Lenvatinib induces death of human hepatocellular carcinoma cells harboring an activated FGF signaling pathway through inhibition of FGFR–MAPK cascades von Hoshi, Taisuke, Watanabe Miyano, Saori, Watanabe, Hideki, Sonobe, Regina Mikie Kanada, Seki, Yuki, Ohta, Etsuko, Nomoto, Kenichi, Matsui, Junji, Funahashi, Yasuhiro

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E7090, a Novel Selective Inhibitor of Fibroblast Growth Factor Receptors, Displays Potent Antitumor Activity and Prolongs Survival in Preclinical Models von Watanabe Miyano, Saori, Yamamoto, Yuji, Kodama, Kotaro, Miyajima, Yukiko, Mikamoto, Masaki, Nakagawa, Takayuki, Kuramochi, Hiroko, Funasaka, Setsuo, Nagao, Satoshi, Sugi, Naoko Hata, Okamoto, Kiyoshi, Minoshima, Yukinori, Nakatani, Yusuke, Karoji, Yuki, Ohashi, Isao, Yamane, Yoshinobu, Okada, Toshimi, Matsushima, Tomohiro, Matsui, Junji, Iwata, Masao, Uenaka, Toshimitsu, Tsuruoka, Akihiko

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Abstract 196: Antitumor activity of lenvatinib against acquired resistance tumor to anti-VEGF therapy in mouse syngeneic tumor models von Ichikawa, Kenji, Miyano, Saori Watanabe, Minoshima, Yukinori, Matsui, Junji, Funahashi, Yasuhiro

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Inhibition of FGFR Reactivates IFNγ Signaling in Tumor Cells to Enhance the Combined Antitumor Activity of Lenvatinib with Anti-PD-1 Antibodies von Adachi, Yusuke, Kamiyama, Hiroshi, Ichikawa, Kenji, Fukushima, Sayo, Ozawa, Yoichi, Yamaguchi, Shogo, Goda, Satoshi, Kimura, Takayuki, Kodama, Kotaro, Matsuki, Masahiro, Miyano, Saori Watanabe, Yokoi, Akira, Kato, Yu, Funahashi, Yasuhiro

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Abstract 190: Lenvatinib induced cell death of cultured human hepatocellular carcinoma (HCC) under nutrient-starved condition through inhibition of FGFR signaling pathway von Hoshi, Taisuke, Miyano, Saori Watanabe, Sonobe, Regina Mikie Kanada, Watanabe, Hideki, Seki, Yuki, Ohta, Etsuko, Nomoto, Kenichi, Matsui, Junji, Funahashi, Yasuhiro

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Abstract 3778: In vitro and in vivo characterization of E7090, a novel and selective FGFR inhibitor, for the treatment of endometrial cancer von Miyano, Saori Watanabe, Yamamoto, Yuji, Kodama, Kotaro, Sugi, Naoko Hata, Minoshima, Yukinori, Matsui, Junji, Iwata, Masao

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Abstract 1830: E7386, a selective inhibitor of the interaction between β-catenin and CREB-binding protein (CBP), in combination with lenvatinib (LEN), exerts antitumor activity in... von Kawano, Satoshi, Adachi, Yusuke, Kuronishi, Megumi, Toshimitsu, Kohta, Kodama, Kotaro, Kimura, Takayuki, Kume, Masahiko, Shen, Jialing, Miyano, Saori Watanabe, Yokoi, Akira, Matsui, Junji, Kato, Yu, Funahashi, Yasuhiro

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Abstract 1374: Lenvatinib, tri-specific targeted therapy to VEGFR/FGFR/RET, suppresses angiogenesis through the inhibition of both VEGFR and FGFR signaling pathways von Ichikawa, Kenji, Miyano, Saori Watanabe, Adachi, Yusuke, Yamamoto, Yuji, Ozawa, Yoichi, Funahashi, Yasuhiro, Okamoto, Kiyoshi, Nomoto, Kenichi, Matsui, Junji

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Synthesis and structure–activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors von Nagao, Satoshi, Yamane, Yoshinobu, Funasaka, Setsuo, Tanaka, Keigo, Miyazaki, Kazuki, Kotake, Yoshihiko, Kamata, Jun-ichi, Watanabe-Miyano, Saori, Toyama, Osamu, Ozawa, Yoichi, Mizui, Yoshiharu, Okamoto, Kiyoshi, Ito, Daisuke

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