tohru, Yamamoto, Tetsuya, Nakajima, Hikaru, Embry, Matthew C., Vaid, Radhe, Luciani, Carla V., Wong, Sze-Wing, Johnson, Martin, Moher, Eric D.

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Cryptophycins-309, 249 and other cryptophycin analogs: preclinical efficacy studies with mouse and human tumors von Liang, Jian, Moore, Richard E, Moher, Eric D, Munroe, John E, Al-awar, Rima S, Hay, David A, Varie, David L, Zhang, Tony Y, Aikins, James A, Martinelli, Michael J, Shih, Chuan, Ray, James E, Gibson, Lowell L, Vasudevan, Vasu, Polin, Lisa, White, Kathryn, Kushner, Juiwanna, Simpson, Chiab, Pugh, Susan, Corbett, Thomas H

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Process Development for a Key Synthetic Intermediate of LY2140023, a Clinical Candidate for the Treatment of Schizophrenia von Waser, Mario, Moher, Eric D., Borders, Sandy S. K., Hansen, Marvin M., Hoard, David W., Laurila, Michael E., LeTourneau, Michael E., Miller, Richard D., Phillips, Michael L., Sullivan, Kevin A., Ward, Jeffrey A., Xie, Chaoyu, Bye, Cheryl A., Leitner, Tanja, Herzog-Krimbacher, Brigitte, Kordian, Marcus, Müllner, Martin

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Synthesis of Cryptophycin 52 Using the Shi Epoxidation von Hoard, David W, Moher, Eric D, Martinelli, Michael J, Norman, Bryan H

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Design, Development, and Scale-Up of a Selective meso-Epoxide Desymmetrization Process von Varie, David L, Beck, Christopher, Borders, Sandra K, Brady, Molly D, Cronin, Jason S, Ditsworth, Tracy K, Hay, David A, Hoard, David W, Hoying, Richard C, Linder, Ryan J, Miller, Richard D, Moher, Eric D, Remacle, Jacob R, Rieck, John A, Anderson, David D, Dodson, Paul N, Forst, Mindy B, Pierson, Duane A, Turpin, Joseph A

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Synthesis of Cryptophycin 52 Using the Sharpless Asymmetric Dihydroxylation:  Diol to Epoxide Transformation Optimized for a Base-Sensitive Substrate von Liang, Jian, Moher, Eric D, Moore, Richard E, Hoard, David W

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(2S,1‘S,2‘R,3‘R)-2-(2‘-Carboxy-3‘-hydroxymethylcyclopropyl) Glycine Is a Highly Potent Group 2 and 3 Metabotropic Glutamate Receptor Agonist with Oral Activity von Collado, Iván, Pedregal, Concepción, Bueno, Ana Belén, Marcos, Alicia, González, Rosario, Blanco-Urgoiti, Jaime, Pérez-Castells, Javier, Schoepp, Darryle D, Wright, Rebecca A, Johnson, Bryan G, Kingston, Ann E, Moher, Eric D, Hoard, David W, Griffey, Kelly I, Tizzano, Joseph P

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Synthetic studies on quassinoids: total synthesis of (-)-chaparrinone, (-)-glaucarubolone, and (+)-glaucarubinone von Grieco, Paul A, Collins, Jon L, Moher, Eric D, Fleck, Thomas J, Gross, Raymond S

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Synthesis of Unit A of Cryptophycin via a [2,3]-Wittig Rearrangement von Liang, Jian, Hoard, David W, Khau, Vien Van, Martinelli, Michael J, Moher, Eric D, Moore, Richard E, Tius, Marcus A

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TMG catalyzed cyclopropanation of cyclopentenone. Illustration by a simple synthesis of bicyclo[3.1.0]hexane-2-one derivatives von Zhang, Fuyao, Moher, Eric D., Zhang, Tony Y.

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Synthetic studies on quassinoids: total synthesis of simalikalactone D and assignment of the absolute configuration of the .alpha.-methylbutyrate ester side chain von Moher, Eric D, Collins, Jon L, Grieco, Paul A

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(R)-(+)- and (S)-(-)-5-Ethyl-5-methyl-1,3-dioxolane-2,4-dione reagents for the direct preparation of .alpha.-hydroxy-.alpha.-methylbutyrate esters: assignment of the absolute confi... von Moher, Eric D, Grieco, Paul A, Collins, Jon L

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Synthetic Studies on Quassinoids:  Transformation of (−)-Glaucarubolone into (−)-Peninsularinone. In Vivo Antitumor Evaluation of (−)-Glaucarubolone, (−)-Chaparrinone, and (−)-Peni... von Moher, Eric D, Reilly, Michael, Grieco, Paul A, Corbett, Thomas H, Valeriote, Frederick A

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Synthesis of (R)-(−)-1-Piperidino-3,3-dimethylbutan-2-ol:  Application in the Molar Scale Asymmetric Ethylation of trans-Crotonaldehyde von Hoard, David W, Moher, Eric D, Turpin, Joseph A

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ChemInform Abstract: Synthesis of Methyl 7,9-Dimethyl-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carboxylate and Its Analogues von Vaid, Radhe K., Boini, Sathish K., Alt, Charles A., Spitler, Jeremy T., Hadden, Chad E., Frank, Scott A., Moher, Eric D.

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