Loss of Bin1 Promotes the Propagation of Tau Pathology von Calafate, Sara, Flavin, William, Verstreken, Patrik, Moechars, Diederik

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BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease von Barão, Soraia, Moechars, Diederik, Lichtenthaler, Stefan F, De Strooper, Bart

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LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis von Matta, Samer, Van Kolen, Kristof, da Cunha, Raquel, van den Bogaart, Geert, Mandemakers, Wim, Miskiewicz, Katarzyna, De Bock, Pieter-Jan, Morais, Vanessa A., Vilain, Sven, Haddad, Dominik, Delbroek, Lore, Swerts, Jef, Chávez-Gutiérrez, Lucía, Esposito, Giovanni, Daneels, Guy, Karran, Eric, Holt, Matthew, Gevaert, Kris, Moechars, Diederik W., De Strooper, Bart, Verstreken, Patrik

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A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment von Van Hove, Hannah, Martens, Liesbet, Scheyltjens, Isabelle, De Vlaminck, Karen, Pombo Antunes, Ana Rita, De Prijck, Sofie, Vandamme, Niels, De Schepper, Sebastiaan, Van Isterdael, Gert, Scott, Charlotte L., Aerts, Jeroen, Berx, Geert, Boeckxstaens, Guy E., Vandenbroucke, Roosmarijn E., Vereecke, Lars, Moechars, Diederik, Guilliams, Martin, Van Ginderachter, Jo A., Saeys, Yvan, Movahedi, Kiavash

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Tau association with synaptic vesicles causes presynaptic dysfunction von Zhou, Lujia, McInnes, Joseph, Wierda, Keimpe, Holt, Matthew, Herrmann, Abigail G., Jackson, Rosemary J., Wang, Yu-Chun, Swerts, Jef, Beyens, Jelle, Miskiewicz, Katarzyna, Vilain, Sven, Dewachter, Ilse, Moechars, Diederik, De Strooper, Bart, Spires-Jones, Tara L., De Wit, Joris, Verstreken, Patrik

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Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation von Calafate, Sara, Buist, Arjan, Miskiewicz, Katarzyna, Vijayan, Vinoy, Daneels, Guy, de Strooper, Bart, de Wit, Joris, Verstreken, Patrik, Moechars, Diederik

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Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo von Vasconcelos, Bruno, Stancu, Ilie-Cosmin, Buist, Arjan, Bird, Matthew, Wang, Peng, Vanoosthuyse, Alexandre, Van Kolen, Kristof, Verheyen, An, Kienlen-Campard, Pascal, Octave, Jean-Noël, Baatsen, Peter, Moechars, Diederik, Dewachter, Ilse

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Clinical evaluation of [18F] JNJ-64326067, a novel candidate PET tracer for the detection of tau pathology in Alzheimer’s disease von Schmidt, Mark E., Janssens, Luc, Moechars, Diederik, Rombouts, Frederik J. R., Timmers, Maarten, Barret, Olivier, Constantinescu, Cristian C., Madonia, Jennifer, Russell, David S., Sandiego, Christine M., Kolb, Hartmuth

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Requirement of central ghrelin signaling for alcohol reward von Jerlhag, Elisabet, Egecioglu, Emil, Landgren, Sara, Salomé, Nicolas, Heilig, Markus, Moechars, Diederik, Datta, Rakesh, Perrissoud, Daniel, Dickson, Suzanne L, Engel, Jörgen A

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LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism von Arranz, Amaia M, Delbroek, Lore, Van Kolen, Kristof, Guimarães, Marco R, Mandemakers, Wim, Daneels, Guy, Matta, Samer, Calafate, Sara, Shaban, Hamdy, Baatsen, Pieter, De Bock, Pieter-Jan, Gevaert, Kris, Vanden Berghe, Pieter, Verstreken, Patrik, De Strooper, Bart, Moechars, Diederik

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Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice von Peeraer, Eve, Bottelbergs, Astrid, Van Kolen, Kristof, Stancu, Ilie-Cosmin, Vasconcelos, Bruno, Mahieu, Michel, Duytschaever, Hilde, Ver Donck, Luc, Torremans, An, Sluydts, Ellen, Van Acker, Nathalie, Kemp, John A, Mercken, Marc, Brunden, Kurt R, Trojanowski, John Q, Dewachter, Ilse, Lee, Virginia M.Y, Moechars, Diederik

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Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice von Stancu, Ilie-Cosmin, Vasconcelos, Bruno, Ris, Laurence, Wang, Peng, Villers, Agnès, Peeraer, Eve, Buist, Arjan, Terwel, Dick, Baatsen, Peter, Oyelami, Tutu, Pierrot, Nathalie, Casteels, Cindy, Bormans, Guy, Kienlen-Campard, Pascal, Octave, Jean-Nöel, Moechars, Diederik, Dewachter, Ilse

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Discovery of N‑(4‑[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer von Rombouts, Frederik J. R, Declercq, Lieven, Andrés, José-Ignacio, Bottelbergs, Astrid, Chen, Lu, Iturrino, Laura, Leenaerts, Joseph E, Mariën, Jonas, Song, Fengbin, Wintmolders, Cindy, Wuyts, Stijn, Xia, Chunfang A, te Riele, Paula, Bormans, Guy, Vandenberghe, Rik, Kolb, Hartmuth, Moechars, Diederik

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The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates von Ferreira, Andreia, Royaux, Ines, Liu, Jian, Wang, Zhangjie, Su, Guowei, Moechars, Diederik, Callewaert, Nico, De Muynck, Louis

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Comparison of New Tau PET-Tracer Candidates With [18F]T808 and [18F]T807 von Declercq, Lieven, Celen, Sofie, Lecina, Joan, Ahamed, Muneer, Tousseyn, Thomas, Moechars, Diederik, Alcazar, Jesus, Ariza, Manuela, Fierens, Katleen, Bottelbergs, Astrid, Mariën, Jonas, Vandenberghe, Rik, Andres, Ignacio Jose, Van Laere, Koen, Verbruggen, Alfons, Bormans, Guy

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Vesicular Glutamate Transporter VGLUT2 Expression Levels Control Quantal Size and Neuropathic Pain von Moechars, Diederik, Weston, Matthew C, Leo, Sandra, Callaerts-Vegh, Zsuzsanna, Goris, Ilse, Daneels, Guy, Buist, A, Cik, M, van der Spek, P, Kass, Stefan, Meert, Theo, D'Hooge, Rudi, Rosenmund, Christian, Hampson, R. Mark

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microRNA-132 regulates gene expression programs involved in microglial homeostasis von Walgrave, Hannah, Penning, Amber, Tosoni, Giorgia, Snoeck, Sarah, Davie, Kristofer, Davis, Emma, Wolfs, Leen, Sierksma, Annerieke, Mars, Mayte, Bu, Taofeng, Thrupp, Nicola, Zhou, Lujia, Moechars, Diederik, Mancuso, Renzo, Fiers, Mark, Howden, Andrew J.M., De Strooper, Bart, Salta, Evgenia

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The Dynamics and Turnover of Tau Aggregates in Cultured Cells von Guo, Jing L., Buist, Arjan, Soares, Alberto, Callaerts, Kathleen, Calafate, Sara, Stevenaert, Frederik, Daniels, Joshua P., Zoll, Bryan E., Crowe, Alex, Brunden, Kurt R., Moechars, Diederik, Lee, Virginia M.Y.

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Fragment Binding to β‑Secretase 1 without Catalytic Aspartate Interactions Identified via Orthogonal Screening Approaches von Rombouts, Frederik J. R, Alexander, Richard, Cleiren, Erna, De Groot, Alex, Carpentier, Michel, Dijkmans, Joyce, Fierens, Katleen, Masure, Stefan, Moechars, Diederik, Palomino-Schätzlein, Martina, Pineda-Lucena, Antonio, Trabanco, Andrés A, Van Glabbeek, Daan, Vos, Ann, Tresadern, Gary

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Time course of tinnitus development following noise exposure in mice von Turner, Jeremy, Larsen, Deb, Hughes, Larry, Moechars, Diederik, Shore, Susan

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