Specific biomarkers for C9orf72 FTD/ALS could expedite the journey towards effective therapies von Balendra, R, Moens, TG, Isaacs, AM

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Genetic models of C9orf72: What is toxic? von Moens, TG, Partridge, L, Isaacs, AM

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Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD von Moens, TG, Mizielinska, S, Niccoli, T, Mitchell, JS, Thoeng, A, Ridler, CE, Grönke, S, Esser, J, Heslegrave, A, Zetterberg, H, Partridge, L, Isaacs, AM

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C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A von Moens, TG, Niccoli, T, Wilson, KM, Atilano, ML, Birsa, N, Gittings, LM, Holbling, BV, Dyson, MC, Thoeng, A, Neeves, J, Glaria, I, Yu, L, Bussmann, J, Storkebaum, E, Pardo, M, Choudhary, JS, Fratta, P, Partridge, L, Isaacs, AM

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G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo von Simone, R, Balendra, R, Moens, TG, Preza, E, Wilson, KM, Heslegrave, A, Woodling, NS, Niccoli, T, Gilbert-Jaramillo, J, Abdelkarim, S, Clayton, EL, Clarke, M, Konrad, M-T, Nicoll, AJ, Mitchell, JS, Calvo, A, Chio, A, Houlden, H, Polke, JM, Ismail, MA, Stephens, CE, Vo, T, Farahat, AA, Wilson, WD, Boykin, DW, Zetterberg, H, Partridge, L, Wray, S, Parkinson, G, Neidle, S, Patani, R, Fratta, P, Isaacs, AM

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A Genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology von Matarin, M, Perona, M, Salih, DA, Yasvoina, M, Cummings, DM, Liu, W, NahabooSolim, MA, Moens, TG, Paublete, RM, Ali, SS, Edwards, FA, Guelfi, S, Hardy, J, Latcham, J, Fulleylove, M, Richardson, JC, Desai, R, Smith, KJ

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