MMP-13 selective alpha-sulfone hydroxamates: Identification of selective P1′ amides von Fobian, Yvette M., Freskos, John N., Barta, Thomas E., Bedell, Louis J., Heintz, Robert, Kassab, Darren J., Kiefer, James R., Mischke, Brent V., Molyneaux, John M., Mullins, Patrick, Munie, Grace E., Becker, Daniel P.

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Design of potent inhibitors of human β-secretase. Part 1 von Freskos, John N., Fobian, Yvette M., Benson, Timothy E., Bienkowski, Michael J., Brown, David L., Emmons, Thomas L., Heintz, Robert, Laborde, Alice, McDonald, Joseph J., Mischke, Brent V., Molyneaux, John M., Moon, Joseph B., Mullins, Patrick B., Bryan Prince, D., Paddock, Donna J., Tomasselli, Alfredo G., Winterrowd, Gregory

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Design, Synthesis, and Biological Evaluation of 3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a Potent, Orally Ac... von Hughes, Robert O, Rogier, D. Joseph, Jacobsen, E. Jon, Walker, John K, MacInnes, Alan, Bond, Brian R, Zhang, Lena L, Yu, Ying, Zheng, Yi, Rumsey, Jeanne M, Walgren, Jennie L, Curtiss, Sandra W, Fobian, Yvette M, Heasley, Steven E, Cubbage, Jerry W, Moon, Joseph B, Brown, David L, Acker, Brad A, Maddux, Todd M, Tollefson, Mike B, Mischke, Brent V, Owen, Dafydd R, Freskos, John N, Molyneaux, John M, Benson, Alan G, Blevis-Bal, Rhadika M

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Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system von Hughes, Robert O., Walker, John K., Cubbage, Jerry W., Fobian, Yvette M., Rogier, D. Joseph, Heasley, Steve E., Blevis-Bal, Rhadika M., Benson, Alan G., Owen, Dafydd R., Jacobsen, E. Jon, Freskos, John N., Molyneaux, John M., Brown, David L., Stallings, William C., Acker, Brad A., Maddux, Todd M., Tollefson, Mike B., Williams, Jennifer M., Moon, Joseph B., Mischke, Brent V., Rumsey, Jeanne M., Zheng, Yi, MacInnes, Alan, Bond, Brian R., Yu, Ying

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Design of potent inhibitors of human β-secretase. Part 2 von Freskos, John N., Fobian, Yvette M., Benson, Timothy E., Moon, Joseph B., Bienkowski, Michael J., Brown, David L., Emmons, Thomas L., Heintz, Robert, Laborde, Alice, McDonald, Joseph J., Mischke, Brent V., Molyneaux, John M., Mullins, Patrick B., Bryan Prince, D., Paddock, Donna J., Tomasselli, Alfredo G., Winterrowd, Greg

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Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors von Owen, Dafydd R., Walker, John K., Jon Jacobsen, E., Freskos, John N., Hughes, Robert O., Brown, David L., Bell, Andrew S., Brown, David G., Phillips, Christopher, Mischke, Brent V., Molyneaux, John M., Fobian, Yvette M., Heasley, Steve E., Moon, Joseph B., Stallings, William C., Joseph Rogier, D., Fox, David N.A., Palmer, Michael J., Ringer, Tracy, Rodriquez-Lens, Margarita, Cubbage, Jerry W., Blevis-Bal, Radhika M., Benson, Alan G., Acker, Brad A., Maddux, Todd M., Tollefson, Michael B., Bond, Brian R., MacInnes, Alan, Yu, Yung

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Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: Discovery of 3-[( trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4- b]py... von Hughes, Robert O., Walker, John K., Joseph Rogier, D., Heasley, Steve E., Blevis-Bal, Rhadika M., Benson, Alan G., Jon Jacobsen, E., Cubbage, Jerry W., Fobian, Yvette M., Owen, Dafydd R., Freskos, John N., Molyneaux, John M., Brown, David L., Acker, Brad A., Maddux, Todd M., Tollefson, Mike B., Moon, Joseph B., Mischke, Brent V., Rumsey, Jeanne M., Zheng, Yi, MacInnes, Alan, Bond, Brian R., Yu, Ying

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Synthesis and identification of conformationally constrained selective MMP inhibitors von Freskos, John N., McDonald, Joseph J., Mischke, Brent V., Mullins, Patrick B., Shieh, Huey-Sheng, Stegeman, Roderick A., Stevens, Anna M.

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Discovery of a novel series of selective MMP inhibitors: Identification of the γ-sulfone-thiols von Freskos, John N., Mischke, Brent V., DeCrescenzo, Gary A., Heintz, Robert, Getman, Daniel P., Howard, Susan C., Kishore, Nandini N., McDonald, Joseph J., Munie, Grace E., Rangwala, Shaukat, Swearingen, Craig A., Voliva, Charles, Welsch, Dean J.

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(Hydroxyethyl) sulfonamide HIV-1 Protease inhibitors: Identification of the 2-methylbenzoyl moiety at P-2 von Freskos, John N., Bertenshaw, Deborah E., Getman, Daniel P., Heintz, Robert M., Mischke, Brent V., Blystone, Lisa W., Bryant, Martin L., Funckes-Shippy, Christine, Houseman, Kathyrn A., Kishore, Nandini N., Kocan, Geralyn P., Mehta, Pramod P.

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Thiol sulfonamide metalloprotease inhibitors von DeCrescenzo, Gary, Abbas, Zaheer S, Freskos, John N, Getman, Daniel P, Heintz, Robert M, Mischke, Brent V, McDonald, Joseph J

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Thiol sulfonamide metalloprotease inhibitors von MISCHKE BRENT V, DECRESCENZO GARY, HEINTZ ROBERT M, FRESKOS JOHN N, GETMAN DANIEL P, ABBAS ZAHEER S, MCDONALD JOSEPH J

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INHIBIDORES DE METALOPROTEASA DE TIOL SULFONA von ABBAS, ZAHEER, S, MISCHKE, BRENT, V, FRESKOS, JOHN, N, DECRESCENZO, GARY, A, GETMAN, DANIEL, P, HEINTZ, ROBERT, M

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Tiolsulfonamidmetalloproteaseinhibitorer, farmasöytisk sammensetning innbefattende samme og anvendelse av samme for fremstilling avmedikament von DECRESCENZO, GARY, FRESKOS, JOHN N, GETMAN, DANIEL P, MISCHKE, BRENT V, MCDONALD, JOSEPH J, ABBAS, ZAHEER, HEINTZ, ROBERT M

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Thiol sulfonamide metalloprotease inhibitors von DECRESCENZO GARY A, MISCHKE BRENT V, HEINTZ ROBERT M, FRESKOS JOHN N, GETMAN DANIEL P, ABBAS ZAHEER S, MCDONALD JOSEPH J

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Sulfonyl aryl or heteroaryl hydroxamic acid compounds von SHASHIDHAR RAO N, VILLAMIL CLARA I, DECRESCENZO GARY A, MISCHKE BRENT V, BEDELL LOUIS J, BARTA THOMAS E, FRESKOS JOHN N, BECKER DANIEL P, GETMAN DANIEL P, MCDONALD JOSEPH J

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Sulfonyl aryl or heteroaryl hydroxamic acid compounds von Bedell, Louis J, McDonald, Joseph J, Barta, Thomas E, Becker, Daniel P, Shashidhar, Rao N, Freskos, John N, Mischke, Brent V, Getman, Daniel P, DeCrescenzo, Gary A, Villamil, Clara I

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THIOL SULFONAMIDE METALLOPROTEASE INHIBITORS von DECRESCENZO, GARY, ABBAS, ZAHEER, S, MISCHKE, BRENT, V, FRESKOS, JOHN, N, GETMAN, DANIEL, P, MCDONALD, JOSEPH, J, HEINTZ, ROBERT, M

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Salts of thiol sulfonamide inhibitors for matrix metalloproteinase 13 (MMP-13) von DECRESCENZO, GARY, FRESKOS, JOHN N, GETMAN, DANIEL P, ABBAS, ZAHEER S, MISCHKE, BRENT V, MCDONALD, JOSEPH J, HEINTZ, ROBERT M

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Thiol sulfonamide metalloprotease inhibitors von JOHN N. FRESKOS, DANIEL P. GETMAN, ZAHEER S. ABBAS, GARY DECRESCENZO, ROBERT M. HEINTZ, BRENT V. MISCHKE, JOSEPH J MCDONALD

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