Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma von Lee, Alexander H., Sun, Lu, Mochizuki, Aaron Y., Reynoso, Jeremy G., Orpilla, Joey, Chow, Frances, Kienzler, Jenny C., Everson, Richard G., Nathanson, David A., Bensinger, Steven J., Liau, Linda M., Cloughesy, Timothy, Hugo, Willy, Prins, Robert M.

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Evidence for Innate and Adaptive Immune Responses in a Cohort of Intractable Pediatric Epilepsy Surgery Patients von Owens, Geoffrey C, Garcia, Alejandro J, Mochizuki, Aaron Y, Chang, Julia W, Reyes, Samuel D, Salamon, Noriko, Prins, Robert M, Mathern, Gary W, Fallah, Aria

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A Pilot Study of Low-Dose Craniospinal Irradiation in Patients With Newly Diagnosed Average-Risk Medulloblastoma von Minturn, Jane E, Mochizuki, Aaron Y, Partap, Sonia, Belasco, Jean B, Lange, Beverly J, Li, Yimei, Phillips, Peter C, Gibbs, Iris C, Fisher, Paul G, Fisher, Michael J, Janss, Anna J

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GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas von Majzner, Robbie G., Ramakrishna, Sneha, Yeom, Kristen W., Patel, Shabnum, Chinnasamy, Harshini, Schultz, Liora M., Richards, Rebecca M., Jiang, Li, Barsan, Valentin, Mancusi, Rebecca, Geraghty, Anna C., Good, Zinaida, Mochizuki, Aaron Y., Gillespie, Shawn M., Toland, Angus Martin Shaw, Mahdi, Jasia, Reschke, Agnes, Nie, Esther H., Chau, Isabelle J., Rotiroti, Maria Caterina, Mount, Christopher W., Baggott, Christina, Mavroukakis, Sharon, Egeler, Emily, Moon, Jennifer, Erickson, Courtney, Green, Sean, Kunicki, Michael, Fujimoto, Michelle, Ehlinger, Zach, Reynolds, Warren, Kurra, Sreevidya, Warren, Katherine E., Prabhu, Snehit, Vogel, Hannes, Rasmussen, Lindsey, Cornell, Timothy T., Partap, Sonia, Fisher, Paul G., Campen, Cynthia J., Filbin, Mariella G., Grant, Gerald, Sahaf, Bita, Davis, Kara L., Feldman, Steven A., Mackall, Crystal L., Monje, Michelle

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Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma von Cloughesy, Timothy F., Mochizuki, Aaron Y., Orpilla, Joey R., Hugo, Willy, Lee, Alexander H., Davidson, Tom B., Wang, Anthony C., Ellingson, Benjamin M., Rytlewski, Julie A., Sanders, Catherine M., Kawaguchi, Eric S., Du, Lin, Li, Gang, Yong, William H., Gaffey, Sarah C., Cohen, Adam L., Mellinghoff, Ingo K., Lee, Eudocia Q., Reardon, David A., O’Brien, Barbara J., Butowski, Nicholas A., Nghiemphu, Phioanh L., Clarke, Jennifer L., Arrillaga-Romany, Isabel C., Colman, Howard, Kaley, Thomas J., de Groot, John F., Liau, Linda M., Wen, Patrick Y., Prins, Robert M.

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Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma von Ladomersky, Erik, Zhai, Lijie, Lauing, Kristen L, Bell, April, Xu, Jiahui, Kocherginsky, Masha, Zhang, Bin, Wu, Jennifer D, Podojil, Joseph R, Platanias, Leonidas C, Mochizuki, Aaron Y, Prins, Robert M, Kumthekar, Priya, Raizer, Jeffrey J, Dixit, Karan, Lukas, Rimas V, Horbinski, Craig, Wei, Min, Zhou, Changyou, Pawelec, Graham, Campisi, Judith, Grohmann, Ursula, Prendergast, George C, Munn, David H, Wainwright, Derek A

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Germline PTCH1: c.361_362insAlu alteration identified by comprehensive exome and RNA sequencing in a patient with Gorlin syndrome von Mochizuki, Aaron Y., Nagaraj, Chinmayee B., Depoorter, Douglas, Schieffer, Kathleen M., Kim, Sun Young

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Precision Medicine in Pediatric Neurooncology: A Review von Mochizuki, Aaron Y, Frost, Isaura M, Mastrodimos, Melina B, Plant, Ashley S, Wang, Anthony C, Moore, Theodore B, Prins, Robert M, Weiss, Paul S, Jonas, Steven J

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IMMU-17. A PHASE I STUDY OF INTRATUMORAL/PERITUMORAL HERPES SIMPLEX VIRUS-1 MUTANT HSV1716 IN PATIENTS WITH REFRACTORY OF RECURRENT HIGH-GRADE GLIOMAS: A PEDIATRIC BRAIN TUMOR CONS... von Mochizuki, Aaron Y, Hummel, Trent R, Cripe, Timothy, Fouladi, Maryam, Stevenson, Charles B, Pollack, Ian, Mitchell, Duane, Poussaint, Tina Young, Onar-Thomas, Arzu, DeWire-Schottmiller, Mariko, Pillay-Smiley, Natasha

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At the forefront of medical research: our cover authors share their hopes for their fields

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Intratumoral/Peritumoral Herpes Simplex Virus-1 Mutant HSV1716 in Pediatric Patients with Refractory or Recurrent High-Grade Gliomas: A Report of the Pediatric Brain Tumor Consorti... von Mochizuki, Aaron Y., Hummel, Trent R., Cripe, Timothy, Fouladi, Maryam, Pollack, Ian F., Mitchell, Duane, Young Poussaint, Tina, Onar-Thomas, Arzu, Pillay-Smiley, Natasha, DeWire-Schottmiller, Mariko, Stevenson, Charles B.

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Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma von Cloughesy, Timothy F, Mochizuki, Aaron Y, Orpilla, Joey R, Hugo, Willy, Lee, Alexander H, Davidson, Tom B, Wang, Anthony C

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Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma von Cloughesy, Timothy F, Mochizuki, Aaron Y, Orpilla, Joey R, Hugo, Willy, Lee, Alexander H, Davidson, Tom B, Wang, Anthony C

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