Discovery of 2-[(E)-2-(7-Fluoro-3-methylquinoxalin-2-yl)vinyl]-6-pyrrolidin-1-yl-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine Hydrochloride as a Highly Selective PDE10A Inhibitor von Kadoh, Yoichi, Miyoshi, Haruko, Matsumura, Takehiko, Tanaka, Yoshihito, Hongu, Mitsuya, Kimura, Mayumi, Takedomi, Kei, Omori, Kenji, Kotera, Jun, Sasaki, Takashi, Kobayashi, Tamaki, Taniguchi, Hiroyuki, Watanabe, Yumi, Kojima, Koki, Sakamoto, Toshiaki, Himiyama, Toshiyuki, Kawanishi, Eiji

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Discovery of Canagliflozin, a Novel C-Glucoside with Thiophene Ring, as Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes Mellitus von Nomura, Sumihiro, Sakamaki, Shigeki, Hongu, Mitsuya, Kawanishi, Eiji, Koga, Yuichi, Sakamoto, Toshiaki, Yamamoto, Yasuo, Ueta, Kiichiro, Kimata, Hirotaka, Nakayama, Keiko, Tsuda-Tsukimoto, Minoru

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Na+-Glucose Cotransporter (SGLT) Inhibitors as Antidiabetic Agents. 4. Synthesis and Pharmacological Properties of 4‘-Dehydroxyphlorizin Derivatives Substituted on the B Ring von Tsujihara, Kenji, Hongu, Mitsuya, Saito, Kunio, Kawanishi, Hiroyuki, Kuriyama, Kayoko, Matsumoto, Mamoru, Oku, Akira, Ueta, Kiichiro, Tsuda, Minoru, Saito, Akira

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Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety von Koizumi, Yuuki, Tanaka, Yoshihito, Matsumura, Takehiko, Kadoh, Yoichi, Miyoshi, Haruko, Hongu, Mitsuya, Takedomi, Kei, Kotera, Jun, Sasaki, Takashi, Taniguchi, Hiroyuki, Watanabe, Yumi, Takakuwa, Misae, Kojima, Koki, Baba, Nobuyuki, Nakamura, Itsuko, Kawanishi, Eiji

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Na+-glucose cotransporter inhibitors as antidiabetics. I. Synthesis and pharmacological properties of 4'-dehydroxyphlorizin derivatives based on a new concept von TSUJIHARA, K, HONGU, M, SAITO, K, INAMASU, M, ARAKAWA, K, OKU, A, MATSUMOTO, M

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Solid-Liquid Phase Transfer Catalyzed Novel Glycosylation Reaction of Phenols von Hongu, Mitsuya, Saito, Kunio, Tsujihara, Kenji

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C-Glucosides with heteroaryl thiophene as novel sodium-dependent glucose cotransporter 2 inhibitors von Koga, Yuichi, Sakamaki, Shigeki, Hongu, Mitsuya, Kawanishi, Eiji, Sakamoto, Toshiaki, Yamamoto, Yasuo, Kimata, Hirotaka, Nakayama, Keiko, Kuriyama, Chiaki, Matsushita, Yasuaki, Ueta, Kiichiro, Tsuda-Tsukimoto, Minoru, Nomura, Sumihiro

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Na+-Glucose Cotransporter Inhibitors as Antidiabetic Agents. II. Synthesis and Structure-Activity Relationships of 4'-Dehydroxyphlorizin Derivatives von HONGU, Mitsuya, TANAKA, Takashi, FUNAMI, Nobuyuki, SAITO, Kunio, ARAKAWA, Kenji, MATSUMOTO, Mamoru, TSUJIHARA, Kenji

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Na+-Glucose Cotransporter Inhibitors as Antidiabetic Agents. III. Synthesis and Pharmacological Properties of 4'-Dehydroxyphlorizin Derivatives Modified at the OH Groups of the Glu... von HONGU, Mitsuya, FUNAMI, Nobuyuki, TAKAHASHI, Youichi, SAITO, Kunio, ARAKAWA, Kenji, MATSUMOTO, Mamoru, YAMAKITA, Hirokazu, TSUJIHARA, Kenji

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Total synthesis of (+)-fumitremorgin B, its epimeric isomers, and demethoxy derivatives von Kodato, Shin-ichi, Nakagawa, Masako, Hongu, Mitsuya, Kawate, Tomohiko, Hino, Tohru

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Synthesis and Biological Activity of O-Alkyl-3-N-aminoacyloxymethyl-5-fluoro-2'-deoxyuridine Derivatives von HARADA, Naoyuki, HONGU, Mitsuya, KAWAGUCHI, Takayuki, OHOHASHI, Motoaki, ODA, Kouji, HASHIYAMA, Tomiki, TSUJIHARA, Kenji

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Compostos de pirazolopirimidina, composições relacionadas e seu uso como inibidores de pde10 von Kawanishi Eiji, Tanaka Yoshihito, Hongu Mitsuya

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PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS von KAWANISHI, EIJI, TANAKA, YOSHIHITO, HONGU, MITSUYA

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Pyrazolopyrimidine compounds and their use as PDE10 inhibitors von TANAKA YOSHIHITO, HONGU MITSUYA, KAWANISHI EIJI

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PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS von KAWANISHI, EIJI, TANAKA, YOSHIHITO, HONGU, MITSUYA

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Pyrazolopyrimidine compounds and their use as PDE10 inhibitors von KAWANISHI, EIJI, TANAKA, YOSHIHITO, HONGU, MITSUYA

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NOVEL SGLT INHIBITORS von NOMURA, SUMIHIRO, HONGU, MITSUYA

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PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS von KAWANISHI, EIJI, TANAKA, YOSHIHITO, HONGU, MITSUYA

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NOVEL SGLT INHIBITORS von NOMURA, SUMIHIRO, HONGU, MITSUYA

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Novel SGLT inhibitors von HONGU MITSUYA, NOMURA SUMIHIRO

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