Managing Difficult Encounters: Understanding Physician, Patient, and Situational Factors von Lorenzetti, Rosemarie Cannarella, MD, MPH, Jacques, C.H. Mitch, MD, PhD, Donovan, Carolyn, DNP, PMHCNS-BC, FNP-C, Cottrell, Scott, EdD, Buck, Joy, RN, PhD

Volltext

Preclinical predictors that the orthosteric mGlu2/3 receptor antagonist LY3020371 will not engender ketamine-associated neurotoxic, motor, cognitive, subjective, or abuse-liability... von Witkin, J M, Monn, J A, Li, J, Johnson, B, McKinzie, D L, Wang, X-S, Heinz, B A, Li, R, Ornstein, P L, Smith, S C, Mitch, C H, Calligaro, D O, Swanson, S, Allen, D, Phillips, K, Gilmour, G

Volltext

Comparative Effects of LY3020371, a Potent and Selective Metabotropic Glutamate (mGlu) 2/3 Receptor Antagonist, and Ketamine, a Noncompetitive N -Methyl-d-Aspartate Receptor Antago... von Witkin, J M, Mitchell, S N, Wafford, K A, Carter, G, Gilmour, G, Li, J, Eastwood, B J, Overshiner, C, Li, X, Rorick-Kehn, L, Rasmussen, K, Anderson, W H, Nikolayev, A, Tolstikov, V V, Kuo, M-S, Catlow, J T, Li, R, Smith, S C, Mitch, C H, Ornstein, P L, Swanson, S, Monn, J A

Volltext

Localization of opioid receptor antagonist [ 3H]-LY255582 binding sites in mouse brain: Comparison with the distribution of mu, delta and kappa binding sites von Gackenheimer, S.L., Suter, T.M., Pintar, J.E., Quimby, S.J., Wheeler, W.J., Mitch, C.H., Gehlert, D.R., Statnick, M.A.

Volltext

Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects von Bymaster, Frank P., Carter, Petra A., Peters, Steven C., Zhang, Wei, Ward, John S., Mitch, Charles H., Calligaro, David O., Whitesitt, Celia A., DeLapp, Neil, Shannon, Harlan E., Rimvall, Karin, Jeppesen, Lone, Sheardown, Malcolm J., Fink-Jensen, Anders, Sauerberg, Per

Volltext

Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines von Sauerberg, Per, Olesen, Preben H, Nielsen, Susanne, Treppendahl, Svend, Sheardown, Malcolm J, Honore, Tage, Mitch, Charles H, Ward, John S, Pike, Andrew J

Volltext

Novel functional M1 selective muscarinic agonists. 2. Synthesis and structure-activity relationships of 3-pyrazinyl-1,2,5,6-tetrahydro-1-methylpyridines. Construction of a molecula... von Ward, John S, Merritt, Leander, Klimkowski, V. J, Lamb, M. L, Mitch, C. H, Bymaster, F. P, Sawyer, B, Shannon, H. E, Olesen, Preben H

Volltext

Muscarinic Analgesics with Potent and Selective Effects on the Gastrointestinal Tract:  Potential Application for the Treatment of Irritable Bowel Syndrome von Mitch, Charles H, Brown, Thomas J, Bymaster, Frank P, Calligaro, David O, Dieckman, Donna, Merrit, Leander, Peters, Steven C, Quimby, Steven J, Shannon, Harlan E, Shipley, Lisa A, Ward, John S, Hansen, Kristian, Olesen, Preben H, Sauerberg, Per, Sheardown, Malcolm J, Swedberg, Michael D. B, Suzdak, Peter, Greenwood, Beverley

Volltext

Synthesis and excitatory amino acid pharmacology of a series of heterocyclic-fused quinoxalinones and quinazolinones von McQuaid, Loretta A, Smith, Edward C. R, South, Kimberly K, Mitch, Charles H, Schoepp, Darryle D, True, Rebecca A, Calligaro, David O, O'Malley, Patrick J, Lodge, David, Ornstein, Paul L

Volltext

1,2,5-Thiadiazole Analogues of Aceclidine as Potent m1 Muscarinic Agonists von Ward, John S, Merritt, Leander, Calligaro, David O, Bymaster, Franklin P, Shannon, Harlan E, Mitch, Charles H, Whitesitt, Celia, Brunsting, David, Sheardown, Malcolm J, Olesen, Preben H, Swedberg, Michael D. B, Jeppesen, Lone, Sauerberg, Per

Volltext

3-(3-Alkylthio-1,2,5-thiadiazol-4-yl)-1-azabicycles. Structure—activity relationships for antinociception mediated by central muscarinic receptors von Olesen, PH, Sauerberg, P, Treppendahl, S, Larsson, O, Sheardown, MJ, Suzdak, PD, Mitch, CH, Ward, JS, Bymaster, FP, Shannon, HE, Swedberg, MDB

Volltext

Potential role of muscarinic receptors in schizophrenia von Bymaster, Frank P., Shannon, Harlan E., Rasmussen, Kurt, DeLapp, Neil W., Ward, John S., Calligaro, David O., Mitch, Charles H., Whitesitt, Celia, Ludvigsen, Thomas S., Sheardown, Malcolm, Swedberg, Michael, Rasmussen, Thøger, Olesen, Preben H., Jeppesen, Lone, Sauerberg, Per, Fink-Jensen, Anders

Volltext

Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5 R,6 R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane von Bymaster, Frank P, Shannon, Harlan E, Rasmussen, Kurt, Delapp, Neil W, Mitch, Charles H, Ward, John S, Calligaro, David O, Ludvigsen, Thomas S, Sheardown, Malcolm J, Olesen, Preben H, Swedberg, Michael D.B, Sauerberg, Per, Fink-Jensen, Anders

Volltext

Application of metalated enamines to alkaloid synthesis. An expedient approach to the synthesis of morphine-based analgesics von Evans, D. A, Mitch, C. H, Thomas, R. C, Zimmerman, D. M, Robey, R. L

Volltext

Novel alkoxy-oxazolyl-tetrahydropyridine muscarinic cholinergic receptor antagonists von Shannon, H E, Bymaster, F P, Hendrix, J C, Quimby, S J, Mitch, C H

Volltext

Steric and electronic requirements for muscarinic receptor-stimulated phosphoinositide turnover in the CNS in a series of arecoline bioisosteres von Ngur, Dan, Roknich, Scott, Mitch, Charles H., Quimby, Steven J., Ward, John S., Merritt, Leander, Sauerberg, Per, Messer, William S., Hoss, Wayne

Volltext

Effect of 4-(4-methoxy-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,3,6-tetrahydropyridine, an analog of MPTP, on mouse heart norepinephrine and brain catecholamines von Hemrick-Luecke, Susan K., Mitch, Charles H., Quimby, Stephen J., Fuller, Ray W.

Volltext

Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for .mu.- and .kappa.-opioid receptors von Zimmerman, Dennis M, Leander, J. David, Cantrell, Buddy E, Reel, Jon K, Snoddy, John, Mendelsohn, Laurane G, Johnson, Bryan G, Mitch, Charles H

Volltext

The muscarinic M1 agonist xanomeline increases soluble amyloid precursor protein release from chinese hamster ovary-m1 cells von Eckols, Kris, Bymaster, Frank P., Mitch, Charles H., Shannon, Harlan E., Ward, John S., DeLapp, Neil W.

Volltext

3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity von Mitch, Charles H, Leander, J. David, Mendelsohn, Laurane G, Shaw, Walter N, Wong, David T, Cantrell, Buddy E, Johnson, Bryan G, Reel, John K, Snoddy, John D

Volltext