Assessment of Presystemic and Systemic Intestinal Availability of Orally Administered Drugs Using In Vitro and In Vivo Data in Humans: Intestinal Sulfation Metabolism Impacts Presy... von Mizuma, Takashi

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Intestinal glucuronidation metabolism may have a greater impact on oral bioavailability than hepatic glucuronidation metabolism in humans: A study with raloxifene, substrate for UG... von Mizuma, Takashi

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Kinetic Impact of Presystemic Intestinal Metabolism on Drug Absorption: Experiment and Data Analysis for the Prediction of In Vivo Absorption from In Vitro Data von Mizuma, Takashi

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Kinetic assessment of luminal degradation of orally effective prodrugs for rational drug development von Mizuma, Takashi

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Dietary polyphenols (−)-epicatechin and chrysin inhibit intestinal glucuronidation metabolism to increase drug absorption von Mizuma, Takashi, Awazu, Shoji

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Concentration-Dependent Atypical Intestinal Absorption of Cyclic Phenylalanylserine: Small Intestine Acts as an Interface between the Body and Ingested Compounds von Mizuma, Takashi, Narasaka, Takuo, Awazu, Shoji

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Does the well-stirred model assess the intestinal first-pass effect well? von Mizuma, Takashi, Tsuji, Akira, Hayashi, Masahiro

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Factors Affecting Glucuronidation Activity in Caco-2 Cells von Mizuma, Takashi, Momota, Ryoichi, Haga, Makoto, Hayashi, Masahiro

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Intestinal transport and metabolism of glucose-conjugated kyotorphin and cyclic kyotorphin: metabolic degradation is crucial to intestinal absorption of peptide drugs von Mizuma, Takashi, Koyanagi, Akihiro, Awazu, Shoji

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Predictability of the covalent binding of acidic drugs in man von Benet, Leslie Z., Spahn-Langguth, Hildegard, Iwakawa, Seigo, Volland, Christine, Mizuma, Takashi, Mayer, Sascha, Mutschler, Ernst, Lin, Emil T.

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A Toxicity Risk Index, An Index for Warning Idiosyncratic Drug Toxicity von Morimoto, Miyoshi, Samizo, Kazuo, Ohta, Shin, Mizuma, Takashi

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Uptake of cyclic dipeptide by PEPT1 in Caco-2 cells: phenolic hydroxyl group of substrate enhances affinity for PEPT1 von Mizuma, Takashi, Narasaka, Takuo, Awazu, Shoji

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Inhibitory effect of phloridzin and phloretin on glucuronidation of p-nitrophenol, acetaminophen and 1-naphthol: kinetic demonstration of the influence of glucuronidation metabolis... von Mizuma, Takashi, Awazu, Shoji

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Impact of intestinal metabolism on drug development von Mizuma, Takashi

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Human serum albumin binding of 3, 5, 6, 7, 8, 3’, 4’- heptamethoxyflavone, a citrus flavonoid possessing a neuroprotective effect von Kakiuchi, Ayano, Ito, Shion, Okuyama, Satoshi, Furukawa, Yoshiko, Mizuma, Takashi

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Intestinal active absorption of sugar-conjugated compounds by glucose transport system: implication of improvement of poorly absorbable drugs von Mizuma, Takashi, Ohta, Kunihiro, Hayashi, Masahiro, Awazu, Shoji

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Pharmacokinetic strategy for designing orally effective prodrugs overcoming biological membrane barriers von Mizuma, Takashi

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Improvement of Intestinal Absorption of Leucine Enkephalin by Sugar Coupling and Peptidase Inhibitors von Mizuma, Takashi, Ohta, Kunihiro, Koyanagi, Akihiro, Awazu, Shoji

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Integrated pharmacokinetic assessment and strategy for orally effective prodrugs overcoming luminal degradation and biological membrane barriers von Mizuma, Takashi

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Pharmacokinetic strategy for designing orally effective prodrugs overcoming biological membrane barriers: proposal of kinetic classification and criteria for membrane-permeable pro... von Mizuma, Takashi

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